Dimaprit (BioDeep_00000011969)
Secondary id: BioDeep_00001869153
human metabolite blood metabolite
代谢物信息卡片
[3-(carbamimidoylsulfanyl)propyl]dimethylamine
化学式: C6H15N3S (161.0987)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 25%
分子结构信息
SMILES: CN(C)CCCSC(=N)N
InChI: InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D017442 - Histamine Agonists
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:81389
- KEGG: C17930
- PubChem: 3077
- HMDB: HMDB0251367
- Metlin: METLIN71952
- ChEMBL: CHEMBL12344
- Wikipedia: Dimaprit
- MeSH: Dimaprit
- chemspider: 2968
- CAS: 65119-89-3
- PMhub: MS000026217
- PubChem: 96024151
- NIKKAJI: J21.390J
- KNApSAcK: 81389
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson. Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis.
Arthritis research & therapy.
2024 Mar; 26(1):61. doi:
10.1186/s13075-024-03295-9. [PMID: 38444034] - Weien Wang, Xiaofeng Zhang. Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164830. [PMID: 34443434] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xu Cao, Ying Zhang, Liangyu Zou, Haibing Xiao, Yinghao Chu, Xiaofan Chu. Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis.
Neuroscience letters.
2010 Jul; 479(2):118-22. doi:
10.1016/j.neulet.2010.05.040. [PMID: 20493926] - Atsuko Motoki, Naoto Adachi, Keyue Liu, Hideo K Takahashi, Masahiro Nishibori, Toshihiro Yorozuya, Tatsuru Arai, Takumi Nagaro. Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats.
Basic & clinical pharmacology & toxicology.
2008 Apr; 102(4):394-8. doi:
10.1111/j.1742-7843.2008.00219.x. [PMID: 18312491] - S Tanda, Y Mori, T Kimura, K Sonomura, T Kusaba, N Kishimoto, H Kameyama, K Tamagaki, M Okigaki, T Hatta, S Sasaki, K Takeda, Y Sado, N Adachi, H Matsubara. Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats.
Kidney international.
2007 Sep; 72(5):608-13. doi:
10.1038/sj.ki.5002370. [PMID: 17568783] - Yuji Sugata, Mitsuhiro Okano, Tazuko Fujiwara, Rie Matsumoto, Hisashi Hattori, Miki Yamamoto, Masahiro Nishibori, Kazunori Nishizaki. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.
Immunology.
2007 Jun; 121(2):266-75. doi:
10.1111/j.1365-2567.2007.02574.x. [PMID: 17346280] - Naoto Adachi, Keyue Liu, Atsuko Motoki, Masahiro Nishibori, Tatsuru Arai. Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats.
European journal of pharmacology.
2006 Aug; 544(1-3):181-7. doi:
10.1016/j.ejphar.2006.06.053. [PMID: 16860312] - Dong-Chan Kim, Sun-Hee Kim, Bo-Hwa Choi, Nam-In Baek, Daeho Kim, Mahn-Joo Kim, Kyong-Tai Kim. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors.
Biological & pharmaceutical bulletin.
2005 Dec; 28(12):2220-4. doi:
10.1248/bpb.28.2220. [PMID: 16327153] - Hideo Kohka Takahashi, Toshihiko Morichika, Hiromi Iwagaki, Ryuji Tamura, Shinichiro Kubo, Tadashi Yoshino, Shuji Mori, Tadaatsu Akagi, Noriaki Tanaka, Masahiro Nishibori. Histamine downregulates CD14 expression via H2 receptors on human monocytes.
Clinical immunology (Orlando, Fla.).
2003 Sep; 108(3):274-81. doi:
10.1016/s1521-6616(03)00140-2. [PMID: 14499251] - Timothy A Esbenshade, Chae Hee Kang, Kathleen M Krueger, Thomas R Miller, David G Witte, Jean M Roch, Jeffrey N Masters, Arthur A Hancock. Differential activation of dual signaling responses by human H1 and H2 histamine receptors.
Journal of receptor and signal transduction research.
2003 Feb; 23(1):17-31. doi:
10.1081/rrs-120018758. [PMID: 12680587] - Hideyuki Itoh, Hideo K Takahashi, Hiromi Iwagaki, Tadashi Yoshino, Yoshinori Morimoto, Shinnya Saito, Takahito Yagi, Tadaatsu Akagi, Masahiro Nishibori, Noriaki Tanaka. Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18.
Transplantation.
2002 Sep; 74(6):864-70. doi:
10.1097/00007890-200209270-00021. [PMID: 12364868] - Junichi Kitanaka, Nobue Kitanaka, Tohru Tsujimura, Nobuyuki Terada, Motohiko Takemura. Expression of diamine oxidase (histaminase) in guinea-pig tissues.
European journal of pharmacology.
2002 Feb; 437(3):179-85. doi:
10.1016/s0014-2999(02)01302-x. [PMID: 11890907] - Y Zhu, D Michalovich, H Wu, K B Tan, G M Dytko, I J Mannan, R Boyce, J Alston, L A Tierney, X Li, N C Herrity, L Vawter, H M Sarau, R S Ames, C M Davenport, J P Hieble, S Wilson, D J Bergsma, L R Fitzgerald. Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Molecular pharmacology.
