pyrazinamide (BioDeep_00000001639)
Main id: BioDeep_00000017883
Volatile Flavor Compounds
代谢物信息卡片
pyrazinamide
化学式: C5H5N3O (123.04326000000002)
中文名称: 吡嗪酰胺
谱图信息:
最多检出来源 Homo sapiens(urine) 70.59%
分子结构信息
SMILES: C1=CN=C(C=N1)C(=O)N
InChI: InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
描述信息
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
KEIO_ID P098
同义名列表
3 个代谢物同义名
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:45285
- KEGG: C01956
- KEGGdrug: D00144
- KEGGdrug: D70481
- PubChem: 1046
- Metlin: METLIN2196
- DrugBank: DB00339
- ChEMBL: CHEMBL614
- MeSH: Pyrazinamide
- CAS: 98-96-4
- MoNA: KO003869
- MoNA: KO003871
- MoNA: KO003872
- MoNA: KO003868
- MoNA: KO003870
- ChEBI: CHEBI:166571
- PubChem: 5057
- PDB-CCD: PZA
- NIKKAJI: J3.990J
- RefMet: Pyrazinamide
- KNApSAcK: 166571
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Devaraj Ezhilarasan. Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms.
Drug metabolism reviews.
2023 May; ?(?):1-15. doi:
10.1080/03602532.2023.2215478. [PMID: 37218081] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Yining Liu, Wenyan Chen, Yanli Cen, Xiaodeng Zhao, Zaiping Chen, Yuedong Liang, Zhongfeng Huang, Xiu He, Guanghong Yang. Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis.
Chemico-biological interactions.
2023 Mar; ?(?):110439. doi:
10.1016/j.cbi.2023.110439. [PMID: 36878459] - Gautam Kumar, Shobhna Kapoor. Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
10.1016/j.bmc.2023.117212. [PMID: 36804747] - Medha Bargaje, Sandeep Bharaswadkar, Sathiyanarayanan Lohidasan, Bijoy Kumar Panda. Plasma drug concentrations of 4-drug fixed-dose combination regimen and its efficacy for treatment of pulmonary tuberculosis under National Tuberculosis Elimination Programme: A prospective pilot study.
The Indian journal of tuberculosis.
2022 Jul; 69(3):311-319. doi:
10.1016/j.ijtb.2021.04.002. [PMID: 35760480] - Daniel Van Aartsen, Museveni Justine, Estomih Mduma, Stellah G Mpagama, Mohammad H Alshaer, Charles A Peloquin, Buliga Mujaga, Athanasia Maro, Jean Gratz, Margaret Kosek, Jie Liu, Elizabeth T Rogawski McQuade, Eric R Houpt, Tania A Thomas, Scott K Heysell. Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study.
The Lancet. Microbe.
2022 Jun; 3(6):e408-e416. doi:
10.1016/s2666-5247(21)00308-6. [PMID: 35659902] - Morris Muliaditan, Donato Teutonico, Fatima Ortega-Muro, Santiago Ferrer, Oscar Della Pasqua. Prediction of lung exposure to anti-tubercular drugs using plasma pharmacokinetic data: Implications for dose selection.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Jun; 173(?):106163. doi:
10.1016/j.ejps.2022.106163. [PMID: 35248733] - Elisa Lopez-Varela, Ahmed A Abulfathi, Natasha Strydom, Pierre Goussard, Abraham C van Wyk, Anne Marie Demers, Anneen Van Deventer, Anthony J Garcia-Prats, Johannes van der Merwe, Matthew Zimmerman, Claire L Carter, Jacques Janson, Julie Morrison, Helmuth Reuter, Eric H Decloedt, James A Seddon, Elin M Svensson, Rob Warren, Radojka M Savic, Véronique Dartois, Anneke C Hesseling. Drug concentration at the site of disease in children with pulmonary tuberculosis.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1710-1719. doi:
10.1093/jac/dkac103. [PMID: 35468189] - Siyang Wang, Jian Ren, Hongxia Wang, Tingting Zhi, Yuanyuan Zhu, Jinxin Feng, Zhen Li, Ruiqin Zhang. Bioequivalence and Pharmacokinetic Evaluation of 2 Pyrazinamide Formulations in Healthy Chinese Adults: A Single-Dose, Open-Label, Randomized-Sequence, 2×2 Crossover Study.
Clinical pharmacology in drug development.
2022 04; 11(4):551-556. doi:
10.1002/cpdd.1035. [PMID: 34784108] - Chaudhary Niraliben Hareshkumar, Prashant Gopal, Pradnya Mukund Diggikar. Tubercular meningitis complicated by weil's Syndrome - Management of tuberculosis in a patient with concurrent hepatic and renal dysfunction.
International journal of mycobacteriology.
2022 Apr; 11(2):205-207. doi:
10.4103/ijmy.ijmy_56_22. [PMID: 35775555] - David Ekqvist, Anna Bornefall, Daniel Augustinsson, Martina Sönnerbrandt, Michaela Jonsson Nordvall, Mats Fredrikson, Björn Carlsson, Mårten Sandstedt, Ulrika S H Simonsson, Jan-Willem C Alffenaar, Jakob Paues, Katarina Niward. Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP).
BMJ open.
2022 03; 12(3):e054788. doi:
10.1136/bmjopen-2021-054788. [PMID: 35273049] - Glauco Henrique Balthazar Nardotto, Valdes Roberto Bollela, Adriana Rocha, Oscar Della Pasqua, Vera Lucia Lanchote. No implication of HIV coinfection on the plasma exposure to rifampicin, pyrazinamide, and ethambutol in tuberculosis patients.
