Cytarabine (BioDeep_00000014663)

 

Secondary id: BioDeep_00000405793

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

化学式: C9H13N3O5 (243.0855168)
中文名称: 阿糖胞苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.92%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

描述信息

Cytarabine, or cytosine arabinoside, a pyrimidine nucleoside analog, is found in mushrooms. Cytarabine is isolated from the mushroom Xerocomus nigromaculatus of unknown palatability. Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle to stop normal cell development and division. Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate). This metabolite then damages DNA by multiple mechanisms, including the inhibition of alpha-DNA polymerase, inhibition of DNA repair through an effect on beta-DNA polymerase, and incorporation into DNA. The latter mechanism is probably the most important. Cytotoxicity is highly specific for the S phase of the cell cycle. Cytarabine is a chemotherapy agent used mainly in the treatment of hematological malignancies such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as ara C. Cytosine arabinoside is an antimetabolic agent with the chemical name of 1 -arabinofuranosylcytosine. Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D000963 - Antimetabolites
COVID info from COVID-19 Disease Map
D000970 - Antineoplastic Agents
KEIO_ID C119; [MS2] KO008896
KEIO_ID C119
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

同义名列表

93 个代谢物同义名

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one; 1-beta-D-Arabinofuranosylcytosine, cytosine arabinoside; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; Cytosine-1-beta-D-arabinofuranoside hydrochloride; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-Amino-1-b-D-arabinofuranosyl-2(1H)-pyrimidinone; Cytosine-1-beta-D-arabinofuranoside; Cytosine 1-beta-D-arabinofuranoside; Cytosine-beta -D-arabinofuranoside; 1-beta -D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-cytosine; 1-beta -D-Arabinofuranosylcytosine; (beta-D-Arabinofuranosyl)cytosine; 1-beta-D-Arabinofuranosylcytosine; Cytosine beta-D-arabinofuranoside; Cytosine-beta-D-arabinofuranoside; 1-beta-D-Arabinofaranosylcytosine; 1beta -D-Arabinofuranosylcytosine; Cytosine-1-β-D-arabinofuranoside; 1beta-D-Arabinofuranosylcytosine; Cytosine-1-b-D-arabinofuranoside; 1beta -Arabinofuranasylcytosine; Cytosine-b-D-arabinofuranoside; 1-b-D-Arabinofuranosylcytosine; 1-Β-D-arabinofuranosylcytosine; Cytosine-β-D-arabinofuranoside; 1beta-Arabinofuranasylcytosine; Cytosine, beta -D-arabinoside; Cytarabine liposome injection; 1-beta-D-Arabinosyl-cytosine; Cytosine, beta-D-arabinoside; Cytosine beta-D-arabinoside; 1-beta-D-Arabinosylcytosine; 1beta -D-Arabinosylcytosine; 1beta-D-Arabinosylcytosine; Cytosine-beta -arabinoside; beta -D-Arabinosylcytosine; 1-Arabinofuranosylcytosine; beta -Cytosine arabinoside; Cytosine arabinofuranoside; Cytosine-beta-arabinoside; beta-D-Arabinosylcytosine; Hydrochloride, cytarabine; beta-Cytosine arabinoside; Arabinofuranosylcytosine; beta -Arabinosylcytosine; Cytarabine hydrochloride; beta-Arabinosylcytosine; Arabinoside, cytosine; Cytosine arabinoside; Cytosinearabinoside; Cytosine arabinose; Arabinosylcytosine; Arabinocytidine; Arabinocytosine; Spongocytidine; Cytarabinoside; Arabinoside C; Cytarabinum; Aracytidine; Citarabina; Cytarabina; beta Ara C; beta-Ara c; cytarabine; Cytosar-u; Cytarabin; Aracytine; Cytosar u; Depocyte; Tarabine; Aracytin; Arabitin; CytosarU; Cytonal; Depocyt; Cytosar; Arafcyt; Erpalfa; Alexan; Iretin; Udicil; Ara-C; Ara C; AraC; Cytosine β-D-arabinofuranoside



