Diphenhydramine (BioDeep_00000001461)
Secondary id: BioDeep_00000398396
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H21NO (255.1623056)
中文名称: 苯海拉明
谱图信息:
最多检出来源 Viridiplantae(plant) 11.11%
分子结构信息
SMILES: CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
描述信息
Diphenhydramine is a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. -- Pubchem; Pseudoephedrine is a phenethylamine, and an isomer of ephedrine. Pseudoephedrine is the International Nonproprietary Name (INN) of the (1S,2S)- diastereomer of ephedrine (which has 1R,2S- configuration). Other names are (+)-pseudoephedrine and D-pseudoephedrine (Reynolds, 1989). The enantiomer (-)-(1R,2R)-Pseudoephedrine has fewer side-effects, fewer central nervous system (CNS) stimulatory effects, does not reduce to d-methamphetamine, yet retains its efficacy as a decongestant.[citation needed] However, the patent holder for (-)-Pseudoephedrine (Pfizer/Warner-Lambert) has not yet sought or received government approval for its sale to the public.(US Patent 6,495,529); Treatment for urinary incontinence is an unlabeled use for these medications. Unlabeled use means doctors can use the medication to treat a condition other than that for which it was first approved by the U.S. Food and Drug Administration (FDA). These medications are approved by the FDA for the treatment of nasal congestion caused by colds or allergies. However it has also been successful in treating stress incontinence by increasing the pressure (tension) exerted by the muscles of the bladder neck and the urethra, which helps retain the urine within the bladder. Despite being one of the oldest antihistamines on the market, it is by and large the most effective antihistamine available, either by prescription or over-the-counter, and has been shown to exceed the effectiveness of even the latest prescription drugs. Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of the (often dangerous) effects of a massive histamine release. However, it is not always the drug of choice for treating allergies. Like many other first generation antihistamines, is also a potent anticholinergic agent. This leads to profound drowsiness as a very common side-effect, along with the possibilities of motor impairment (ataxia), dry mouth and throat, flushed skin, rapid or irregular heartbeat (tachycardia), blurred vision at near point due to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), pupil dilatation, urinary retention, constipation, difficulty concentrating, short-term memory loss, visual disturbances, hallucinations, confusion, erectile dysfunction, and delirium. -- Wikipedia;.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. -- Pubchem; Pseudoephedrine is a phenethylamine, and an isomer of ephedrine. Pseudoephedrine is the International Nonproprietary Name (INN) of the (1S,2S)- diastereomer of ephedrine (which has 1R,2S- configuration). Other names are (+)-pseudoephedrine and D-pseudoephedrine (Reynolds, 1989). The enantiomer (-)-(1R,2R)-Pseudoephedrine has fewer side-effects, fewer central nervous system (CNS) stimulatory effects, does not reduce to d-methamphetamine, yet retains its efficacy as a decongestant.[citation needed] However, the patent holder for (-)-Pseudoephedrine (Pfizer/Warner-Lambert) has not yet sought or received government approval for its sale to the public.(US Patent 6,495,529); Treatment for urinary incontinence is an unlabeled use for these medications. Unlabeled use means doctors can use the medication to treat a condition other than that for which it was first approved by the U.S. Food and Drug Administration (FDA). These medications are approved by the FDA for the treatment of nasal congestion caused by colds or allergies. However it has also been successful in treating stress incontinence by increasing the pressure (tension) exerted by the muscles of the bladder neck and the urethra, which helps retain the urine within the bladder.; Despite being one of the oldest antihistamines on the market, it is by and large the most effective antihistamine available, either by prescription or over-the-counter, and has been shown to exceed the effectiveness of even the latest prescription drugs. Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of the (often dangerous) effects of a massive histamine release. However, it is not always the drug of choice for treating allergies. Like many other first generation antihistamines, is also a potent anticholinergic agent. This leads to profound drowsiness as a very common side-effect, along with the possibilities of motor impairment (ataxia), dry mouth and throat, flushed skin, rapid or irregular heartbeat (tachycardia), blurred vision at near point due to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), pupil dilatation, urinary retention, constipation, difficulty concentrating, short-term memory loss, visual disturbances, hallucinations, confusion, erectile dysfunction, and delirium. -- Wikipedia [HMDB]
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3352
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3].
同义名列表
44 个代谢物同义名
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine; beta-Dimethylaminoethanol diphenylmethyl ether; alpha-(2-Dimethylaminoethoxy)diphenylmethane; b-Dimethylaminoethanol diphenylmethyl ether; Β-dimethylaminoethanol diphenylmethyl ether; Α-(2-dimethylaminoethoxy)diphenylmethane; 2-Diphenylmethoxy-N,N-dimethylethylamine; beta-Dimethylaminoethyl benzhydryl ether; 2-(Benzhydryloxy)-N,N-dimethylethylamine; a-(2-Dimethylaminoethoxy)diphenylmethane; [2-(diphenylmethoxy)ethyl]dimethylamine; 2-Diphenylmethoxy-N,N-demthylethanamine; b-Dimethylaminoethyl benzhydryl ether; Β-dimethylaminoethyl benzhydryl ether; O-Benzhydryldimethylaminoethanol; Dimethylamine benzhydryl ester; Hydrochloride, diphenhydramine; Diphenhydramine citrate (1:1); Diphenhydramine Hydrochloride; Citrate, diphenhydramine; Diphenhydramine citrate; Diphenylhydramine; Diphenylhydramin; Diphenhydraminum; diphenhydramine; Difenhidramina; Difenhydramine; Benzhydramine; Benhydramin; Dimedrolum; Diphantine; Benzantin; Allergina; Allerdryl; Bendylate; Diphamine; Alledryl; Restamin; Benadryl; Allergan; Dimedrol; Dobacen; Benylin; Dormin
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:4636
- KEGG: C06960
- KEGGdrug: D00300
- PubChem: 3100
- HMDB: HMDB0001927
- Metlin: METLIN2312
- DrugBank: DB01075
- ChEMBL: CHEMBL657
- Wikipedia: Diphenhydramine
- MeSH: Diphenhydramine
- foodb: FDB022744
- chemspider: 2989
- CAS: 2122800-18-2
- CAS: 110491-04-8
- CAS: 147-24-0
- CAS: 58-73-1
- MoNA: EQ335201
- MoNA: EQ335204
- MoNA: EQ335208
- MoNA: EQ335209
- MoNA: EQ335205
- MoNA: EQ335207
- MoNA: EQ335206
- MoNA: EQ335202
- MoNA: EQ335203
- PMhub: MS000000575
- PubChem: 9174
- PDB-CCD: 2PM
- RefMet: Diphenhydramine
- medchemexpress: HY-B0303
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Dongqi Zhou, Ting Zhou, Shiyun Tang, Qing Li, Wen Li, Gaofeng Gan, Mingqiao Li, Qiu Chen. Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy.
Frontiers in endocrinology.
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NanoImpact.
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Chemosphere.
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The Veterinary record.
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Veterinary dermatology.
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Complementary therapies in medicine.
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