Clinical and translational science.
2022 02; 15(2):514-523. doi:
10.1111/cts.13169. [PMID: 34670022] - Rovina Ruslami, Fajri Gafar, Vycke Yunivita, Ida Parwati, Ahmad R Ganiem, Rob E Aarnoutse, Bob Wilffert, Jan-Willem C Alffenaar, Heda M Nataprawira. Pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents treated for tuberculous meningitis.
Archives of disease in childhood.
2022 01; 107(1):70-77. doi:
10.1136/archdischild-2020-321426. [PMID: 34183327] - Sirus Amini, Jalil Kardan-Yamchi, Hossein Kazemian, Mohammad Javad Nasiri, Gholamreza Hamzehloo, Sven Hoffner, Mohammad Mehdi Feizabadi. The 7H11 Agar Medium Supplemented with Calf Bovine Serum for Susceptibility Testing of Mycobacterium tuberculosis Isolates Against Pyrazinamide.
Microbial drug resistance (Larchmont, N.Y.).
2021 Dec; 27(12):1652-1657. doi:
10.1089/mdr.2020.0509. [PMID: 34077245] - Agnija Kivrane, Solveiga Grinberga, Eduards Sevostjanovs, Viktorija Igumnova, Ilva Pole, Anda Viksna, Dace Bandere, Alvils Krams, Andra Cirule, Osvalds Pugovics, Renate Ranka. LC-MS/MS method for simultaneous quantification of the first-line anti-tuberculosis drugs and six primary metabolites in patient plasma: Implications for therapeutic drug monitoring.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Nov; 1185(?):122986. doi:
10.1016/j.jchromb.2021.122986. [PMID: 34688197] - Katie A Lien, Kayla Dinshaw, Robert J Nichols, Caleb Cassidy-Amstutz, Matthew Knight, Rahul Singh, Lindsay D Eltis, David F Savage, Sarah A Stanley. A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis.
eLife.
2021 11; 10(?):. doi:
10.7554/elife.74358. [PMID: 34751132] - Andrew D McCallum, Henry E Pertinez, Laura J Else, Sujan Dilly-Penchala, Aaron P Chirambo, Irene Sheha, Madalitso Chasweka, Alex Chitani, Rose D Malamba, Jamilah Z Meghji, Stephen B Gordon, Geraint R Davies, Saye H Khoo, Derek J Sloan, Henry C Mwandumba. Intrapulmonary Pharmacokinetics of First-line Anti-tuberculosis Drugs in Malawian Patients With Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 11; 73(9):e3365-e3373. doi:
10.1093/cid/ciaa1265. [PMID: 32856694] - Xubin Zheng, Ziwei Bao, Lina Davies Forsman, Yi Hu, Weihua Ren, Yazhou Gao, Xuliang Li, Sven Hoffner, Judith Bruchfeld, Jan-Willem Alffenaar. Drug Exposure and Minimum Inhibitory Concentration Predict Pulmonary Tuberculosis Treatment Response.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 11; 73(9):e3520-e3528. doi:
10.1093/cid/ciaa1569. [PMID: 33070176] - Helen Humphries, Lisa Almond, Alexander Berg, Iain Gardner, Oliver Hatley, Xian Pan, Ben Small, Mian Zhang, Masoud Jamei, Klaus Romero. Development of physiologically-based pharmacokinetic models for standard of care and newer tuberculosis drugs.
CPT: pharmacometrics & systems pharmacology.
2021 11; 10(11):1382-1395. doi:
10.1002/psp4.12707. [PMID: 34623770] - Mercedes Gonzalez-Juarrero, Pradeep B Lukka, Santosh Wagh, Amanda Walz, Jennifer Arab, Camron Pearce, Zohaib Ali, Josiah T Ryman, Keyur Parmar, Zaid Temrikar, Juan Munoz-Gutierrez, Gregory T Robertson, Jiuyu Liu, Anne J Lenaerts, Charles Daley, Richard E Lee, Miriam Braunstein, Anthony J Hickey, Bernd Meibohm. Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
ACS infectious diseases.
2021 10; 7(10):2850-2863. doi:
10.1021/acsinfecdis.1c00213. [PMID: 34546724] - Sharon Slomovich, Kyung Taek Oh, Nikolaos A Diakos, Susan W Restaino, Kevin J Clerkin, Farhana Latif, Jeremy T Miyauchi, Anna Lee, Gabriel T Sayer, Nir Uriel. A Rare Case of Disseminated Tuberculosis and Hematological Malignancy in a Heart Transplant Recipient.
Transplantation proceedings.
2021 Oct; 53(8):2626-2629. doi:
10.1016/j.transproceed.2021.07.037. [PMID: 34399971] - Xuehua Wu, Xiaoming Che, Zhixue Qiu, Jingyuan Chao, Zhanping Kong, Haili Li. Simultaneous determination of three antituberculosis drugs in the serum of patients with spinal tuberculosis by capillary electrophoresis.
Analytical methods : advancing methods and applications.
2021 09; 13(37):4307-4313. doi:
10.1039/d1ay00711d. [PMID: 34473140] - Prabhakar S Achanta, Shao-Nong Chen, Guido F Pauli. Plain 1 H nuclear magnetic resonance analysis streamlines the quality control of antiviral favipiravir and congeneric World Health Organization essential medicines.
Magnetic resonance in chemistry : MRC.
