3-Hydroxyphenylacetic acid (BioDeep_00000001235)

 

Secondary id: BioDeep_00000229587

human metabolite blood metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


(3-Hydroxy-phenyl)-acetic acid

化学式: C8H8O3 (152.0473418)
中文名称: 3-羟基苯乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.26%

分子结构信息

SMILES: C1=CC(=CC(=C1)O)CC(=O)O
InChI: InChI=1S/C8H8O3/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

描述信息

3-Hydroxyphenylacetic acid is a rutin metabolite and an antioxidant. It has a protective biological activity in human. It is a substrate of enzyme 4-hydroxyphenylacetate 3-monooxygenase [EC 1.14.13.3] in the pathway tyrosine metabolism (KEGG, PMID 155437). 3-Hydroxyphenylacetic acid is found to be associated with phenylketonuria, which is an inborn error of metabolism. It is also a marker of gut Clostridium species. Higher levels are associated with higher levels of Clostridia (PMID: 27123458). 3-Hydroxyphenylacetic acid can also be found in Klebsiella (PMID: 1851804).
3-Hydroxyphenylacetic acid is a rutin metabolite and an antioxidant. It has a protective biological activity in human. It is a substrate of enzyme 4-hydroxyphenylacetate 3-monooxygenase [EC 1.14.13.3] in the pathway tyrosine metabolism. (KEGG, PMID 155437) [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 156
CONFIDENCE standard compound; INTERNAL_ID 45
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
3-Hydroxyphenylacetic acid is an endogenous metabolite.

同义名列表

17 个代谢物同义名

(3-Hydroxy-phenyl)-acetic acid; 2-(3-Hydroxyphenyl)acetic acid; Meta-hydroxyphenylacetic acid; 3-Hydroxy-benzeneacetic acid; (m-Hydroxyphenyl)acetic acid; 3-Hydroxybenzeneacetic acid; 3-Hydroxyphenylacetic acid; (3-Hydroxy-phenyl)-acetate; m-Hydroxyphenylacetic acid; (m-Hydroxyphenyl)acetate; 3-Hydroxy-benzeneacetate; 3-Hydroxybenzeneacetate; m-Hydroxyphenylacetate; 3-Hydroxyphenylacetate; 3-Hydroxyphenylacetic acid; 3-Hydroxyphenylacetate; 3-Hydroxyphenylacetic acid