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jie Ding, Yang Su, Yinglu Ruan, Nan Li, Qianchao Meng, Jiabang Yang, Li Chen, Chi Liu. Clinical features and outcomes of patients with acute myeloid leukemia: the single-center experience of 668 patients in China. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2310960. doi: 10.1080/16078454.2024.2310960. [PMID: 38323781]
  • David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Gerardo Barragán Mejía. Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain. Scientific reports. 2024 05; 14(1):10835. doi: 10.1038/s41598-024-61766-0. [PMID: 38736022]
  • Yan Jia, Xiyu Li, Lulu Chen, Ling Li, Suzhen Zhang, Wenhui Huang, Hao Zhang. AHR signaling pathway mediates mitochondrial oxidative phosphorylation which leads to cytarabine resistance. Acta biochimica et biophysica Sinica. 2024 04; 56(4):597-606. doi: 10.3724/abbs.2024022. [PMID: 38404179]
  • Monika Jamioł, Magdalena Sozoniuk, Jacek Wawrzykowski, Marta Kankofer. Changes in plasma PLAC-1 concentration and its expression during early-mid pregnancy in bovine placental tissues - a pilot study. BMC veterinary research. 2024 Feb; 20(1):59. doi: 10.1186/s12917-024-03898-z. [PMID: 38378537]
  • Yihan Zhao, Shiqing Jiang, Yujun Tang, Lin Zhao. Venetoclax with CAG regimen for early T-cell precursor acute lymphoblastic leukemia: a case report and literature review. International journal of hematology. 2023 Oct; 118(4):483-488. doi: 10.1007/s12185-023-03623-w. [PMID: 37269505]
  • Mi-Rae Park, Hye-Jin Lee, Hye-Min Jang, Nam Hoon Kim, Jun-Seok Lee, Yong Taek Jeong, Inho Kim, Sang-Hyun Choi, Kwan Sik Seo, Dong-Hoon Kim. Cytarabine induces cachexia with lipid malabsorption via zippering the junctions of lacteal in murine small intestine. Journal of lipid research. 2023 06; 64(6):100387. doi: 10.1016/j.jlr.2023.100387. [PMID: 37201659]
  • Han Yao, Cheng Zhang, Xu Tan, Jieping Li, Xiaolin Yin, Xiaojuan Deng, Ting Chen, Jun Rao, Lei Gao, Peiyan Kong, Xi Zhang. Efficacy and toxicity of CLAG combined with pegylated liposomal doxorubicin in the treatment of refractory or relapsed acute myeloid leukemia. Cancer medicine. 2023 06; 12(11):12377-12387. doi: 10.1002/cam4.5938. [PMID: 37161845]
  • Zhixin Ma, Wenle Ye, Jinghan Wang, Xin Huang, Jiansong Huang, Xia Li, Chao Hu, Chenying Li, Yile Zhou, Xiangjie Lin, Wenwen Wei, Yu Qian, Yutong Zhou, Shihui Mao, Xiufeng Yin, Bo Zhu, Jie Jin. Glutamate dehydrogenase 1: A novel metabolic target in inhibiting acute myeloid leukaemia progression. British journal of haematology. 2023 May; ?(?):. doi: 10.1111/bjh.18884. [PMID: 37231991]
  • Wei Chu, Ya-Ling Li, Jun-Jie Li, Jia Lin, Mi Li, Jiao Wang, Jian-Zheng He, Yue-Mei Zhang, Juan Yao, Xiao-Jie Jin, Hui Cai, Yong-Qi Liu. Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114902. doi: 10.1016/j.biopha.2023.114902. [PMID: 37209628]
  • Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife M S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian J P Huntly, Paolo Gallipoli. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications. 2023 04; 14(1):2132. doi: 10.1038/s41467-023-37652-0. [PMID: 37059720]
