Prostaglandin E2 (BioDeep_00000001683)

 

Secondary id: BioDeep_00000629489, BioDeep_00001867832

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid

化学式: C20H32O5 (352.225)
中文名称: 前列腺素 E2, 地诺前列酮
谱图信息: 最多检出来源 Homo sapiens(plant) 13.8%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Prostaglandin E2. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/prostaglandin_e2 (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001683). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

描述信息

The naturally occurring prostaglandin E2 (PGE2) is known in medicine as dinoprostone, and it is the most common and most biologically active of the mammalian prostaglandins. It has important effects during labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bones mineralized matrix). PGE2 is also the prostaglandin that ultimately induces fever. PGE2 has been shown to increase vasodilation and cAMP production, enhance the effects of bradykinin and histamine, and induce uterine contractions and platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus, decreasing T-cell proliferation and lymphocyte migration, and activating the secretion of IL-1α and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation, and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC). PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype (PMID:16978535). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signalling pathways.
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2) and the most common and most biologically active of the mammalian prostaglandins. It has important effects in labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bones mineralized matrix). PGE2 has been shown to increase vasodilation and cAMP production, to enhance the effects of bradykinin and histamine, induction of uterine contractions and of platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus; decreasing T-cell proliferation and lymphocyte migration and activating the secretion of IL-1α and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC), and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. (PMID: 16978535)
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02A - Uterotonics > G02AD - Prostaglandins
Chemical was purchased from CAY14010, (Lot 0410966-34); Diagnostic ions: 351.8, 333.1, 271.1, 188.9
D012102 - Reproductive Control Agents > D010120 - Oxytocics
C78568 - Prostaglandin Analogue
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

同义名列表

60 个代谢物同义名

(5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid; (e,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid; (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,e)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid; (e,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoate; (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,e)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoate; (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-Oic acid; (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid; (5Z,11a,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-Oic acid; (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-Oate; (5Z,11Α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-Oic acid; (5Z,13E,15S)-11-alpha,15-Dihydroxy-9-oxoprost-5,13-dienoic acid; (5Z,11a,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-Oate; (5Z,11Α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-Oate; (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-11Α,15-dihydroxy-9-oxoprosta-5,13-dienoic acid; (5Z,13E)-(15S)-11a,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid; (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoic acid; (5Z,13E,15S)-11-alpha,15-Dihydroxy-9-oxoprost-5,13-dienoate; (5Z,13E)-(15S)-11a,15-Dihydroxy-9-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-11Α,15-dihydroxy-9-oxoprosta-5,13-dienoate; (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate; (5Z,13E)-(15S)-11a,15-Dihydroxy-9-oxoprost-13-enoic acid; (5Z,13E)-(15S)-11Α,15-dihydroxy-9-oxoprost-13-enoic acid; (5Z,13E)-(15S)-11a,15-Dihydroxy-9-oxoprost-13-enoate; (5Z,13E)-(15S)-11Α,15-dihydroxy-9-oxoprost-13-enoate; 9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid; e2 alpha, Prostaglandin; alpha, Prostaglandin e2; (15S)-Prostaglandin e2; Prostaglandin e2 alpha; e2alpha, Prostaglandin; Prostaglandin e2alpha; ent-Prostaglandin E2; (-)-Prostaglandin e2; L-Prostaglandin e2; e2, Prostaglandin; Prostaglandin E2; Prostaglandin e; Minprositin e2; Gel, prepidil; Minprostin e2; Dinoprostonum; Dinoprostone; 5-trans-PGE2; Prostarmon e; Prepidil gel; Dinoprostona; Dinoproston; alpha, PGE2; Prostin E2; PGE2 alpha; PGE2alpha; Prostenon; Cervidil; Prepidil; Prostin; Propess; Glandin; PGE2; Prostaglandin E2



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(11)

BioCyc(0)

PlantCyc(0)

代谢反应

233 个相关的代谢反应过程信息。

Reactome(181)

BioCyc(0)

