2'-Deoxyuridine 5'-monophosphate disodium salt (BioDeep_00000001602)

 

Secondary id: BioDeep_00000400397, BioDeep_00000406128

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


{[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C9H13N2O8P (308.041)
中文名称: 2-脱氧胸苷-5-三磷酸三钠二水, 2-脱氧尿嘧啶核苷-5'-单磷酸, 脱氧尿苷酸, 2'-脱氧尿苷-5'-单磷酸(DUMP)
谱图信息: 最多检出来源 Homo sapiens(plant) 13.18%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

2'-Deoxyuridine 5'-monophosphate disodium salt. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2_-deoxyuridine_5_-monophosphate_disodium_salt (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001602). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)O)O
InChI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1

描述信息

Deoxyuridine monophosphate (dUMP), also known as deoxyuridylic acid or deoxyuridylate in its conjugate acid and conjugate base forms, respectively, is a deoxynucleotide. It belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleoside monophosphates. These are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. dUMP exists in all living species, ranging from bacteria to humans. Within humans, dUMP participates in a number of enzymatic reactions. In particular, dUMP can be biosynthesized from dCMP through its interaction with the enzyme deoxycytidylate deaminase. In addition, dUMP can be biosynthesized from deoxyuridine; which is mediated by the enzyme thymidine kinase, cytosolic. In humans, dUMP is involved in pyrimidine metabolism. A pyrimidine 2-deoxyribonucleoside 5-monophosphate having uracil as the nucleobase. Outside of the human body, dUMP has been detected, but not quantified in several different foods, such as breadnut tree seeds, sea-buckthornberries, sour cherries, black walnuts, and common oregano.
dUMP is formed by the reduction of ribonucleotides to deoxyribonucleotides by ribonucleoside diphosphate reductase [EC 1.17.4.1]. dUMP by the action of by thymidylate synthetase [EC 2.1.1.45] produces dTMP (5,10-Methylene-5,6,7,8-tetrahydrofolate is a cofactor for the reaction). The nuclear form of uracil-DNA glycosylase (UNG2), that its major role is to remove misincorporated dUMP residues (cells deficient in removal of misincorporated dUMP accumulate uracil residues). (PMID 11554311) [HMDB]. dUMP is found in many foods, some of which are ginger, evergreen huckleberry, vanilla, and common walnut.

dUMP. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=964-26-1 (retrieved 2024-07-15) (CAS RN: 964-26-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

27 个代谢物同义名

{[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid; 2-Deoxyuridine-5-monophosphate disodium salt; 2-Deoxyuridine 5-monophosphate (dUMP); 2-Deoxyuridine 5-monophosphoric acid; 2-Deoxyuridylic acid, disodium salt; Deoxyuridine monophosphate (dUMP); 2-Deoxyuridine 5-phosphoric acid; Deoxyuridine monophosphoric acid; 2-Deoxyuridine-5-monophosphate; Deoxyuridine 5-phosphoric acid; 2-Deoxyuridine 5-monophosphate; Deoxyuridine 5-monophosphate; 2-Deoxyuridine 5-phosphate; Deoxyuridine monophosphate; Deoxyuridine 5-phosphate; 2-Deoxy-5-uridylic acid; 2-Deoxyuridylic acid; 2-Deoxy-5-uridylate; Deoxyuridylic acid; 2-Deoxyuridylate; SCHEMBL21941035; Deoxyuridylate; Deoxy-UMP; dUMP; 2'-Deoxyuridine 5'-phosphate(dUMP); dUMP; 2'-Deoxyuridine 5'-monophosphate



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

53 个相关的代谢反应过程信息。

Reactome(9)

BioCyc(11)

WikiPathways(3)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(26)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANG, DCK, DHFR, DNPH1, DTYMK, HMGB1, SPX, TYMS
Peripheral membrane protein 1 HMGB1
Nucleus 10 ANG, DCK, DNPH1, DTYMK, DUT, HMGB1, PCNA, RPA2, TYMS, UNG
cytosol 10 ANG, CDA, DCK, DHFR, DNPH1, DTYMK, PPAT, TYMP, TYMS, UPP1
nuclear body 2 PCNA, RPA2
centrosome 1 PCNA
nucleoplasm 7 DCK, DUT, HMGB1, PCNA, RPA2, UNG, UPP1
Cell membrane 1 HMGB1
Cytoplasmic granule 1 RNASE2
cell surface 1 HMGB1
growth cone 1 ANG
mitochondrial inner membrane 1 TYMS
neuronal cell body 1 ANG
Cytoplasmic vesicle, secretory vesicle 1 SPX
Lysosome 1 RNASE2
endosome 1 HMGB1
plasma membrane 3 HMGB1, IFNLR1, TCN2
Membrane 1 IFNLR1
extracellular exosome 4 DNPH1, DUT, PCNA, RNASE2
endoplasmic reticulum 1 HMGB1
extracellular space 5 ANG, HMGB1, RNASE2, SPX, TCN2
lysosomal lumen 1 TCN2
mitochondrion 6 DCK, DHFR, DTYMK, DUT, TYMS, UNG
Single-pass type I membrane protein 1 IFNLR1
Secreted 3 ANG, HMGB1, TCN2
extracellular region 6 ANG, CDA, HMGB1, RNASE2, SPX, TCN2
Mitochondrion matrix 1 TYMS
mitochondrial matrix 2 DTYMK, TYMS
Extracellular side 1 HMGB1
external side of plasma membrane 1 TCN2
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Mitochondrion inner membrane 1 TYMS
basement membrane 1 ANG
Nucleus, PML body 1 RPA2
PML body 1 RPA2
chromatin 2 PCNA, RPA2
Chromosome 2 ANG, HMGB1
Secreted, extracellular space 1 SPX
Nucleus, nucleolus 1 ANG
nuclear replication fork 1 PCNA
chromosome, telomeric region 2 PCNA, RPA2
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
replication fork 1 PCNA
ficolin-1-rich granule lumen 2 CDA, HMGB1
secretory granule lumen 2 CDA, HMGB1
transcription repressor complex 1 HMGB1
male germ cell nucleus 1 PCNA
tertiary granule lumen 1 CDA
dense core granule 1 SPX
endocytic vesicle 1 ANG
transport vesicle 1 SPX
azurophil granule lumen 1 RNASE2
nuclear lamina 1 PCNA
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
[Isoform 2]: Nucleus 1 DUT
condensed chromosome 1 HMGB1
[Isoform 3]: Mitochondrion 1 DUT
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
angiogenin-PRI complex 1 ANG
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
DNA replication factor A complex 1 RPA2
interleukin-28 receptor complex 1 IFNLR1


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