20-Hydroxyeicosatetraenoic acid (BioDeep_00000001716)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid

化学式: C20H32O3 (320.23513219999995)
中文名称: 20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.24%

分子结构信息

SMILES: C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO
InChI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-

描述信息

20-Hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid. Cytochrome P450 enzymes of the 4A and 4F families catalyze the omega-hydroxylation of arachidonic acid and produce 20-HETE. 20-HETE is a potent constrictor of renal, cerebral, and mesenteric arteries. The vasoconstrictor response to 20-HETE is associated with activation of protein kinase, Rho kinase, and the mitogen-activated protein (MAP) kinase pathway C. 20-HETE also increases intracellular Ca2+ by causing the depolarization of vascular smooth muscle membrane secondary to blocking the large-conductance Ca2+-activated K+-channels and by a direct effect on L-type Ca channels. Elevations in the production of 20-HETE mediate the myogenic response of skeletal, renal, and cerebral arteries to elevations in transmural pressure. There is an important interaction between nitric oxide (NO) and the formation of 20-HETE production. NO inhibits the formation of 20-HETE formation in renal and cerebral arteries. A fall in levels of 20-HETE contributes to the cyclic GMP-independent dilator effect of NO to activate the large-conductance Ca2+-activated K+-channels and to dilate the cerebral arteries (PMID: 16258232).
Metabolite produced during NADPH dependent enzymatic oxidation of arachidonic acid. Potent vasoconstrictor [CCD]

同义名列表

20 个代谢物同义名

(5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid; (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate; (all-Z)-20-Hydroxy-5,8,11,14-eicosatetraenoic acid; 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid; 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; (all-Z)-20-Hydroxy-5,8,11,14-eicosatetraenoate; 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate; 20-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate; 20-Hydroxy-5,8,11,14-eicosatetraenoic acid; 20-Hydroxy-5,8,11,14-eicosatetraenoate; 20-Hydroxyeicosatetraenoic acid; 20-Hydroxyicosatetraenoic acid; 20-Hydroxyeicosatetraenoate; 20-Hydroxyarachlidonic acid; 20-hydroxy Arachidonic Acid; 20-Hydroxyicosatetraenoate; 20-Hydroxyarachidonic acid; 20-Hydroxy arachidonate; 20-Hydroxyarachidonate; 20-HETE