WikiPathways(5)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

67 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, ALOX5, CAT, NFE2L2, NOS2, PTGS1, SLCO2A1, STAT3
Peripheral membrane protein 2 ALOX5, PTGS1
Endosome membrane 1 CD14
Endoplasmic reticulum membrane 2 HMOX1, PTGS1
Nucleus 5 ALB, HMOX1, NFE2L2, NOS2, STAT3
cytosol 7 ALB, ALOX5, CAT, HMOX1, NFE2L2, NOS2, STAT3
centrosome 2 ALB, NFE2L2
nucleoplasm 5 ALOX5, HMOX1, NFE2L2, NOS2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 CD14, CYSLTR2, SLCO2A1
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 2 CYSLTR2, SLCO2A1
Synapse 2 ACAN, TAC1
cell surface 1 PLA2G1B
glutamatergic synapse 1 ACAN
Golgi apparatus 4 ALB, CD14, NFE2L2, PTGS1
neuronal cell body 1 TAC1
Cytoplasm, cytosol 3 ALOX5, NFE2L2, NOS2
Lysosome 1 SLCO2A1
plasma membrane 8 CD14, CYSLTR2, NFE2L2, NOS2, REN, SLCO2A1, STAT3, TNFRSF11B
Membrane 4 CAT, HMOX1, REN, SLCO2A1
axon 1 TAC1
basolateral plasma membrane 1 SLCO2A1
extracellular exosome 4 ALB, CAT, CD14, PTGS1
endoplasmic reticulum 2 ALB, HMOX1
extracellular space 13 ACAN, ALB, ALOX5, CD14, GAST, HMOX1, IL17A, IL2, IL5, PLA2G1B, REN, TAC1, TNFRSF11B
lysosomal lumen 1 ACAN
perinuclear region of cytoplasm 3 ALOX5, HMOX1, NOS2
mitochondrion 1 CAT
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 2 CAT, PTGS1
Microsome membrane 1 PTGS1
Secreted 9 ALB, CD14, GAST, IL17A, IL2, IL5, PLA2G1B, REN, TNFRSF11B
extracellular region 13 ACAN, ALB, ALOX5, CAT, CD14, GAST, IL17A, IL2, IL5, PLA2G1B, REN, TAC1, TNFRSF11B
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 STAT3
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 2 CD14, IL17A
Secreted, extracellular space, extracellular matrix 1 ACAN
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
apical part of cell 1 REN
Cytoplasm, perinuclear region 2 ALOX5, NOS2
Membrane raft 1 CD14
focal adhesion 1 CAT
GABA-ergic synapse 1 ACAN
extracellular matrix 1 TNFRSF11B
Peroxisome 2 CAT, NOS2
basement membrane 1 ACAN
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ACAN
receptor complex 1 TNFRSF11B
neuron projection 1 PTGS1
ciliary basal body 1 ALB
chromatin 2 NFE2L2, STAT3
mediator complex 1 NFE2L2
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 CD14
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 1 PTGS1
side of membrane 1 CD14
basal plasma membrane 1 SLCO2A1
lipopolysaccharide receptor complex 1 CD14
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 2 ALOX5, CAT
secretory granule membrane 1 CD14
Golgi lumen 1 ACAN
endoplasmic reticulum lumen 1 ALB
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 ALB
perineuronal net 1 ACAN
Single-pass type IV membrane protein 1 HMOX1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
Basal cell membrane 1 SLCO2A1
protein-DNA complex 1 NFE2L2
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
Nucleus intermembrane space 1 ALOX5
perisynaptic extracellular matrix 1 ACAN
ciliary transition fiber 1 ALB