2021 07; 59(7):746-751. doi:
10.1002/mrc.5154. [PMID: 33742475] - Lindsey H M Te Brake, Veronique de Jager, Kim Narunsky, Naadira Vanker, Elin M Svensson, Patrick P J Phillips, Stephen H Gillespie, Norbert Heinrich, Michael Hoelscher, Rodney Dawson, Andreas H Diacon, Rob E Aarnoutse, Martin J Boeree. Increased bactericidal activity but dose-limiting intolerability at 50 mg·kg-1 rifampicin.
The European respiratory journal.
2021 07; 58(1):. doi:
10.1183/13993003.00955-2020. [PMID: 33542056] - Jesper Sundell, Marie Wijk, Emile Bienvenu, Angela Äbelö, Kurt-Jürgen Hoffmann, Michael Ashton. Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing.
Antimicrobial agents and chemotherapy.
2021 06; 65(7):e0004621. doi:
10.1128/aac.00046-21. [PMID: 33875424] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Varsha Sharma, Rajwinder Kaur, Vijay Lakshmi Sharma. Ameliorative potential of Adhatoda vasica against anti-tubercular drugs induced hepatic impairments in female Wistar rats in relation to oxidative stress and xeno-metabolism.
Journal of ethnopharmacology.
2021 Apr; 270(?):113771. doi:
10.1016/j.jep.2020.113771. [PMID: 33388427] - Satomi Suga, Yasuhiko Mukai, Satoshi Ishikawa, Shiomi Yoshida, Sarad Paudel, Takayuki Wada. INTENSIVE TREATMENT OF A CAPTIVE BORNEAN ELEPHANT (ELEPHAS MAXIMUS BORNEENSIS) INFECTED WITH MYCOBACTERIUM CAPRAE IN JAPAN.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Jan; 51(4):1062-1066. doi:
10.1638/2019-0152. [PMID: 33480591] - Oswaldo Hernández-González, Sergio Zarazúa, José Ignacio Veytia-Bucheli, Marco Martín González-Chávez, Cristian Jazmín Rodríguez-Pinal, Susanna Edith Medellín-Garibay, Edith Elena Uresti-Rivera, Francisco Javier Pérez-Vázquez, Diana Patricia Portales-Pérez, Silvia Romano-Moreno, Rosa Del Carmen Milán-Segovia. Quantification of pyrazinamide, isoniazid, acetyl-isoniazid, and rifampicin by a high-performance liquid chromatography method in human plasma from patients with tuberculosis.
Journal of separation science.
2021 Jan; 44(2):521-529. doi:
10.1002/jssc.202000672. [PMID: 33200497] - Navarat Panjasawatwong, Thanaporn Wattanakul, Richard M Hoglund, Nguyen Duc Bang, Thomas Pouplin, Wichit Nosoongnoen, Vi Nguyen Ngo, Jeremy N Day, Joel Tarning. Population Pharmacokinetic Properties of Antituberculosis Drugs in Vietnamese Children with Tuberculous Meningitis.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.00487-20. [PMID: 33139294] - Xubin Zheng, Erwin M Jongedijk, Yi Hu, Johanna Kuhlin, Rongrong Zheng, Katarina Niward, Jakob Paues, Biao Xu, Lina Davies Forsman, Thomas Schön, Judith Bruchfeld, Jan-Willem C Alffenaar. Development and validation of a simple LC-MS/MS method for simultaneous determination of moxifloxacin, levofloxacin, prothionamide, pyrazinamide and ethambutol in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Nov; 1158(?):122397. doi:
10.1016/j.jchromb.2020.122397. [PMID: 33091676] - Jun Wang, Jing Wang, Yadong Du, Ru Guo, Xiqin Han, Qingfeng Wang, Yu Pang, Naihui Chu. Effect of interval between food intake and drug administration at fasting condition on the plasma concentrations of first-line anti-tuberculosis drugs in Chinese population.
Medicine.
2020 Oct; 99(44):e22258. doi:
10.1097/md.0000000000022258. [PMID: 33126298] - In Hee Lee, Seong Gyu Kim, Joong Goo Kwon, Chun-Seok Yang, Sungmin Kang, Min-Kyung Kim, Dong Jik Ahn. Intestinal tuberculosis in a patient with end-stage renal disease on hemodialysis: A case report.
Medicine.
2020 Aug; 99(32):e21641. doi:
10.1097/md.0000000000021641. [PMID: 32769931] - Wanying Tan, Ke Zhao, Jufang Xiang, Xue Zhou, Fangyin Cao, Wenhao Song, Qi Liu, Xiu Zhang, Xiaoyuan Li, Zhenghuai Tan. Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7α-hydroxylase and lipoprotein lipase.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Aug; 151(?):105402. doi:
10.1016/j.ejps.2020.105402. [PMID: 32492461] - Linsheng Liu, Xianglian Li, Chenrong Huang, Yicong Bian, Xiaoxue Liu, Jun Cao, Wenhao Qu, Liyan Miao. Bile acids, lipid and purine metabolism involved in hepatotoxicity of first-line anti-tuberculosis drugs.
Expert opinion on drug metabolism & toxicology.
2020 Jun; 16(6):527-537. doi:
10.1080/17425255.2020.1758060. [PMID: 32436768] - Tsegahun Manyazewal, Yimtubezinash Woldeamanuel, David P Holland, Abebaw Fekadu, Henry M Blumberg, Vincent C Marconi. Electronic pillbox-enabled self-administered therapy versus standard directly observed therapy for tuberculosis medication adherence and treatment outcomes in Ethiopia (SELFTB): protocol for a multicenter randomized controlled trial.
Trials.
