Cytarabine (BioDeep_00000014663)

 

Secondary id: BioDeep_00000405793

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Cytotoxicity


代谢物信息卡片


4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

化学式: C9H13N3O5 (243.0855)
中文名称: 阿糖胞苷
谱图信息: 最多检出来源 Homo sapiens(blood) 10.65%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

描述信息

Cytarabine, or cytosine arabinoside, a pyrimidine nucleoside analog, is found in mushrooms. Cytarabine is isolated from the mushroom Xerocomus nigromaculatus of unknown palatability. Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle to stop normal cell development and division. Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate). This metabolite then damages DNA by multiple mechanisms, including the inhibition of alpha-DNA polymerase, inhibition of DNA repair through an effect on beta-DNA polymerase, and incorporation into DNA. The latter mechanism is probably the most important. Cytotoxicity is highly specific for the S phase of the cell cycle. Cytarabine is a chemotherapy agent used mainly in the treatment of hematological malignancies such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as ara C. Cytosine arabinoside is an antimetabolic agent with the chemical name of 1 -arabinofuranosylcytosine. Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected. Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D000963 - Antimetabolites
COVID info from COVID-19 Disease Map
D000970 - Antineoplastic Agents
KEIO_ID C119; [MS2] KO008896
KEIO_ID C119
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

同义名列表

94 个代谢物同义名

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one; 1-beta-D-Arabinofuranosylcytosine, cytosine arabinoside; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; Cytosine-1-beta-D-arabinofuranoside hydrochloride; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-Amino-1-b-D-arabinofuranosyl-2(1H)-pyrimidinone; Cytosine-1-beta-D-arabinofuranoside; Cytosine 1-beta-D-arabinofuranoside; Cytosine-beta -D-arabinofuranoside; 1-beta -D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-cytosine; 1-beta -D-Arabinofuranosylcytosine; (beta-D-Arabinofuranosyl)cytosine; 1-beta-D-Arabinofuranosylcytosine; Cytosine beta-D-arabinofuranoside; Cytosine-beta-D-arabinofuranoside; 1-beta-D-Arabinofaranosylcytosine; 1beta -D-Arabinofuranosylcytosine; Cytosine-1-β-D-arabinofuranoside; 1beta-D-Arabinofuranosylcytosine; Cytosine-1-b-D-arabinofuranoside; 1beta -Arabinofuranasylcytosine; Cytosine-b-D-arabinofuranoside; 1-b-D-Arabinofuranosylcytosine; 1-Β-D-arabinofuranosylcytosine; Cytosine-β-D-arabinofuranoside; 1beta-Arabinofuranasylcytosine; Cytosine, beta -D-arabinoside; Cytarabine liposome injection; 1-beta-D-Arabinosyl-cytosine; Cytosine, beta-D-arabinoside; Cytosine beta-D-arabinoside; 1-beta-D-Arabinosylcytosine; 1beta -D-Arabinosylcytosine; 1beta-D-Arabinosylcytosine; Cytosine-beta -arabinoside; beta -D-Arabinosylcytosine; 1-Arabinofuranosylcytosine; beta -Cytosine arabinoside; Cytosine arabinofuranoside; Cytosine-beta-arabinoside; beta-D-Arabinosylcytosine; Hydrochloride, cytarabine; beta-Cytosine arabinoside; Arabinofuranosylcytosine; beta -Arabinosylcytosine; Cytarabine hydrochloride; beta-Arabinosylcytosine; Arabinoside, cytosine; Cytosine arabinoside; Cytosinearabinoside; Cytosine arabinose; Arabinosylcytosine; Arabinocytidine; Arabinocytosine; Spongocytidine; Cytarabinoside; Arabinoside C; Cytarabinum; Aracytidine; Citarabina; Cytarabina; beta Ara C; beta-Ara c; cytarabine; Cytosar-u; Cytarabin; Aracytine; Cytosar u; Depocyte; Tarabine; Aracytin; Arabitin; CytosarU; Cytonal; Depocyt; Cytosar; Arafcyt; Erpalfa; Alexan; Iretin; Udicil; Ara-C; Ara C; AraC; Cytosine β-D-arabinofuranoside; Cytarabine



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, AXIN2, CASP3, MMP3, POMC, PTGS2, VEGFA
Peripheral membrane protein 2 AP1S2, PTGS2
Endoplasmic reticulum membrane 2 CD4, PTGS2
Nucleus 5 ALB, AXIN2, CASP3, MMP3, VEGFA
cytosol 5 ALB, AP1S2, AXIN2, CASP3, MMP3
centrosome 2 ALB, AXIN2
nucleoplasm 1 CASP3
Cell membrane 3 CD4, CD8A, TNF
Cytoplasmic side 1 AP1S2
Synapse 1 ACAN
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 ACAN, CASP3
Golgi apparatus 3 ALB, AP1S2, VEGFA
Golgi membrane 2 AP1S2, INS
lysosomal membrane 1 AP1S2
neuronal cell body 2 CASP3, TNF
plasma membrane 5 AXIN2, CD4, CD8A, IFNLR1, TNF
Membrane 3 IFNLR1, MMP13, VEGFA
caveola 1 PTGS2
extracellular exosome 1 ALB
endoplasmic reticulum 3 ALB, PTGS2, VEGFA
extracellular space 13 ACAN, ALB, CRP, CXCL8, IL10, IL6, INS, MMP1, MMP13, MMP3, POMC, TNF, VEGFA
lysosomal lumen 1 ACAN
adherens junction 1 VEGFA
mitochondrion 1 MMP3
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 1 AP1S2
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, CD8A, IFNLR1
