Dactinomycin (BioDeep_00000001608)

 

Secondary id: BioDeep_00000175725, BioDeep_00000641137

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N1,N9-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

化学式: C62H86N12O16 (1254.6284436)
中文名称: 放线菌素D
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChI: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)

描述信息

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DA - Actinomycines
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents

同义名列表

21 个代谢物同义名

N1,N9-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide; 2-Amino-N,n-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide; Merck sharp and dohme brand OF dactinomycin; Merck frosst brand OF dactinomycin; Lemery brand OF dactinomycin; Merck brand OF dactinomycin; MSD Brand OF dactinomycin; Lyovac, cosmegen; Lyovac-cosmegen; Cosmegen lyovac; Lyovac cosmegen; Meractinomycin; Actinomycin C1; Actinomycin IV; LyovacCosmegen; actinomycin D; Dactinomycin; Actinomycin; Cosmegen; Ac-de; ActD



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ting Liu, Tianqi Xu, Chen Hu, Dayuan Sun, Guangxiong Zhou. Hemiactinomycin, an undescribed intermediate of actinomycin biosynthesis from an actinomycetes strain Streptomyces antibioticus H41-55. Natural product research. 2024 May; 38(9):1577-1582. doi: 10.1080/14786419.2022.2161541. [PMID: 36564053]
  • Liangliang Gao, Meiling Huang, Qin Xiong, Yan Liang, Lanfang Mi, Yueming Jiang, Jun Zhang. Antibacterial Mechanism, Control Efficiency, and Nontarget Toxicity Evaluation of Actinomycin X2 against Xanthomonas citri Subsp. citri. Journal of agricultural and food chemistry. 2024 Mar; 72(9):4788-4800. doi: 10.1021/acs.jafc.3c08600. [PMID: 38377546]
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  • Ngoc Tung Quach, Thi Hanh Nguyen Vu, Thi Lien Bui, Anh Tuan Pham, Thi Thu An Nguyen, Thi Thanh Xuan Le, Thi Thu Thuy Ta, Pravin Dudhagara, Quyet-Tien Phi. Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum. Polish journal of microbiology. 2022 Sep; 71(3):381-394. doi: 10.33073/pjm-2022-034. [PMID: 36185028]
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  • Yanxue Zhao, Lei Wang, Xuwu Sun, Yiqun Bao, Hao Liu, Yanxue Zhao. Inhibition of ribosome biogenesis by actinomycin D affects Arabidopsis root development. Biochemical and biophysical research communications. 2022 01; 588(?):61-67. doi: 10.1016/j.bbrc.2021.12.030. [PMID: 34952471]
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  • Kamal A Qureshi, Avinash D Bholay, Pankaj K Rai, Hamdoon A Mohammed, Riaz A Khan, Faizul Azam, Mariusz Jaremko, Abdul-Hamid Emwas, Piotr Stefanowicz, Mateusz Waliczek, Monika Kijewska, Ehab A Ragab, Medhat Rehan, Gamal O Elhassan, Md Jamir Anwar, Dinesh K Prajapati. Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23. Scientific reports. 2021 07; 11(1):14539. doi: 10.1038/s41598-021-93285-7. [PMID: 34267232]
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  • Hironao Nakayama, Masako Nakahara, Erina Matsugi, Midori Soda, Tomoka Hattori, Koki Hara, Ayuki Usami, Chiaki Kusumoto, Shigeki Higashiyama, Kiyoyuki Kitaichi. Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells. Molecules (Basel, Switzerland). 2020 Dec; 26(1):. doi: 10.3390/molecules26010090. [PMID: 33379243]
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  • Fu-Juan Jia, Zhuo Han, Jia-Hui Ma, Shi-Qing Jiang, Xing-Ming Zhao, Hang Ruan, Wei-Dong Xie, Xia Li. Involvement of Reactive Oxygen Species in the Hepatorenal Toxicity of Actinomycin V In Vitro and In Vivo. Marine drugs. 2020 Aug; 18(8):. doi: 10.3390/md18080428. [PMID: 32824227]
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