Thymine (BioDeep_00000001451)

 

Secondary id: BioDeep_00000400265, BioDeep_00000865358

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C5H6N2O2 (126.04292559999999)
中文名称: 胸腺嘧啶
谱图信息: 最多检出来源 Viridiplantae(plant) 0.04%

分子结构信息

SMILES: CC(=C1)C(=O)NC(=O)N1
InChI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

描述信息

Thymine, also known as 5-methyluracil, belongs to the class of organic compounds known as hydroxypyrimidines. These are organic compounds containing a hydroxyl group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. Thymine was first isolated in 1893 by Albrecht Kossel and Albert Neumann from calves thymus glands, hence its name. Thymine is one of the 4 nuelcoebases found in DNA and is essential to all life. Thymine exists in all living species, ranging from bacteria to plants to humans. Thymine combined with deoxyribose creates the nucleoside deoxythymidine (also called thymidine) which when phosphorylated to dTDP can be incorporated into DNA via DNA polymerases. Thymidine can be phosphorylated with up to three phosphoric acid groups, producing dTMP (deoxythymidine monophosphate) dTDP and/or dTTP. In RNA thymine is replaced with uracil in most cases. In DNA, thymine binds to adenine via two hydrogen bonds to assist in stabilizing the nucleic acid structures. Within humans, thymine participates in a number of enzymatic reactions. In particular, thymine and deoxyribose 1-phosphate can be biosynthesized from thymidine through its interaction with the enzyme thymidine phosphorylase. In addition, thymine can be converted into dihydrothymine; which is mediated by the enzyme dihydropyrimidine dehydrogenase [NADP(+)].
One of the pyrimidine bases of living matter. Derivation: Hydrolysis of deoxyribonucleic acid, from methylcyanoacetylurea by catalytic reduction. Use: Biochemical research. (Hawleys Condensed Chemical Dictionary)
Acquisition and generation of the data is financially supported in part by CREST/JST.
COVID info from COVID-19 Disease Map
Corona-virus
KEIO_ID T015
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.

同义名列表

16 个代谢物同义名

5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 4-Hydroxy-5-methylpyrimidin-2(1H)-one; 5-Methyl-2,4(1H,3H)-pyrimidinedione; 5-Methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-2,4-dihydroxypyrimidine; 2,4-Dihydroxy-5-methylpyrimidine; 5-Methylpyrimidine-2,4-dione; 5-Methyluracil; 5 Methyluracil; thymine; Thymin; Thy; T; Thymine; Thymine; Thymine



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(5)

PlantCyc(0)

代谢反应

175 个相关的代谢反应过程信息。

Reactome(61)

BioCyc(83)

WikiPathways(2)

Plant Reactome(0)

INOH(3)

PlantCyc(5)

COVID-19 Disease Map(1)

PathBank(20)

PharmGKB(0)