Secreted 10 ALB, CRP, CXCL8, IL10, IL6, INS, MMP13, MMP3, POMC, VEGFA
extracellular region 14 ACAN, ALB, CD8A, CRP, CXCL8, IL10, IL6, INS, MMP1, MMP13, MMP3, POMC, TNF, VEGFA
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, CD8A, TNF
Secreted, extracellular space, extracellular matrix 4 ACAN, MMP1, MMP13, VEGFA
beta-catenin destruction complex 1 AXIN2
Early endosome 2 AP1S2, CD4
Membrane, clathrin-coated pit 1 AP1S2
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
GABA-ergic synapse 1 ACAN
extracellular matrix 4 MMP1, MMP13, MMP3, VEGFA
basement membrane 1 ACAN
collagen-containing extracellular matrix 1 ACAN
secretory granule 2 POMC, VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 CD8A
neuron projection 1 PTGS2
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 1 AP1S2
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AP1S2
trans-Golgi network membrane 1 AP1S2
plasma membrane raft 1 CD8A
secretory granule lumen 2 INS, POMC
Golgi lumen 2 ACAN, INS
endoplasmic reticulum lumen 5 ALB, CD4, IL6, INS, PTGS2
platelet alpha granule lumen 2 ALB, VEGFA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perineuronal net 1 ACAN
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
perisynaptic extracellular matrix 1 ACAN
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jie Ding, Yang Su, Yinglu Ruan, Nan Li, Qianchao Meng, Jiabang Yang, Li Chen, Chi Liu. Clinical features and outcomes of patients with acute myeloid leukemia: the single-center experience of 668 patients in China. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2310960. doi: 10.1080/16078454.2024.2310960. [PMID: 38323781]
  • David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Gerardo Barragán Mejía. Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain. Scientific reports. 2024 05; 14(1):10835. doi: 10.1038/s41598-024-61766-0. [PMID: 38736022]
  • Yan Jia, Xiyu Li, Lulu Chen, Ling Li, Suzhen Zhang, Wenhui Huang, Hao Zhang. AHR signaling pathway mediates mitochondrial oxidative phosphorylation which leads to cytarabine resistance. Acta biochimica et biophysica Sinica. 2024 04; 56(4):597-606. doi: 10.3724/abbs.2024022. [PMID: 38404179]
  • Monika Jamioł, Magdalena Sozoniuk, Jacek Wawrzykowski, Marta Kankofer. Changes in plasma PLAC-1 concentration and its expression during early-mid pregnancy in bovine placental tissues - a pilot study. BMC veterinary research. 2024 Feb; 20(1):59. doi: 10.1186/s12917-024-03898-z. [PMID: 38378537]
  • Yihan Zhao, Shiqing Jiang, Yujun Tang, Lin Zhao. Venetoclax with CAG regimen for early T-cell precursor acute lymphoblastic leukemia: a case report and literature review. International journal of hematology. 2023 Oct; 118(4):483-488. doi: 10.1007/s12185-023-03623-w. [PMID: 37269505]
  • Mi-Rae Park, Hye-Jin Lee, Hye-Min Jang, Nam Hoon Kim, Jun-Seok Lee, Yong Taek Jeong, Inho Kim, Sang-Hyun Choi, Kwan Sik Seo, Dong-Hoon Kim. Cytarabine induces cachexia with lipid malabsorption via zippering the junctions of lacteal in murine small intestine. Journal of lipid research. 2023 06; 64(6):100387. doi: 10.1016/j.jlr.2023.100387. [PMID: 37201659]
  • Han Yao, Cheng Zhang, Xu Tan, Jieping Li, Xiaolin Yin, Xiaojuan Deng, Ting Chen, Jun Rao, Lei Gao, Peiyan Kong, Xi Zhang. Efficacy and toxicity of CLAG combined with pegylated liposomal doxorubicin in the treatment of refractory or relapsed acute myeloid leukemia. Cancer medicine. 2023 06; 12(11):12377-12387. doi: 10.1002/cam4.5938. [PMID: 37161845]
  • Zhixin Ma, Wenle Ye, Jinghan Wang, Xin Huang, Jiansong Huang, Xia Li, Chao Hu, Chenying Li, Yile Zhou, Xiangjie Lin, Wenwen Wei, Yu Qian, Yutong Zhou, Shihui Mao, Xiufeng Yin, Bo Zhu, Jie Jin. Glutamate dehydrogenase 1: A novel metabolic target in inhibiting acute myeloid leukaemia progression. British journal of haematology. 2023 May; ?(?):. doi: 10.1111/bjh.18884. [PMID: 37231991]
  • Wei Chu, Ya-Ling Li, Jun-Jie Li, Jia Lin, Mi Li, Jiao Wang, Jian-Zheng He, Yue-Mei Zhang, Juan Yao, Xiao-Jie Jin, Hui Cai, Yong-Qi Liu. Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114902. doi: 10.1016/j.biopha.2023.114902. [PMID: 37209628]
  • Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife M S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian J P Huntly, Paolo Gallipoli. Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications. 2023 04; 14(1):2132. doi: 10.1038/s41467-023-37652-0. [PMID: 37059720]
  • Shuzhen Han, Minghui Xiu, Shuang Li, Yan Shi, Xiaoqian Wang, Xingyao Lin, Hui Cai, Yongqi Liu, Jianzheng He. Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114265. doi: 10.1016/j.biopha.2023.114265. [PMID: 36652735]
