Pantoprazole (BioDeep_00000001555)

 

Secondary id: BioDeep_00000229724

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole

化学式: C16H15F2N3O4S (383.0751)
中文名称: 左旋泮托拉唑, 泮托拉唑
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 45.06%

分子结构信息

SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
InChI: InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)

描述信息

Pantozol; Pantoprazole (brand names Pantopan in Italy; Protium; Protonix; Pantozol; Pantor; Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained; Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained. Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance; Protium; Pantor; Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained; Protonix; Pantoprazole (brand names Pantopan in Italy.
Pantozol; Pantoprazole (brand names Pantopan in Italy; Protium; Protonix; Pantozol; Pantor; Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained; Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained.
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BC - Proton pump inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 8336
CONFIDENCE standard compound; INTERNAL_ID 2274

同义名列表

14 个代谢物同义名

6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole; Pantoprazole Sodium Hydrate; Pantoprazole sodium; SK And F-96022; SK And F 96022; Pantoprazolum; SK And F96022; Protonix i.v.; pantoprazole; Pantoprazol; Protonix; Pantoloc; Pantozol; Pantoprazole



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, BCL2, CAT, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS2, VASP
Peripheral membrane protein 2 CYP1B1, PTGS2
Endoplasmic reticulum membrane 8 BCL2, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS2
Mitochondrion membrane 1 ABCG2
Nucleus 1 BCL2
cytosol 5 ATP12A, BCL2, CAT, SST, VASP
mitochondrial membrane 1 ABCG2
nucleoplasm 2 ABCG2, ATP2B1
Cell membrane 4 ABCB1, ABCG2, ATP2B1, TNF
lamellipodium 1 VASP
Multi-pass membrane protein 4 ABCB1, ABCG2, ATP12A, ATP2B1
Synapse 1 ATP2B1
cell surface 2 ABCB1, TNF
glutamatergic synapse 2 ATP2B1, VASP
Golgi membrane 1 INS
neuronal cell body 2 SST, TNF
postsynapse 1 VASP
presynaptic membrane 1 ATP2B1
plasma membrane 8 ABCB1, ABCG2, ATP12A, ATP2B1, CYP2C19, CYP2C9, TNF, VASP
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCB1, ABCG2, ATP2B1, BCL2, CAT, CYP1B1, CYP2D6, CYP3A4
apical plasma membrane 3 ABCB1, ABCG2, ATP12A
basolateral plasma membrane 2 ATP12A, ATP2B1
caveola 1 PTGS2
extracellular exosome 4 ABCB1, ATP2B1, CAT, VASP
endoplasmic reticulum 3 BCL2, CYP2D6, PTGS2
extracellular space 6 GAST, IL6, INS, PTH, SST, TNF
Cell junction, tight junction 1 VASP
bicellular tight junction 1 VASP
mitochondrion 4 BCL2, CAT, CYP1B1, CYP2D6
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 8 ATP2B1, CAT, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
Microsome membrane 6 CYP1A2, CYP1B1, CYP2C9, CYP2D6, CYP3A4, PTGS2
filopodium 1 VASP
Secreted 4 GAST, IL6, INS, SST
extracellular region 7 CAT, GAST, IL6, INS, PTH, SST, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP2D6
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
actin cytoskeleton 2 ATP12A, VASP
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 3 ABCB1, ABCG2, ATP12A
Cell projection, lamellipodium 1 VASP
Membrane raft 2 ABCG2, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 VASP
focal adhesion 2 CAT, VASP
GABA-ergic synapse 1 SST
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
cell projection 2 ATP2B1, VASP
phagocytic cup 1 TNF
cytoskeleton 1 VASP
brush border membrane 1 ABCG2
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
filopodium membrane 1 VASP
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 SST