34 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shangyu Gao, Yu Sun, Xiaoguang Chen, Changhua Zhu, Xiaoye Liu, Wenlei Wang, Lijun Gan, Yanwu Lu, Frank Schaarschmidt, Marco Herde, Claus-Peter Witte, Mingjia Chen. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA. Nucleic acids research. 2023 Jun; ?(?):. doi: 10.1093/nar/gkad529. [PMID: 37334828]
  • Dawei Chen, Yating Liang, Jiaojiao Liang, Feifei Shen, Yue Cheng, Hengxian Qu, Yunchao Wa, Congcong Guo, Ruixia Gu, Jianya Qian, Xia Chen, Chenchen Zhang, Chengran Guan. Beneficial effects of Lactobacillus rhamnosus hsryfm 1301 fermented milk on rats with nonalcoholic fatty liver disease. Journal of dairy science. 2023 Mar; 106(3):1533-1548. doi: 10.3168/jds.2022-22383. [PMID: 36710180]
  • Chao Qin, Ying-Xin Lu, Thomas Borch, Ling-Ling Yang, Yan-Wen Li, Hai-Ming Zhao, Xiaojie Hu, Yanzheng Gao, Lei Xiang, Ce-Hui Mo, Qing X Li. Interactions between Extracellular DNA and Perfluoroalkyl Acids (PFAAs) Decrease the Bioavailability of PFAAs in Pakchoi (Brassica chinensis L.). Journal of agricultural and food chemistry. 2022 Nov; 70(46):14622-14632. doi: 10.1021/acs.jafc.2c04597. [PMID: 36375011]
  • Guilian Xiao, Junzhi Zhou, Zhiheng Huo, Tong Wu, Yingchun Li, Yajing Li, Yanxia Wang, Mengcheng Wang. The Shift in Synonymous Codon Usage Reveals Similar Genomic Variation during Domestication of Asian and African Rice. International journal of molecular sciences. 2022 Oct; 23(21):. doi: 10.3390/ijms232112860. [PMID: 36361651]
  • Yujing Miao, Haimei Chen, Wanqi Xu, Chang Liu, Linfang Huang. Cistanche Species Mitogenomes Suggest Diversity and Complexity in Lamiales-Order Mitogenomes. Genes. 2022 10; 13(10):. doi: 10.3390/genes13101791. [PMID: 36292676]
  • Khalid O Abulnaja, Kurunthachalam Kannan, Ashgan Mohammed K Al-Manzlawi, Taha A Kumosani, Mohamed Qari, Said S Moselhy. Ajwa date flavonoids mitigate neutrophil migration and interferon-γ-induced renal injury by ultraviolet C radiation in rats. Environmental science and pollution research international. 2022 Oct; 29(47):71607-71613. doi: 10.1007/s11356-022-20956-x. [PMID: 35604596]
  • Yanni Wang, Chaowu Dai, Wei Huang, Tingting Ni, Jianping Cao, Jiangmei Pang, Huining Wei, Chaojie Wang. Density Functional Method Study on the Cooperativity of Intermolecular H-bonding and π-π+ Stacking Interactions in Thymine-[Cnmim]Br (n = 2, 4, 6, 8, 10) Microhydrates. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196242. [PMID: 36234781]
  • Alexandre de Fátima Cobre, Monica Surek, Dile Pontarolo Stremel, Mariana Millan Fachi, Helena Hiemisch Lobo Borba, Fernanda Stumpf Tonin, Roberto Pontarolo. Diagnosis and prognosis of COVID-19 employing analysis of patients' plasma and serum via LC-MS and machine learning. Computers in biology and medicine. 2022 Jul; 146(?):105659. doi: 10.1016/j.compbiomed.2022.105659. [PMID: 35751188]
  • Yang Li, Wen Sun, Danyan Luo, Zhaoyi Yang, Wei He, Zhen Huang. Sulfur atom modification on thymine improves the specificity and sensitivity of DNA polymerization and detection. The Analyst. 2022 May; 147(10):2164-2169. doi: 10.1039/d1an02017j. [PMID: 35441615]
  • Penghua Li, Liqun Wang, Meng Sun, Jiyuan Yao, Wenhui Li, Wangting Lu, Youhua Zhou, Geng Zhang, Chenglong Hu, Wanquan Zheng, Feng Wei. Binding affinity and conformation of a conjugated AS1411 aptamer at a cationic lipid bilayer interface. Physical chemistry chemical physics : PCCP. 2022 Apr; 24(15):9018-9028. doi: 10.1039/d1cp05753g. [PMID: 35381056]