  • Lei Li, Hailong Tian, Zhe Zhang, Ning Ding, Kai He, Shuaijun Lu, Ruolan Liu, Peijie Wu, Yu Wang, Bo He, Maochao Luo, Peilan Peng, Mao Yang, Edouard C Nice, Canhua Huang, Na Xie, Dong Wang, Wei Gao. Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer. ACS applied materials & interfaces. 2023 Jan; 15(1):452-468. doi: 10.1021/acsami.2c17579. [PMID: 36538368]
  • Ting Li, Jiesen Yu, Mengyuan Hou, Sijie Zha, Qingqing Cheng, Qingshan Zheng, Lujin Li. Quantitative evaluation of therapy options for relapsed/refractory diffuse large B-cell lymphoma: A model-based meta-analysis. Pharmacological research. 2023 01; 187(?):106592. doi: 10.1016/j.phrs.2022.106592. [PMID: 36470547]
  • Ya-Ling Li, Wei Chu, Jun-Jie Li, Juan-Juan Dong, Gao-Qin Li, Xiao-Jie Jin, Juan Yao, Yong-Qi Liu. [Animal Model Establishment and Its Mechanism of Cytarabine-Iduced Myelosuppression]. Zhongguo shi yan xue ye xue za zhi. 2022 Oct; 30(5):1376-1383. doi: 10.19746/j.cnki.issn.1009-2137.2022.05.012. [PMID: 36208238]
  • I Koca, M Ucar, H O Arik, M Yilmaz, R Dokuyucu. Alpha-lipoic acid could be a promising treatment in steroid-induced osteonecrosis. European review for medical and pharmacological sciences. 2022 10; 26(20):7404-7412. doi: 10.26355/eurrev_202210_30009. [PMID: 36314310]
  • Karine Marchioro Leal, Mariana Barcelos Rocha, Fernanda Venzon Varela, Luana Rodrigues, Priscila Viau Furtado, Fernanda Vieira Amorim da Costa, Álan Gomes Pöppl. Is Methylprednisolone Acetate-Related Insulin Resistance Preventable in Cats?. Topics in companion animal medicine. 2022 Jul; 49(?):100648. doi: 10.1016/j.tcam.2022.100648. [PMID: 35202848]
  • Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier, Lionel Adès, Alexandre Puissant, Raphael Itzykson. A multiparametric niche-like drug screening platform in acute myeloid leukemia. Blood cancer journal. 2022 06; 12(6):95. doi: 10.1038/s41408-022-00689-3. [PMID: 35750691]
  • Emmanuel Gyan, Arnaud Pigneux, Mathilde Hunault, Pierre Peterlin, Martin Carré, Jacques-Olivier Bay, Caroline Bonmati, Maria-Pilar Gallego-Hernanz, Bruno Lioure, Philippe Bertrand, Nicolas Vallet, David Ternant, François Darrouzain, Frédéric Picou, Marie-Christine Béné, Christian Récher, Olivier Hérault. Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML. Scientific reports. 2022 06; 12(1):9748. doi: 10.1038/s41598-022-13626-y. [PMID: 35697729]
  • Yanjie Zhang, Hezhou Guo, Zhaoli Zhang, Wei Lu, Jiang Zhu, Jun Shi. IL-6 promotes chemoresistance via upregulating CD36 mediated fatty acids uptake in acute myeloid leukemia. Experimental cell research. 2022 06; 415(1):113112. doi: 10.1016/j.yexcr.2022.113112. [PMID: 35346671]
  • Sha Li, Shi Zeng, Bo-Ping Wei, Qiang Wu, Chang Liu, Pei-Ying Song. Determination of free and encapsulated cytarabine and daunorubicin in rat plasma after intravenous administration of liposomal formulation using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123275. doi: 10.1016/j.jchromb.2022.123275. [PMID: 35551041]
  • Rim Rakez, Wiem Boufrikha, Sana Lakhal, Amel Boughammoura, Mohamed Adnene Laatiri. The diagnostic dilemma of idiopathic intracranial hypertension in a child with acute lymphoblastic leukemia: COVID-19 or cytosine arabinoside?. BMC neurology. 2022 May; 22(1):163. doi: 10.1186/s12883-022-02689-z. [PMID: 35501718]
  • Zhen Xing Gao, Ze Long Cui, Min Ran Zhou, Yue Fu, Fen Liu, Lu Zhang, Sai Ma, Chun Yan Chen. The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia. Biochemical pharmacology. 2022 04; 198(?):114948. doi: 10.1016/j.bcp.2022.114948. [PMID: 35192847]
  • Jiang-Zhao Zhang, Min Liu, Zhi-Ping Huang. [Influence of Serum TGF-β1 and EGFR Levels on the Therapeutic Effect of High-Dose AraC in Patients with Acute Myeloid Leukemia Based on the Decision Curve]. Zhongguo shi yan xue ye xue za zhi. 2022 Apr; 30(2):. doi: 10.19746/j.cnki.issn.1009-2137.2022.02.014. [PMID: 35400362]
  • Jiang-Zhao Zhang, Min Liu, Zhi-Ping Huang. [Influence of Serum TGF-β1 and EGFR Levels on the Therapeutic Effect of High-Dose AraC in Patients with Acute Myeloid Leukemia Based on the Decision Curve]. Zhongguo shi yan xue ye xue za zhi. 2022 Apr; 30(2):407-412. doi: 10.19746/j.cnki.issn.1009-2137.2022.02.014. [PMID: 35395971]
  • Bei Zhang, Zhixin Pei, Hongxia Wang, Huimin Wu, Junjie Wang, Junjun Bai, Qinglin Song. Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation. Acta medica Okayama. 2022 Feb; 76(1):63-70. doi: 10.18926/amo/63213. [PMID: 35237000]
  • Shifen Fan, Jiao Chen, Zhouyang Liu, Juan Xiao, Fan Jiang, Xiaomei Liu, Yuan Sun. Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation with Cocktail Conditioning Regimen for the Treatment of Pediatric Patients with Chronic Active Epstein-Barr Virus: A Retrospective Observational Study. Stem cells and development. 2022 01; 31(1-2):26-31. doi: 10.1089/scd.2021.0205. [PMID: 34779276]
  • Ibrahim Khater, Aaya Nassar. Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis. PloS one. 2022; 17(5):e0268909. doi: 10.1371/journal.pone.0268909. [PMID: 35639751]
