Pargyline (BioDeep_00000001509)

 

Secondary id: BioDeep_00001867836

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


benzyl(methyl)(prop-2-yn-1-yl)amine

化学式: C11H13N (159.1048)
中文名称: N-甲基-N-炔丙基苯甲胺
谱图信息: 最多检出来源 Homo sapiens(blood) 11.34%

分子结构信息

SMILES: C#CCN(C)Cc(c1)cccc1
InChI: InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3

描述信息

Pargyline is only found in individuals that have used or taken this drug. It is a monoamine oxidase inhibitor with antihypertensive properties. [PubChem]MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system.
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4653; ORIGINAL_PRECURSOR_SCAN_NO 4650
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4679; ORIGINAL_PRECURSOR_SCAN_NO 4674
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4619; ORIGINAL_PRECURSOR_SCAN_NO 4616
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4667; ORIGINAL_PRECURSOR_SCAN_NO 4664
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4647; ORIGINAL_PRECURSOR_SCAN_NO 4643
CONFIDENCE standard compound; INTERNAL_ID 504; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4653; ORIGINAL_PRECURSOR_SCAN_NO 4652
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KC - Mao inhibitors
CONFIDENCE Parent Substance with Reference Standard (Level 1); INTERNAL_ID 1400
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3004
KEIO_ID M071

同义名列表

19 个代谢物同义名

benzyl(methyl)(prop-2-yn-1-yl)amine; N-Benzyl-N-methyl-2-propyn-1-amine; N-Benzyl-N-methyl-2-propynylamine; N-Methyl-N-2-propynylbenzylamine; N-Methyl-N-propagylbenzylamine; Benzyl-methyl-2-propinylamin; Methylbenzylpropynylamine; Hydrochloride, pargyline; pargyline hydrochloride; Pargyline chloride; PAR_160.1122_8.5; Pargylamine; Paragyline; Pargyline; Pargylin; Eutonyl; Eutron; Pargyline; Pargyline



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AR, BCL2, CAT, CDH1, DBH, DDC, HDC, PRL, TH
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 2 BCL2, PNMT
Mitochondrion membrane 2 MAOA, PNMT
Nucleus 7 AR, BCL2, CDH1, HDC, KDM1A, PRL, TH
cytosol 11 AR, BCL2, CAT, CDH1, COMT, DDC, HDC, MAOA, PNMT, SST, TH
dendrite 5 COMT, HTR1A, HTR2A, MAOB, TH
mitochondrial membrane 1 PNMT
trans-Golgi network 1 CDH1
nucleoplasm 4 AR, CDH1, KDM1A, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 6 ADRB3, CDH1, COMT, HTR1A, HTR2A, SLC6A4
Cytoplasmic side 2 MAOA, MAOB
lamellipodium 1 CDH1
Cell projection, axon 2 HTR2A, TH
Multi-pass membrane protein 5 ADRB3, HTR1A, HTR2A, PNMT, SLC6A4
Synapse 4 COMT, DBH, HTR1A, SLC6A4
cell junction 1 CDH1
dendritic shaft 1 HTR2A
glutamatergic synapse 2 CDH1, HTR2A
Golgi apparatus 1 CDH1
Golgi membrane 1 INS
neuronal cell body 3 HTR2A, MAOB, SST
postsynapse 1 CDH1
presynaptic membrane 2 HTR2A, SLC6A4
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Presynapse 2 HTR2A, SLC6A4
endosome 1 CDH1
plasma membrane 7 ADRB3, AR, CDH1, COMT, HTR1A, HTR2A, SLC6A4
terminal bouton 1 TH
Membrane 9 AR, BCL2, CAT, CDH1, COMT, DBH, HDC, MAOA, SLC6A4
axon 3 COMT, HTR2A, TH
caveola 1 HTR2A
extracellular exosome 4 CAT, CDH1, COMT, DDC
endoplasmic reticulum 3 BCL2, DBH, PNMT
extracellular space 4 DBH, INS, PRL, SST
perinuclear region of cytoplasm 2 CDH1, TH
adherens junction 1 CDH1
mitochondrion 6 BCL2, CAT, MAOA, MAOB, PNMT, TH
protein-containing complex 4 AR, BCL2, CAT, KDM1A
intracellular membrane-bounded organelle 4 CAT, COMT, DBH, PNMT
Single-pass type I membrane protein 1 CDH1
Secreted 4 DBH, INS, PRL, SST
extracellular region 6 CAT, CDH1, DBH, INS, PRL, SST
cytoplasmic side of plasma membrane 2 CDH1, TH
Mitochondrion outer membrane 3 BCL2, MAOA, MAOB
Single-pass membrane protein 2 BCL2, MAOA
mitochondrial outer membrane 3 BCL2, MAOA, MAOB
mitochondrial matrix 1 CAT
Extracellular side 1 COMT
transcription regulator complex 1 KDM1A
centriolar satellite 1 DBH
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
actin cytoskeleton 1 CDH1
perikaryon 1 TH
cytoplasmic vesicle 2 HTR2A, TH
Melanosome membrane 1 TH
Single-pass type II membrane protein 2 COMT, DBH
postsynaptic membrane 2 HTR2A, SLC6A4
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 SLC6A4
pore complex 1 BCL2
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 2 CAT, SLC6A4
GABA-ergic synapse 1 SST
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 CDH1
nuclear speck 1 AR
receptor complex 1 ADRB3
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 SLC6A4, TH
chromatin 3 AR, KDM1A, PRL
Chromosome 1 KDM1A
Golgi apparatus, trans-Golgi network 1 CDH1
chromosome, telomeric region 1 KDM1A
Endomembrane system 1 SLC6A4
endosome lumen 2 INS, PRL
Membrane, caveola 1 HTR2A
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
cell body fiber 1 HTR2A
Cell projection, dendrite 2 HTR1A, HTR2A
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, DBH, INS
secretory granule membrane 1 DBH
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 MAOB
neuronal dense core vesicle 1 SST
Single-pass type IV membrane protein 2 MAOA, MAOB
neurofilament 1 HTR2A
[Isoform 2]: Nucleus 1 CDH1
apical junction complex 1 CDH1
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
DNA repair complex 1 KDM1A
[Isoform 2]: Endoplasmic reticulum membrane 1 PNMT
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 1 DBH
catalase complex 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
BAD-BCL-2 complex 1 BCL2
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
G protein-coupled serotonin receptor complex 1 HTR2A
serotonergic synapse 1 SLC6A4


文献列表

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  • Yana Kleiner, Orit Bar-Am, Tamar Amit, Alexandra Berdichevski, Esti Liani, Gila Maor, Irina Reiter, Moussa B H Youdim, Ofer Binah. TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity. Journal of cardiovascular pharmacology. 2008 Sep; 52(3):268-77. doi: 10.1097/fjc.0b013e3181862441. [PMID: 18806608]
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