2020 May; 21(1):383. doi:
10.1186/s13063-020-04324-z. [PMID: 32370774] - Mariana Millan Fachi, Raquel Oliveira Vilhena, Beatriz Boger, Eric Luiz Domingos, Josiane Marlei Müller Fernandes Dos Santos, Allan Michael Junkert, Alexandre de Fátima Cobre, Danilo Raul Ossufo Momade, Francisco Beraldi-Magalhães, Marcus Vinicius de Liz, Marcelo Cordeiro-Santos, Roberto Pontarolo. LC-QToF-MS method for quantification of ethambutol, isoniazid, pyrazinamide and rifampicin in human plasma and its application.
Biomedical chromatography : BMC.
2020 May; 34(5):e4812. doi:
10.1002/bmc.4812. [PMID: 32068899] - Charlotte Schutz, Maxwell Chirehwa, David Barr, Amy Ward, Saskia Janssen, Rosie Burton, Robert J Wilkinson, Muki Shey, Lubbe Wiesner, Paolo Denti, Helen McIlleron, Gary Maartens, Graeme Meintjes. Early antituberculosis drug exposure in hospitalized patients with human immunodeficiency virus-associated tuberculosis.
British journal of clinical pharmacology.
2020 05; 86(5):966-978. doi:
10.1111/bcp.14207. [PMID: 31912537] - Andreas H Diacon, Veronique R De Jager, Rodney Dawson, Kim Narunsky, Naadira Vanker, Divan A Burger, Daniel Everitt, Frances Pappas, Jerry Nedelman, Carl M Mendel. Fourteen-Day Bactericidal Activity, Safety, and Pharmacokinetics of Linezolid in Adults with Drug-Sensitive Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.02012-19. [PMID: 31988102] - Geetha Ramachandran, Padmapriyadarshini Chandrasekaran, Sanjay Gaikwad, Hemanth Kumar Agibothu Kupparam, Kannan Thiruvengadam, Nikhil Gupte, Mandar Paradkar, Kavitha Dhanasekaran, Gomathi Narayan Sivaramakrishnan, Anju Kagal, Beena Thomas, Neeta Pradhan, Dileep Kadam, Luke Elizabeth Hanna, Usha Balasubramanian, Vandana Kulkarni, Lakshmi Murali, Jonathan Golub, Akshay Gupte, Shri Vijay Bala Yogendra Shivakumar, Soumya Swaminathan, Kelly E Dooley, Amita Gupta, Vidya Mave. Subtherapeutic Rifampicin Concentration Is Associated With Unfavorable Tuberculosis Treatment Outcomes.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 03; 70(7):1463-1470. doi:
10.1093/cid/ciz380. [PMID: 31075166] - Museveni Justine, Anita Yeconia, Ingi Nicodemu, Domitila Augustino, Jean Gratz, Estomih Mduma, Scott K Heysell, Sokoine Kivuyo, Sayoki Mfinanga, Charles A Peloquin, Theodore Zagurski, Gibson S Kibiki, Blandina Mmbaga, Eric R Houpt, Tania A Thomas. Pharmacokinetics of First-Line Drugs Among Children With Tuberculosis in Rural Tanzania.
Journal of the Pediatric Infectious Diseases Society.
2020 Feb; 9(1):14-20. doi:
10.1093/jpids/piy106. [PMID: 30395239] - Lingjie Wu, Zhenjie Ye, Hui Liu, Hongliang Guo, Jing Lin, Ling Zheng, Nannan Chu, Xiaolong Liu. Rapid and highly sensitive quantification of the anti-tuberculosis agents isoniazid, ethambutol, pyrazinamide, rifampicin and rifabutin in human plasma by UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 180(?):113076. doi:
10.1016/j.jpba.2019.113076. [PMID: 31896523] - Arpitha Rao, Guruprasad Nayak, Sandhya Kumari, Sneha Guruprasad Kalthur, Sadhana P Mutalik, Srinivas Mutalik, Satish Kumar Adiga, Guruprasad Kalthur. Exposure to first line anti-tuberculosis drugs in prepubertal age reduces the quality and functional competence of spermatozoa and oocytes in Swiss albino mice.
Environmental toxicology and pharmacology.
2020 Jan; 73(?):103292. doi:
10.1016/j.etap.2019.103292. [PMID: 31765964] - R Perumal, K Naidoo, A Naidoo, G Ramachandran, A Requena-Mendez, C Sekaggya-Wiltshire, S G Mpagama, A Matteelli, J Fehr, S K Heysell, N Padayatchi. A systematic review and meta-analysis of first-line tuberculosis drug concentrations and treatment outcomes.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2020 01; 24(1):48-64. doi:
10.5588/ijtld.19.0025. [PMID: 32005307] - Taísa Busaranho Franchin, Bruna Cristina Ulian Silva, Rone Aparecido DeGrandis, Michelle Fidelis Corrêa, Cecília Maria Simões de Queiroz Aranha, Joáo Paulo S Fernandes, Michel Leandro Campos, Rosângela Gonçalves Peccinini. Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives.
Current drug metabolism.
2020; 21(9):714-721. doi:
10.2174/1389200221666200907145722. [PMID: 32895039] - Edgar A Florentini, Noelia Angulo, Robert H Gilman, Roberto Alcántara, Elisa Roncal, Ricardo Antiparra, Emily Toscano, Katherine Vallejos, Danni Kirwan, Mirko Zimic, Patricia Sheen. Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis.
PloS one.