  • Xue Tang, Ju Gao, Zhi-Gui Ma, Xia Guo, Qiang Li, Zhi Wan, Jing-Jing Sun. Clinical and prognostic characteristics of 95 cases of Langerhans cell histiocytosis in children: a single-institute experience from 2013 to 2020. Annals of medicine. 2021 12; 53(1):1537-1546. doi: 10.1080/07853890.2021.1966085. [PMID: 34459688]
  • Chun Tong, Fang Ye, Ning-Ning Li, Huan Wang, Ya-Nan Shu, Ling Wang, Li-Nan Zhang. [Efficacy and Safety of Different Dosages of Decitabine in the Treatment of High-Risk Patients with Myelodysplastic Syndrome]. Zhongguo shi yan xue ye xue za zhi. 2021 Dec; 29(6):1845-1850. doi: 10.19746/j.cnki.issn.1009-2137.2021.06.026. [PMID: 34893121]
  • Shelly Roselyn Van Eyssen, Doga Kavaz. An evaluative in vitro investigation of the delivery of cytarabine with RGD decorated solid lipid nanoparticles. Journal of microencapsulation. 2021 Nov; 38(7-8):546-558. doi: 10.1080/02652048.2021.1992028. [PMID: 34632926]
  • Mélanie Donnette, Mourad Hamimed, Joseph Ciccolini, Yael Berda-Haddad, Elise Kaspi, Geoffroy Venton, Bruno Lacarelle, Regis Costello, L''Houcine Ouafik, Laure Farnault, Raphaelle Fanciullino. Pharmacokinetics and pharmacogenetics of liposomal cytarabine in AML patients treated with CPX-351. Journal of controlled release : official journal of the Controlled Release Society. 2021 10; 338(?):244-252. doi: 10.1016/j.jconrel.2021.08.023. [PMID: 34416320]
  • Hilary A Levitin, Kari D Foss, Zhong Li, Jennifer M Reinhart, Devon W Hague, Timothy M Fan. Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):696-704. doi: 10.1111/jvp.12980. [PMID: 34080695]
  • Danyang Wu, Xiaoxuan Lu, Xiaojing Yan, Ran Gao. Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations. Diagnostic pathology. 2021 Aug; 16(1):82. doi: 10.1186/s13000-021-01141-z. [PMID: 34465355]
  • Yan-Na Wang, Tong Wei, Ya-Ming Xi, Ming-Yue Yang, Lu Niu, Xiao-Ling Wang. [The Relationship between Body Mass Index and Adult Acute Myeloid Leukemia]. Zhongguo shi yan xue ye xue za zhi. 2021 Jun; 29(3):677-684. doi: 10.19746/j.cnki.issn.1009-2137.2021.03.004. [PMID: 34105456]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Matthijs van der Meulen, Linda Dirven, Katerina Bakunina, Martin J van den Bent, Samar Issa, Jeanette K Doorduijn, Jacoline E C Bromberg. MMSE is an independent prognostic factor for survival in primary central nervous system lymphoma. Journal of neuro-oncology. 2021 Apr; 152(2):357-362. doi: 10.1007/s11060-021-03708-8. [PMID: 33611761]
  • Rui-Hua Mi, Lin Chen, Hai-Ping Yang, Xian-Jing Wang, Shu-Li Guo, Lin Shi, Qing-Song Yin, Xu-Dong Wei. [CLAG Regimen Composed of Continuous Intravenous Infusion of Cladribine in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia]. Zhongguo shi yan xue ye xue za zhi. 2021 Apr; 29(2):333-338. doi: 10.19746/j.cnki.issn.1009-2137.2021.02.005. [PMID: 33812396]
  • Ai-Mei Liao, Bangrong Cai, Ji-Hong Huang, Ming Hui, Kyung-Ku Lee, Kwang Youl Lee, ChangJu Chun. Synthesis, anticancer activity and potential application of diosgenin modified cancer chemotherapeutic agent cytarabine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Feb; 148(?):111920. doi: 10.1016/j.fct.2020.111920. [PMID: 33346046]
  • Colin P Bergstrom, Saurabh Dahiya, Weina Chen, Cheng Cheng Zhang, Hong Zhu, Jingsheng Yan, Yazan Madanat, Prapti Patel, Madhuri Vusirkala, Praveen Ramakrishnan, Syed Rizvi, Stephen Chung, Farrukh Awan, Larry D Anderson, Robert Collins, Ankit Kansagra. The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement. Leukemia research. 2021 01; 100(?):106480. doi: 10.1016/j.leukres.2020.106480. [PMID: 33285315]
  • Esther M Millares-Ramirez, Khristine Picotte, Jean-Pierre Lavoie. Pulmonary response of severely asthmatic horses after intra-articular administration of methylprednisolone. Equine veterinary journal. 2021 Jan; 53(1):78-84. doi: 10.1111/evj.13272. [PMID: 32348605]
  • Karen Yee, Cristina Papayannidis, Norbert Vey, Michael J Dickinson, Kevin R Kelly, Sarit Assouline, Margaret Kasner, Karen Seiter, Mark W Drummond, Sung-Soo Yoon, Je-Hwan Lee, Steven Blotner, Lori Jukofsky, William E Pierceall, Jianguo Zhi, Silke Simon, Brian Higgins, Gwen Nichols, Annabelle Monnet, Susanne Muehlbauer, Marion Ott, Lin-Chi Chen, Giovanni Martinelli. Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆. Leukemia research. 2021 01; 100(?):106489. doi: 10.1016/j.leukres.2020.106489. [PMID: 33302031]
  • Hiroki Doi, Taei Matsui, Johannes M Dijkstra, Atsushi Ogasawara, Yuki Higashimoto, Seiji Imamura, Tamae Ohye, Hiromu Takematsu, Itsuro Katsuda, Hidehiko Akiyama. Andrographolide, isolated from Andrographis paniculata, induces apoptosis in monocytic leukemia and multiple myeloma cells via augmentation of reactive oxygen species production. F1000Research. 2021; 10(?):542. doi: 10.12688/f1000research.53595.3. [PMID: 35528957]