文献列表

  • Yazhen Xie, Haifeng Xu, Zhijuan Gu. Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2024 Dec; 44(1):2337691. doi: 10.1080/01443615.2024.2337691. [PMID: 38594870]
  • Xiaoying Wu, Li Li, Jinhabure, Xiaofeng, Eerdunchaolu. Radix Sophorae Flavescentis of Sophora flavescens Aiton inhibits LPS-induced macrophage pro-inflammatory response via regulating CFHR2 expression. Journal of ethnopharmacology. 2024 Sep; 331(?):118210. doi: 10.1016/j.jep.2024.118210. [PMID: 38641074]
  • Larisse Ricardo Gadelha, Maria Juliana Bezerra Costa, João Paulo Alecrim de Abreu, Larissa Paola Rodrigues Venancio, Mary Hellen Fabres-Klein, Raphael Contelli Klein, Jonilson Berlink Lima, Théo Araújo-Santos. Prostaglandin E2/Leukotriene B4 balance and viral load in distinct clinical stages of COVID-19: A cross-sectional study. Prostaglandins & other lipid mediators. 2024 Jun; 172(?):106820. doi: 10.1016/j.prostaglandins.2024.106820. [PMID: 38346573]
  • Ian E Cock. Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels. Inflammopharmacology. 2024 Jun; 32(3):1839-1853. doi: 10.1007/s10787-024-01462-7. [PMID: 38581641]
  • Karen T Feehan, Hannah E Bridgewater, Jan Stenkiewicz-Witeska, Roel P H De Maeyer, John Ferguson, Matthias Mack, Jeremy Brown, Giuseppe Ercoli, Connar M Mawer, Arne N Akbar, James R W Glanville, Parinaaz Jalali, Olivia V Bracken, Anna Nicolaou, Alexandra C Kendall, Michelle A Sugimoto, Derek W Gilroy. Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia. Nature communications. 2024 May; 15(1):4326. doi: 10.1038/s41467-024-48138-y. [PMID: 38773113]
  • Luisa Frusciante, Michela Geminiani, Alfonso Trezza, Tommaso Olmastroni, Pierfrancesco Mastroeni, Laura Salvini, Stefania Lamponi, Andrea Bernini, Daniela Grasso, Elena Dreassi, Ottavia Spiga, Annalisa Santucci. Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract. Marine drugs. 2024 May; 22(5):. doi: 10.3390/md22050226. [PMID: 38786617]
  • Zhi-Qiang Lin, Yao Yao, Yu-Fei Zhang, Xiao-Yan Zhang, You-Fei Guan. Role of prostaglandin E2 and its receptors in chronic liver disease. Sheng li xue bao : [Acta physiologica Sinica]. 2024 Apr; 76(2):329-340. doi: ". [PMID: 38658381]
  • Sapna I, A Jayadeep. Enzyme-treated red rice (Oryza sativa L.) bran extracts mitigate inflammatory markers in RAW 264.7 macrophage cells and exhibit anti-inflammatory efficacy greater/comparable to ferulic acid, catechin, γ-tocopherol, and γ-oryzanol. Journal of ethnopharmacology. 2024 Apr; 323(?):117616. doi: 10.1016/j.jep.2023.117616. [PMID: 38142877]
  • Shu-Tao Chen, Shuang Ji, Mei-Na Guo, Li-Hong Chen. [Research advances of prostaglandin E2 receptor 1 (EP1)]. Sheng li xue bao : [Acta physiologica Sinica]. 2024 Feb; 76(1):105-118. doi: ". [PMID: 38444136]
  • Guo-Liang Shao, Shao-Lei Huang, Rui Li, Dian-Hui Yang, Meng-Meng Wang. The curative efficacy of auricular comprehensive therapy on menstrual migraine and its effect on serum prostaglandin. Zhen ci yan jiu = Acupuncture research. 2024 Feb; 49(2):177-184. doi: 10.13702/j.1000-0607.20221424. [PMID: 38413039]
  • Cheng-Chao Xu, Xu-Hao Li, Jin-Ling Li. Comparative study on curative effect and recurrence rate of chronic scapulohumeral periarthritis treated with different acupuncture techniques. Zhen ci yan jiu = Acupuncture research. 2024 Feb; 49(2):164-170. doi: 10.13702/j.1000-0607.20221004. [PMID: 38413037]
  • Yiyun Geng, Weichao Li, Nai-Kei Wong, Fuchong Xue, Qing Li, Yang Zhang, Jingyuan Xu, Zhangshuang Deng, Yiqing Zhou. Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics. Journal of medicinal chemistry. 2024 Feb; 67(3):2083-2094. doi: 10.1021/acs.jmedchem.3c01989. [PMID: 38287228]
  • Xin Qi, Xin Chen, Wen-Bo An, Zhi-Ming Xu, Duo-Xian Wang, Peng-Fei Luo, Yi-Xin Chen, Jiao-Jiao Ma, Zi-Yang Hu, Wei Qi, Jian-Jun Liu, Jun-Xi Liu. [Ligusticum cycloprolactam inhibits IL-1β-induced apoptosis and inflammation of rat chondrocytes via HMGB1/TLR4/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):1007-1016. doi: 10.19540/j.cnki.cjcmm.20230904.401. [PMID: 38621908]
  • Yingke Liu, Jiao He, Man Li, Kebai Ren, Zhihe Zhao. Inflammation-Driven Nanohitchhiker Enhances Postoperative Immunotherapy by Alleviating Prostaglandin E2-Mediated Immunosuppression. ACS applied materials & interfaces. 2024 Feb; ?(?):. doi: 10.1021/acsami.3c17357. [PMID: 38300288]