2020; 15(11):e0241600. doi:
10.1371/journal.pone.0241600. [PMID: 33151985] - Charles M Mtabho, Hadija H Semvua, Jossy van den Boogaard, Constantine F Irongo, Martin J Boeree, Angela Colbers, David M Burger, Reinout van Crevel, Andre J A M van der Ven, Gibson S Kibiki, Alma Tostmann, Rob E Aarnoutse. Effect of diabetes mellitus on TB drug concentrations in Tanzanian patients.
The Journal of antimicrobial chemotherapy.
2019 12; 74(12):3537-3545. doi:
10.1093/jac/dkz368. [PMID: 31651031] - Yu Yan, Jicheng Ma, Xiangjie Bo, Liping Guo. Rod-like Co based metal-organic framework embedded into mesoporous carbon composite modified glassy carbon electrode for effective detection of pyrazinamide and isonicotinyl hydrazide in biological samples.
Talanta.
2019 Dec; 205(?):120138. doi:
10.1016/j.talanta.2019.120138. [PMID: 31450409] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Qian Lei, Hao Wang, Yuan Zhao, Liyun Dang, Changsheng Zhu, Xiaohui Lv, Hui Wang, Jun Zhou. Determinants of serum concentration of first-line anti-tuberculosis drugs from China.
Medicine.
2019 Oct; 98(41):e17523. doi:
10.1097/md.0000000000017523. [PMID: 31593125] - Hanbin Li, David H Salinger, Daniel Everitt, Mengchun Li, Angelo Del Parigi, Carl Mendel, Jerry R Nedelman. Long-Term Effects on QT Prolongation of Pretomanid Alone and in Combinations in Patients with Tuberculosis.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00445-19. [PMID: 31358590] - R Stemkens, C H C Litjens, S Dian, A R Ganiem, V Yunivita, R van Crevel, L H M Te Brake, R Ruslami, R E Aarnoutse. Pharmacokinetics of pyrazinamide during the initial phase of tuberculous meningitis treatment.
International journal of antimicrobial agents.
2019 Sep; 54(3):371-374. doi:
10.1016/j.ijantimicag.2019.06.010. [PMID: 31202922] - Pierre Mugabo, Mwila Mulubwa. Population Pharmacokinetic Modelling of Pyrazinamide and Pyrazinoic Acid in Patients with Multi-Drug Resistant Tuberculosis.
European journal of drug metabolism and pharmacokinetics.
2019 Aug; 44(4):519-530. doi:
10.1007/s13318-018-00540-w. [PMID: 30617957] - Jonathan I Kremer, Stephanie Pickard, Lara F Stadlmair, Anika Glaß-Theis, Leon Buckel, Tamara Bakuradze, Gerhard Eisenbrand, Elke Richling. Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body.
Molecular nutrition & food research.
2019 07; 63(14):e1801341. doi:
10.1002/mnfr.201801341. [PMID: 31125183] - Huidong Liu, Nan Hao, Yuhuan Jia, Xingqian Liu, Xilu Ni, Meng Wang, Wenzhe Liu. The ethylene receptor regulates Typha angustifolia leaf aerenchyma morphogenesis and cell fate.
Planta.
2019 Jul; 250(1):381-390. doi:
10.1007/s00425-019-03177-4. [PMID: 31062160] - Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding, Chih-Ming Ho, Yuefen Lou, Guorong Fan. Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC-MS/MS method coupled with 96-well format plate.
Journal of pharmaceutical and biomedical analysis.
2019 May; 168(?):44-54. doi:
10.1016/j.jpba.2019.02.006. [PMID: 30784889] - Aparna Mukherjee, Rakesh Lodha, S K Kabra. Pharmacokinetics of First-Line Anti-Tubercular Drugs.
Indian journal of pediatrics.
2019 05; 86(5):468-478. doi:
10.1007/s12098-019-02911-w. [PMID: 30915644] - Stefania de Medeiros Araujo Lucena, Carlos Augusto Abreu Alberio, Ana Carla Godinho Pinto, José Luiz Fernandes Vieira. Serum pyrazinamide concentrations in patients with pulmonary tuberculosis.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.
2019 04; 45(2):e20180254. doi:
10.1590/1806-3713/e20180254. [PMID: 31017228] - Natasha Strydom, Sneha V Gupta, William S Fox, Laura E Via, Hyeeun Bang, Myungsun Lee, Seokyong Eum, TaeSun Shim, Clifton E Barry, Matthew Zimmerman, Véronique Dartois, Radojka M Savic. Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization.
PLoS medicine.
2019 04; 16(4):e1002773. doi:
10.1371/journal.pmed.1002773. [PMID: 30939136] - Radhika Sharma, Neha Goyal, Mandakini Singla, Vijay Lakshmi Sharma. Berberis aristata Ameliorates Testicular Toxicity Induced by Combination of First-Line Tuberculosis Drugs (Rifampicin + Isoniazid + Pyrazinamide) in Normal Wistar Rats.
Journal of dietary supplements.
2019; 16(4):417-430. doi:
10.1080/19390211.2018.1470127. [PMID: 29953299] - Q X Liu, D T Guo, L Chen, S P Ou, L Huang, H Yan, X C Zheng, C X Weng, J Y Zhang. [Measurement of rifampicin concentrations in tuberculous pleural effusion before and after combination treatment with oral and local rifampicin].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2018 Nov; 41(11):853-856. doi:
10.3760/cma.j.issn.1001-0939.2018.11.005. [PMID: 30423627] - Lisa C Martial, Jordy Kerkhoff, Nilza Martinez, Mabel Rodríguez, Rosarito Coronel, Gladys Molinas, Myriam Roman, Roscio Gomez, Sarita Aguirre, Erwin Jongedijk, Justine Huisman, Daan J Touw, Domingo Pérez, Gilberto Chaparro, Felipe Gonzalez, Rob E Aarnoutse, Jan-Willem Alffenaar, Cecile Magis-Escurra. Evaluation of dried blood spot sampling for pharmacokinetic research and therapeutic drug monitoring of anti-tuberculosis drugs in children.
