(R)-Amphetamine (BioDeep_00000001455)

Secondary id: BioDeep_00000033201, BioDeep_00000397495

human metabolite Chemicals and Drugs

代谢物信息卡片

(R)-alpha-Methyl-benzeneethanamine

化学式: C9H13N (135.1047938)
中文名称: 1-甲基-2-苯乙胺, 1-苯基-2-丙胺, 左苯丙胺
谱图信息: 最多检出来源 Viridiplantae(plant) 0.41%

分子结构信息

SMILES: CC(CC1=CC=CC=C1)N
InChI: InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3

描述信息

==(R)==-Amphetamine is an enantiomer of amphetamine that is urinary metabolite from selegeline (drug used for the treatment of early-stage Parkinsons disease, depression and senile dementia). ==(R)==-Amphetamine as stereoisomer is not considered psychoactive and has little abuse potential. The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of R-methamphetamine. If anyone is prescribed and takes selegiline, they can and will test positive for amphetamine/methamphetamine on most drug tests. [HMDB]
(R)-amphetamine is an enantiomer of amphetamine that is urinary metabolite from selegeline (drug used for the treatment of early-stage Parkinsons disease, depression and senile dementia). (R)-amphetamine as stereoisomer is not considered psychoactive and has little abuse potential. The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of R-methamphetamine. If anyone is prescribed and takes selegiline, they can and will test positive for amphetamine/methamphetamine on most drug tests.
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics > N06BA - Centrally acting sympathomimetics
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

38 个代谢物同义名

(R)-alpha-Methyl-benzeneethanamine; Miquel brand OF amfetamine sulfate; (R)-alpha-Methylbenzeneethanamine; (R)-alpha-Methylphenethylamine; (R)-a-Methyl-benzeneethanamine; (R)-Α-methylbenzeneethanamine; (R)-a-Methylbenzeneethanamine; Benzeneethanamine, a-methyl-; L-alpha-Methylphenethylamine; (2R)-1-phenylpropan-2-amine; (R)-Α-methylphenethylamine; (R)-a-Methylphenethylamine; Amphetamine sulfate (2:1); (-)-Phenylisopropylamine; (R)-Phenylisopropylamine; L-a-Methylphenethylamine; Sulfate, amphetamine; amphetamine sulfate; L-(R)-Amphetamine; Desoxynorephedrin; Levo amphetamine; Levo-amphetamine; (R)-Amphetamine; Levoamphetamine; (-)-Amphetamine; Levamphetamine; (R)-Phenaminum; Levamfetamine; l-amphetamine; L Amphetamine; AMPHETAMINE; Phenopromin; Centramina; Amfetamine; Thyramine; Phenamine; Fenamine; Mydrial

数据库引用编号

24 个数据库交叉引用编号

ChEBI: CHEBI:132233
ChEBI: CHEBI:42724
ChEBI: CHEBI:2679
KEGG: C07514
KEGGdrug: D07445
KEGGdrug: D03740
PubChem: 32893
PubChem: 3007
HMDB: HMDB0012128
Metlin: METLIN2403
DrugBank: DB00182
ChEMBL: CHEMBL19393
ChEMBL: CHEMBL405
MeSH: Amphetamine
MetaCyc: CPD-7659
foodb: FDB028792
chemspider: 30477
CAS: 156-34-3
CAS: 300-62-9
CAS: 60-15-1
PMhub: MS000000560
PubChem: 9717
KNApSAcK: C00042226
NIKKAJI: J231.296D

分类词条

Amphetamines and derivatives

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

9606 - Homo sapiens: -
138013 - Senegalia berlandieri: 10.1016/S0031-9422(97)00240-9