external side of apical plasma membrane 2 ABCB1, ABCG2
lamellipodium membrane 1 VASP
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP12A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Finnian Freeling, Dominic Armbruster, Karsten Nödler, Uwe Kunkel, Marco Scheurer, Jan Koschorreck, Thomas A Ternes. Metabolites are overlooked in environmental risk assessments and monitoring of pharmaceuticals: The case study of pantoprazole. Water research. 2024 Jun; 256(?):121596. doi: 10.1016/j.watres.2024.121596. [PMID: 38685172]
  • Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang. Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults. Atherosclerosis. 2022 10; 358(?):47-54. doi: 10.1016/j.atherosclerosis.2022.09.001. [PMID: 36113328]
  • Keith Feldman, Gregory L Kearns, Robin E Pearce, Susan M Abdel-Rahman, James Steven Leeder, Alec Friesen, Vincent S Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich. Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children. Clinical and translational science. 2022 05; 15(5):1155-1166. doi: 10.1111/cts.13232. [PMID: 35099109]
  • C Zeng, T Neogi, A T Chan, J Wei, D Misra, N Lu, H K Choi, G Lei, Y Zhang. Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study. Osteoarthritis and cartilage. 2022 04; 30(4):559-569. doi: 10.1016/j.joca.2021.12.010. [PMID: 35031493]
  • Michael A Fawzy, Sherif A Maher, Mahmoud A El-Rehany, Nermeen N Welson, Nisreen K A Albezrah, Gaber El-Saber Batiha, Moustafa Fathy. Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041383. [PMID: 35209172]
  • Michael Poppe, Christian Clodi, Christoph Schriefl, Matthias Mueller, Raute Sunder-Plaßmann, Birgit Reiter, Maximilian Rechenmacher, Wisse van Os, J G Coen van Hasselt, Michael Holzer, Harald Herkner, Michael Schwameis, Bernd Jilma, Christian Schoergenhofer, Christoph Weiser. Targeted temperature management after cardiac arrest is associated with reduced metabolism of pantoprazole - A probe drug of CYP2C19 metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112573. doi: 10.1016/j.biopha.2021.112573. [PMID: 34959115]
  • Bhargavi V Desai, Misbah N Qadri, Bhavin A Vyas. Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel. European journal of clinical pharmacology. 2022 Jan; 78(1):35-41. doi: 10.1007/s00228-021-03237-3. [PMID: 34714373]
  • Michael A Fawzy, Sherif A Maher, Sally M Bakkar, Mahmoud A El-Rehany, Moustafa Fathy. Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)-NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats. International journal of molecular sciences. 2021 Oct; 22(19):. doi: 10.3390/ijms221910669. [PMID: 34639009]
  • Eman Ghonaim, Sahar El-Haggar, Suzy Gohar. Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial. Medical oncology (Northwood, London, England). 2021 Aug; 38(9):108. doi: 10.1007/s12032-021-01558-y. [PMID: 34357466]
  • Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric-Coated Tablets in Healthy Subjects. Clinical pharmacology in drug development. 2021 05; 10(5):502-509. doi: 10.1002/cpdd.888. [PMID: 33128847]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Burcu Kaya, Halime Mualla Nizam, Arzu Velioglu, Deniz Filinte, Handan Kaya, Serhan Tuglular. Granulomatous Interstitial Nephritis Associated With Pantoprazole. American journal of therapeutics. 2021 04; 29(1):e143-e146. doi: 10.1097/mjt.0000000000001368. [PMID: 33852474]
  • Jian Le, Yuehua Liao, Shengni Li, Xiujuan Chen, Zhanying Hong. High-throughput LC-MS/MS Method for Simultaneous Determination of Pantoprazole and Atorvastatin in Rat Plasma: Application to a Pharmacokinetic Interaction Study. Current drug metabolism. 2021; 22(6):481-490. doi: 10.2174/1389200222666210520090632. [PMID: 34455944]