  • Shelby L Mancini, Peter J Early, Bethany O Pastina, Natasha J Olby, Christopher L Mariani, Karen R Munana. The bioavailability of cytarabine in dogs with meningoencephalitis of unknown etiology through iontophoresis and rectal delivery. Open veterinary journal. 2021 Jan; 11(1):36-38. doi: 10.4314/ovj.v11i1.6. [PMID: 33898281]
  • Susanne Ghandili, Susanne Pfefferle, Kevin Roedl, Piet Sonnemann, Panagiotis Karagiannis, Olaf Boenisch, Stefan Kluge, Stefan Schmiedel, Harald Ittrich, Holger Rohde, Marc Lütgehetmann, Katja Weisel, Carsten Bokemeyer, Dominic Wichmann, Walter Fiedler, Dominik Jarczak, Franziska Modemann. Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients. Blood advances. 2020 12; 4(23):5936-5941. doi: 10.1182/bloodadvances.2020002543. [PMID: 33275765]
  • Ellen J B Derissen, Jos H Beijnen. Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action. Clinical pharmacokinetics. 2020 12; 59(12):1521-1550. doi: 10.1007/s40262-020-00934-7. [PMID: 33064276]
  • Wenxiu Qi, Xiuci Yan, Xiaohao Xu, Bailin Song, Liping Sun, Daqing Zhao, Liwei Sun. The effects of cytarabine combined with ginsenoside compound K synergistically induce DNA damage in acute myeloid leukemia cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110812. doi: 10.1016/j.biopha.2020.110812. [PMID: 33059263]
  • Jiaoyang Zhang, Lingli Zhou, Yu Zhang, Haibing He, Tian Yin, Jingxin Gou, Yanjiao Wang, Xing Tang. Contrastive Studies of Cytarabine/Daunorubicin Dual-Loaded Liposomes Prepared by pH Gradient and Cu2+ Gradient Method. AAPS PharmSciTech. 2020 Nov; 21(8):325. doi: 10.1208/s12249-020-01867-x. [PMID: 33206247]
  • Qi Wang, Paul Tardi, Nicole Sadowski, Sherwin Xie, Dennis Heller, Lawrence Mayer. Pharmacokinetics, drug metabolism, and tissue distribution of CPX-351 in animals. Nanomedicine : nanotechnology, biology, and medicine. 2020 11; 30(?):102275. doi: 10.1016/j.nano.2020.102275. [PMID: 32750494]
  • Guido Lancman, John Mascarenhas, Michal Bar-Natan. Severe COVID-19 virus reactivation following treatment for B cell acute lymphoblastic leukemia. Journal of hematology & oncology. 2020 10; 13(1):131. doi: 10.1186/s13045-020-00968-1. [PMID: 33008453]
  • Xinping Zhou, Chen Mei, Jin Zhang, Ying Lu, Jianping Lan, Shengyun Lin, Yuefeng Zhang, Yuemin Kuang, Yanling Ren, Liya Ma, Juying Wei, Li Ye, Weilai Xu, Kongfei Li, Chenxi Lu, Jie Jin, Hongyan Tong. Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher-risk myelodysplastic syndromes: a prospective multicenter single-arm trial. Hematological oncology. 2020 Oct; 38(4):531-540. doi: 10.1002/hon.2755. [PMID: 32469434]
  • Zhi-Qing Wang, Xing-Bin Dai, Hai-Ying Hua, Hua-Qiang Gao, Wen-Yan Zhu, Ye Zhou, Yan Zhang, Shuang Wu, Jin Li, Ying Zhao, Zu-Qiong Xu, Xue-Jun Zhu, Xue-Mei Sun. [Curative Efficacy and Survival Analysis of Low-Intensity Traditional Chemotherapy Regimen in the Elderly Patients with Acute Myeloid Leukemia (non-M3)]. Zhongguo shi yan xue ye xue za zhi. 2020 Oct; 28(5):1516-1522. doi: 10.19746/j.cnki.issn.1009-2137.2020.05.015. [PMID: 33067947]
  • Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W C Yu, Ninib Baryawno, Elizabeth W Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B Sykes, Mark A Keibler, Sudeshna Das, John N Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J Logan, Stuart Schreiber, Gregory Stephanopoulos, William B Rizzo, David T Scadden. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 09; 136(11):1303-1316. doi: 10.1182/blood.2019001808. [PMID: 32458004]
  • Aydın Yıldız, Müşerref Hilal Şehitoğlu, İhsan Karaboğa, Sedat Arıkan. Ozone treatment for high-dose systemic Steroid-Induced retinal injury. Cutaneous and ocular toxicology. 2020 Sep; 39(3):274-280. doi: 10.1080/15569527.2020.1790590. [PMID: 32619116]
  • Qiu-Jin Yang, Jie Zheng, Fu-Tao Dang, Yue-Meng Wan, Jing Yang. Acute pancreatitis induced by combination chemotherapy used for the treatment of acute myeloid leukemia: A case report. Medicine. 2020 Aug; 99(35):e21848. doi: 10.1097/md.0000000000021848. [PMID: 32871908]
  • Carole Lacout, Corentin Orvain, Valérie Seegers, Manon De Vries, Mélanie Mercier, Jonathan Farhi, Aline Clavert, Sylvain Thepot, Marie-Pierre Moles, Norbert Ifrah, Mathilde Hunault-Berger, Aline Tanguy-Schmidt. R-DHA-oxaliplatin (R-DHAOx) versus R-DHA-cisplatin (R-DHAP) regimen in B-cell lymphoma treatment: A eight-year trajectory study. European journal of haematology. 2020 Aug; 105(2):223-230. doi: 10.1111/ejh.13429. [PMID: 32302426]