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Marina Bellot, Fernando Soria, Raul López-Arnau, Cristian Gómez-Canela, Carlos Barata. Daphnia magna an emerging environmental model of neuro and cardiotoxicity of illicit drugs. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 344(?):123355. doi: 10.1016/j.envpol.2024.123355. [PMID: 38228265]
Mariana Angoa-Perez, Donald M Kuhn. The pharmacology and neurotoxicology of synthetic cathinones. Advances in pharmacology (San Diego, Calif.). 2024; 99(?):61-82. doi: 10.1016/bs.apha.2023.12.001. [PMID: 38467489]
Rong Chen. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). 2024; 99(?):35-59. doi: 10.1016/bs.apha.2023.09.004. [PMID: 38467486]
Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek. Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach. The Science of the total environment. 2023 May; ?(?):164386. doi: 10.1016/j.scitotenv.2023.164386. [PMID: 37263433]
Su Zhang, Jun Luo, YiWei Zeng, Huan Ren, Zhihan Chen, Yulan Ren. Acupuncture for protracted amphetamine abstinence syndrome: study protocol for a systematic review and meta-analysis. BMJ open. 2023 04; 13(4):e062491. doi: 10.1136/bmjopen-2022-062491. [PMID: 37085314]
Rui Zeng, Hong-Yu Pu, Xin-Yue Zhang, Meng-Lin Yao, Qin Sun. Methamphetamine: Mechanism of Action and Chinese Herbal Medicine Treatment for Its Addiction. Chinese journal of integrative medicine. 2023 Apr; ?(?):. doi: 10.1007/s11655-023-3635-y. [PMID: 37074617]
Taja Verovšek, Ariana Šuštarič, Maria Laimou-Geraniou, Ivona Krizman-Matasic, Helena Prosen, Tina Eleršek, Vlasta Kramarič Zidar, Vesna Mislej, Boštjan Mišmaš, Marjeta Stražar, Marjetka Levstek, Bernardka Cimrmančič, Simon Lukšič, Nataša Uranjek, Tjaša Kozlovič-Bobič, Tina Kosjek, David Kocman, David Heath, Ester Heath. Removal of residues of psychoactive substances during wastewater treatment, their occurrence in receiving river waters and environmental risk assessment. The Science of the total environment. 2023 Mar; 866(?):161257. doi: 10.1016/j.scitotenv.2022.161257. [PMID: 36608822]
Shiyu Wang, Anna I Neel, Kristen L Adams, Haiguo Sun, Sara R Jones, Allyn C Howlett, Rong Chen. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters. Neuropharmacology. 2023 03; 225(?):109387. doi: 10.1016/j.neuropharm.2022.109387. [PMID: 36567004]
Tzu-Yun Wang, Ru-Band Lu, Sheng-Yu Lee, Yun-Hsuan Chang, Shiou-Lan Chen, Tsung-Yu Tsai, Huai-Hsuan Tseng, Po See Chen, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong. Association Between Inflammatory Cytokines, Executive Function, and Substance Use in Patients With Opioid Use Disorder and Amphetamine-Type Stimulants Use Disorder. The international journal of neuropsychopharmacology. 2023 01; 26(1):42-51. doi: 10.1093/ijnp/pyac069. [PMID: 36181736]
Valtieri Bortoluzzi Lima, Altevir Rossato Viana, Daniel Santos, Narieli Felipetto, Natália Fernandes Mezzomo, Adriana Maria Zago, Erico Marlon Moraes Flores, Alencar Kolinski Machado, Alexandre Krause, Luis Ricardo Peroza, Larissa Finger Schaffer, Luciana Maria Fontanari Krause. Ethyl Acetate Fraction of Harpagophytum procumbens Prevents Oxidative Stress In Vitro and Amphetamine-Induced Alterations in Mice Behavior. Neurochemical research. 2023 Jan; ?(?):. doi: 10.1007/s11064-022-03846-z. [PMID: 36648708]
Han Qu, Fang Wang, Holly Barrett, Bin Wang, Jiajun Han, Junxue Wu, Xiaochen Huang, Yongxia Hu, Gang Yu. Synthetical effect of microplastics and chiral drug amphetamine on a primary food source algae Chlorella pyrenoids. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Nov; 169(?):113415. doi: 10.1016/j.fct.2022.113415. [PMID: 36096289]
Noah A Omeiza, Adewale G Bakre, Halimat A Abdulrahim, Happy Isibor, Precious U Ezurike, Abimbola A Sowunmi, Benneth Ben-Azu, Adegbuyi O Aderibigbe. Pretreatment with Carpolobia lutea ethanol extract prevents schizophrenia-like behavior in mice models of psychosis. Journal of ethnopharmacology. 2022 Sep; 295(?):115432. doi: 10.1016/j.jep.2022.115432. [PMID: 35659625]
Roberta Zilles Hahn, Marcos Frank Bastiani, Lilian de Lima Feltraco Lizot, Anelise Schneider, Isabela Caroline da Silva Moreira, Yasmin Fazenda Meireles, Mariana Freitas Viana, Carlos Augusto do Nascimento, Rafael Linden. Long-term monitoring of drug consumption patterns during the COVID-19 pandemic in a small-sized community in Brazil through wastewater-based epidemiology. Chemosphere. 2022 Sep; 302(?):134907. doi: 10.1016/j.chemosphere.2022.134907. [PMID: 35561781]