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maritza S Diaz, Susanne U Mertens-Talcott, Stephen T Talcott. Intestinal Microbiome Metabolism of Cranberry (Vaccinium macrocarpon) Proanthocyanidin Dimers, but Not Trimers, Is Altered by Dysbiosis in Ulcerative Colitis Ex Vivo. Journal of agricultural and food chemistry. 2024 Feb; 72(8):4184-4194. doi: 10.1021/acs.jafc.4c00042. [PMID: 38350030]
  • Alicia P Cárdenas-Castro, Víctor M Zamora-Gasga, Emilio Alvarez-Parrilla, Víctor M Ruíz-Valdiviezo, Koen Venema, Sonia G Sáyago-Ayerdi. In vitro gastrointestinal digestion and colonic fermentation of tomato (Solanum lycopersicum L.) and husk tomato (Physalis ixocarpa Brot.): Phenolic compounds released and bioconverted by gut microbiota. Food chemistry. 2021 Oct; 360(?):130051. doi: 10.1016/j.foodchem.2021.130051. [PMID: 34020365]
  • Volha Zabela, Chethan Sampath, Mouhssin Oufir, Veronika Butterweck, Matthias Hamburger. Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. Fitoterapia. 2020 Apr; 142(?):104526. doi: 10.1016/j.fitote.2020.104526. [PMID: 32097685]
  • Xueqing Hu, Jiaying Shen, Xueyan Pu, Ningning Zheng, Zhongping Deng, Zean Zhang, Houkai Li. Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2017 03; 156(1):123-132. doi: 10.1093/toxsci/kfw244. [PMID: 28115647]
  • Xiyue Xiong, Dan Liu, Yichao Wang, Ting Zeng, Ying Peng. Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. BioMed research international. 2016; 2016(?):9485412. doi: 10.1155/2016/9485412. [PMID: 27123458]
  • Lee Cheng Phua, Clive H Wilder-Smith, Yee Min Tan, Theebarina Gopalakrishnan, Reuben K Wong, Xinhua Li, Mary E Kan, Jia Lu, Ali Keshavarzian, Eric Chun Yong Chan. Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes. Journal of proteome research. 2015 Nov; 14(11):4734-42. doi: 10.1021/acs.jproteome.5b00603. [PMID: 26506213]
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  • Özgül İnceoğlu, Joana Falcão Salles, Jan Dirk van Elsas. Soil and cultivar type shape the bacterial community in the potato rhizosphere. Microbial ecology. 2012 Feb; 63(2):460-70. doi: 10.1007/s00248-011-9930-8. [PMID: 21898103]
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  • Qiang Gao, Kai Jin, Sheng-Hua Ying, Yongjun Zhang, Guohua Xiao, Yanfang Shang, Zhibing Duan, Xiao Hu, Xue-Qin Xie, Gang Zhou, Guoxiong Peng, Zhibing Luo, Wei Huang, Bing Wang, Weiguo Fang, Sibao Wang, Yi Zhong, Li-Jun Ma, Raymond J St Leger, Guo-Ping Zhao, Yan Pei, Ming-Guang Feng, Yuxian Xia, Chengshu Wang. Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS genetics. 2011 Jan; 7(1):e1001264. doi: 10.1371/journal.pgen.1001264. [PMID: 21253567]
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  • Chris I R Gill, Gordon J McDougall, Sheila Glidewell, Derek Stewart, Qing Shen, Kieran Tuohy, Aine Dobbin, Adele Boyd, Emma Brown, Sumanto Haldar, Ian R Rowland. Profiling of phenols in human fecal water after raspberry supplementation. Journal of agricultural and food chemistry. 2010 Oct; 58(19):10389-95. doi: 10.1021/jf1017143. [PMID: 20809621]
  • Constance Bock, Waldemar Ternes. The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea). Nutrition research (New York, N.Y.). 2010 May; 30(5):348-57. doi: 10.1016/j.nutres.2010.05.005. [PMID: 20579527]
  • Ronald L Prior, Theodore R Rogers, Ramesh C Khanal, Samuel E Wilkes, Xianli Wu, Luke R Howard. Urinary excretion of phenolic acids in rats fed cranberry. Journal of agricultural and food chemistry. 2010 Apr; 58(7):3940-9. doi: 10.1021/jf9028392. [PMID: 20052972]
  • Raika Koli, Iris Erlund, Antti Jula, Jukka Marniemi, Pirjo Mattila, Georg Alfthan. Bioavailability of various polyphenols from a diet containing moderate amounts of berries. Journal of agricultural and food chemistry. 2010 Apr; 58(7):3927-32. doi: 10.1021/jf9024823. [PMID: 20073463]
  • Sonia de Pascual-Teresa, Diego A Moreno, Cristina García-Viguera. Flavanols and anthocyanins in cardiovascular health: a review of current evidence. International journal of molecular sciences. 2010 Apr; 11(4):1679-703. doi: 10.3390/ijms11041679. [PMID: 20480037]
  • Hanne Winning, Eduvigis Roldán-Marín, Lars O Dragsted, Nanna Viereck, Morten Poulsen, Concepción Sánchez-Moreno, M Pilar Cano, Søren B Engelsen. An exploratory NMR nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake. The Analyst. 2009 Nov; 134(11):2344-51. doi: 10.1039/b918259d. [PMID: 19838425]
  • Suri Roowi, William Mullen, Christine A Edwards, Alan Crozier. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular nutrition & food research. 2009 May; 53 Suppl 1(?):S68-75. doi: 10.1002/mnfr.200800287. [PMID: 19415668]
  • Maaike M Appeldoorn, Jean-Paul Vincken, Anna-Marja Aura, Peter C H Hollman, Harry Gruppen. Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. Journal of agricultural and food chemistry. 2009 Feb; 57(3):1084-92. doi: 10.1021/jf803059z. [PMID: 19191673]
  • William Mullen, Jean-Max Rouanet, Cyril Auger, Pierre-Louis Teissèdre, Stuart T Caldwell, Richard C Hartley, Micheal E J Lean, Christine A Edwards, Alan Crozier. Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats. Journal of agricultural and food chemistry. 2008 Dec; 56(24):12127-37. doi: 10.1021/jf802754s. [PMID: 19053221]
  • Chooi Yeng Lee, Si Mui Sim, Hwee Ming Cheng. Phenylacetic acids were detected in the plasma and urine of rats administered with low-dose mulberry leaf extract. Nutrition research (New York, N.Y.). 2008 Aug; 28(8):555-63. doi: 10.1016/j.nutres.2008.05.001. [PMID: 19083460]
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