  • Hazim F El-Sharif, Nicholas W Turner, Subrayal M Reddy, Mark V Sullivan. Application of thymine-based nucleobase-modified acrylamide as a functional co-monomer in electropolymerised thin-film molecularly imprinted polymer (MIP) for selective protein (haemoglobin) binding. Talanta. 2022 Apr; 240(?):123158. doi: 10.1016/j.talanta.2021.123158. [PMID: 34952354]
  • Fatemeh Khalili, Mohsen Vafaee, Babak Shokri. Attosecond charge migration following oxygen K-shell ionization in DNA bases and base pairs. Physical chemistry chemical physics : PCCP. 2021 Oct; 23(40):23005-23013. doi: 10.1039/d1cp02920g. [PMID: 34611693]
  • Muhammad Wasif Saif, Carlos R Becerra, Marwan G Fakih, Weijing Sun, Lazar Popovic, Smitha Krishnamurthi, Thomas J George, Michelle A Rudek, Dale R Shepard, Jiri Skopek, Vladimir Sramek, Bojan Zaric, Ikuo Yamamiya, Karim A Benhadji, Kensuke Hamada, Yaohua He, Lee Rosen. A phase I, open-label study evaluating the safety and pharmacokinetics of trifluridine/tipiracil in patients with advanced solid tumors and varying degrees of renal impairment. Cancer chemotherapy and pharmacology. 2021 09; 88(3):485-497. doi: 10.1007/s00280-021-04308-z. [PMID: 34097100]
  • Masanobu Takahashi, Yasuhiro Sakamoto, Hisatsugu Ohori, Yasushi Tsuji, Michio Kuroki, Satoshi Kato, Kazunori Otsuka, Keigo Komine, Masahiro Takahashi, Shin Takahashi, Hidekazu Shirota, Kota Ouchi, Yoshikazu Takahashi, Hiroo Imai, Hiroyuki Shibata, Takashi Yoshioka, Masaki Tanaka, Hiroaki Yamaguchi, Takuhiro Yamaguchi, Hideki Shimodaira, Chikashi Ishioka. Phase II study of trifluridine/tipiracil (TAS-102) therapy in elderly patients with colorectal cancer (T-CORE1401): geriatric assessment tools and plasma drug concentrations as possible predictive biomarkers. Cancer chemotherapy and pharmacology. 2021 09; 88(3):393-402. doi: 10.1007/s00280-021-04277-3. [PMID: 34028598]
  • Yang Li, Yingying Zhou, Danyan Luo, Zhaoyi Yang, Lillian Ruoduo Hu, Zhen Huang. Selenium-atom-modified thymidine enhances the specificity and sensitivity of DNA polymerization and detection. Chemical communications (Cambridge, England). 2021 Jun; 57(44):5434-5437. doi: 10.1039/d0cc07922g. [PMID: 33949414]
  • Kathryn E Burns, Ottiniel Chavani, Soo Hee Jeong, John A Duley, David Porter, Michael Findlay, R Matthew Strother, Nuala A Helsby. Comparison of a thymine challenge test and endogenous uracil-dihydrouracil levels for assessment of fluoropyrimidine toxicity risk. Cancer chemotherapy and pharmacology. 2021 05; 87(5):711-716. doi: 10.1007/s00280-021-04240-2. [PMID: 33687515]
  • Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, Andrzej Joachimiak. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Communications biology. 2021 02; 4(1):193. doi: 10.1038/s42003-021-01735-9. [PMID: 33564093]
  • Xiaoyan He, Tianyao Zhang, Lijuan Wu, Yongcan Wu, Xin Zhou. The effect of trifluridine/tipiracil for patients with heavily pretreated metastatic gastric cancer: A protocol for systematic review and meta-analysis. Medicine. 2021 Jan; 100(2):e24110. doi: 10.1097/md.0000000000024110. [PMID: 33466182]
  • Yi-Lin Chai, Zi-Bo Gao, Zhuang Li, Lei-Liang He, Fei Yu, Song-Cheng Yu, Jia Wang, Yong-Mei Tian, Li-E Liu, Yi-Lin Wang, Yong-Jun Wu. A novel fluorescent nanoprobe that based on poly(thymine) single strand DNA-templated copper nanocluster for the detection of hydrogen peroxide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Oct; 239(?):118546. doi: 10.1016/j.saa.2020.118546. [PMID: 32505107]