Andrea Estévez-Danta, Lubertus Bijlsma, Ricardo Capela, Rafael Cela, Alberto Celma, Félix Hernández, Unax Lertxundi, João Matias, Rosa Montes, Gorka Orive, Ailette Prieto, Miguel M Santos, Rosario Rodil, José Benito Quintana. Use of illicit drugs, alcohol and tobacco in Spain and Portugal during the COVID-19 crisis in 2020 as measured by wastewater-based epidemiology. The Science of the total environment. 2022 Aug; 836(?):155697. doi: 10.1016/j.scitotenv.2022.155697. [PMID: 35523346]
J M González-Soler, M Muñoz-Bartual, S Armenta, J M Herrero-Martínez, F A Esteve-Turrillas. Paper-based monolith extraction of psychoactive substances from biological fluids. Talanta. 2022 Aug; 246(?):123536. doi: 10.1016/j.talanta.2022.123536. [PMID: 35580378]
László Institóris, Előd Hidvégi, Katalin Kovács, Ákos Jámbor, Adrienn Dobos, Ferenc Rárosi, Gábor Süvegh, Tibor Varga, Éva M Kereszty. Drug consumption of suspected drug-influenced drivers in Hungary (2016-2018). Forensic science international. 2022 Jul; 336(?):111325. doi: 10.1016/j.forsciint.2022.111325. [PMID: 35569293]
Amr Said Shalaby, Abdullah Osama Bahanan, Mishal Hasan Alshehri, Khaled Ahmed Elag. Sleep Deprivation & Amphetamine Induced Psychosis. Psychopharmacology bulletin. 2022 06; 52(3):31-40. doi: . [PMID: 35815175]
Karolina E Kolaczynska, Paula Ducret, Daniel Trachsel, Marius C Hoener, Matthias E Liechti, Dino Luethi. Pharmacological characterization of 3,4-methylenedioxyamphetamine (MDA) analogs and two amphetamine-based compounds: N,α-DEPEA and DPIA. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2022 06; 59(?):9-22. doi: 10.1016/j.euroneuro.2022.03.006. [PMID: 35378384]
Eloir Gallegos, Marisol Ascona, Juana Monroy, Marta Elena Castro-Manrreza, Andrés Aragón-Martínez, María Elena Ayala. p-Chloroamphetamine decreases serotonin and induces apoptosis in granulosa cells and follicular atresia in prepubertal female rats. Reproductive toxicology (Elmsford, N.Y.). 2022 06; 110(?):150-160. doi: 10.1016/j.reprotox.2022.04.006. [PMID: 35460820]
Isabel Gomila Muñiz, Elena Lendoiro, Ana de-Castro-Ríos, Miguel Ángel Elorza Guerrero, Jordi Puiguriguer Ferrando, Laura Sahuquillo Frias, Pilar Sanchís Cortés, Bernardino Barceló Martín. Detection of unsuspected cathinone and piperazine-type drugs in urine samples positive for methamphetamine and amphetamine collected in emergency departments. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2022 06; 34(3):174-180. doi: . [PMID: 35736521]
Jonas Asgaard Bojsen, Line Lunau, Nina Ttn Nguyen, Benjamin Schnack Brandt Rasmussen. [Amphetamine-induced toxic encephalopathy]. Ugeskrift for laeger. 2022 05; 184(21):. doi: . [PMID: 35656615]
Jordan T Lloyd, Andrew G Yee, Prasanna K Kalligappa, Anower Jabed, Pang Y Cheung, Kathryn L Todd, Rashika N Karunasinghe, Srdjan M Vlajkovic, Peter S Freestone, Janusz Lipski. Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model. Neuroscience. 2022 05; 491(?):43-64. doi: 10.1016/j.neuroscience.2022.03.019. [PMID: 35331847]
Mitchell R McGill, David L Findley, Anna Mazur, Eric U Yee, Felicia D Allard, Allison Powers, Lori Coward, Eric R Blough, Greg Gorman, Michael D Hambuchen. Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats. European journal of drug metabolism and pharmacokinetics. 2022 May; 47(3):319-330. doi: 10.1007/s13318-022-00755-y. [PMID: 35137360]
Likai Qi, Xinyi Jiang, Ning Wu, Jingjing Li, Bin Di, Fang Yan. Synthesis of a novel polydopamine and C18 dual-functionalized magnetic core-shell mesoporous nanocomposite for enrichment and analysis of widely abused illegal drugs in urine samples on site and in the laboratory. Journal of pharmaceutical and biomedical analysis. 2022 Apr; 212(?):114656. doi: 10.1016/j.jpba.2022.114656. [PMID: 35168125]
Vanessa Hofmann, Tom Richard Sundermann, Aysche Landmann, Stefanie Rechtsteiner, Georg Schmitt, Marc Bartel. Simultaneous Determination of 5- and 6-APB in Blood, Other Body Fluids, Hair and Various Tissues by HPLC--MS-MS. Journal of analytical toxicology. 2022 Mar; 46(3):264-269. doi: 10.1093/jat/bkab018. [PMID: 33576419]
Huan Ren, Yiwei Zeng, Min Zhang, Su Zhang, Zhihan Chen, Binbin Wu, Jun Liu, Yulan Ren. Electro-acupuncture for protracted amphetamine abstinence syndrome: study protocol for a pragmatic randomized controlled trial. Trials. 2022 Mar; 23(1):216. doi: 10.1186/s13063-022-06154-7. [PMID: 35292088]