  • Nadine Farah, Richard Burt, Amr R Ibrahim, Robert Baker, Panagiotis D Kottaridis. Concerns about how to use established minimal residual disease monitoring in the treatment of NPM1-mutant acute myeloid leukaemia (AML) following reduced intensity chemotherapy protocols for AML given as a result of the COVID-19 pandemic. British journal of haematology. 2020 08; 190(4):e208-e210. doi: 10.1111/bjh.16985. [PMID: 32609881]
  • Irene B Vazquez Fuster, Amanda R Taylor, Annette N Smith, Sue H Duran, William R Ravis, Shanese L Jasper, Robert D Arnold. Pharmacokinetics of multivesicular liposomal encapsulated cytarabine when administered subcutaneously in dogs. Journal of veterinary internal medicine. 2020 Jul; 34(4):1563-1569. doi: 10.1111/jvim.15809. [PMID: 32442344]
  • Yanshan Sheng, Wei Dai, Jun Gao, Hongda Li, Wensheng Tan, Jingwei Wang, Linhong Deng, Yong Kong. pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability. Materials science & engineering. C, Materials for biological applications. 2020 Jul; 112(?):110888. doi: 10.1016/j.msec.2020.110888. [PMID: 32409046]
  • Fangli Chen, Xue Wu, Cristina Niculite, Marilena Gilca, Daniela Petrusca, Adriana Rogozea, Susan Rice, Bin Guo, Shawn Griffin, George A Calin, H Scott Boswell, Heiko Konig. Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications. Journal of cellular and molecular medicine. 2020 07; 24(13):7378-7392. doi: 10.1111/jcmm.15339. [PMID: 32450611]
  • Brendan O'Kelly, Padraig McGettrick, Daniel Angelov, Michael Fay, Tara McGinty, Aoife G Cotter, Gerard Sheehan, John S Lambert. Outcome of a patient with refractory Hodgkin lymphoma on pembrolizumab, infected with SARS-CoV-2. British journal of haematology. 2020 Jul; 190(1):e1-e3. doi: 10.1111/bjh.16798. [PMID: 32379903]
  • Amir Kiani, Shadi Heydari Nik, Adineh Khodadoost, Ahmad Salimi, Jalal Pourahmad. Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity. Drug research. 2020 Jun; 70(6):265-272. doi: 10.1055/a-1154-8672. [PMID: 32365382]
  • Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Caleb A Class, Koji Sasaki, Farhad Ravandi, Jorge E Cortes, Naval Daver, Koichi Takahashi, Nicholas J Short, Courtney D DiNardo, Elias Jabbour, Gautam Borthakur, Kiran Naqvi, Ghayas C Issa, Marina Konopleva, Joseph D Khoury, Mark Routbort, Sherry Pierce, Kim-Anh Do, Carlos Bueso-Ramos, Keyur Patel, Hagop Kantarjian, Guillermo Garcia-Manero, Tapan M Kadia. Outcomes of acute myeloid leukemia with myelodysplasia related changes depend on diagnostic criteria and therapy. American journal of hematology. 2020 06; 95(6):612-622. doi: 10.1002/ajh.25769. [PMID: 32112433]
  • Wei Wang, Yan Zhang, Lu Zhang, Chen Yang, Jun Feng, Huacong Cai, Miao Chen, Xinxin Cao, Junling Zhuang, Tienan Zhu, Minghui Duan, Wei Zhang, Jian Li, Daobin Zhou. Intravenous methotrexate at a dose of 1 g/m2 incorporated into RCHOP prevented CNS relapse in high-risk DLBCL patients: A prospective, historic controlled study. American journal of hematology. 2020 04; 95(4):E80-E83. doi: 10.1002/ajh.25723. [PMID: 31925808]
  • Caitlin R Rausch, Elias J Jabbour, Hagop M Kantarjian, Tapan M Kadia. Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management. Cancer. 2020 03; 126(6):1152-1160. doi: 10.1002/cncr.32606. [PMID: 31794095]
  • Kento Umino, Kaoru Hatano, Shin-Ichi Ochi, Harunobu Genda, Takashi Ikeda, Shin-Ichiro Kawaguchi, Yumiko Toda, Shoko Ito, Takashi Nagayama, Kiyomi Mashima, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Kaoru Morita, Chihiro Yamamoto, Masahiro Ashizawa, Kazuya Sato, Iekuni Oh, Shin-Ichiro Fujiwara, Ken Ohmine, Kazuo Muroi, Yoshinobu Kanda. The impact of overweight on renal toxicity in patients treated with dexamethasone, high-dose cytarabine, and cisplatin. International journal of hematology. 2020 Mar; 111(3):396-400. doi: 10.1007/s12185-019-02779-8. [PMID: 31728828]
  • Marina Nayeli Medina-Rosales, Susana Godina-González, Mariana Haydee García-Hernández. T Regulatory Cell Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia. Iranian journal of immunology : IJI. 2020 Mar; 17(1):87-93. doi: 10.22034/iji.2020.80297. [PMID: 32224544]
  • Kirk E Cahill, Yasmin H Karimi, Theodore G Karrison, Nitin Jain, Margaret Green, Howard Weiner, Noreen Fulton, Sabah Kadri, Lucy A Godley, Andrew S Artz, Hongtao Liu, Michael J Thirman, Michelle M Le Beau, Megan E McNerney, Jeremy Segal, Richard A Larson, Wendy Stock, Olatoyosi Odenike. A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia. Blood advances. 2020 02; 4(4):599-606. doi: 10.1182/bloodadvances.2019000795. [PMID: 32074275]
  • Young-Woong Won, Hyewon Lee, Hyeon-Seok Eom, Jin Seok Kim, Cheolwon Suh, Dok Hyun Yoon, Jung Yong Hong, Hye Jin Kang, Jae Hoon Lee, Won Seog Kim, Seok Jin Kim, Won-Sik Lee, Myung Hee Chang, Young Rok Do, Jun Ho Yi, Inho Kim, Jong-Ho Won, Kyoungha Kim, Sung Yong Oh, Jae-Cheol Jo. A phase II study of etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin (ESHAOx) for patients with refractory or relapsed Hodgkin's lymphoma. Annals of hematology. 2020 Feb; 99(2):255-264. doi: 10.1007/s00277-019-03891-9. [PMID: 31897676]