  • John L Marshall. Third-line treatments for the management of metastatic colorectal cancer: why to change the mechanism of action after frontline chemotherapy, and insights into management during the COVID-19 pandemic. Clinical advances in hematology & oncology : H&O. 2020 10; 18 Suppl 16(10):6-14. doi: NULL. [PMID: 33843850]
  • Axel Grothey, Fortunato Ciardiello, John L Marshall. How to incorporate a chemo-free interval into the management of metastatic colorectal cancer. Clinical advances in hematology & oncology : H&O. 2020 Oct; 18 Suppl 16(10):1-24. doi: NULL. [PMID: 33843848]
  • Jishuai Zhang, Wenjuan Zeng, Kui Wu, Juan Ye, Yiyu Cheng, Yang Cheng, Tao Zou, Na Peng, Xiaoqin Wu, Yao Zhao, Fuyi Wang. Unexpected Thymine Oxidation and Collision-Induced Thymine-Pt-guanine Cross-Linking on 5'-TpG and 5'-GpT by a Photoactivatable Diazido Pt(IV) Anticancer Complex. Inorganic chemistry. 2020 Jun; 59(12):8468-8480. doi: 10.1021/acs.inorgchem.0c00894. [PMID: 32450042]
  • Noe Baruch-Torres, Junpei Yamamoto, Víctor Juárez-Quintero, Shigenori Iwai, Luis G Brieba. Plant organellar DNA polymerases bypass thymine glycol using two conserved lysine residues. The Biochemical journal. 2020 03; 477(5):1049-1059. doi: 10.1042/bcj20200043. [PMID: 32108856]
  • Geoffroy Desbuissons, Liliane Ngango, Isabelle Brochériou, Philippe Fournier. IgA Nephropathy Associated with Trifluridine/Tipiracil: A Case Report. Nephron. 2020; 144(10):506-508. doi: 10.1159/000509375. [PMID: 32799198]
  • Nuala A Helsby, John Duley, Kathryn E Burns, Claire Bonnet, Soo Hee Jeong, Elliott Brenman, Paula Barlow, Katrina Sharples, David Porter, Michael Findlay. A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity. British journal of clinical pharmacology. 2020 01; 86(1):155-164. doi: 10.1111/bcp.14153. [PMID: 31658382]
  • T Yoshino, J M Cleary, E Van Cutsem, R J Mayer, A Ohtsu, E Shinozaki, A Falcone, K Yamazaki, T Nishina, R Garcia-Carbonero, Y Komatsu, H Baba, G Argilés, A Tsuji, A Sobrero, K Yamaguchi, M Peeters, K Muro, A Zaniboni, N Sugimoto, Y Shimada, Y Tsuji, H S Hochster, T Moriwaki, B Tran, T Esaki, C Hamada, T Tanase, F Benedetti, L Makris, F Yamashita, H-J Lenz. Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials. Annals of oncology : official journal of the European Society for Medical Oncology. 2020 01; 31(1):88-95. doi: 10.1016/j.annonc.2019.10.005. [PMID: 31912801]
  • Qiong Wang, Jing Zhang, Qi Li, Xingjia Guo, Lei Zhang. Fabrication of WO2/W@C core-shell nanospheres for voltammetric simultaneous determination of thymine and cytosine. Mikrochimica acta. 2019 12; 187(1):62. doi: 10.1007/s00604-019-3987-3. [PMID: 31853653]
  • Hongzhang Deng, Lisen Lin, Sheng Wang, Guocan Yu, Zijian Zhou, Yijing Liu, Gang Niu, Jibin Song, Xiaoyuan Chen. X-ray-Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery. Advanced materials (Deerfield Beach, Fla.). 2019 Sep; 31(37):e1903443. doi: 10.1002/adma.201903443. [PMID: 31379091]
  • Christiane Kiefer, Eva-Maria Willing, Wen-Biao Jiao, Hequan Sun, Mathieu Piednoël, Ulrike Hümann, Benjamin Hartwig, Marcus A Koch, Korbinian Schneeberger. Interspecies association mapping links reduced CG to TG substitution rates to the loss of gene-body methylation. Nature plants. 2019 08; 5(8):846-855. doi: 10.1038/s41477-019-0486-9. [PMID: 31358959]
  • Elizabeth T Nguyen, Sarah Berman, Joshua Streicher, Christina M Estrada, Jody L Caldwell, Valentina Ghisays, Yvonne Ulrich-Lai, Matia B Solomon. Effects of combined glucocorticoid/mineralocorticoid receptor modulation (CORT118335) on energy balance, adiposity, and lipid metabolism in male rats. American journal of physiology. Endocrinology and metabolism. 2019 08; 317(2):E337-E349. doi: 10.1152/ajpendo.00018.2019. [PMID: 31112405]