Naomi Reymond, Erik Emke, Thea Boucheron, Thomas Ter Laak, Pim de Voogt, Pierre Esseiva, Frederic Been. Retrospective suspect and non-target screening combined with similarity measures to prioritize MDMA and amphetamine synthesis markers in wastewater. The Science of the total environment. 2022 Mar; 811(?):152139. doi: 10.1016/j.scitotenv.2021.152139. [PMID: 34871677]
Osama Refai, Shaili Aggarwal, Mary Hongying Cheng, Zayna Gichi, Joseph M Salvino, Ivet Bahar, Randy D Blakely, Ole V Mortensen. Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1. Molecular pharmacology. 2022 03; 101(3):123-131. doi: 10.1124/molpharm.121.000400. [PMID: 34906999]
Maria D Chermá, Gunnel H Nilsson, Anna Johansson, Anna K Jönsson, Johan Ahlner. Use of Lisdexamfetamine or Amphetamine? Interpretation of Chiral Amphetamine Analyses. Journal of analytical toxicology. 2022 Feb; 46(1):10-16. doi: 10.1093/jat/bkaa170. [PMID: 33216112]
Sergi Pascual-Caro, Francesc Borrull, Carme Aguilar, Marta Calull. Comparison of different chiral selectors for the enantiomeric determination of amphetamine-type substances in human urine by solid-phase extraction followed by capillary electrophoresis-tandem mass spectrometry. Electrophoresis. 2022 02; 43(3):437-445. doi: 10.1002/elps.202100231. [PMID: 34652814]
André Niebel, Fritz Pragst, Franziska Krumbiegel, Sven Hartwig. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international. 2022 Feb; 331(?):111148. doi: 10.1016/j.forsciint.2021.111148. [PMID: 34923263]
Caline S Karam, Brenna L Williams, Sandra K Jones, Jonathan A Javitch. The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila. Neurochemical research. 2022 Jan; 47(1):177-189. doi: 10.1007/s11064-021-03275-4. [PMID: 33630236]
Katarina Ilic, Alan R Kugler, Brian Yan, Nora McNamara. Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4-5 Years with Attention-Deficit/Hyperactivity Disorder. CNS drugs. 2022 01; 36(1):71-81. doi: 10.1007/s40263-021-00870-5. [PMID: 34826114]
João F C Pedrazzi, Amanda J Sales, Francisco S Guimarães, Sâmia R L Joca, José A S Crippa, Elaine Del Bel. Cannabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatum. Progress in neuro-psychopharmacology & biological psychiatry. 2021 12; 111(?):110352. doi: 10.1016/j.pnpbp.2021.110352. [PMID: 34015384]
Nikki J Clauss, Wouter Koek, Lynette C Daws. Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413420. [PMID: 34948221]
Wojciech Glac, Joanna Dunacka, Beata Grembecka, Grzegorz Świątek, Irena Majkutewicz, Danuta Wrona. Prolonged Peripheral Immunosuppressive Responses as Consequences of Random Amphetamine Treatment, Amphetamine Withdrawal and Subsequent Amphetamine Challenges in Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021 12; 16(4):870-887. doi: 10.1007/s11481-021-09988-1. [PMID: 33586062]
Burkhard Madea, Elvira Ruppel, Julian Prangenberg, Michael Krämer, Elke Doberentz. Expression of heat shock proteins 27, 60, and 70 in amphetamine and cocaine associated deaths. Forensic science international. 2021 Dec; 329(?):111088. doi: 10.1016/j.forsciint.2021.111088. [PMID: 34773820]
Rita R Fagan, Patrick J Kearney, Dino Luethi, Nicholas C Bolden, Harald H Sitte, Patrick Emery, Haley E Melikian. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Molecular psychiatry. 2021 12; 26(12):7793-7802. doi: 10.1038/s41380-021-01275-y. [PMID: 34471250]
Moritz Losacker, Stefan W Toennes, Elizabeth B de Sousa Fernandes Perna, Johannes G Ramaekers, Joerg Roehrich, Cornelius Hess. Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration: Can (R)/(S)-Concentration Ratios Help in Interpreting Forensic Cases?. Journal of analytical toxicology. 2021 Nov; 45(9):985-992. doi: 10.1093/jat/bkaa156. [PMID: 33031519]
Radharani Benvenutti, Matheus Gallas-Lopes, Adrieli Sachett, Matheus Marcon, Nathan Ryzewski Strogulski, Carlos Guilherme Reis, Rafael Chitolina, Angelo Piato, Ana Paula Herrmann. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. Journal of neuroscience research. 2021 11; 99(11):2844-2859. doi: 10.1002/jnr.24948. [PMID: 34496062]
Moritz Losacker, Joerg Roehrich, Cornelius Hess. Enantioselective determination of plasma protein binding of common amphetamine-type stimulants. Journal of pharmaceutical and biomedical analysis. 2021 Oct; 205(?):114317. doi: 10.1016/j.jpba.2021.114317. [PMID: 34419812]
