Sulfadoxine (BioDeep_00000001439)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

化学式: C12H14N4O4S (310.07357240000005)
中文名称: 磺胺多辛, 磺胺邻二甲氧嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 3.16%

分子结构信息

SMILES: COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

描述信息

Sulfadoxine is only found in individuals that have used or taken this drug. It is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. [PubChem]Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or Sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1010

同义名列表

20 个代谢物同义名

4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide; 4-Sulphanilamido-5,6-dimethoxypyrimidine; 4-Sulfanilamido-5,6-dimethoxypyrimidine; Roche brand OF sulfadoxine; Sulfadoxine roche brand; Sulphorthodimethoxine; Sulphormethoxine; Sulphorthomidine; Sulforthomidine; Sulformethoxine; Sulformetoxine; Sulphormetoxin; Sulphadoxinum; Sulphadoxine; Sulfadoxinum; Sulphadoxina; Sulfadoxina; SULFADOXINE; Fanasil; Sulfadoxine

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:9329
KEGG: C07630
KEGGdrug: D00580
PubChem: 17134
HMDB: HMDB0015413
Metlin: METLIN2542
DrugBank: DB01299
ChEMBL: CHEMBL1539
Wikipedia: Sulfadoxine
MeSH: Sulfadoxine
chemspider: 16218
CAS: 1173021-35-6
CAS: 2447-57-6
MoNA: AU101001
PMhub: MS000000536
PubChem: 9832
NIKKAJI: J21.373J
RefMet: Sulfadoxine
KNApSAcK: 9329