International journal of antimicrobial agents.
2018 Jul; 52(1):109-113. doi:
10.1016/j.ijantimicag.2018.04.020. [PMID: 29751121] - Wael A Alghamdi, Mohammad H Al-Shaer, Charles A Peloquin. Protein Binding of First-Line Antituberculosis Drugs.
Antimicrobial agents and chemotherapy.
2018 07; 62(7):. doi:
10.1128/aac.00641-18. [PMID: 29735566] - Agibothu Kupparam Hemanth Kumar, Alok Kumar, Thiruvengadam Kannan, Rakesh Bhatia, Dipti Agarwal, Santosh Kumar, Rajeshwar Dayal, Sheo Pratap Singh, Geetha Ramachandran. Pharmacokinetics of Second-Line Antituberculosis Drugs in Children with Multidrug-Resistant Tuberculosis in India.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
10.1128/aac.02410-17. [PMID: 29463539] - Federica Fregonese, Shama D Ahuja, Onno W Akkerman, Denise Arakaki-Sanchez, Irene Ayakaka, Parvaneh Baghaei, Didi Bang, Mayara Bastos, Andrea Benedetti, Maryline Bonnet, Adithya Cattamanchi, Peter Cegielski, Jung-Yien Chien, Helen Cox, Martin Dedicoat, Connie Erkens, Patricio Escalante, Dennis Falzon, Anthony J Garcia-Prats, Medea Gegia, Stephen H Gillespie, Judith R Glynn, Stefan Goldberg, David Griffith, Karen R Jacobson, James C Johnston, Edward C Jones-López, Awal Khan, Won-Jung Koh, Afranio Kritski, Zhi Yi Lan, Jae Ho Lee, Pei Zhi Li, Ethel L Maciel, Rafael Mello Galliez, Corinne S C Merle, Melinda Munang, Gopalan Narendran, Viet Nhung Nguyen, Andrew Nunn, Akihiro Ohkado, Jong Sun Park, Patrick P J Phillips, Chinnaiyan Ponnuraja, Randall Reves, Kamila Romanowski, Kwonjune Seung, H Simon Schaaf, Alena Skrahina, Dick van Soolingen, Payam Tabarsi, Anete Trajman, Lisa Trieu, Velayutham V Banurekha, Piret Viiklepp, Jann-Yuan Wang, Takashi Yoshiyama, Dick Menzies. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.
The Lancet. Respiratory medicine.
2018 04; 6(4):265-275. doi:
10.1016/s2213-2600(18)30078-x. [PMID: 29595509] - Jun Cao, Yijun Mi, Cuilin Shi, Yicong Bian, Chenrong Huang, Zhijian Ye, Linsheng Liu, Liyan Miao. First-line anti-tuberculosis drugs induce hepatotoxicity: A novel mechanism based on a urinary metabolomics platform.
Biochemical and biophysical research communications.
2018 03; 497(2):485-491. doi:
10.1016/j.bbrc.2018.02.030. [PMID: 29454961] - A K Hemanth Kumar, V Chandrasekaran, T Kannan, J Lavanya, Soumya Swaminathan, Geetha Ramachandran. Intrapatient variability in plasma rifampicin & isoniazid in tuberculosis patients.
The Indian journal of medical research.
2018 03; 147(3):287-292. doi:
10.4103/ijmr.ijmr_1961_16. [PMID: 29923518] - Shouhong Gao, Zhipeng Wang, Xinfang Xie, Chunhua You, Yang Yang, Yanhai Xi, Wansheng Chen. Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring.
Tuberculosis (Edinburgh, Scotland).
2018 03; 109(?):28-34. doi:
10.1016/j.tube.2017.11.012. [PMID: 29559118] - Isaac Zentner, Chawangwa Modongo, Nicola M Zetola, Jotam G Pasipanodya, Shashikant Srivastava, Scott K Heysell, Stellah Mpagama, Hans P Schlect, Tawanda Gumbo, Gregory P Bisson, Christopher Vinnard. Urine colorimetry for therapeutic drug monitoring of pyrazinamide during tuberculosis treatment.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2018 Mar; 68(?):18-23. doi:
10.1016/j.ijid.2017.12.017. [PMID: 29253711] - Mansoor Ahmed, Mohsin Ali, Seyed Abdulmajid Ayatollahi, Marjan Esfahanizadeh, Farzad Kobarfard, Ameer Hasan, Khalid Mohammed Khan, Syed Moazzam Haider. Short Communication - Synthesis of drug metal complexes and their influence on human platelet aggregation.
Pakistan journal of pharmaceutical sciences.
2018 Mar; 31(2):587-591. doi:
NULL. [PMID: 29618452] - Nivea M F Voelkner, Alexander Voelkner, Juliana Costa, Sherwin K B Sy, Juliane Hermes, Johanna Weitzel, Sebastian Morales, Hartmut Derendorf. Dermal pharmacokinetics of pyrazinamide determined by microdialysis sampling in rats.
International journal of antimicrobial agents.