Ornella Valenti, Alice Zambon, Stefan Boehm. Orchestration of Dopamine Neuron Population Activity in the Ventral Tegmental Area by Caffeine: Comparison With Amphetamine. The international journal of neuropsychopharmacology. 2021 10; 24(10):832-841. doi: 10.1093/ijnp/pyab049. [PMID: 34278424]
Stéphane Krief, Isabelle Berrebi-Bertrand, Isabelle Nagmar, Martin Giret, Simon Belliard, David Perrin, Marilyne Uguen, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Olivier Finance, Xavier Ligneau. Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol. Pharmacology research & perspectives. 2021 10; 9(5):e00855. doi: 10.1002/prp2.855. [PMID: 34423920]
Selina Hemmer, Lea Wagmann, Markus R Meyer. Altered metabolic pathways elucidated via untargeted in vivo toxicometabolomics in rat urine and plasma samples collected after controlled application of a human equivalent amphetamine dose. Archives of toxicology. 2021 10; 95(10):3223-3234. doi: 10.1007/s00204-021-03135-8. [PMID: 34414480]
Anders Helander, Tomas Villen. [Drug use and drug trends in Sweden 2010-2020 - results from urine drug testing in the workplace]. Lakartidningen. 2021 09; 118(?):. doi: NULL. [PMID: 34515329]
Ngoc Tu Le, Quynh Long Khuong, Thi Tuong Vi Vu, Thanh Truc Thai, Huynh Thi Cam Hong Le, Phuoc Thang Dao, Sy Hieu Le, Thi Thu Van Tieu, Van Dung Do. Prevalence of Amphetamine-Type Stimulant Use and Related Factors among Methadone Maintenance Patients in Ho Chi Minh City Vietnam: A Cross-Sectional Study. Journal of psychoactive drugs. 2021 Sep; 53(4):355-363. doi: 10.1080/02791072.2020.1871126. [PMID: 33504276]
Jin Sol Gene Lee, Ian Elliott Brown, Alison M Semrad, Amir A Zeki. Getting around the gut: a unique management challenge of thyroid storm precipitated by amphetamine-associated duodenal ischaemia leading to compromised enteric absorption. BMJ case reports. 2021 Aug; 14(8):. doi: 10.1136/bcr-2020-238889. [PMID: 34413029]
Xiuping Fu, Aparna P Shah, Jacqueline Keighron, Ta-Chung M Mou, Bruce Ladenheim, Jesse Alt, Daisuke Fukudome, Minae Niwa, Kellie L Tamashiro, Gianluigi Tanda, Akira Sawa, Jean-Lud Cadet, Rana Rais, Jay M Baraban. Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity. Translational psychiatry. 2021 08; 11(1):427. doi: 10.1038/s41398-021-01547-9. [PMID: 34392304]
Andrea N Belovich, Jenny I Aguilar, Samuel J Mabry, Mary H Cheng, Daniele Zanella, Peter J Hamilton, Daniel J Stanislowski, Aparna Shekar, James D Foster, Ivet Bahar, Heinrich J G Matthies, Aurelio Galli. A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster. Molecular psychiatry. 2021 08; 26(8):4417-4430. doi: 10.1038/s41380-019-0620-0. [PMID: 31796894]
Christopher Wohkittel, Petra Högger, Stefanie Fekete, Marcel Romanos, Manfred Gerlach. Relationship Between Amphetamine Concentrations in Saliva and Serum in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Therapeutic drug monitoring. 2021 08; 43(4):564-569. doi: 10.1097/ftd.0000000000000831. [PMID: 33149054]
Ewa Domagalska, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Marzena Kata, Beata Szpiech, Michał Kaliszan. Fatal N-Ethylhexedrone Intoxication. Journal of analytical toxicology. 2021 Jul; 45(6):e1-e6. doi: 10.1093/jat/bkaa159. [PMID: 33048166]
Sarah Meyers, Elisha M Wachman. A Case of False-positive Amphetamine Results on Urine Toxicology Testing Secondary to Imatinib. Journal of addiction medicine. 2021 Jul; 15(4):349-351. doi: 10.1097/adm.0000000000000766. [PMID: 33181576]
Mohamed Abou El Hassan, David Colantonio, Sergei Likhodii, Bassam A Nassar. The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard. Clinical biochemistry. 2021 Jul; 93(?):99-103. doi: 10.1016/j.clinbiochem.2021.04.003. [PMID: 33844982]
Nadine Theofel, Dennis Budach, Elke Vejmelka, Stefan Scholtis, Michael Tsokos. Toxicological investigations in a death involving 2-MAPB. Forensic science, medicine, and pathology. 2021 Jun; 17(2):317-321. doi: 10.1007/s12024-021-00366-0. [PMID: 33877515]
Zebin Lin, Chenyang Liu, Enshan Fan, Yurong Zhang, Shuiqing Zheng, Yulan Rao. An efficient and label-free LC-MS/MS method for assessing drug's activity at dopamine and serotonin transporters using transporter-transfected HEK293T cells. Journal of psychopharmacology (Oxford, England). 2021 Jun; 35(6):693-700. doi: 10.1177/02698811211008576. [PMID: 33888022]
Robin Wijngaard, Marina Parra-Robert, Lourdes Marés, Anna Escalante, Emilio Salgado, Bernardino González-de-la-Presa, Jordi To-Figueras, Mercè Brunet. Tetracaine from urethral ointment causes false positive amphetamine results by immunoassay. Clinical toxicology (Philadelphia, Pa.). 2021 06; 59(6):500-505. doi: 10.1080/15563650.2020.1834114. [PMID: 33112680]