  • Ahmet Sevki Taskiran, Mustafa Ergul, Handan Gunes, Aysegul Ozturk, Bilal Sahin, Ercan Ozdemir. The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line. Cellular and molecular neurobiology. 2021 Jan; 41(1):173-183. doi: 10.1007/s10571-020-00956-6. [PMID: 32862257]
  • Taavi J K Kaartinen, Aleksi Tornio, Tuija Tapaninen, Terhi Launiainen, Nina Isoherranen, Mikko Niemi, Janne T Backman. Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19. Clinical pharmacology and therapeutics. 2020 12; 108(6):1254-1264. doi: 10.1002/cpt.1949. [PMID: 32558923]
  • Syed Mohammed Basheeruddin Asdaq, Earla Swathi, Sunil S Dhamanigi, Mohammed Asad, Yahya Ali Mohzari, Ahmed A Alrashed, Abdulrahman S Alotaibi, Batool Mohammed Alhassan, Sreeharsha Nagaraja. Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225287. [PMID: 33202703]
  • Jae Ho Cho, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee. Efficacy of DA-5204 (Stillen 2X) for patients with gastroesophageal reflux disease: A randomized, double-blind, placebo-controlled pilot study. Medicine. 2020 Oct; 99(44):e22729. doi: 10.1097/md.0000000000022729. [PMID: 33126310]
  • Gaurav Taneja, Punniyakoti V Thanikachalam, Satyendra K Rajput. Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue. Toxicology letters. 2020 Oct; 333(?):97-104. doi: 10.1016/j.toxlet.2020.07.031. [PMID: 32763312]
  • Doaa El-Bohy, Magdy El Sharkawy, Soheir Abo-Elazm, Sara Shahin, Waleed Bchari, Azza Mancy, Manal El Hamamsy. Esomeprazole vs pantoprazole effects on cyclosporine levels in kidney transplantation: A randomized clinical trial. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2020 Oct; 24(5):591-598. doi: 10.1111/1744-9987.13464. [PMID: 31856374]
  • Sara Blanco Dorado, Olalla Maroñas Amigo, Ana Latorre-Pellicer, María Teresa Rodríguez Jato, Ana López-Vizcaíno, Aurea Gómez Márquez, Belén Bardán García, Dolores Belles Medall, Gema Barbeito Castiñeiras, María Luisa Pérez Del Molino Bernal, Manuel Campos-Toimil, Francisco Otero Espinar, Andrés Blanco Hortas, Irene Zarra Ferro, Ángel Carracedo, María Jesús Lamas, Anxo Fernández-Ferreiro. A multicentre prospective study evaluating the impact of proton-pump inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations. British journal of clinical pharmacology. 2020 08; 86(8):1661-1666. doi: 10.1111/bcp.14267. [PMID: 32110830]
  • Andreas Kofoed, Anders Perner, Søren Marker, Nicolai Haase, Lars B Holst, Morten Hylander Møller. Effects of simulated sample sizes on the mortality effect estimates in three randomized intensive care unit trials. Acta anaesthesiologica Scandinavica. 2020 08; 64(7):976-981. doi: 10.1111/aas.13585. [PMID: 32236941]
  • Lu-Ning Sun, Ye Zhang, Yu-Qing Yang, Ye Shen, Yu-Wen Ying, Yu-Wen Su, Xue-Hui Zhang, Yun Liu, Xu Huang, Yong-Qing Wang. Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography-tandem mass spectrometry. Journal of separation science. 2020 Aug; 43(16):3183-3196. doi: 10.1002/jssc.202000226. [PMID: 32495501]
  • Dolores Ochoa, Manuel Román, Teresa Cabaleiro, Miriam Saiz-Rodríguez, Gina Mejía, Francisco Abad-Santos. Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole. BMC pharmacology & toxicology. 2020 07; 21(1):54. doi: 10.1186/s40360-020-00433-2. [PMID: 32711578]
  • Raed S Ismail, Mohammed S El-Awady, Memy H Hassan. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. 2020 07; 393(7):1161-1171. doi: 10.1007/s00210-020-01823-3. [PMID: 31950223]
  • Felicitas Stoll, Antje Blank, Gerd Mikus, David Czock, Kathrin I Foerster, Simon Hermann, Katja Häußler, Amin Muhareb, Simone Hummler, Johanna Weiss, Jürgen Burhenne, Walter E Haefeli. Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jun; 21(1):584. doi: 10.1186/s13063-020-04476-y. [PMID: 32600363]