  • Shuzhen Han, Minghui Xiu, Shuang Li, Yan Shi, Xiaoqian Wang, Xingyao Lin, Hui Cai, Yongqi Liu, Jianzheng He. Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114265. doi: 10.1016/j.biopha.2023.114265. [PMID: 36652735]
  • Lei Li, Hailong Tian, Zhe Zhang, Ning Ding, Kai He, Shuaijun Lu, Ruolan Liu, Peijie Wu, Yu Wang, Bo He, Maochao Luo, Peilan Peng, Mao Yang, Edouard C Nice, Canhua Huang, Na Xie, Dong Wang, Wei Gao. Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer. ACS applied materials & interfaces. 2023 Jan; 15(1):452-468. doi: 10.1021/acsami.2c17579. [PMID: 36538368]
  • Ting Li, Jiesen Yu, Mengyuan Hou, Sijie Zha, Qingqing Cheng, Qingshan Zheng, Lujin Li. Quantitative evaluation of therapy options for relapsed/refractory diffuse large B-cell lymphoma: A model-based meta-analysis. Pharmacological research. 2023 01; 187(?):106592. doi: 10.1016/j.phrs.2022.106592. [PMID: 36470547]
  • Ya-Ling Li, Wei Chu, Jun-Jie Li, Juan-Juan Dong, Gao-Qin Li, Xiao-Jie Jin, Juan Yao, Yong-Qi Liu. [Animal Model Establishment and Its Mechanism of Cytarabine-Iduced Myelosuppression]. Zhongguo shi yan xue ye xue za zhi. 2022 Oct; 30(5):1376-1383. doi: 10.19746/j.cnki.issn.1009-2137.2022.05.012. [PMID: 36208238]
  • I Koca, M Ucar, H O Arik, M Yilmaz, R Dokuyucu. Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis. European review for medical and pharmacological sciences. 2022 10; 26(20):7404-7412. doi: 10.26355/eurrev_202210_30009. [PMID: 36314310]
  • Karine Marchioro Leal, Mariana Barcelos Rocha, Fernanda Venzon Varela, Luana Rodrigues, Priscila Viau Furtado, Fernanda Vieira Amorim da Costa, Álan Gomes Pöppl. Is Methylprednisolone Acetate-Related Insulin Resistance Preventable in Cats?. Topics in companion animal medicine. 2022 Jul; 49(?):100648. doi: 10.1016/j.tcam.2022.100648. [PMID: 35202848]
  • Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson. A multiparametric niche-like drug screening platform in acute myeloid leukemia. Blood cancer journal. 2022 06; 12(6):95. doi: 10.1038/s41408-022-00689-3. [PMID: 35750691]
  • Emmanuel Gyan, Arnaud Pigneux, Mathilde Hunault, Pierre Peterlin, Martin Carré, Jacques-Olivier Bay, Caroline Bonmati, Maria-Pilar Gallego-Hernanz, Bruno Lioure, Philippe Bertrand, Nicolas Vallet, David Ternant, François Darrouzain, Frédéric Picou, Marie-Christine Béné, Christian Récher, Olivier Hérault. Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML. Scientific reports. 2022 06; 12(1):9748. doi: 10.1038/s41598-022-13626-y. [PMID: 35697729]
  • Yanjie Zhang, Hezhou Guo, Zhaoli Zhang, Wei Lu, Jiang Zhu, Jun Shi. IL-6 promotes chemoresistance via upregulating CD36 mediated fatty acids uptake in acute myeloid leukemia. Experimental cell research. 2022 06; 415(1):113112. doi: 10.1016/j.yexcr.2022.113112. [PMID: 35346671]
  • Sha Li, Shi Zeng, Bo-Ping Wei, Qiang Wu, Chang Liu, Pei-Ying Song. Determination of free and encapsulated cytarabine and daunorubicin in rat plasma after intravenous administration of liposomal formulation using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123275. doi: 10.1016/j.jchromb.2022.123275. [PMID: 35551041]