Emre Dokuzparmak, Kelly Brown, Lynn Dennany. Electrochemiluminescent screening for methamphetamine metabolites. The Analyst. 2021 May; 146(10):3336-3345. doi: 10.1039/d1an00226k. [PMID: 33999061]
Rachel C Dale, Loretta T Ford, Catherine Street. Are point-of-care urine drug testing devices suitable for antenatal drug screening? A study verifying the Alere® Drug Screen Test Cup for the detection of six classes of drug in a pregnant population. Annals of clinical biochemistry. 2021 05; 58(3):166-173. doi: 10.1177/0004563221990699. [PMID: 33435699]
Asmaa F Sharif, Eman Elsheikh, Abdullah Z Al-Asmari, Dina El Gameel. Potential Role of Serum S-100β Protein as a Predictor of Cardiotoxicity and Clinical Poor Outcome in Acute Amphetamine Intoxication. Cardiovascular toxicology. 2021 05; 21(5):375-386. doi: 10.1007/s12012-020-09630-1. [PMID: 33423174]
Barry K Herman, Mohammed Bouhajib, Thomas R King, Judith C Kando, Antonio Pardo. Single-Dose Pharmacokinetics of Amphetamine Extended-Release Oral Suspension in Healthy Adults. Journal of attention disorders. 2021 04; 25(6):803-808. doi: 10.1177/1087054719841131. [PMID: 31027435]
Claudia Mariottini, Ilkka Ojanperä, Pirkko Kriikku. Increase in drugs-of-abuse findings in post-mortem toxicology due to COVID-19 restrictions-First observations in Finland. Drug testing and analysis. 2021 Apr; 13(4):867-870. doi: 10.1002/dta.2982. [PMID: 33217177]
Ilchung Shin, Hyeyoung Choi, Seojin Kang, Jihyun Kim, Yuran Park, Wonkyung Yang. Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. Journal of analytical toxicology. 2021 Feb; 45(1):99-104. doi: 10.1093/jat/bkaa058. [PMID: 32476010]
Toshiko Tanaka, Shiomi Yoshizumi, Kentaro Kasai, Kosho Yoshida, Hiroaki Sato. Efficacy of DRIVEN-FLOW® M7-II, a new on-site drug screening kit in postmortem urine compared with Triage DOA®. Legal medicine (Tokyo, Japan). 2021 Feb; 48(?):101804. doi: 10.1016/j.legalmed.2020.101804. [PMID: 33152676]
Edouard Coupet, Gail D'Onofrio, Marek Chawarski, E J Edelman, Patrick G O'Connor, Patricia Owens, Shara Martel, David A Fiellin, Ethan Cowan, Lynne Richardson, Kristen Huntley, Lauren K Whiteside, Michael S Lyons, Richard E Rothman, Michael Pantalon, Kathryn Hawk. Emergency department patients with untreated opioid use disorder: A comparison of those seeking versus not seeking referral to substance use treatment. Drug and alcohol dependence. 2021 02; 219(?):108428. doi: 10.1016/j.drugalcdep.2020.108428. [PMID: 33307301]
Shovkatjon Akhunov, Khatam Ashurov, Sherzod Axmedov, Beknazar Kasimov, Vladimir Rotshteyn, Azim Radjabov, Dilshadbek Usmanov. Development of surface ionization mass spectrometry for detection of stimulants in human urine. European journal of mass spectrometry (Chichester, England). 2021 Feb; 27(1):29-38. doi: 10.1177/14690667211002777. [PMID: 33745338]
Bárbara Nunes Krum, Catiuscia Molz de Freitas, Ana Paula Chiapinotto Ceretta, Caroline Pilecco Barbosa, Elizete de Moraes Reis, Rahisa Scussel, Emily da Silva Córneo, Ricardo Andrez Machado-de-Ávila, Aline Augusti Boligon, Roselei Fachinetto. Kava decreases the stereotyped behavior induced by amphetamine in mice. Journal of ethnopharmacology. 2021 Jan; 265(?):113293. doi: 10.1016/j.jep.2020.113293. [PMID: 32841698]
Rebeca Mejias, Juan J Rodriguez-Gotor, Minae Niwa, Irina N Krasnova, Abby Adamczyk, Mei Han, Gareth M Thomas, Zheng-Xiong Xi, Richard L Huganir, Mikhail V Pletnikov, Akira Sawa, Jean-Lud Cadet, Tao Wang. Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice. Translational psychiatry. 2021 01; 11(1):65. doi: 10.1038/s41398-020-01194-6. [PMID: 33462194]
Emily M Black, Rodrigo A España. D-amphetamine maintenance treatment goes a long way: lasting therapeutic effects on cocaine behavioral effects and cocaine potency at the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 01; 46(2):275-276. doi: 10.1038/s41386-020-00825-2. [PMID: 32859997]
Padmanabhan Mannangatti, Durairaj Ragu Varman, Sammanda Ramamoorthy, Lankupalle D Jayanthi. Neurokinin-1 Antagonism Distinguishes the Role of Norepinephrine Transporter from Dopamine Transporter in Mediating Amphetamine Behaviors. Pharmacology. 2021; 106(11-12):597-605. doi: 10.1159/000518033. [PMID: 34515205]
