NCBI Taxonomy: 67381

Streptomyces violascens (ncbi_taxid: 67381)

found 122 associated metabolites at species taxonomy rank level.

Child Taxonomies: none taxonomy data.

Dactinomycin

N1,N9-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

C62H86N12O16 (1254.6284436)

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DA - Actinomycines C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000970 - Antineoplastic Agents

Cyclooctatin

C20H34O3 (322.25078140000005)

A diterpenoid characterized by a 5-8-5 dodecahydrodicyclopenta[a,d]cyclooctene fused-ring system, with a single double bond and one isopropyl, two hydroxy, one hydroxymethyl and two methyl substituents.

actinomycin D

2-amino-4,6-dimethyl-3-oxo-N1,N9-bis[2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-3H-phenoxazine-1,9-dicarboxamide

C62H86N12O16 (1254.6284436)

D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000970 - Antineoplastic Agents

Cosmegen

actinomycin D

C62H86N12O16 (1254.6284436)

2,7,7-trimethyltricyclo[6.2.1.0¹,⁵]undec-5-ene-6-carboxylic acid

C15H22O2 (234.1619712)

4-hydroxy-3-methyl-6-[(5s)-5-methylheptyl]pyran-2-one

C14H22O3 (238.1568862)

4-(hydroxymethyl)-12-isopropyl-1,8-dimethyltricyclo[9.3.0.0³,⁷]tetradec-10-ene-6,8-diol

C20H34O3 (322.25078140000005)

4-(hydroxymethyl)-12-isopropyl-1,8-dimethyltricyclo[9.3.0.0³,⁷]tetradec-10-ene-6,8,12-triol

C20H34O4 (338.24569640000004)

(1r,3r,4r,6r,7s,8s,12s)-4-(hydroxymethyl)-12-isopropyl-1,8-dimethyltricyclo[9.3.0.0³,⁷]tetradec-10-ene-6,8,12-triol

C20H34O4 (338.24569640000004)

4-methoxy-3-methyl-6-(4-methylpentyl)pyran-2-one

C13H20O3 (224.14123700000002)

6-heptyl-4-methoxy-3-methylpyran-2-one

C14H22O3 (238.1568862)

2-amino-n1-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14,17-pentaoxo-3h,6h,9h,10h,13h,16h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-n9-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

2-amino-n1-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14,17-pentaoxo-3h,6h,9h,10h,13h,16h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-n9-{11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl}-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C62H84N12O17 (1268.6077094)

(1r,3r,4s,6r,10s,11s,12r,14r)-14-(hydroxymethyl)-6-isopropyl-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-ene-4,10,12-triol

C20H34O4 (338.24569640000004)

4-methoxy-3-methyl-6-(5-methylheptyl)pyran-2-one

C15H24O3 (252.1725354)

2-[10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl 2-[2-hydroxy-3,5-dimethyl-6-(3-oxopentan-2-yl)oxan-2-yl]propanoate

C35H58O8 (606.4131468)

(10z)-4-(hydroxymethyl)-12-isopropyl-1,8-dimethyltricyclo[9.3.0.0³,⁷]tetradec-10-ene-6,8-diol

C20H34O3 (322.25078140000005)

(1s,7ar)-1,5,5,7a-tetramethyl-2,3,6,7-tetrahydro-1h-indene-4-carboxylic acid

C14H22O2 (222.1619712)

4-hydroxy-6-(5-hydroxy-5-methylhexyl)-3-methylpyran-2-one

C13H20O4 (240.136152)

(2s)-2-[(1r,3r,6r,10s,11s,12r,14r)-10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl (2s)-2-[(2r,3r,5r,6s)-2-hydroxy-3,5-dimethyl-6-[(2s)-3-oxohexan-2-yl]oxan-2-yl]propanoate

(2s)-2-[(1r,3r,6r,10s,11s,12r,14r)-10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl (2s)-2-[(2r,3r,5r,6s)-2-hydroxy-3,5-dimethyl-6-[(2s)-3-oxohexan-2-yl]oxan-2-yl]propanoate

C36H60O8 (620.428796)

(1r,3r,4r,6r,10s,11s,12r,14r)-14-(hydroxymethyl)-6-isopropyl-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-ene-4,10,12-triol

C20H34O4 (338.24569640000004)

4-methoxy-3-methyl-6-(5-methylhexyl)pyran-2-one

C14H22O3 (238.1568862)

2-amino-n1,n9-bis({11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl})-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

2-amino-n1,n9-bis({11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl})-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C62H86N12O16 (1254.6284436)

4-hydroxy-3-methyl-6-(5-methylhexyl)pyran-2-one

C13H20O3 (224.14123700000002)

14-(hydroxymethyl)-6-isopropyl-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-ene-4,10,12-triol

C20H34O4 (338.24569640000004)

(1r,2s,4r,8s)-6-(hydroxymethyl)-2,7,7-trimethyltricyclo[6.2.1.0¹,⁵]undec-5-en-4-ol

C15H24O2 (236.1776204)

4-hydroxy-3-methyl-6-(5-methylheptyl)pyran-2-one

C14H22O3 (238.1568862)

(1r,2s,8s)-2,7,7-trimethyltricyclo[6.2.1.0¹,⁵]undec-5-ene-6-carboxylic acid

C15H22O2 (234.1619712)

n1,n9-bis[(6s,9r,10s,13r,18as)-11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

n1,n9-bis[(6s,9r,10s,13r,18as)-11-hydroxy-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,14-tetraoxo-3h,6h,9h,10h,13h,16h,17h,18h,18ah-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboximidic acid

C62H86N12O16 (1254.6284436)

(2s)-2-[(1r,3r,6r,10s,11s,12r,14r)-10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl (2s)-2-[(2r,3r,5r,6s)-2-hydroxy-3,5-dimethyl-6-[(2s)-3-oxopentan-2-yl]oxan-2-yl]propanoate

C35H58O8 (606.4131468)

4-hydroxy-6-(6-hydroxy-5-methylheptyl)-3-methylpyran-2-one

C14H22O4 (254.1518012)

4-hydroxy-3-methyl-6-(4-methylpentyl)pyran-2-one

C12H18O3 (210.1255878)

(2s)-2-[(1r,3r,6r,10s,11s,12r,14r)-10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl (2r)-2-[(2r,3r,5r,6s)-2-hydroxy-3,5-dimethyl-6-[(2s)-3-oxopentan-2-yl]oxan-2-yl]propanoate

(2s)-2-[(1r,3r,6r,10s,11s,12r,14r)-10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl (2r)-2-[(2r,3r,5r,6s)-2-hydroxy-3,5-dimethyl-6-[(2s)-3-oxopentan-2-yl]oxan-2-yl]propanoate

C35H58O8 (606.4131468)

2-[10,12-dihydroxy-14-(hydroxymethyl)-3,10-dimethyltricyclo[9.3.0.0³,⁷]tetradec-7-en-6-yl]propyl 2-[2-hydroxy-3,5-dimethyl-6-(3-oxohexan-2-yl)oxan-2-yl]propanoate

C36H60O8 (620.428796)