  • Ke Li, Feng Wang, Zhao-Na Yang, Bing Cui, Ping-Ping Li, Zhen-Yu Li, Zhuo-Wei Hu, Hong-Hu Zhu. PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia. Theranostics. 2020; 10(22):10326-10340. doi: 10.7150/thno.45924. [PMID: 32929351]
  • Hongzhang Wu, Xurui Cheng, Feiyan Huang, Gang Shao, Yueming Meng, Lingfei Wang, Tao Wang, Xiaoyuan Jia, Tianxin Yang, Xi Wang, Caiyun Fu. Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo. Drug design, development and therapy. 2020; 14(?):2413-2422. doi: 10.2147/dddt.s244648. [PMID: 32606608]
  • Laura Hrehová, Kamal Mezian, Levent Özçakar. Ultrasonographic approach for a foot ganglion after sewing masks in the COVID-19 pandemic: Blessing in disguise. Work (Reading, Mass.). 2020; 67(4):763-765. doi: 10.3233/wor-203328. [PMID: 33325426]
  • Na Qi, Yu Zhang, Xing Tang, Aimin Li. Cationic/Anionic Polyelectrolyte (PLL/PGA) Coated Vesicular Phospholipid Gels (VPGs) Loaded with Cytarabine for Sustained Release and Anti-glioma Effects. Drug design, development and therapy. 2020; 14(?):1825-1836. doi: 10.2147/dddt.s248362. [PMID: 32494124]
  • Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo, Deming Xie. Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia. Nanoscale. 2019 Dec; 11(47):23000-23012. doi: 10.1039/c9nr07391d. [PMID: 31769777]
  • Jan-Paul Bohn, Vera Reinstadler, Georg Pall, Günther Stockhammer, Michael Steurer, Herbert Oberacher, Dominik Wolf. Cerebrospinal Fluid Drug Concentrations and Clinical Outcome of Patients with Neoplastic Meningitis Treated with Liposomal Cytarabine. European journal of drug metabolism and pharmacokinetics. 2019 Dec; 44(6):845-851. doi: 10.1007/s13318-019-00572-w. [PMID: 31435852]
  • Jason T Anderson, Shuiying Hu, Qiang Fu, Sharyn D Baker, Alex Sparreboom. Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice. Pharmacology research & perspectives. 2019 12; 7(6):e00534. doi: 10.1002/prp2.534. [PMID: 31832201]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Aslynn Jones, Stephanie McGrath, Daniel L Gustafson. The pharmacokinetics of cytarabine administered at three distinct subcutaneous dosing protocols in dogs with meningoencephalomyelitis of unknown origin. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):588-592. doi: 10.1111/jvp.12809. [PMID: 31490575]
  • Zheng-Ping Yu, Jia-Hua Ding, Ai-Ning Sun, Bao-An Chen, Zheng Ge, De-Pei Wu. A New Conditioning Regimen Can Significantly Promote Post-Transplant Immune Reconstitution and Improve the Outcome of Umbilical Cord Blood Transplantation for Patients. Stem cells and development. 2019 10; 28(20):1376-1383. doi: 10.1089/scd.2019.0139. [PMID: 31464164]
  • Ida Sofie Grønningsæter, Hanne Kristin Fredly, Bjørn Tore Gjertsen, Kimberley Joanne Hatfield, Øystein Bruserud. Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy. Cells. 2019 10; 8(10):. doi: 10.3390/cells8101229. [PMID: 31658693]
  • F Sosa-Albacete, A Pappolla, S Hem, D Kohan, V Otero, M C Zurru-Ganen, M Rugiero. [Primary neurolymphomatosis in the cauda equina as the initial symptom of human immunodeficiency virus]. Revista de neurologia. 2019 Oct; 69(7):301-302. doi: 10.33588/rn.6907.2019244. [PMID: 31559629]
  • Melanie Donnette, Caroline Solas, Madeleine Giocanti, Geoffroy Venton, Laure Farnault, Yael Berda-Haddad, Le Thi Thu Hau, Régis Costello, L'Houcine Ouafik, Bruno Lacarelle, Joseph Ciccolini, Raphaëlle Fanciullino. Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Sep; 1126-1127(?):121770. doi: 10.1016/j.jchromb.2019.121770. [PMID: 31454720]
  • Fuze Sun, Niannian Li, Xiaoling Tong, Jie Zeng, Songzhen He, Tingting Gai, Yanmin Bai, Lanlan Liu, Kunpeng Lu, Jianghong Shen, Minjin Han, Cheng Lu, Fangyin Dai. Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1. Cell cycle (Georgetown, Tex.). 2019 09; 18(18):2293-2306. doi: 10.1080/15384101.2019.1644913. [PMID: 31322047]
  • Tara L Lin, Laura F Newell, Robert K Stuart, Laura C Michaelis, Eric Rubenstein, Helen S Pentikis, Timothy Callahan, Donna Alvarez, Barry D Liboiron, Lawrence D Mayer, Qi Wang, Kamalika Banerjee, Arthur C Louie. A phase 2 study to assess the pharmacokinetics and pharmacodynamics of CPX-351 and its effects on cardiac repolarization in patients with acute leukemias. Cancer chemotherapy and pharmacology. 2019 07; 84(1):163-173. doi: 10.1007/s00280-019-03856-9. [PMID: 31098682]
  • Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong Shen. Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloid leukemia. Frontiers of medicine. 2019 Jun; 13(3):378-387. doi: 10.1007/s11684-018-0658-4. [PMID: 30635781]
  • Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E Fox, Samy A F Morad, Dhimant Desai, Kenichiro Doi, Mark R Conaway, Shantu Amin, David F Claxton, Hong-Gang Wang, Mark Kester, Myles C Cabot, David J Feith, Thomas P Loughran. Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation. Journal of lipid research. 2019 06; 60(6):1078-1086. doi: 10.1194/jlr.m091876. [PMID: 30962310]
  • Qi Wang, Kamalika Banerjee, Grygoriy Vasilinin, J F Marier, Jacqueline A Gibbons. Population Pharmacokinetics and Exposure-Response Analyses for CPX-351 in Patients With Hematologic Malignancies. Journal of clinical pharmacology. 2019 05; 59(5):748-762. doi: 10.1002/jcph.1366. [PMID: 30566230]
  • Mojtaba Ghadiany, Mahdi Tabarraee, Sina Salari, Shirin Haghighi, Hamid Rezvani, Seyedeh Najmeh Ghasemi, Hamidreza Karimi-Sari. Adding Oral Pioglitazone to Standard Induction Chemotherapy of Acute Myeloid Leukemia: A Randomized Clinical Trial. Clinical lymphoma, myeloma & leukemia. 2019 04; 19(4):206-212. doi: 10.1016/j.clml.2019.01.006. [PMID: 30770307]
  • Matthew Ettleson, Kale S Bongers, Kaitlyn Vitale, Anthony J Perissinotti, Tycel Phillips, Bernard L Marini. Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2019 Apr; 25(3):731-734. doi: 10.1177/1078155217754244. [PMID: 29385883]
  • Shawn Patrick Zinnen, Alexander Karpeisky, Daniel D Von Hoff, Larisa Plekhova, Alexander Alexandrov. First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease. The oncologist. 2019 03; 24(3):303-e102. doi: 10.1634/theoncologist.2018-0707. [PMID: 30413669]
  • X Wang, M Nachliely, J S Harrison, M Danilenko, G P Studzinski. Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen. The Journal of steroid biochemistry and molecular biology. 2019 03; 187(?):166-173. doi: 10.1016/j.jsbmb.2018.11.015. [PMID: 30508644]
  • Fabienne Kunz, Evangelia Kontopoulou, Katarina Reinhardt, Maren Soldierer, Sarah Strachan, Dirk Reinhardt, Basant Kumar Thakur. Detection of AML-specific mutations in pediatric patient plasma using extracellular vesicle-derived RNA. Annals of hematology. 2019 03; 98(3):595-603. doi: 10.1007/s00277-019-03608-y. [PMID: 30673813]
  • Yingping Cao, Conglian Wu, Yanfang Song, Zhen Lin, Yanli Kang, Pingxia Lu, Chenqing Zhang, Qinghua Huang, Taisen Hao, Xianjin Zhu, Jianda Hu. Cyr61 decreases Cytarabine chemosensitivity in acute lymphoblastic leukemia cells via NF-κB pathway activation. International journal of molecular medicine. 2019 Feb; 43(2):1011-1020. doi: 10.3892/ijmm.2018.4018. [PMID: 30535449]
  • Michelina Santopietro, Maurizio Miano, Giovanna Palumbo, Kejian Zhang, Luisa Cardarelli, Sabina Chiaretti, Nadia Peragine, Mauro Nanni, Daniela Diverio, Francesca Mancini, Anna Maria Testi, Maria Luisa Moleti, Robin Foà, Fiorina Giona. Atypical Chronic Myeloid Leukemia in a Patient with Aplastic Anemia. Acta haematologica. 2019; 142(3):185-186. doi: 10.1159/000497137. [PMID: 31112981]
  • Zheng Ding, Huifeng Shi, Wei Yang. Osteoprotective Effect of Cimiracemate in Glucocorticoid-Induced Osteoporosis by Osteoprotegerin/Receptor Activator of Nuclear Factor κ B/Receptor Activator of Nuclear Factor Kappa-Β Ligand Signaling. Pharmacology. 2019; 103(3-4):163-172. doi: 10.1159/000495509. [PMID: 30695776]
  • David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Ernestina Hernández García, Francisca Trujillo Jiménez, Gerardo Barragán Mejía. Cytarabine and Ferric Carboxymaltose (Fe+3) Increase Oxidative Damage and Alter Serotonergic Metabolism in Brain. CNS & neurological disorders drug targets. 2019; 18(2):149-155. doi: 10.2174/1871527318666181128144343. [PMID: 30484410]
  • Ruiling Liu, Yue Jiang, Xu Hu, Jilian Wu, Wei Jiang, Guoxia Jin, Yuxia Luan. A preclinical evaluation of cytarabine prodrug nanofibers assembled from cytarabine-lauric acid conjugate toward solid tumors. International journal of pharmaceutics. 2018 Dec; 552(1-2):111-118. doi: 10.1016/j.ijpharm.2018.09.043. [PMID: 30268848]
  • Yoko Tabe, Kaori Saitoh, Haeun Yang, Kazumasa Sekihara, Kotoko Yamatani, Vivian Ruvolo, Hikari Taka, Naoko Kaga, Mika Kikkawa, Hajime Arai, Takashi Miida, Michael Andreeff, Paul A Spagnuolo, Marina Konopleva. Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine. Scientific reports. 2018 11; 8(1):16837. doi: 10.1038/s41598-018-35198-6. [PMID: 30442990]
  • Wei Wei, Zhonggui He, Jincheng Yang, Mengchi Sun, Jin Sun. Cytosine arabinoside prodrug designed to bind plasma serum albumin for drug delivery. Drug delivery and translational research. 2018 10; 8(5):1162-1170. doi: 10.1007/s13346-018-0534-4. [PMID: 29748833]
  • B Pastina, P J Early, R L Bergman, J Nettifee, A Maller, K Y Bray, R J Waldron, A M Castel, K R Munana, M G Papich, K M Messenger. The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology. Journal of veterinary pharmacology and therapeutics. 2018 Oct; 41(5):638-643. doi: 10.1111/jvp.12667. [PMID: 29761906]