Melike Aydoğdu, Serap Annette Akgür. Urine drug-testing tampering approaches: Turkish probationers. Medicine, science, and the law. 2021 Jan; 61(1):6-13. doi: 10.1177/0025802420956453. [PMID: 32924786]
Eloisa Comiran, Graciela Carlos, Fabiano Barreto, Flavio Pechanksy, Pedro E Fröehlich, Renata P Limberger. Lisdexamfetamine and amphetamine pharmacokinetics in oral fluid, plasma, and urine after controlled oral administration of lisdexamfetamine. Biopharmaceutics & drug disposition. 2021 Jan; 42(1):3-11. doi: 10.1002/bdd.2254. [PMID: 33119133]
Muhammad O Chohan, Sari Esses, Julia Haft, Susanne E Ahmari, Jeremy Veenstra-VanderWeele. Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice. Psychopharmacology. 2020 Dec; 237(12):3553-3568. doi: 10.1007/s00213-020-05635-4. [PMID: 32778904]
Marek C Chawarski, Kathryn Hawk, E Jennifer Edelman, Patrick O'Connor, Patricia Owens, Shara Martel, Edouard Coupet, Lauren Whiteside, Judith I Tsui, Richard Rothman, Ethan Cowan, Lynne Richardson, Michael S Lyons, David A Fiellin, Gail D'Onofrio. Use of Amphetamine-Type Stimulants Among Emergency Department Patients With Untreated Opioid Use Disorder. Annals of emergency medicine. 2020 12; 76(6):782-787. doi: 10.1016/j.annemergmed.2020.06.046. [PMID: 32782084]
Antonio Pardo, Judith C Kando, Thomas R King, Eman Rafla, Barry K Herman. Single-dose pharmacokinetics of amphetamine extended-release tablets compared with amphetamine extended-release oral suspension. CNS spectrums. 2020 12; 25(6):774-781. doi: 10.1017/s1092852919001676. [PMID: 31964449]
Rajesh Narendran, Neale Scott Mason, Michael L Himes, W Gordon Frankle. Imaging Cortical Dopamine Transmission in Cocaine Dependence: A [11C]FLB 457-Amphetamine Positron Emission Tomography Study. Biological psychiatry. 2020 11; 88(10):788-796. doi: 10.1016/j.biopsych.2020.04.001. [PMID: 32507390]
Fabrizzio G Guajardo, Victoria B Velásquez, Daniela Raby, Gabriel Núñez-Vivanco, Patricio Iturriaga-Vásquez, Rodrigo A España, Miguel Reyes-Parada, Ramón Sotomayor-Zárate. Pharmacological Characterization of 4-Methylthioamphetamine Derivatives. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225310. [PMID: 33203055]
Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225222. [PMID: 33182534]
Derek Blevins, Kenneth M Carpenter, Diana Martinez, John J Mariani, Frances R Levin. An adaptive clinical trial design for cocaine use disorder: Extended-release amphetamine salts for early behavioral intervention non-responders. Contemporary clinical trials. 2020 11; 98(?):106187. doi: 10.1016/j.cct.2020.106187. [PMID: 33086160]
Anders Helander, Tomas Villen, Elin Widing. [Harmonized measurement and reporting of chiral amphetamine in the follow-up of ADHD treatment]. Lakartidningen. 2020 10; 117(?):. doi: . [PMID: 33107581]
Lucia Caffino, Michel M M Verheij, Karine Roversi, Giorgia Targa, Francesca Mottarlini, Piotr Popik, Agnieska Nikiforuk, Joanna Golebiowska, Fabio Fumagalli, Judith R Homberg. Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens. British journal of pharmacology. 2020 10; 177(19):4532-4547. doi: 10.1111/bph.15211. [PMID: 32721055]
H Z Rosa, H J Segat, R C S Barcelos, Kr Roversi, D R Rossato, G F de Brum, M E Burger. Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters. Pharmacology, biochemistry, and behavior. 2020 10; 197(?):173000. doi: 10.1016/j.pbb.2020.173000. [PMID: 32702398]
Fawaz Alasmari, Sary Alsanea, Afshan Masood, Khalid Alhazzani, Ibrahim O Alanazi, Mohthash Musambil, Assim A Alfadda, Musaad A Alshammari, Abdullah F Alasmari, Hicham Benabdelkamel. Serum proteomic profiling of patients with amphetamine use disorder. Drug and alcohol dependence. 2020 09; 214(?):108157. doi: 10.1016/j.drugalcdep.2020.108157. [PMID: 32652378]
Hilde Havnen, Miriam Hansen, Olav Spigset, Solfrid Hegstad. Enantiomeric separation and quantification of R/S-amphetamine in serum using semi-automated liquid-liquid extraction and ultra-high performance supercritical fluid chromatography-tandem mass spectrometry. Drug testing and analysis. 2020 Sep; 12(9):1344-1353. doi: 10.1002/dta.2879. [PMID: 32536030]
Suji Kim, Won-Jun Jang, Hyerim Yu, Jihyun Kim, Sang-Ki Lee, Chul-Ho Jeong, Sooyeun Lee. Revealing Metabolic Perturbation Following Heavy Methamphetamine Abuse by Human Hair Metabolomics and Network Analysis. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21176041. [PMID: 32839415]
