7a-Hydroxytestosterone (BioDeep_00000001275)

Main id: BioDeep_00000016688

 

human metabolite


代谢物信息卡片


(7R,8R,9S,10R,13S,14R,17S)-7,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

化学式: C19H28O3 (304.2038338)
中文名称: 4-羟基-睾酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC(=O)C=C1CC(O)C1C2CCC2(C)C(O)CCC12
InChI: InChI=1S/C19H28O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,16,21-22H,3-10H2,1-2H3/t11?,12?,13?,16-,18+,19-/m0/s1

描述信息

4-Hydroxytestosterone is the 17-hydroxylated analog to formestane. It is commercially available on the internet as anabolic steroid for oral self-administration and does not have any therapeutic indication. Hence, only little information is available about its metabolism. So far, most studies dealt with 4-hydroxytestosterone as metabolite of formestane while one study investigated the glucuronic acid conjugates of metabolic products of 4-hydroxytestosterone. This substance is prohibited in sports by the World Anti-Doping Agency; there is to a considerable increase of structurally related steroids with anabolic effects offered via the internet. 4-Hydroxytestosterone is a metabolite of the steroidal aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4OHA). (PMID: 17724580, 17610244, 17207827, 1284430) [HMDB]
4-Hydroxytestosterone is the 17-hydroxylated analog to formestane. It is commercially available on the internet as anabolic steroid for oral self-administration and does not have any therapeutic indication. Hence, only little information is available about its metabolism. So far, most studies dealt with 4-hydroxytestosterone as metabolite of formestane while one study investigated the glucuronic acid conjugates of metabolic products of 4-hydroxytestosterone. This substance is prohibited in sports by the World Anti-Doping Agency; there is to a considerable increase of structurally related steroids with anabolic effects offered via the internet. 4-Hydroxytestosterone is a metabolite of the steroidal aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4OHA). (PMID: 17724580, 17610244, 17207827, 1284430).

同义名列表

15 个代谢物同义名

(7R,8R,9S,10R,13S,14R,17S)-7,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; (2R,14S,15S)-6,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; (17beta)-4,17-Dihydroxy-androst-4-en-3-one; 4,17 beta-Dihydroxy-4-androstene-3-one; 4-Androstene-7alpha-17beta-diol-3-one; 4,17beta-Dihydroxy-4-androstene-3-one; 7,17-dihydroxyandrost-4-en-3-one; (3b,17a)-Androst-5-ene-3,17-diol; 3b,17a-Dihydroxyandrost-5-ene; 7alpha-Hydroxytestosterone; D5-Androstene-3b,17a-diol; Androst-5-ene-3b,17a-diol; 4-Hydroxy Testosterone; 7a-Hydroxytestosterone; 4-OHT



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Almut Schulze, Barbara Nicke, Patricia H Warne, Simon Tomlinson, Julian Downward. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Molecular biology of the cell. 2004 Jul; 15(7):3450-63. doi: 10.1091/mbc.e03-11-0807. [PMID: 15090615]
  • Hetal R Sheth, Gwyn Lord, Katherine Tkaczuk, Malcolm Danton, Lynn M Lewis, Patricia Langenberg, Chang K Lim, Jodi Anne Flaws. Aging may be associated with concentrations of tamoxifen and its metabolites in breast cancer patients. Journal of women's health (2002). 2003 Oct; 12(8):799-808. doi: 10.1089/154099903322447765. [PMID: 14588130]
  • C J Newton. Estrogen receptor blockade by the pure antiestrogen, ZM 182780, induces death of pituitary tumour cells. The Journal of steroid biochemistry and molecular biology. 1995 Dec; 55(3-4):327-36. doi: 10.1016/0960-0760(95)00191-3. [PMID: 8541229]
  • H Vanderstichele, W Eechaute, E Lacroix, I Leusen. Influence of neonatal androgenization on the testicular steroidogenesis in the adult rat. Journal of steroid biochemistry. 1987 Oct; 28(4):421-7. doi: 10.1016/0022-4731(87)91060-0. [PMID: 2959818]