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

111 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Karla Johanna Ruth Hoyer-Allo, Martin Richard Späth, Susanne Brodesser, Yiyi Zhu, Julia Binz-Lotter, Martin Höhne, Hella Brönneke, Katrin Bohl, Marc Johnsen, Torsten Kubacki, Katharina Kiefer, Lisa Seufert, Felix Carlo Koehler, Franziska Grundmann, Matthias J Hackl, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, Roman-Ulrich Müller. Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury. Kidney international. 2022 09; 102(3):560-576. doi: 10.1016/j.kint.2022.04.033. [PMID: 35654224]
  • Teng Wang, Yiqun Han, Haonan Li, Yanhua Fang, Pengfei Liang, Yanwen Wang, Xi Chen, Xinghua Qiu, Jicheng Gong, Weiju Li, Tong Zhu. Fine particulate matter and vasoactive 20-hydroxyeicosatetraenoic acid: Insights into the mechanisms of the prohypertensive effects of particulate air pollution. The Science of the total environment. 2022 Feb; 806(Pt 3):151298. doi: 10.1016/j.scitotenv.2021.151298. [PMID: 34749965]
  • Ghezal Froogh, Victor Garcia, Michal Laniado Schwartzman. The CYP/20-HETE/GPR75 axis in hypertension. Advances in pharmacology (San Diego, Calif.). 2022; 94(?):1-25. doi: 10.1016/bs.apha.2022.02.003. [PMID: 35659370]
  • Mercedes Muñoz, Elvira López-Oliva, Estéfano Pinilla, Claudia Rodríguez, María Pilar Martínez, Cristina Contreras, Alfonso Gómez, Sara Benedito, Javier Sáenz-Medina, Luis Rivera, Dolores Prieto. Differential contribution of renal cytochrome P450 enzymes to kidney endothelial dysfunction and vascular oxidative stress in obesity. Biochemical pharmacology. 2022 01; 195(?):114850. doi: 10.1016/j.bcp.2021.114850. [PMID: 34822809]
  • Matthew J Kuhn, Lorraine M Sordillo. Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes. Journal of animal physiology and animal nutrition. 2022 Jan; 106(1):55-60. doi: 10.1111/jpn.13547. [PMID: 33851747]
  • Michał Majewski, Jerzy Juśkiewicz, Magdalena Krajewska-Włodarczyk, Leszek Gromadziński, Katarzyna Socha, Ewelina Cholewińska, Katarzyna Ognik. The Role of 20-HETE, COX, Thromboxane Receptors, and Blood Plasma Antioxidant Status in Vascular Relaxation of Copper-Nanoparticle-Fed WKY Rats. Nutrients. 2021 Oct; 13(11):. doi: 10.3390/nu13113793. [PMID: 34836047]
  • Anne Barden, Michael Phillips, Sujata Shinde, Tomas Corcoran, Trevor A Mori. The effects of perioperative dexamethasone on eicosanoids and mediators of inflammation resolution: A sub-study of the PADDAG trial. Prostaglandins, leukotrienes, and essential fatty acids. 2021 10; 173(?):102334. doi: 10.1016/j.plefa.2021.102334. [PMID: 34455200]
  • Agnieszka Kij, Anna Bar, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Agnieszka Jasztal, Anna Kieronska-Rudek, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Anna Tworzydlo, Camilla Enggaard, Pernille B Lærkegaard Hansen, Boye Jensen, Maria Walczak, Stefan Chlopicki. Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168664. [PMID: 34445374]
  • Yedan Liu, Huawei Zhang, Celeste Yc Wu, Tina Yu, Xing Fang, Jane J Ryu, Baoying Zheng, Zongbo Chen, Richard J Roman, Fan Fan. 20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility. Prostaglandins & other lipid mediators. 2021 06; 154(?):106548. doi: 10.1016/j.prostaglandins.2021.106548. [PMID: 33753221]
  • Jonathan V Pascale, Pamela A Lucchesi, Victor Garcia. Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches. Journal of cardiovascular pharmacology. 2021 06; 77(6):707-717. doi: 10.1097/fjc.0000000000001013. [PMID: 34016841]
  • Khong Trong Quan, Byung Gu Min, In Hyun Hwang, Yeon Jung Choi, Sang Kyum Kim, MinKyun Na. Oleanane triterpenoids from Rubia philippinensis and their inhibitory effect on 20-HETE synthesis. Natural product research. 2021 Apr; 35(8):1267-1273. doi: 10.1080/14786419.2019.1645656. [PMID: 31343260]
  • Wenxing Cui, Xun Wu, Yingwu Shi, Wei Guo, Jianing Luo, Haixiao Liu, Longlong Zheng, Yong Du, Ping Wang, Qiang Wang, Dayun Feng, Shunnan Ge, Yan Qu. 20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study. Cell proliferation. 2021 Feb; 54(2):e12964. doi: 10.1111/cpr.12964. [PMID: 33314534]