2018 Feb; 51(2):190-196. doi:
10.1016/j.ijantimicag.2017.10.001. [PMID: 29032112] - Parveen Kumar Sharma, Rekha Bansal, Ashok Kumar Bhardwaj, Vivek Sood, Atal Sood, Yogendra Padwad. Plasma levels of Rifampicin and Pyrazinamide with pre and post meal administration in tuberculosis patients.
The Indian journal of tuberculosis.
2018 Jan; 65(1):35-40. doi:
10.1016/j.ijtb.2017.08.004. [PMID: 29332645] - R E Aarnoutse, G S Kibiki, K Reither, H H Semvua, F Haraka, C M Mtabho, S G Mpagama, J van den Boogaard, I M Sumari-de Boer, C Magis-Escurra, M Wattenberg, J G M Logger, L H M Te Brake, M Hoelscher, S H Gillespie, A Colbers, P P J Phillips, G Plemper van Balen, M J Boeree. Pharmacokinetics, Tolerability, and Bacteriological Response of Rifampin Administered at 600, 900, and 1,200 Milligrams Daily in Patients with Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 11; 61(11):. doi:
10.1128/aac.01054-17. [PMID: 28827417] - Ghada Bouz, Martin Juhás, Pavlína Niklová, Ondřej Janďourek, Pavla Paterová, Jiří Janoušek, Lenka Tůmová, Zuzana Kovalíková, Petr Kastner, Martin Doležal, Jan Zitko. Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors.
Molecules (Basel, Switzerland).
2017 Oct; 22(10):. doi:
10.3390/molecules22101797. [PMID: 29065539] - Claire M Naftalin, Rupangi Verma, Meera Gurumurthy, Qingshu Lu, Matthew Zimmerman, Benjamin Chaik Meng Yeo, Kin Hup Tan, Wenwei Lin, Buduo Yu, Véronique Dartois, Nicholas I Paton. Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model.
Antimicrobial agents and chemotherapy.
2017 10; 61(10):. doi:
10.1128/aac.00482-17. [PMID: 28739782] - Ariana Díaz, Bettina Bongiovanni, Luciano D'Attilio, Natalia Santucci, Griselda Dídoli, Rocío Del Valle Fernández, Leandro Kovalevski, Susana Lioi, Walter Gardeñez, Nadia Brandan, Luis J Nannini, Hugo Besedovsky, Adriana Del Rey, Oscar Bottasso, María Luisa Bay. The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses.
Pathogens and disease.
2017 09; 75(7):. doi:
10.1093/femspd/ftx087. [PMID: 28854691] - Michael Czapka, Shuchin Shukla, Magdalena Slosar-Cheah. Urine trouble: genitourinary tuberculosis and subsequent DRESS syndrome.
BMJ case reports.
2017 Aug; 2017(?):. doi:
10.1136/bcr-2017-220440. [PMID: 28784884] - V Indumati, V Vijay, D Krishnaswamy, V Rajeshwari, A Ramesh, D Shantala, A Shilpa. Serum levels of soluble urokinase plasminogen activator receptor (suPAR) as a marker of tuberculosis treatment efficacy.
The Indian journal of tuberculosis.
2017 Jul; 64(3):206-211. doi:
10.1016/j.ijtb.2017.01.012. [PMID: 28709490] - Piero L Olliaro, Corinne Merle, Thuli Mthiyane, Boubacar Bah, Ferdinand Kassa, Evans Amukoye, Alimatou N Diaye, Christian Perronne, Christian Lienhardt, Helen McIlleron, Katherine Fielding. Effects on the QT Interval of a Gatifloxacin-Containing Regimen versus Standard Treatment of Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 07; 61(7):. doi:
10.1128/aac.01834-16. [PMID: 28438924] - Xiangzhong Sun, Yaxin Li, Wenrong He, Chenggong Ji, Peixue Xia, Yichuan Wang, Shuo Du, Hongjiang Li, Natasha Raikhel, Junyu Xiao, Hongwei Guo. Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase.
Nature communications.
2017 06; 8(?):15758. doi:
10.1038/ncomms15758. [PMID: 28604689] - Russell R Kempker, M Tobias Heinrichs, Ketino Nikolaishvili, Irina Sabulua, Nino Bablishvili, Shota Gogishvili, Zaza Avaliani, Nestani Tukvadze, Brent Little, Adam Bernheim, Timothy D Read, Jeannette Guarner, Hartmut Derendorf, Charles A Peloquin, Henry M Blumberg, Sergo Vashakidze. Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.00226-17. [PMID: 28373198] - Abdullah Alsultan, Rada Savic, Kelly E Dooley, Marc Weiner, William Whitworth, William R Mac Kenzie, Charles A Peloquin. Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.02625-16. [PMID: 28289033] - Neesha Rockwood, Jotam G Pasipanodya, Paolo Denti, Frederick Sirgel, Maia Lesosky, Tawanda Gumbo, Graeme Meintjes, Helen McIlleron, Robert J Wilkinson. Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2017 May; 64(10):1350-1359. doi:
10.1093/cid/cix158. [PMID: 28205671] - Geetha Ramachandran, Hemanth Kumar Agibothu Kupparam, Chandrasekaran Vedhachalam, Kannan Thiruvengadam, Vijayalakshmi Rajagandhi, Azger Dusthackeer, Ramesh Karunaianantham, Lavanya Jayapal, Soumya Swaminathan. Factors Influencing Tuberculosis Treatment Outcome in Adult Patients Treated with Thrice-Weekly Regimens in India.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02464-16. [PMID: 28242663] - Agibothu Kupparam Hemanth Kumar, Vedachalam Chandrasekaran, Angadi Kiran Kumar, M Kawaskar, J Lavanya, Soumya Swaminathan, Geetha Ramachandran. Food significantly reduces plasma concentrations of first-line anti-tuberculosis drugs.
