dTDP (BioDeep_00000001708)
Secondary id: BioDeep_00000400418, BioDeep_00001868846
natural product human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C10H16N2O11P2 (402.0229)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(otcml) 7.85%
分子结构信息
SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1
描述信息
Is an intermediate in the Thymidylate kinase (EC 2.7.4.9; ATP:dTMP phosphotransferase) catalyzes the phosphorylation of dTMP (to form dTDP) in the dTTP synthesis pathway for DNA synthesis. (OMIM 188345 ) [HMDB]. dTDP is found in many foods, some of which are bog bilberry, poppy, garden tomato, and chanterelle.
Is an intermediate in the Thymidylate kinase (EC 2.7.4.9; ATP:dTMP phosphotransferase) catalyzes the phosphorylation of dTMP (to form dTDP) in the dTTP synthesis pathway for DNA synthesis. (OMIM 188345 )
Acquisition and generation of the data is financially supported in part by CREST/JST.
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents
同义名列表
19 个代谢物同义名
{[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy}phosphonic acid; 2-Deoxyribosylthymine 5-(trihydrogen diphosphoric acid); 2-Deoxyribosylthymine 5-(trihydrogen diphosphate); Thymidine-5-diphosphate sodium salt; Deoxythymidine 5-diphosphate (dTDP); Deoxythymidine 5-diphosphoric acid; Thymidine 5-pyrophosphoric acid; THYMIDINE-5- diphosphoric acid; 2-Deoxythymidine 5-diphosphate; Thymidine 5-diphosphoric acid; Deoxythymidine 5-diphosphate; Thymidine 5-pyrophosphate; THYMIDINE-5- diphosphATE; Thymidine 5-diphosphate; Thymidine-5-diphosphate; Deoxy-TDP; dTDP; TDP; dTDP
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:18075
- KEGG: C00363
- PubChem: 164628
- PubChem: 1124
- HMDB: HMDB0001274
- Metlin: METLIN3520
- DrugBank: DB03103
- ChEMBL: CHEMBL259724
- Wikipedia: Thymidine_diphosphate
- MetaCyc: TDP
- KNApSAcK: C00019696
- foodb: FDB022528
- chemspider: 144320
- CAS: 491-97-4
- MoNA: PR100610
- MoNA: PS035707
- MoNA: PS035711
- MoNA: PS035708
- MoNA: PS035702
- MoNA: PS035704
- MoNA: PS035703
- PMhub: MS000001021
- PubChem: 3654
- PDB-CCD: TYD
- 3DMET: B01229
- NIKKAJI: J247.693B
- RefMet: dTDP
- KNApSAcK: 18075
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
33 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(3)
- pyrimidine deoxyribonucleotides de novo biosynthesis I:
H2O + dCTP ⟶ ammonia + dUTP - purine and pyrimidine metabolism:
adenosine + phosphate ⟶ α-D-ribose-1-phosphate + adenine - pyrimidine deoxyribonucleotides de novo biosynthesis I:
H2O + dCTP ⟶ ammonia + dUTP
Plant Reactome(0)
INOH(3)
- ATP + dTMP = ADP + dTDP ( Pyrimidine Nucleotides and Nucleosides metabolism ):
ATP + dTMP ⟶ ADP + dTDP - Pyrimidine Nucleotides and Nucleosides metabolism ( Pyrimidine Nucleotides and Nucleosides metabolism ):
Deoxy-cytidine + H2O ⟶ Deoxy-uridine + NH3 - ATP + dTDP = ADP + dTTP ( Pyrimidine Nucleotides and Nucleosides metabolism ):
ADP + dTTP ⟶ ATP + dTDP
PlantCyc(0)
PathBank(25)
- MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Pyrimidine Metabolism:
Hydrogen Ion + N-carbamoyl-L-aspartate ⟶ 4,5-Dihydroorotic acid + Water - Pyrimidine Metabolism:
Hydrogen Ion + N-carbamoyl-L-aspartate ⟶ 4,5-Dihydroorotic acid + Water - Pyrimidine Deoxyribonucleosides Salvage:
Deoxycytidine + Hydrogen Ion + Water ⟶ Ammonium + Deoxyuridine - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - beta-Ureidopropionase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Dihydropyrimidinase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - UMP Synthase Deficiency (Orotic Aciduria):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis:
L-Glutamic acid + dTDP-4-dehydro-6-deoxy-D-glucose ⟶ Oxoglutaric acid + dTDP-thomosamine - Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis 2:
L-Glutamic acid + dTDP-4-dehydro-6-deoxy-D-glucose ⟶ Oxoglutaric acid + dTDP-thomosamine - Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis 3:
L-Glutamic acid + dTDP-4-dehydro-6-deoxy-D-glucose ⟶ Oxoglutaric acid + dTDP-D-Fucosamine - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - beta-Ureidopropionase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Dihydropyrimidinase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - UMP Synthase Deficiency (Orotic Aciduria):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Pyrimidine Metabolism:
Hydrogen Ion + N-carbamoyl-L-aspartate ⟶ 4,5-Dihydroorotic acid + Water - Pyrimidine Metabolism:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - beta-Ureidopropionase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - UMP Synthase Deficiency (Orotic Aciduria):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - Dihydropyrimidinase Deficiency:
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine - MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy):
Deoxycytidine + Water ⟶ Ammonia + Deoxyuridine
PharmGKB(0)
4 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5665 - Leishmania mexicana: 10.1016/J.IJPDDR.2019.05.003
- 5691 - Trypanosoma brucei: 10.1371/JOURNAL.PNTD.0001618
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.
Chemico-biological interactions.
2015 Jun; 234(?):114-25. doi:
10.1016/j.cbi.2014.12.013. [PMID: 25526675] - Yun-Gon Kim, Hyung-Yeon Park, Dongwon Yoo, Changmin Sung, Eunjung Song, Jae-Hun Lee, Yun-Hui Choi, Yong-Hyun Kim, Chang-Soo Lee, Kyungmoon Park, Byung-Gee Kim, Yung-Hun Yang. Selective derivatization of nucleotide diphosphate (NDP)-4-keto sugars for electrospray ionization-mass spectrometry (ESI-MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Apr; 893-894(?):177-81. doi:
10.1016/j.jchromb.2012.02.045. [PMID: 22459405] - N Tarbouriech, S J Charnock, G J Davies. Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases.
Journal of molecular biology.
2001 Dec; 314(4):655-61. doi:
10.1006/jmbi.2001.5159. [PMID: 11733986] - H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor.
The Biochemical journal.
1975 Dec; 152(3):601-7. doi:
10.1042/bj1520601. [PMID: 5997]