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Gabrielle Ange Amang À Ngnoung, Yves Oscar Nganso Ditchou, Peron Bosco Leutcha, Darline Dize, Simplice Joël Ndendoung Tatsimo, Lauve Rachel Yamthe Tchokouaha, Theodora Kopa Kowa, Babalwa Tembeni, Hamadou Mamoudou, Madan Poka, Patrick Hulisani Demana, Xavier Siwe Noundou, Fabrice Fekam Boyom, Alain Meli Lannang. Antiplasmodial and Antileishmanial Activities of a New Limonoid and Other Constituents from the Stem Bark of Khaya senegalensis. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207227. [PMID: 37894704]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Stella Wanjiku Gikunju, Eric L Agola, Raphael Omusebe Ondondo, Johnson Kinyua, Francis Kimani, Angelle Desiree LaBeaud, Indu Malhotra, Charles King, Kelvin Thiong'o, Francis Mutuku. Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya. Malaria journal. 2020 May; 19(1):190. doi: 10.1186/s12936-020-03263-z. [PMID: 32448228]
Wigilya P Mikomangwa, Omary Minzi, Ritah Mutagonda, Vito Baraka, Eulambius M Mlugu, Eleni Aklillu, Appolinary A R Kamuhabwa. Effect of sulfadoxine-pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania. Malaria journal. 2020 Apr; 19(1):160. doi: 10.1186/s12936-020-03234-4. [PMID: 32306955]
Charles P Tsouvalas, George Mousa, Anna H Lee, Jane A Philip, Diane Levine. Chryseobacterium gleum Isolation from Respiratory Culture Following Community-Acquired Pneumonia. The American journal of case reports. 2020 Mar; 21(?):e921172. doi: 10.12659/ajcr.921172. [PMID: 32114590]
Brandi K Torrevillas, Sarah M Garrison, Alexander J McKeeken, Dharmeshkumar Patel, James T Van Leuven, Nathaniel I Dizon, Karina I Rivas, Nicholas J Hathaway, Jeffrey A Bailey, John N Waitumbi, Carolyne M Kifude, Janet Oyieko, V Ann Stewart, Shirley Luckhart. Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya. Frontiers in cellular and infection microbiology. 2020; 10(?):600112. doi: 10.3389/fcimb.2020.600112. [PMID: 33324580]
Ngwene Hycentha Diengou, Samuel Nambile Cumber, Claude Ngwayu Nkfusai, Mbuh Salioh Mbinyui, Vecheusi Zennobia Viyoff, Fala Bede, Lilian Akwah, Joyce Mahlako Tsoka-Gwegweni, Anchang-Kimbi Judith. Factors associated with the uptake of intermittent preventive treatment of malaria in pregnancy in the Bamenda health districts, Cameroon. The Pan African medical journal. 2020; 35(?):42. doi: 10.11604/pamj.2020.35.42.17600. [PMID: 32499857]
Jean Claude Djontu, Yukie Michelle Lloyd, Rosette Megnekou, Reine Medouen Ndeumou Seumko'o, Ali Salanti, Diane Wallace Taylor, Rose Gana Fomban Leke. Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon. PloS one. 2020; 15(8):e0237671. doi: 10.1371/journal.pone.0237671. [PMID: 32797068]
Isabella Quakyi, Bernard Tornyigah, Pascal Houze, Kwadwo A Kusi, Nathaniel Coleman, Guillaume Escriou, Amos Laar, Michel Cot, Julius Fobil, Gloria Quansah Asare, Philippe Deloron, Abraham K Anang, Gilles Cottrell, Michael F Ofori, Nicaise Tuikue Ndam. High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana. Scientific reports. 2019 12; 9(1):19034. doi: 10.1038/s41598-019-55046-5. [PMID: 31836735]
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Andrew Teo, Louise M Randall, Mwayiwawo Madanitsa, Victor Mwapasa, Linda Kalilani Phiri, Carole Khairallah, Christelle Buffet, Amalia Karahalios, David L Narum, Feiko O Ter Kuile, Stephen J Rogerson. Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women. Scientific reports. 2019 05; 9(1):7878. doi: 10.1038/s41598-019-44340-x. [PMID: 31133672]
Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson. Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection. Scientific reports. 2019 02; 9(1):2260. doi: 10.1038/s41598-019-38821-2. [PMID: 30783215]
Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon. Antimicrobial agents and chemotherapy. 2019 02; 63(2):. doi: 10.1128/aac.01113-18. [PMID: 30455233]
Abigail Ward, Andrea Guillot, Lyudmila E Nepomnyashchiy, Justin C Graves, Kathleen Maloney, Omowunmi F Omoniwa, Leslie Emegbuonye, Charles Opondo, Marko Kerac, Elizabeth Omoluabi, Antoinette Bhattacharya, Karen Milch Hariharan, Owens Wiwa, Justin M Cohen, Arnaud Le Menach. Seasonal malaria chemoprevention packaged with malnutrition prevention in northern Nigeria: A pragmatic trial (SMAMP study) with nested case-control. PloS one. 2019; 14(1):e0210692. doi: 10.1371/journal.pone.0210692. [PMID: 30682069]
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Melissa D Conrad, Daniel Mota, Marissa Foster, Stephen Tukwasibwe, Jennifer Legac, Patrick Tumwebaze, Meghan Whalen, Abel Kakuru, Patience Nayebare, Erika Wallender, Diane V Havlir, Prasanna Jagannathan, Liusheng Huang, Francesca Aweeka, Moses R Kamya, Grant Dorsey, Philip J Rosenthal. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. The Journal of infectious diseases. 2017 11; 216(8):1008-1017. doi: 10.1093/infdis/jix421. [PMID: 28968782]
Sam Salman, Francesca Baiwog, Madhu Page-Sharp, Kay Kose, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis. Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. International journal of antimicrobial agents. 2017 Oct; 50(4):542-551. doi: 10.1016/j.ijantimicag.2017.05.011. [PMID: 28669839]
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Sam Salman, Francisca Baiwog, Madhu Page-Sharp, Susan Griffin, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis. Optimal Antimalarial Dose Regimens for Sulfadoxine-Pyrimethamine with or without Azithromycin in Pregnancy Based on Population Pharmacokinetic Modeling. Antimicrobial agents and chemotherapy. 2017 05; 61(5):. doi: 10.1128/aac.02291-16. [PMID: 28242669]
Chunyan Nong, Zongliang Niu, Pengyao Li, Chunping Wang, Wanyu Li, Yingying Wen. Dual-cloud point extraction coupled to high performance liquid chromatography for simultaneous determination of trace sulfonamide antimicrobials in urine and water samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Apr; 1051(?):9-16. doi: 10.1016/j.jchromb.2017.02.031. [PMID: 28279875]
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Lalita Sharma, Geeta Shukla. Treatment of pregnant BALB/c mice with sulphadoxine pyrimethamine or chloroquine abrogates Plasmodium berghei induced placental pathology. Parasitology international. 2014 Feb; 63(1):49-56. doi: 10.1016/j.parint.2013.08.016. [PMID: 24013006]
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