  • Ankit Gilani, Kevin Agostinucci, Sakib Hossain, Jonathan V Pascale, Victor Garcia, Adeniyi Michael Adebesin, John R Falck, Michal Laniado Schwartzman. 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance. Prostaglandins & other lipid mediators. 2021 02; 152(?):106485. doi: 10.1016/j.prostaglandins.2020.106485. [PMID: 33011364]
  • Bijun Zhang, Runhong Xu, Guicun Fang, Yanyan Zhao. 20-HETE downregulates Na/K-ATPase α1 expression via the ubiquitination pathway. Prostaglandins & other lipid mediators. 2021 02; 152(?):106503. doi: 10.1016/j.prostaglandins.2020.106503. [PMID: 33199266]
  • Jingjing Wu, Guangrui Lai, Fangjie Chen, Bijun Zhang, Yanyan Zhao. Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice. Kidney & blood pressure research. 2021; 46(5):601-612. doi: 10.1159/000517382. [PMID: 34320496]
  • Miriam C Wolters, Julia Schmetzer, Christine V Möser, Lisa Hahnefeld, Carlo Angioni, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers. Cells. 2020 09; 9(9):. doi: 10.3390/cells9092111. [PMID: 32948055]
  • Olga Gawrys, Zuzana Husková, Iwona Baranowska, Agnieszka Walkowska, Janusz Sadowski, Soňa Kikerlová, Zdeňka Vaňourková, Zuzana Honetschlägerová, Petra Škaroupková, Luděk Červenka, John R Falck, John D Imig, Elzbieta Kompanowska-Jezierska. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. Journal of hypertension. 2020 09; 38(9):1802-1810. doi: 10.1097/hjh.0000000000002462. [PMID: 32384390]
  • Vengai Mavangira, Jennifer Brown, Jeffery C Gandy, Lorraine M Sordillo. 20-hydroxyeicosatetraenoic acid alters endothelial cell barrier integrity independent of oxidative stress and cell death. Prostaglandins & other lipid mediators. 2020 08; 149(?):106425. doi: 10.1016/j.prostaglandins.2020.106425. [PMID: 32032703]
  • Yoshiko Ogawa, Junta Takahashi, Akihiro Sakuyama, Lusi Xu, Takahiro Miura, Yoshikazu Muroya, Daisuke Ito, Masahiro Kohzuki, Osamu Ito. Exercise training delays renal disorders with decreasing oxidative stress and increasing production of 20-hydroxyeicosatetraenoic acid in Dahl salt-sensitive rats. Journal of hypertension. 2020 07; 38(7):1336-1346. doi: 10.1097/hjh.0000000000002409. [PMID: 32205560]
  • Hanan Al-Lawati, Mohammad Reza Vakili, Afsaneh Lavasanifar, Surur Ahmed, Fakhreddin Jamali. Reduced Heart Exposure of Diclofenac by Its Polymeric Micellar Formulation Normalizes CYP-Mediated Metabolism of Arachidonic Acid Imbalance in An Adjuvant Arthritis Rat Model: Implications in Reduced Cardiovascular Side Effects of Diclofenac by Nanodrug Delivery. Molecular pharmaceutics. 2020 04; 17(4):1377-1386. doi: 10.1021/acs.molpharmaceut.0c00069. [PMID: 32023064]
  • Farsad Afshinnia, Lixia Zeng, Jaeman Byun, Stefanie Wernisch, Rajat Deo, Jing Chen, Lee Hamm, Edgar R Miller, Eugene P Rhee, Michael J Fischer, Kumar Sharma, Harold I Feldman, George Michailidis, Subramaniam Pennathur. Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2020 02; 35(2):303-312. doi: 10.1093/ndt/gfy232. [PMID: 30137494]
  • Danilo Giusepponi, Roberta Galarini, Carolina Barola, Pierangelo Torquato, Desirée Bartolini, Simone Moretti, Giorgio Saluti, Antimo Gioiello, Carmelo Libetta, Francesco Galli. LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum. Free radical biology & medicine. 2019 11; 144(?):134-143. doi: 10.1016/j.freeradbiomed.2019.04.017. [PMID: 31009660]
  • Rambabu Dakarapu, Ramu Errabelli, Vijaya L Manthati, Adeniyi Michael Adebesin, Deb K Barma, Deepan Barma, Victor Garcia, Fan Zhang, Michal Laniado Schwartzman, John R Falck. 19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. Bioorganic & medicinal chemistry letters. 2019 10; 29(19):126616. doi: 10.1016/j.bmcl.2019.08.020. [PMID: 31439380]
  • Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu, Andreas Pohlmann, Jan Hentschel, Karen Arakelyan, Erdmann Seeliger, Bert Flemming, Dennis Gürgen, Michael Rothe, Thoralf Niendorf, Vijaya L Manthati, John R Falck, Michael Haase, Wolf-Hagen Schunck, Duska Dragun. A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury. Acta physiologica (Oxford, England). 2019 10; 227(2):e13297. doi: 10.1111/apha.13297. [PMID: 31077555]