Vitor S Tardelli, Adam Bisaga, Felipe B Arcadepani, Gilberto Gerra, Frances R Levin, Thiago M Fidalgo. Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis. Psychopharmacology. 2020 Aug; 237(8):2233-2255. doi: 10.1007/s00213-020-05563-3. [PMID: 32601988]
Santiago Cuesta, José Maria Restrepo-Lozano, Christina Popescu, Susan He, Lauren M Reynolds, Sonia Israel, Giovanni Hernandez, Rana Rais, Barbara S Slusher, Cecilia Flores. DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence. Addiction biology. 2020 07; 25(4):e12791. doi: 10.1111/adb.12791. [PMID: 31192517]
Ana Carolina Faria, Helena Carmo, Félix Carvalho, João Pedro Silva, Maria de Lourdes Bastos, Diana Dias da Silva. Drinking to death: Hyponatraemia induced by synthetic phenethylamines. Drug and alcohol dependence. 2020 07; 212(?):108045. doi: 10.1016/j.drugalcdep.2020.108045. [PMID: 32460203]
Weize Huang, Lindsay C Czuba, Nina Isoherranen. Mechanistic PBPK Modeling of Urine pH Effect on Renal and Systemic Disposition of Methamphetamine and Amphetamine. The Journal of pharmacology and experimental therapeutics. 2020 06; 373(3):488-501. doi: 10.1124/jpet.120.264994. [PMID: 32198137]
Suzanne M Underhill, Mark S Colt, Susan G Amara. Amphetamine Stimulates Endocytosis of the Norepinephrine and Neuronal Glutamate Transporters in Cultured Locus Coeruleus Neurons. Neurochemical research. 2020 Jun; 45(6):1410-1419. doi: 10.1007/s11064-019-02939-6. [PMID: 31912366]
Soumen Saha, Venu Yakati, Gajji Shankar, Madan Mohan Chandra Sekhar Jaggarapu, Gopikrishna Moku, Kuncha Madhusudana, Rajkumar Banerjee, Sistla Ramkrishna, Ragampeta Srinivas, Arabinda Chaudhuri. Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma. Journal of materials chemistry. B. 2020 05; 8(19):4318-4330. doi: 10.1039/c9tb02700a. [PMID: 32330214]
Xun Zhou, Jamal Bouitbir, Matthias E Liechti, Stephan Krähenbühl, Riccardo V Mancuso. Para-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells. International journal of molecular sciences. 2020 Apr; 21(8):. doi: 10.3390/ijms21082841. [PMID: 32325754]
Marion Leclercq, Marion Soichot, Brigitte Delhotal-Landes, Emmanuel Bourgogne, Hervé Gourlain, Bruno Mégarbane, Laurence Labat. False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology. Journal of analytical toxicology. 2020 Mar; 44(2):200-205. doi: 10.1093/jat/bkz051. [PMID: 31384953]
Domen Pregeljc, Diana Teodorescu-Perijoc, Robert Vianello, Nejc Umek, Janez Mavri. How Important Is the Use of Cocaine and Amphetamines in the Development of Parkinson Disease? A Computational Study. Neurotoxicity research. 2020 Mar; 37(3):724-731. doi: 10.1007/s12640-019-00149-0. [PMID: 31828739]
Catherine F Moore, Michael Z Leonard, Nicholas M Micovic, Klaus A Miczek, Valentina Sabino, Pietro Cottone. Reward sensitivity deficits in a rat model of compulsive eating behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020 03; 45(4):589-596. doi: 10.1038/s41386-019-0550-1. [PMID: 31622973]
Carolina Roset Ferrer, Isabel Gomila Muñiz, Miguel Ángel Elorza Guerrero, Jordi Puiguriguer Ferrando, María Ángeles Leciñena Estean, Gaspar Tuero León, Laura Sahuquillo Frías, Tomás Ripoll Vera, Lorenzo Socias Crespi, Pilar Sanchís Cortés, Bernardino Barceló Martín. Amphetamine and methamphetamine poisonings attended in hospital emergency departments: clinical features and the usefulness of laboratory confirmation. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2020 02; 32(1):26-32. doi: NULL. [PMID: 31909909]
Andrea Marraffino, Carolyn R Sikes, Thomas Laage, Andrew Volosov, Alison Hart, Dorothy Engelking. An Open-Label, Multicenter, Single-Dose Pharmacokinetic Study of a Novel Amphetamine Extended-Release Orally Disintegrating Tablet in Preschool-Aged Children. Journal of child and adolescent psychopharmacology. 2020 02; 30(1):15-20. doi: 10.1089/cap.2019.0042. [PMID: 31295008]
Ana Celia Muñoz-Muñoz, Teresa Pekol, Dana Schubring, Robin Hyland, Charlene Johnson, Lawrence Andrade. Characterization of an Amphetamine Interference from Gabapentin in an LC-HRMS Method. Journal of analytical toxicology. 2020 Jan; 44(1):36-40. doi: 10.1093/jat/bkz046. [PMID: 31263895]
Maarten E A Reith, Margaret E Gnegy. Molecular Mechanisms of Amphetamines. Handbook of experimental pharmacology. 2020; 258(?):265-297. doi: 10.1007/164_2019_251. [PMID: 31286212]
João V Nani, Camila M Yonamine, Diego Castro Musial, Caroline Dal Mas, Jair J Mari, Mirian A F Hayashi. ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2020 01; 21(1):53-63. doi: 10.1080/15622975.2019.1583372. [PMID: 30806143]