  • Yue He, Fengyu Tian, Jing Zhou, Bining Jiao. Alkaline phosphatase determination via regulation of enzymatically generated poly(thymine) as a template for fluorescent copper nanoparticle formation. Analytical and bioanalytical chemistry. 2019 Jul; 411(17):3811-3818. doi: 10.1007/s00216-019-01851-w. [PMID: 31104084]
  • Wenjuan Zeng, Yanyan Zhang, Wei Zheng, Qun Luo, Juanjuan Han, Jian'an Liu, Yao Zhao, Feifei Jia, Kui Wu, Fuyi Wang. Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101852. [PMID: 31091778]
  • Fatemeh Mortazavi Moghadam, Mahdi Rahaie. A signal-on nanobiosensor for VEGF165 detection based on supraparticle copper nanoclusters formed on bivalent aptamer. Biosensors & bioelectronics. 2019 May; 132(?):186-195. doi: 10.1016/j.bios.2019.02.046. [PMID: 30875630]
  • Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Alice Pébay, Anthony L Cook, Helena H Liang, Raymond C B Wong, Jamie E Craig, Guei-Sheung Liu, Sandy S Hung, Alex W Hewitt. Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant. Molecular vision. 2019; 25(?):174-182. doi: NULL. [PMID: 30996586]
  • Jianyu Hu, Chaoqun Wang, Rui Liu, Yingying Su, Yi Lv. Poly(thymine)-CuNPs: Bimodal Methodology for Accurate and Selective Detection of TNT at Sub-PPT Levels. Analytical chemistry. 2018 12; 90(24):14469-14474. doi: 10.1021/acs.analchem.8b04161. [PMID: 30458612]
  • Lisa L Koorneef, José K van den Heuvel, Jan Kroon, Mariëtte R Boon, Peter A C 't Hoen, Kristina M Hettne, Nienke M van de Velde, Kelsey B Kolenbrander, Trea C M Streefland, Isabel M Mol, Hetty C M Sips, Szymon M Kielbasa, Hailiang Mei, Joseph K Belanoff, Alberto M Pereira, Maaike H Oosterveer, Hazel Hunt, Patrick C N Rensen, Onno C Meijer. Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice. Endocrinology. 2018 12; 159(12):3925-3936. doi: 10.1210/en.2018-00671. [PMID: 30321321]
  • Kenji Tsuchihashi, Mamoru Ito, Toshikazu Moriwaki, Shota Fukuoka, Hiroya Taniguchi, Atsuo Takashima, Yosuke Kumekawa, Takeshi Kajiwara, Kentaro Yamazaki, Taito Esaki, Akitaka Makiyama, Tadamichi Denda, Hironaga Satake, Takeshi Suto, Naotoshi Sugimoto, Kenji Katsumata, Toshiaki Ishikawa, Tomomi Kashiwada, Eiji Oki, Yoshito Komatsu, Hiroyuki Okuyama, Daisuke Sakai, Hideki Ueno, Takao Tamura, Kimihiro Yamashita, Junji Kishimoto, Yasuhiro Shimada, Eishi Baba. Role of Predictive Value of the Modified Glasgow Prognostic Score for Later-line Chemotherapy in Patients With Metastatic Colorectal Cancer. Clinical colorectal cancer. 2018 12; 17(4):e687-e697. doi: 10.1016/j.clcc.2018.07.004. [PMID: 30149986]
  • Alexander B Aria, Leon Chen, William F Glass, Amit Lahoti, Susan Y Chon. Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment. Dermatology online journal. 2018 Oct; 24(10):. doi: NULL. [PMID: 30677817]
  • Jing Han, Yafeng Li, Lingpeng Zhan, Jinjuan Xue, Jie Sun, Caiqiao Xiong, Zongxiu Nie. A novel mass spectrometry method based on competitive non-covalent interaction for the detection of biomarkers. Chemical communications (Cambridge, England). 2018 Sep; 54(76):10726-10729. doi: 10.1039/c8cc06100a. [PMID: 30187034]
  • Hualin Yang, Jiujun Wang, Qinghua Wu, Yun Wang, Li Li, Baomiao Ding. Simple and Label-Free Fluorescent Detection of Melamine Based on Melamine⁻Thymine Recognition. Sensors (Basel, Switzerland). 2018 Sep; 18(9):. doi: 10.3390/s18092968. [PMID: 30200586]