The Indian journal of medical research.
2017 Apr; 145(4):530-535. doi:
10.4103/ijmr.ijmr_552_15. [PMID: 28862186] - Radhika Sharma, Vijay L Sharma. Deleterious effects of 28-day oral co-administration of first-line anti-TB drugs on spleen, blood and bone marrow chromosomes in normal rat.
Drug and chemical toxicology.
2017 Apr; 40(2):154-163. doi:
10.1080/01480545.2016.1188398. [PMID: 27250504] - Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga. Enhancement of pharmacological effects of uricosuric agents by concomitant treatment with pyrazinamide in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Mar; 390(3):253-260. doi:
10.1007/s00210-016-1324-5. [PMID: 27933340] - Sampson Antwi, Hongmei Yang, Anthony Enimil, Anima M Sarfo, Fizza S Gillani, Daniel Ansong, Albert Dompreh, Antoinette Orstin, Theresa Opoku, Dennis Bosomtwe, Lubbe Wiesner, Jennifer Norman, Charles A Peloquin, Awewura Kwara. Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children with Tuberculosis with or without HIV Coinfection.
Antimicrobial agents and chemotherapy.
2017 02; 61(2):. doi:
10.1128/aac.01701-16. [PMID: 27855070] - Christopher Vinnard, Shruthi Ravimohan, Neo Tamuhla, Jotam Pasipanodya, Shashikant Srivastava, Chawangwa Modongo, Nicola M Zetola, Drew Weissman, Tawanda Gumbo, Gregory P Bisson. Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation.
PloS one.
2017; 12(11):e0187624. doi:
10.1371/journal.pone.0187624. [PMID: 29095954] - A K Hemanth Kumar, V Chandrasekaran, T Kannan, A Lakshmi Murali, J Lavanya, V Sudha, Soumya Swaminathan, Geetha Ramachandran. Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus.
European journal of clinical pharmacology.
2017 Jan; 73(1):65-70. doi:
10.1007/s00228-016-2132-z. [PMID: 27651240] - Zhuo Zhang, Alvaro A Ordonez, Peter Smith-Jones, Hui Wang, Kayla R Gogarty, Fereidoon Daryaee, Lauren E Bambarger, Yong S Chang, Sanjay K Jain, Peter J Tonge. The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography.
PloS one.
2017; 12(2):e0170871. doi:
10.1371/journal.pone.0170871. [PMID: 28151985] - M S Attia, Najlaa S Al-Radadi. Nano optical sensor binuclear Pt-2-pyrazinecarboxylic acid -bipyridine for enhancement of the efficiency of 3-nitrotyrosine biomarker for early diagnosis of liver cirrhosis with minimal hepatic encephalopathy.
Biosensors & bioelectronics.
2016 Dec; 86(?):406-412. doi:
10.1016/j.bios.2016.06.074. [PMID: 27414246] - Babita Tanwar, Asim Kumar, Perumal Yogeeswari, Dharmarajan Sriram, Asit K Chakraborti. Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leads.
Bioorganic & medicinal chemistry letters.
2016 12; 26(24):5960-5966. doi:
10.1016/j.bmcl.2016.10.082. [PMID: 27839684] - Yun Zhang, Hongli Guo, Hozeifa M Hassan, Ping-Ping Ding, Yijing Su, Yuming Song, Tao Wang, Lixin Sun, Luyong Zhang, Zhenzhou Jiang. Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway.
Journal of applied toxicology : JAT.
2016 12; 36(12):1579-1590. doi:
10.1002/jat.3319. [PMID: 27071702] - Julie B Prahl, Marika Lundqvist, Justyna M C Bahl, Isik S Johansen, Åse B Andersen, Niels Frimodt-Møller, Arieh S Cohen. Simultaneous quantification of isoniazid, rifampicin, ethambutol and pyrazinamide by liquid chromatography/tandem mass spectrometry.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2016 Nov; 124(11):1004-1015. doi:
10.1111/apm.12590. [PMID: 27546025] - Neesha Rockwood, Graeme Meintjes, Maxwell Chirehwa, Lubbe Wiesner, Helen McIlleron, Robert J Wilkinson, Paolo Denti. HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.
Antimicrobial agents and chemotherapy.
2016 10; 60(10):6050-9. doi:
10.1128/aac.00480-16. [PMID: 27480859] - Suresh Mallikaarjun, Charles Wells, Carolyn Petersen, Anne Paccaly, Susan E Shoaf, Shiva Patil, Lawrence Geiter. Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2016 10; 60(10):5976-85. doi:
10.1128/aac.00509-16. [PMID: 27458223] - Meenu Pichholiya, Arvind Kumar Yadav, S K Luhadia, Jameela Tahashildar, M L Aseri. A comparative study of efficacy and safety of febuxostat and allopurinol in pyrazinamide-induced hyperuricemic tubercular patients.
Indian journal of pharmacology.
2016 Sep; 48(5):522-525. doi:
10.4103/0253-7613.190729. [PMID: 27721537] - Roger K Verbeeck, Gunar Günther, Dan Kibuule, Christian Hunter, Tim W Rennie. Optimizing treatment outcome of first-line anti-tuberculosis drugs: the role of therapeutic drug monitoring.
European journal of clinical pharmacology.
2016 Aug; 72(8):905-16. doi:
10.1007/s00228-016-2083-4. [PMID: 27305904]