3-Hydroxyphenylacetic acid (BioDeep_00000001235)

 

Secondary id: BioDeep_00000229587

human metabolite blood metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


(3-Hydroxy-phenyl)-acetic acid

化学式: C8H8O3 (152.0473)
中文名称: 3-羟基苯乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 17.3%

分子结构信息

SMILES: C1=CC(=CC(=C1)O)CC(=O)O
InChI: InChI=1S/C8H8O3/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

描述信息

3-Hydroxyphenylacetic acid is a rutin metabolite and an antioxidant. It has a protective biological activity in human. It is a substrate of enzyme 4-hydroxyphenylacetate 3-monooxygenase [EC 1.14.13.3] in the pathway tyrosine metabolism (KEGG, PMID 155437). 3-Hydroxyphenylacetic acid is found to be associated with phenylketonuria, which is an inborn error of metabolism. It is also a marker of gut Clostridium species. Higher levels are associated with higher levels of Clostridia (PMID: 27123458). 3-Hydroxyphenylacetic acid can also be found in Klebsiella (PMID: 1851804).
3-Hydroxyphenylacetic acid is a rutin metabolite and an antioxidant. It has a protective biological activity in human. It is a substrate of enzyme 4-hydroxyphenylacetate 3-monooxygenase [EC 1.14.13.3] in the pathway tyrosine metabolism. (KEGG, PMID 155437) [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 156
CONFIDENCE standard compound; INTERNAL_ID 45
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
3-Hydroxyphenylacetic acid is an endogenous metabolite.

同义名列表

17 个代谢物同义名

(3-Hydroxy-phenyl)-acetic acid; 2-(3-Hydroxyphenyl)acetic acid; Meta-hydroxyphenylacetic acid; 3-Hydroxy-benzeneacetic acid; (m-Hydroxyphenyl)acetic acid; 3-Hydroxybenzeneacetic acid; 3-Hydroxyphenylacetic acid; (3-Hydroxy-phenyl)-acetate; m-Hydroxyphenylacetic acid; (m-Hydroxyphenyl)acetate; 3-Hydroxy-benzeneacetate; 3-Hydroxybenzeneacetate; m-Hydroxyphenylacetate; 3-Hydroxyphenylacetate; 3-Hydroxyphenylacetic acid; 3-Hydroxyphenylacetate; 3-Hydroxyphenylacetic acid



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AHR, CACNA1A, CYP2E1, EGFR, GSTZ1, HPGDS, MC1R, MITF, NOS3, POMC, PTGS2, TH, TNK1, TYR
Peripheral membrane protein 3 CYP2E1, PTGS2, TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 CYP2E1, EGFR, PTGS2
Nucleus 9 AHR, CACNA1A, EGFR, GABPA, GPX4, MITF, NOS3, TH, TIPARP
cytosol 10 AHR, FAH, GCLC, GPX4, GSTZ1, HGD, HPGDS, MITF, NOS3, TH
dendrite 1 TH
nucleoplasm 5 AHR, GABPA, HPGDS, MITF, NOS3
Cell membrane 3 CACNA1A, EGFR, MC1R
ruffle membrane 1 EGFR
Cell projection, axon 1 TH
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 CACNA1A, MC1R
Synapse 1 CACNA1A
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 1 EGFR
Golgi apparatus 1 NOS3
Golgi membrane 2 EGFR, NOS3
lysosomal membrane 1 MITF
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 1 CACNA1A
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Lysosome 1 TYR
endosome 1 EGFR
plasma membrane 5 CACNA1A, EGFR, MC1R, NOS3, TNK1
terminal bouton 1 TH
Membrane 4 CACNA1A, EGFR, MC1R, TNK1
apical plasma membrane 1 EGFR
axon 1 TH
basolateral plasma membrane 1 EGFR
caveola 2 NOS3, PTGS2
extracellular exosome 3 FAH, GPX4, HGD
Lysosome membrane 1 MITF
endoplasmic reticulum 1 PTGS2
extracellular space 2 EGFR, POMC
perinuclear region of cytoplasm 4 EGFR, NOS3, TH, TYR
mitochondrion 4 GCLC, GPX4, GSTZ1, TH
protein-containing complex 5 AHR, EGFR, GPX4, MITF, PTGS2
intracellular membrane-bounded organelle 3 CYP2E1, HPGDS, TYR
Microsome membrane 2 CYP2E1, PTGS2
Single-pass type I membrane protein 2 EGFR, TYR
Secreted 1 POMC
extracellular region 1 POMC
cytoplasmic side of plasma membrane 1 TH
mitochondrial matrix 1 GSTZ1
transcription regulator complex 1 AHR
nuclear membrane 1 EGFR
perikaryon 1 TH
cytoplasmic vesicle 1 TH
Melanosome membrane 2 TH, TYR
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Golgi-associated vesicle 1 TYR
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 EGFR
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
secretory granule 1 POMC
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 2 PTGS2, TH
chromatin 3 AHR, GABPA, MITF
cell projection 1 CACNA1A
cytoskeleton 1 NOS3
nuclear envelope 1 GPX4
monoatomic ion channel complex 1 CACNA1A
aryl hydrocarbon receptor complex 1 AHR
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 1 PTGS2
voltage-gated calcium channel complex 1 CACNA1A
endocytic vesicle membrane 1 NOS3
clathrin-coated endocytic vesicle membrane 1 EGFR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Isoform Mitochondrial]: Mitochondrion 1 GPX4
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
[Isoform Cytoplasmic]: Cytoplasm 1 GPX4
glutamate-cysteine ligase complex 1 GCLC


文献列表

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