  • Shashank Shekhar, Kevin Varghese, Man Li, Letao Fan, George W Booz, Richard J Roman, Fan Fan. Conflicting Roles of 20-HETE in Hypertension and Stroke. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184500. [PMID: 31514409]
  • Shumei Ding, Jiajun Huang, Hongmei Qiu, Rongchun Chen, Jie Zhang, Bo Huang, Oumei Cheng, Qingsong Jiang. Effects of PPARs/20-HETE on the renal impairment under diabetic conditions. Experimental cell research. 2019 09; 382(1):111455. doi: 10.1016/j.yexcr.2019.05.036. [PMID: 31163124]
  • Shumei Ding, Hongmei Qiu, Jiajun Huang, Rongchun Chen, Jie Zhang, Bo Huang, Xunliang Zou, Oumei Cheng, Qingsong Jiang. Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy. Chemico-biological interactions. 2019 Jul; 307(?):116-124. doi: 10.1016/j.cbi.2019.05.004. [PMID: 31063766]
  • Li Chen, Samantha Tang, Frank F Zhang, Victor Garcia, John R Falck, Michal L Schwartzman, Ali S Arbab, Austin M Guo. CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells. American journal of physiology. Heart and circulatory physiology. 2019 06; 316(6):H1468-H1479. doi: 10.1152/ajpheart.00690.2018. [PMID: 30951365]
  • Petra Rocic, Michal Laniado Schwartzman. 20-HETE in the regulation of vascular and cardiac function. Pharmacology & therapeutics. 2018 12; 192(?):74-87. doi: 10.1016/j.pharmthera.2018.07.004. [PMID: 30048707]
  • Sara Bonafini, Alice Giontella, Angela Tagetti, Denise Marcon, Martina Montagnana, Marco Benati, Rossella Gaudino, Paolo Cavarzere, Mirjam Karber, Michael Rothe, Pietro Minuz, Franco Antonazzi, Claudio Maffeis, Wolf Hagen Schunck, Cristiano Fava. Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children. Nutrients. 2018 Nov; 10(11):. doi: 10.3390/nu10111689. [PMID: 30400671]
  • Yeon Jung Choi, Khong Trong Quan, InWha Park, Seung Jin Lee, Keon Wook Kang, MinKyun Na, Sang Kyum Kim. Discovery of rubiarbonone C as a selective inhibitor of cytochrome P450 4F enzymes. Archives of toxicology. 2018 11; 92(11):3325-3336. doi: 10.1007/s00204-018-2315-8. [PMID: 30259074]
  • Cristiano Fava, Sara Bonafini. Eicosanoids via CYP450 and cardiovascular disease: Hints from genetic and nutrition studies. Prostaglandins & other lipid mediators. 2018 11; 139(?):41-47. doi: 10.1016/j.prostaglandins.2018.10.001. [PMID: 30296490]
  • Ankit Gilani, Varunkumar Pandey, Victor Garcia, Kevin Agostinucci, Shailendra P Singh, Joseph Schragenheim, Lars Bellner, John R Falck, Mahesh P Paudyal, Jorge H Capdevila, Nader G Abraham, Michal Laniado Schwartzman. High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology. 2018 11; 315(5):R934-R944. doi: 10.1152/ajpregu.00125.2018. [PMID: 30088983]
  • Rong Rong, Gaizun Hu, Wanting Wang, Yoshikazu Muroya, Takahiro Miura, Yoshiko Ogawa, Masahiro Kohzuki, Osamu Ito. Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor. Prostaglandins & other lipid mediators. 2018 11; 139(?):80-86. doi: 10.1016/j.prostaglandins.2018.09.003. [PMID: 30227249]
  • Lenka Sedláková, Soňa Kikerlová, Zuzana Husková, Lenka Červenková, Věra Čertíková Chábová, Josef Zicha, John R Falck, John D Imig, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Vojtěch Krátký, Luděk Červenka, Libor Kopkan. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. Bioscience reports. 2018 10; 38(5):. doi: 10.1042/bsr20171496. [PMID: 30054426]
  • Chao Zhang, George W Booz, Qing Yu, Xiaochen He, Shaoxun Wang, Fan Fan. Conflicting roles of 20-HETE in hypertension and renal end organ damage. European journal of pharmacology. 2018 Aug; 833(?):190-200. doi: 10.1016/j.ejphar.2018.06.010. [PMID: 29886242]
  • Michael M Yeboah, Md Abdul Hye Khan, Marla A Chesnik, Melissa Skibba, Lauren L Kolb, John D Imig. Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2018 08; 33(8):1333-1343. doi: 10.1093/ndt/gfx354. [PMID: 29361048]
  • Xiaofan Zhang, Nagat El Demerdash, John R Falck, Sailu Munnuri, Raymond C Koehler, Zeng-Jin Yang. The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury. Prostaglandins & other lipid mediators. 2018 07; 137(?):63-68. doi: 10.1016/j.prostaglandins.2018.07.001. [PMID: 30041768]
