6-Hydroxynicotinic acid (BioDeep_00000001220)

 

Secondary id: BioDeep_00000399966, BioDeep_00000400302

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


1,6-dihydro-6-oxo-3-Pyridinecarboxylic acid

化学式: C6H5NO3 (139.0269)
中文名称: 6-羟基烟酸, 6-羟基吡啶-3-羧酸
谱图信息: 最多检出来源 Homo sapiens(feces) 28.28%

分子结构信息

SMILES: C1=CC(=O)NC=C1C(=O)O
InChI: InChI=1S/C6H5NO3/c8-5-2-1-4(3-7-5)6(9)10/h1,3H,2H2,(H,9,10)

描述信息

6-Hydroxynicotinic acid (6-OHNA) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. Among the common bacteria causing urinary infection, only P. aeruginosa produces 6-hydroxynicotinic acid from nicotinic acid. Pseudomonas aeruginosa infection has been reported to be the third leading cause of urinary infection, accounting for 11\\\% of such infections, the first and second being Escherichia coli and Klebsiella pneumonia, respectively. Analyses of the NMR spectra of the bacterial media with variable cell count of P. aeruginosa, shows that the intensity of the signals of the 6-hydroxynicotinic acid increases with increasing number of bacterial cells (PMID:3926801, 15759292). 6-hydroxynicotinic acid can also be found in Achromobacter and Serratia.
6-hydroxynicotinic acid (6-OHNA) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. Among the common bacteria causing urinary infection, only P. aeruginosa produces 6-hydroxynicotinic acid from nicotinic acid. Pseudomonas aeruginosa infection has been reported to be the third leading cause of urinary infection, accounting for 11\\\% of such infections, the first and second being Escherichia coli and Klebsiella pneumonia, respectively. Analyses of the NMR spectra of the bacterial media with variable cell count of P. aeruginosa, shows that the intensity of the signals of the 6-hydroxynicotinic acid increases with increasing number of bacterial cells. (PMID: 3926801, 15759292) [HMDB]
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID H015
6-Hydroxynicotinic acid is an endogenous metabolite.

同义名列表

15 个代谢物同义名

1,6-dihydro-6-oxo-3-Pyridinecarboxylic acid; 6-oxo-1H-pyridine-3-carboxylic acid; 6-Hydroxypyridine-3-carboxylic acid; 2-Hydroxypyridine-5-carboxylic acid; 1,6-dihydro-6-oxo-Nicotinic acid; 2-Pyridone-5-carboxylic acid; 2-Hydroxy-5-carboxypyridine; 6-Hydroxy-nicotinic acid; 6-Hydroxynicotinic Acid; 5-Carboxy-2-pyridone; 6-Hydroxynicotinate; 6-Hydroxyniacin; 6-Hydroxynicotinic acid; 6-Hydroxynicotinate; 6-Hydroxynicotinic acid



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CEP104, EGFR, NAAA, PDGFRA, PGD, PMP2, TNK1, XDH, ZMYND8
Peripheral membrane protein 3 HSD17B6, NAAA, TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, PDGFRA
Nucleus 5 EGFR, PDGFRA, PGD, PMP2, ZMYND8
cytosol 5 GPT, PGD, PMP2, SDSL, XDH
centrosome 1 CEP104
nucleoplasm 2 PDGFRA, ZMYND8
Cell membrane 2 EGFR, PDGFRA
ruffle membrane 1 EGFR
Early endosome membrane 2 EGFR, HSD17B6
cell junction 2 EGFR, PDGFRA
cell surface 1 EGFR
dendritic shaft 1 ZMYND8
glutamatergic synapse 3 EGFR, PTPRD, TNC
Golgi apparatus 1 PDGFRA
Golgi membrane 1 EGFR
presynaptic membrane 1 PTPRD
Lysosome 1 NAAA
endosome 1 EGFR
plasma membrane 4 EGFR, PDGFRA, PTPRD, TNK1
Membrane 6 EGFR, NAAA, PDGFRA, PTPRD, TNC, TNK1
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 5 GPT, NAAA, PGD, PMP2, PTPRD
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 4 AMH, EGFR, TNC, XDH
lysosomal lumen 1 NAAA
perinuclear region of cytoplasm 1 EGFR
Schaffer collateral - CA1 synapse 1 PTPRD
mitochondrion 1 HIBADH
protein-containing complex 2 EGFR, PDGFRA
intracellular membrane-bounded organelle 1 HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 3 EGFR, PDGFRA, PTPRD
Secreted 2 AMH, PRB1
extracellular region 3 AMH, PRB1, TNC
hippocampal mossy fiber to CA3 synapse 1 PTPRD
mitochondrial matrix 1 HIBADH
Cell projection, cilium 2 CEP104, PDGFRA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CEP104
nuclear membrane 1 EGFR
external side of plasma membrane 1 PDGFRA
Secreted, extracellular space, extracellular matrix 1 TNC
dendritic spine 1 ZMYND8
nucleolus 1 ZMYND8
Membrane raft 1 EGFR
focal adhesion 2 EGFR, TNC
Peroxisome 1 XDH
basement membrane 1 TNC
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 TNC
receptor complex 2 EGFR, PDGFRA
cilium 2 CEP104, PDGFRA
chromatin 1 ZMYND8
Chromosome 1 ZMYND8
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CEP104
centriole 1 CEP104
spindle pole 1 CEP104
microvillus 1 PDGFRA
myelin sheath 1 PMP2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 1 TNC
clathrin-coated endocytic vesicle membrane 1 EGFR
extracellular matrix of synaptic cleft 1 TNC
site of DNA damage 1 ZMYND8
interstitial matrix 1 TNC
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
tenascin complex 1 TNC
perisynaptic extracellular matrix 1 TNC


文献列表

  • Upasana Kapoor, M K Srivastava, Purushottam Trivedi, Veena Garg, L P Srivastava. Disposition and acute toxicity of imidacloprid in female rats after single exposure. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Jun; 68(?):190-5. doi: 10.1016/j.fct.2014.03.019. [PMID: 24662525]
  • Thomas Paternoster, Urska Vrhovsek, Ilaria Pertot, Brion Duffy, Cesare Gessler, Fulvio Mattivi. Determination and confirmation of nicotinic acid and its analogues and derivates in pear and apple blossoms using high-performance liquid chromatography-diode array-electrospray ionization mass spectrometry. Journal of agricultural and food chemistry. 2009 Nov; 57(21):10038-43. doi: 10.1021/jf902342b. [PMID: 19835358]
  • Ashish Gupta, Mayank Dwivedi, G A Nagana Gowda, Archana Ayyagari, A A Mahdi, M Bhandari, C L Khetrapal. (1)H NMR spectroscopy in the diagnosis of Pseudomonas aeruginosa-induced urinary tract infection. NMR in biomedicine. 2005 Aug; 18(5):293-9. doi: 10.1002/nbm.957. [PMID: 15759292]
  • S Shiraishi, N Sakamoto, K Maeda, T Ohki, M Hosoi, K Ohta, N Yamanaka. Availability of 6-hydroxynicotinic acid for rapid identification of Pseudomonas aeruginosa and Serratia marcescens. Journal of chromatography. 1985 Feb; 338(1):51-9. doi: 10.1016/0378-4347(85)80069-4. [PMID: 3926801]