  • Rim Rakez, Wiem Boufrikha, Sana Lakhal, Amel Boughammoura, Mohamed Adnene Laatiri. The diagnostic dilemma of idiopathic intracranial hypertension in a child with acute lymphoblastic leukemia: COVID-19 or cytosine arabinoside?. BMC neurology. 2022 May; 22(1):163. doi: 10.1186/s12883-022-02689-z. [PMID: 35501718]
  • Zhen Xing Gao, Ze Long Cui, Min Ran Zhou, Yue Fu, Fen Liu, Lu Zhang, Sai Ma, Chun Yan Chen. The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia. Biochemical pharmacology. 2022 04; 198(?):114948. doi: 10.1016/j.bcp.2022.114948. [PMID: 35192847]
  • Jiang-Zhao Zhang, Min Liu, Zhi-Ping Huang. [Influence of Serum TGF-β1 and EGFR Levels on the Therapeutic Effect of High-Dose AraC in Patients with Acute Myeloid Leukemia Based on the Decision Curve]. Zhongguo shi yan xue ye xue za zhi. 2022 Apr; 30(2):. doi: 10.19746/j.cnki.issn.1009-2137.2022.02.014. [PMID: 35400362]
  • Jiang-Zhao Zhang, Min Liu, Zhi-Ping Huang. [Influence of Serum TGF-β1 and EGFR Levels on the Therapeutic Effect of High-Dose AraC in Patients with Acute Myeloid Leukemia Based on the Decision Curve]. Zhongguo shi yan xue ye xue za zhi. 2022 Apr; 30(2):407-412. doi: 10.19746/j.cnki.issn.1009-2137.2022.02.014. [PMID: 35395971]
  • Bei Zhang, Zhixin Pei, Hongxia Wang, Huimin Wu, Junjie Wang, Junjun Bai, Qinglin Song. Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation. Acta medica Okayama. 2022 Feb; 76(1):63-70. doi: 10.18926/amo/63213. [PMID: 35237000]
  • Shifen Fan, Jiao Chen, Zhouyang Liu, Juan Xiao, Fan Jiang, Xiaomei Liu, Yuan Sun. Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation with Cocktail Conditioning Regimen for the Treatment of Pediatric Patients with Chronic Active Epstein-Barr Virus: A Retrospective Observational Study. Stem cells and development. 2022 01; 31(1-2):26-31. doi: 10.1089/scd.2021.0205. [PMID: 34779276]
  • Ibrahim Khater, Aaya Nassar. Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis. PloS one. 2022; 17(5):e0268909. doi: 10.1371/journal.pone.0268909. [PMID: 35639751]
  • Xue Tang, Ju Gao, Zhi-Gui Ma, Xia Guo, Qiang Li, Zhi Wan, Jing-Jing Sun. Clinical and prognostic characteristics of 95 cases of Langerhans cell histiocytosis in children: a single-institute experience from 2013 to 2020. Annals of medicine. 2021 12; 53(1):1537-1546. doi: 10.1080/07853890.2021.1966085. [PMID: 34459688]
  • Chun Tong, Fang Ye, Ning-Ning Li, Huan Wang, Ya-Nan Shu, Ling Wang, Li-Nan Zhang. [Efficacy and Safety of Different Dosages of Decitabine in the Treatment of High-Risk Patients with Myelodysplastic Syndrome]. Zhongguo shi yan xue ye xue za zhi. 2021 Dec; 29(6):1845-1850. doi: 10.19746/j.cnki.issn.1009-2137.2021.06.026. [PMID: 34893121]
  • Shelly Roselyn Van Eyssen, Doga Kavaz. An evaluative in vitro investigation of the delivery of cytarabine with RGD decorated solid lipid nanoparticles. Journal of microencapsulation. 2021 Nov; 38(7-8):546-558. doi: 10.1080/02652048.2021.1992028. [PMID: 34632926]
  • Mélanie Donnette, Mourad Hamimed, Joseph Ciccolini, Yael Berda-Haddad, Elise Kaspi, Geoffroy Venton, Bruno Lacarelle, Regis Costello, L''Houcine Ouafik, Laure Farnault, Raphaelle Fanciullino. Pharmacokinetics and pharmacogenetics of liposomal cytarabine in AML patients treated with CPX-351. Journal of controlled release : official journal of the Controlled Release Society. 2021 10; 338(?):244-252. doi: 10.1016/j.jconrel.2021.08.023. [PMID: 34416320]