  • Jianmin Chen, Alexander J P Hamers, Michaela Finsterbusch, Gianmichele Massimo, Maleeha Zafar, Roger Corder, Romain A Colas, Jesmond Dalli, Christoph Thiemermann, Amrita Ahluwalia. Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 07; 32(7):3816-3831. doi: 10.1096/fj.201701303r. [PMID: 29465314]
  • Ali Aghazadeh-Habashi, Waheed Asghar, Fakhreddin Jamali. Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid. Journal of pharmaceutical sciences. 2018 02; 107(2):756-763. doi: 10.1016/j.xphs.2017.09.020. [PMID: 28989019]
  • Guangrui Lai, Ru Sun, Jingjing Wu, Bijun Zhang, Yanyan Zhao. 20-HETE regulated PSMB5 expression via TGF-β/Smad signaling pathway. Prostaglandins & other lipid mediators. 2018 01; 134(?):123-130. doi: 10.1016/j.prostaglandins.2017.08.005. [PMID: 28807746]
  • Teresa Auguet, Gemma Aragonès, Marina Colom, Carmen Aguilar, Vicente Martín-Paredero, Núria Canela, Xavier Ruyra, Cristóbal Richart. Targeted metabolomic approach in men with carotid plaque. PloS one. 2018; 13(7):e0200547. doi: 10.1371/journal.pone.0200547. [PMID: 30011297]
  • Jessica L Faulkner, Nicole L Plenty, Kedra Wallace, Lorena M Amaral, Mark W Cunningham, Sydney Murphy, Babbette LaMarca. Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia. Prostaglandins & other lipid mediators. 2018 01; 134(?):108-113. doi: 10.1016/j.prostaglandins.2017.09.004. [PMID: 28951260]
  • Jianzhu Zhao, Bijun Zhang, Guangrui Lai, Runhong Xu, Guoming Chu, Yanyan Zhao. 20-Hydroxyeicosatetraenoic acid regulates the expression of Nedd4‑2 in kidney and liver through a neddylation modification pathway. Molecular medicine reports. 2017 Dec; 16(6):9671-9677. doi: 10.3892/mmr.2017.7803. [PMID: 29039560]
  • Varunkumar Pandey, Victor Garcia, Ankit Gilani, Priyanka Mishra, Frank Fan Zhang, Mahesh P Paudyal, John R Falck, Alberto Nasjletti, Wen-Hui Wang, Michal Laniado Schwartzman. The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis. The Journal of pharmacology and experimental therapeutics. 2017 12; 363(3):412-418. doi: 10.1124/jpet.117.243618. [PMID: 28912346]
  • Vacis Tatarunas, Nora Kupstyte, Agne Giedraitiene, Vilius Skipskis, Valdas Jakstas, Vaidotas Zvikas, Vaiva Lesauskaite. The impact of CYP2C19*2, CYP4F2*3, and clinical factors on platelet aggregation, CYP4F2 enzyme activity, and 20-hydroxyeicosatetraenoic acid concentration in patients treated with dual antiplatelet therapy. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2017 Dec; 28(8):658-664. doi: 10.1097/mbc.0000000000000658. [PMID: 28806186]
  • Anne E Barden, Venus Chavez, Michael Phillips, Emilie Mas, Lawrence J Beilin, Kevin D Croft, Trevor A Mori, Ian B Puddey. A Randomized Trial of Effects of Alcohol on Cytochrome P450 Eicosanoids, Mediators of Inflammation Resolution, and Blood Pressure in Men. Alcoholism, clinical and experimental research. 2017 Oct; 41(10):1666-1674. doi: 10.1111/acer.13466. [PMID: 28767146]
  • Mohamed M Katary, Chelsey Pye, Ahmed A Elmarakby. Meloxicam fails to augment the reno-protective effects of soluble epoxide hydrolase inhibition in streptozotocin-induced diabetic rats via increased 20-HETE levels. Prostaglandins & other lipid mediators. 2017 09; 132(?):3-11. doi: 10.1016/j.prostaglandins.2016.08.004. [PMID: 27596333]
  • Feifei Huang, Yang Liu, Xia Yang, Di Che, Kaifeng Qiu, Bruce D Hammock, Jingfeng Wang, Mong-Heng Wang, Jie Chen, Hui Huang. Shexiang Baoxin pills promotes angiogenesis in myocardial infarction rats via up-regulation of 20-HETE-mediated endothelial progenitor cells mobilization. Atherosclerosis. 2017 08; 263(?):184-191. doi: 10.1016/j.atherosclerosis.2017.06.012. [PMID: 28646793]
  • Matthew E Albertolle, Donghak Kim, Leslie D Nagy, Chul-Ho Yun, Ambra Pozzi, Üzen Savas, Eric F Johnson, F Peter Guengerich. Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. The Journal of biological chemistry. 2017 07; 292(27):11230-11242. doi: 10.1074/jbc.m117.792200. [PMID: 28533430]
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