  • Yuan Sun, Zhaoyao Qi, Yuanhui Xu, Chenyang Li, Jun Zhao, Tao Liu. Anti-inflammatory, analgesic, antitussive and antipyretic activities of polyphenol-enriched fraction from Nymphaea candida. Journal of ethnopharmacology. 2024 Jan; 324(?):117789. doi: 10.1016/j.jep.2024.117789. [PMID: 38266950]
  • Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Ling. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. 2024 Jan; 10(1):5. doi: 10.1038/s41540-024-00329-5. [PMID: 38218856]
  • Luís Almeida, Ruthger van Roey, Thiago Andrade Patente, Frank Otto, Tom Veldhuizen, Mohan Ghorasaini, Angela van Diepen, Gabriele Schramm, Jianyang Liu, Helena Idborg, Marina Korotkova, Per-Johan Jakobsson, Martin Giera, Cornelis Hendrik Hokke, Bart Everts. High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2. Frontiers in immunology. 2024; 15(?):1372927. doi: 10.3389/fimmu.2024.1372927. [PMID: 38742105]
  • Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong. Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway. International journal of radiation biology. 2024; 100(5):791-801. doi: 10.1080/09553002.2024.2324475. [PMID: 38442139]
  • V A Shipelin, N A Biryulina, Yu S Sidorova, N A Petrov, S N Zorin, V K Mazo, V V Bessonov. [Physiological and biochemical in vivo study of polyphenols and 20-hydroxyecdisone from quinoa grains effect on resistance to physical exercise in Wistar rats]. Voprosy pitaniia. 2024; 93(1):80-91. doi: 10.33029/0042-8833-2024-93-1-80-91. [PMID: 38555612]
  • Yifei Xu, Linsun Lin, Huantian Zheng, Siyuan Xu, Xinxin Hong, Tiantian Cai, Jianqu Xu, Weijian Zhang, Yanzhen Mai, Jingwei Li, Bin Huang, Zhu Liu, Shaoju Guo. Protective effect of Amauroderma rugosum ethanol extract and its primary bioactive compound, ergosterol, against acute gastric ulcers based on LXR-mediated gastric mucus secretions. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155236. doi: 10.1016/j.phymed.2023.155236. [PMID: 38016383]
  • Mario F C Santos, Karen de J Nicácio, Albert Katchborian-Neto, Miller S Ferreira, Daniel de Oliveira Miranda, João V Andrade, Herinque de A Pereira, Ester Gonçalves de Jesus, Thamires B, Silva Souza, Raquel P Morais-Urano, Danielle Ferreira Dias, Daniela A Chagas-Paula, Marisi G Soares. Ex vivo inhibition of PGE2 formation in human blood by four bicyclico [3.2.1] octane neolignans isolated from Aniba firmula bark, two with unusual structural pattern. Natural product research. 2024 Jan; 38(3):393-401. doi: 10.1080/14786419.2022.2124248. [PMID: 36106991]
  • Jorge Cuenca-Escalona, Georgina Flórez-Grau, Koen van den Dries, Alessandra Cambi, I Jolanda M de Vries. PGE2-EP4 signaling steers cDC2 maturation toward the induction of suppressive T-cell responses. European journal of immunology. 2023 Dec; ?(?):e2350770. doi: 10.1002/eji.202350770. [PMID: 38088451]
  • Xu Yang, Yunyuan Tian, Jincai Liu, Yaoyao Kou, Yanhua Xie, Siwang Wang, Ye Zhao. Peony Pollen Protects against Primary Dysmenorrhea in Mice by Inhibiting Inflammatory Response and Regulating the COX2/PGE2 Pathway. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417245. [PMID: 38139073]
  • Stefan Gahbauer, Chelsea DeLeon, Joao M Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A Fink, Ivan S Kondratov, Yurii S Moroz, John J Irwin, Allan I Basbaum, Bryan L Roth, Brian K Shoichet. Docking for EP4R antagonists active against inflammatory pain. Nature communications. 2023 Dec; 14(1):8067. doi: 10.1038/s41467-023-43506-6. [PMID: 38057319]
  • Mengyao Song, Cheng Qian, Teng Zhang, Yu Tang, Yueke Zhou, Zhonghong Wei, Aiyun Wang, Chongjin Zhong, Yang Zhao, Yin Lu. Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade. Journal of ethnopharmacology. 2023 Nov; 316(?):116735. doi: 10.1016/j.jep.2023.116735. [PMID: 37286115]
  • Taylor Richards, Scarlett Burron, Terence Connor McCorkell, Luciano Trevizan, Keely Patterson, Debbie Minikhiem, David W L Ma, Wendy Pearson, Anna K Shoveller. Effects of dietary camelina, flaxseed, and canola oil supplementation on transepidermal water loss, skin and coat health parameters, and plasma prostaglandin E2, glycosaminoglycan, and nitric oxide concentrations in healthy adult horses. Journal of animal science. 2023 Nov; ?(?):. doi: 10.1093/jas/skad373. [PMID: 37935917]
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