NCBI Taxonomy: 1169025

Streptomyces pratensis (ncbi_taxid: 1169025)

found 15 associated metabolites at species taxonomy rank level.

Child Taxonomies: Streptomyces pratensis ATCC 33331

Dactinomycin

N1,N9-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

C62H86N12O16 (1254.6284)

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DA - Actinomycines C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000970 - Antineoplastic Agents

actinomycin D

2-amino-4,6-dimethyl-3-oxo-N1,N9-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-3H-phenoxazine-1,9-dicarboxamide

C62H86N12O16 (1254.6284)

D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000970 - Antineoplastic Agents

Cosmegen

actinomycin D

C62H86N12O16 (1254.6284)

{[(2r,3s,6s)-6-{[(2r,3r,4s,6s)-6-{[(2r,3r,4r,6r)-6-[(1s,4as,5s,6s,12bs)-5-(acetyloxy)-4a,6,8,12b-tetrahydroxy-1-{[(2r,4r,5r,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}methanimidic acid

{[(2r,3s,6s)-6-{[(2r,3r,4s,6s)-6-{[(2r,3r,4r,6r)-6-[(1s,4as,5s,6s,12bs)-5-(acetyloxy)-4a,6,8,12b-tetrahydroxy-1-{[(2r,4r,5r,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}methanimidic acid

C48H65NO21 (991.4049)

7-methoxy-6'-methyl-3'-oxaspiro[isoindole-1,2'-tricyclo[6.3.1.0⁴,¹²]dodecane]-1'(12'),4',6',8',10'-pentaene-3,11'-diol

C20H15NO4 (333.1001)

[(6-{[6-({6-[5-(acetyloxy)-4a,6,8,12b-tetrahydroxy-1-[(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl}oxy)-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl)oxy]methanimidic acid

[(6-{[6-({6-[5-(acetyloxy)-4a,6,8,12b-tetrahydroxy-1-[(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl}oxy)-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl)oxy]methanimidic acid

C48H65NO21 (991.4049)

6-hydroxy-4-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl]-4,5-dihydro-3h-pyridin-2-one

C15H17NO4 (275.1158)

2-amino-n1,n9-bis[11-hydroxy-6-isopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-13-(sec-butyl)-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

2-amino-n1,n9-bis[11-hydroxy-6-isopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-13-(sec-butyl)-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C64H90N12O16 (1282.6597)

2-amino-n1,n9-bis({11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl})-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

2-amino-n1,n9-bis({11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl})-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C62H86N12O16 (1254.6284)

11'-hydroxy-2-(2-hydroxyethyl)-7-methoxy-6'-methyl-3'-oxaspiro[isoindole-1,2'-tricyclo[6.3.1.0⁴,¹²]dodecane]-1'(12'),4',6',8',10'-pentaen-3-one

C22H19NO5 (377.1263)

n1,n9-bis[(6s,9r,10s,13r,18as)-11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

n1,n9-bis[(6s,9r,10s,13r,18as)-11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C62H86N12O16 (1254.6284)

2-amino-n9-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-n1-[11-hydroxy-6-isopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-13-(sec-butyl)-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

2-amino-n9-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-n1-[11-hydroxy-6-isopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-13-(sec-butyl)-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C63H88N12O16 (1268.6441)

[(6-{[6-({6-[5-(acetyloxy)-4,4a,6,8,12b-pentahydroxy-1-[(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl}oxy)-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl)oxy]methanimidic acid

[(6-{[6-({6-[5-(acetyloxy)-4,4a,6,8,12b-pentahydroxy-1-[(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy]-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl}oxy)-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl)oxy]methanimidic acid

C48H65NO22 (1007.3998)

4-methoxy-6'-methyl-3'-oxaspiro[isoindole-1,2'-tricyclo[6.3.1.0⁴,¹²]dodecane]-1'(12'),4',6',8',10'-pentaene-3,11'-diol

C20H15NO4 (333.1001)

{[(2r,3s,6s)-6-{[(2r,3r,4s,6s)-6-{[(2r,3r,4r,6r)-6-[(1s,4as,5s,6s,12bs)-5-(acetyloxy)-4,4a,6,8,12b-pentahydroxy-1-{[(2r,4r,5r,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}methanimidic acid

{[(2r,3s,6s)-6-{[(2r,3r,4s,6s)-6-{[(2r,3r,4r,6r)-6-[(1s,4as,5s,6s,12bs)-5-(acetyloxy)-4,4a,6,8,12b-pentahydroxy-1-{[(2r,4r,5r,6s)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-3-methyl-7,12-dioxo-1,4,5,6-tetrahydrotetraphen-9-yl]-3-hydroxy-2-methyloxan-4-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl]oxy}-2-methyloxan-3-yl]oxy}methanimidic acid

C48H65NO22 (1007.3998)