  • Hilary A Levitin, Kari D Foss, Zhong Li, Jennifer M Reinhart, Devon W Hague, Timothy M Fan. Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):696-704. doi: 10.1111/jvp.12980. [PMID: 34080695]
  • Danyang Wu, Xiaoxuan Lu, Xiaojing Yan, Ran Gao. Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations. Diagnostic pathology. 2021 Aug; 16(1):82. doi: 10.1186/s13000-021-01141-z. [PMID: 34465355]
  • Yan-Na Wang, Tong Wei, Ya-Ming Xi, Ming-Yue Yang, Lu Niu, Xiao-Ling Wang. [The Relationship between Body Mass Index and Adult Acute Myeloid Leukemia]. Zhongguo shi yan xue ye xue za zhi. 2021 Jun; 29(3):677-684. doi: 10.19746/j.cnki.issn.1009-2137.2021.03.004. [PMID: 34105456]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Matthijs van der Meulen, Linda Dirven, Katerina Bakunina, Martin J van den Bent, Samar Issa, Jeanette K Doorduijn, Jacoline E C Bromberg. MMSE is an independent prognostic factor for survival in primary central nervous system lymphoma. Journal of neuro-oncology. 2021 Apr; 152(2):357-362. doi: 10.1007/s11060-021-03708-8. [PMID: 33611761]
  • Rui-Hua Mi, Lin Chen, Hai-Ping Yang, Xian-Jing Wang, Shu-Li Guo, Lin Shi, Qing-Song Yin, Xu-Dong Wei. [CLAG Regimen Composed of Continuous Intravenous Infusion of Cladribine in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia]. Zhongguo shi yan xue ye xue za zhi. 2021 Apr; 29(2):333-338. doi: 10.19746/j.cnki.issn.1009-2137.2021.02.005. [PMID: 33812396]
  • Ai-Mei Liao, Bangrong Cai, Ji-Hong Huang, Ming Hui, Kyung-Ku Lee, Kwang Youl Lee, ChangJu Chun. Synthesis, anticancer activity and potential application of diosgenin modified cancer chemotherapeutic agent cytarabine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Feb; 148(?):111920. doi: 10.1016/j.fct.2020.111920. [PMID: 33346046]
  • Colin P Bergstrom, Saurabh Dahiya, Weina Chen, Cheng Cheng Zhang, Hong Zhu, Jingsheng Yan, Yazan Madanat, Prapti Patel, Madhuri Vusirkala, Praveen Ramakrishnan, Syed Rizvi, Stephen Chung, Farrukh Awan, Larry D Anderson, Robert Collins, Ankit Kansagra. The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement. Leukemia research. 2021 01; 100(?):106480. doi: 10.1016/j.leukres.2020.106480. [PMID: 33285315]
  • Esther M Millares-Ramirez, Khristine Picotte, Jean-Pierre Lavoie. Pulmonary response of severely asthmatic horses after intra-articular administration of methylprednisolone. Equine veterinary journal. 2021 Jan; 53(1):78-84. doi: 10.1111/evj.13272. [PMID: 32348605]
  • Karen Yee, Cristina Papayannidis, Norbert Vey, Michael J Dickinson, Kevin R Kelly, Sarit Assouline, Margaret Kasner, Karen Seiter, Mark W Drummond, Sung-Soo Yoon, Je-Hwan Lee, Steven Blotner, Lori Jukofsky, William E Pierceall, Jianguo Zhi, Silke Simon, Brian Higgins, Gwen Nichols, Annabelle Monnet, Susanne Muehlbauer, Marion Ott, Lin-Chi Chen, Giovanni Martinelli. Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆. Leukemia research. 2021 01; 100(?):106489. doi: 10.1016/j.leukres.2020.106489. [PMID: 33302031]
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