  • Dawei Zhang, Qingkun Liu, Rayshan Visvanathan, Michael R Tuchband, Ghadah H Sheetah, Benjamin D Fairbanks, Noel A Clark, Ivan I Smalyukh, Christopher N Bowman. A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases. Soft matter. 2018 Aug; 14(34):7045-7051. doi: 10.1039/c8sm01383g. [PMID: 30112539]
  • John A Duley, Ming Ni, Catherine Shannon, Ross L Norris, Leslie Sheffield, David Cowley, Marion Harris, André B P van Kuilenburg, Nuala Helsby, Rani George, Bruce G Charles. Preliminary Evidence for Enhanced Thymine Absorption: A Putative New Phenotype Associated With Fluoropyrimidine Toxicity in Cancer Patients. Therapeutic drug monitoring. 2018 08; 40(4):495-502. doi: 10.1097/ftd.0000000000000532. [PMID: 29846282]
  • Yunxia Qi, Xiaowei Zhao, Dongwei Huang, Xiaocheng Pan, Yongxin Yang, Huiling Zhao, Han Hu, Guanglong Cheng. Exploration of the Relationship between Intestinal Colostrum or Milk, and Serum Metabolites in Neonatal Calves by Metabolomics Analysis. Journal of agricultural and food chemistry. 2018 Jul; 66(27):7200-7208. doi: 10.1021/acs.jafc.8b01621. [PMID: 29920084]
  • Giovanni N Roviello. Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine. Amino acids. 2018 Jul; 50(7):933-941. doi: 10.1007/s00726-018-2562-2. [PMID: 29766280]
  • Johannes J M Kwakman, G Vink, J H Vestjens, L V Beerepoot, J W de Groot, R L Jansen, F L Opdam, H Boot, G J Creemers, J M van Rooijen, M Los, A J E Vulink, H Schut, E van Meerten, A Baars, P Hamberg, E Kapiteijn, D W Sommeijer, C J A Punt, M Koopman. Feasibility and effectiveness of trifluridine/tipiracil in metastatic colorectal cancer: real-life data from The Netherlands. International journal of clinical oncology. 2018 Jun; 23(3):482-489. doi: 10.1007/s10147-017-1220-0. [PMID: 29204933]
  • Aigui Xu, Long Chao, Hongbo Xiao, Yuyun Sui, Jia Liu, Qingji Xie, Shouzhuo Yao. Ultrasensitive electrochemical sensing of Hg2+ based on thymine-Hg2+-thymine interaction and signal amplification of alkaline phosphatase catalyzed silver deposition. Biosensors & bioelectronics. 2018 May; 104(?):95-101. doi: 10.1016/j.bios.2018.01.005. [PMID: 29328971]
  • Pinky Dhatterwal, Sandhya Mehrotra, Rajesh Mehrotra. Optimization of PCR conditions for amplifying an AT-rich amino acid transporter promoter sequence with high number of tandem repeats from Arabidopsis thaliana. BMC research notes. 2017 Nov; 10(1):638. doi: 10.1186/s13104-017-2982-1. [PMID: 29183338]
  • Mingjian Chen, Xinying Xiang, Kefeng Wu, Hailun He, Hanchun Chen, Changbei Ma. A Novel Detection Method of Human Serum Albumin Based on the Poly(Thymine)-Templated Copper Nanoparticles. Sensors (Basel, Switzerland). 2017 Nov; 17(11):. doi: 10.3390/s17112684. [PMID: 29160831]
  • Khan Loon Ng, Sook Mei Khor. Graphite-Based Nanocomposite Electrochemical Sensor for Multiplex Detection of Adenine, Guanine, Thymine, and Cytosine: A Biomedical Prospect for Studying DNA Damage. Analytical chemistry. 2017 09; 89(18):10004-10012. doi: 10.1021/acs.analchem.7b02432. [PMID: 28845664]
  • Carlos R Becerra, Kenichiro Yoshida, Hirokazu Mizuguchi, Manish Patel, Daniel Von Hoff. A Phase 1, Open-Label, Randomized, Crossover Study Evaluating the Bioavailability of TAS-102 (Trifluridine/Tipiracil) Tablets Relative to an Oral Solution Containing Equivalent Amounts of Trifluridine and Tipiracil. Journal of clinical pharmacology. 2017 06; 57(6):751-759. doi: 10.1002/jcph.856. [PMID: 28070894]
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