  • Isabel J B van der Zalm, Tom J M Tobé, Susan J J Logtenberg. Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report. Journal of medical case reports. 2020 Jun; 14(1):83. doi: 10.1186/s13256-020-02423-8. [PMID: 32594911]
  • Andrew Sunderland, Graeme Russ, Benedetta Sallustio, Matthew Cervelli, David Joyce, Esther Ooi, Gary Jeffrey, Neil Boudville, Aron Chakera, Gursharan Dogra, Doris Chan, Germaine Wong, Wai H Lim. Effect of the proton-pump Inhibitor pantoprazole on MycoPhenolic ACid exposure in kidney and liver transplant recipienTs (IMPACT study): a randomized trial. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2020 06; 35(6):1060-1070. doi: 10.1093/ndt/gfaa111. [PMID: 32516810]
  • Varun Vohra, Jeanna M Marraffa, Susan M Wojcik, William Eggleston. An assessment of urine THC immunoassay in healthy volunteers receiving an oral proton-pump inhibitor. Clinical toxicology (Philadelphia, Pa.). 2020 06; 58(6):498-500. doi: 10.1080/15563650.2019.1662917. [PMID: 31566030]
  • Qi Huang, Qiong Liu, Tao Yin, Lin Hu, Hanjun Ding, Shao Liu, Yueping Jiang. Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases. European journal of clinical pharmacology. 2020 Jun; 76(6):833-842. doi: 10.1007/s00228-020-02841-z. [PMID: 32157329]
  • Ken Ogasawara, Bradley Vince, Christine Xu, Meng Zhang, Maria Palmisano, Gopal Krishna. A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects. Cancer chemotherapy and pharmacology. 2020 05; 85(5):995-1001. doi: 10.1007/s00280-020-04074-4. [PMID: 32318809]
  • Lina A Dahabiyeh, Eman Y Abu-Rish, Mutasem O Taha. Inhibition of monoglyceride lipase by proton pump inhibitors: investigation using docking and in vitro experiments. Pharmacological reports : PR. 2020 Apr; 72(2):435-442. doi: 10.1007/s43440-019-00013-0. [PMID: 32048247]
  • Martin Schnierer, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, Lenka Nosáková, Peter Bánovčin, Peter Galajda, Ján Stasko, Peter Kubisz, Rudolf Hyrdel, Marián Mokáň. The Effect of Proton Pump Inhibitor Withdrawal on Dabigatran Etexilate Plasma Levels in Patients With Atrial Fibrillation: A Washout Study. Journal of cardiovascular pharmacology. 2020 04; 75(4):333-335. doi: 10.1097/fjc.0000000000000791. [PMID: 31895873]
  • Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Gerhard Dammann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism. Pharmacopsychiatry. 2020 Mar; 53(2):65-70. doi: 10.1055/a-1021-8827. [PMID: 31614374]
  • Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study. Current drug metabolism. 2020; 21(2):126-131. doi: 10.2174/1389200221666200218121050. [PMID: 32067615]
  • Sara Kadkhodaei, Farideh Siavoshi, Alireza Foroumadi, Abdolfattah Sarrafnejad, Shadi Kolahdoozan. Proton Pump Inhibitor-Treated H. pylori Adjust Cell Envelope Fatty Acid and Cholesterol Content to Survive. Archives of Iranian medicine. 2020 01; 23(1):7-14. doi: . [PMID: 31910629]
  • Masoomeh Shaghaghi, Samaneh Rashtbari, Asma Abdollahi, Gholamreza Dehghan, Abolghasem Jouyban. A Sensitive, Simple and Direct Determination of Pantoprazole Based on a 'Turn off-on' Fluorescence Nanosensor by Using Terbium-1,10-phenanthroline-silver Nanoparticles. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2020; 36(11):1345-1352. doi: 10.2116/analsci.20p142. [PMID: 33177314]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jie Ying, Liu-Cheng Li, Cui-Yun Wu, Zhen-Wei Yu, Lian-Di Kan. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2019 Oct; 111(10):738-743. doi: 10.17235/reed.2019.6155/2019. [PMID: 31373505]
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