2001 Mar; 59(3):434-41. doi:
10.1124/mol.59.3.434. [PMID: 11179436] - G Coruzzi, E Poli, C Pozzoli, G Bertaccini, H Timmerman. Histamine receptor-independent muscle relaxation elicited by a series of histamine H2-receptor agonists on the isolated guinea pig duodenum: a study into the mechanism of action.
General pharmacology.
1998 Oct; 31(4):643-51. doi:
10.1016/s0306-3623(98)00077-9. [PMID: 9792230] - R M van der Weiden, F M Helmerhorst, M J Keirse. Which prostanoid metabolites should be determined for the study of reproductive processes?.
Prostaglandins, leukotrienes, and essential fatty acids.
1998 Mar; 58(3):205-7. doi:
10.1016/s0952-3278(98)90115-6. [PMID: 9610843] - L W Fu, H L Pan, J C Longhurst. Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors.
The American journal of physiology.
1997 12; 273(6):H2726-37. doi:
10.1152/ajpheart.1997.273.6.h2726. [PMID: 9435609] - T Nakamura, Y Ueno, Y Goda, A Nakamura, K Shinjo, A Nagahisa. Efficacy of a selective histamine H2 receptor agonist, dimaprit, in experimental models of endotoxin shock and hepatitis in mice.
European journal of pharmacology.
1997 Mar; 322(1):83-9. doi:
10.1016/s0014-2999(96)00987-9. [PMID: 9088875] - N A Payne, J G Gerber. Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin.
Digestion.
1997; 58(4):352-60. doi:
10.1159/000201465. [PMID: 9324162] - K Sekizawa, H Nakazawa, M Morikawa, K Yamauchi, K Maeyama, T Watanabe, H Sasaki. Histamine N-methyltransferase inhibitor potentiates histamine- and antigen-induced airway microvascular leakage in guinea pigs.
The Journal of allergy and clinical immunology.
1995 Dec; 96(6 Pt 1):910-6. doi:
10.1016/s0091-6749(95)70228-8. [PMID: 8543749] - S Kohno, S Nakao, K Ogawa, H Yamamura, T Nabe, K Ohata. Possible participation of histamine H3-receptors in the regulation of anaphylactic histamine release from isolated rat peritoneal mast cells.
Japanese journal of pharmacology.
1994 Oct; 66(2):173-80. doi:
10.1254/jjp.66.173. [PMID: 7532731] - A Gadek-Michalska, J Borycz, J Bugajski. Pituitary-adrenocortical responsiveness to histaminergic stimulation during social stress of crowding in rats.
Agents and actions.
1994 Jun; 41 Spec No(?):C80-1. doi:
10.1007/bf02007776. [PMID: 7976812] - A Gadek-Michalska, J Bugajski. Antagonistic action of naloxone on central histamine receptors-stimulated corticosterone secretion in rats under stress.
Agents and actions.
1989 Nov; 28(3-4):159-63. doi:
10.1007/bf01967395. [PMID: 2531971] - J Bugajski, A Gadek. Hyperlipemic responses induced by centrally administered histamine H1- and H2-receptor agonists in rats.
Agents and actions.
1987 Apr; 20(3-4):255-7. doi:
10.1007/bf02074684. [PMID: 2955677] - G F Di Renzo, V Basile, S Amoroso, M Taglialatela, F Maurano, L Annunziato. Possible inhibitory role of histamine H2 receptors in the control of basal TSH secretion in male rats: studies with dimaprit, a selective H2 receptor agonist.
Journal of neural transmission.
1987; 69(3-4):313-8. doi:
10.1007/bf01244351. [PMID: 2957467] - J R Sedor, H E Abboud. Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors.
The Journal of clinical investigation.
1985 May; 75(5):1679-89. doi:
10.1172/jci111876. [PMID: 2582001] - E Masini, J Phanchenault, F Pezziardi, P Gautier, J P Gagnol. Histamine release during an experimental coronary thrombosis in awake dog.
Agents and actions.
1985 Apr; 16(3-4):227-30. doi:
10.1007/bf01983146. [PMID: 2409772] - J Bugajski, A Gadek. Effect of intracerebroventricular impromidine on pituitary-adrenocortical response to stress in rats.
Agents and actions.
1984 Jun; 14(5-6):569-73. doi:
10.1007/bf01978888. [PMID: 6236678] - P Andersson, H Bergstrand. Changes in bronchial anaphylactic reactivity induced in guinea-pigs by long-term treatment with histamine H2-agents.
British journal of pharmacology.
1984 May; 82(1):207-16. doi:
10.1111/j.1476-5381.1984.tb16460.x. [PMID: 6203589] - V Basile, S Amoroso, G F Di Renzo. [Effects of dimaprit, an H2 receptor agonist, on blood levels of corticosterone in the rat].
Bollettino della Societa italiana di biologia sperimentale.
1983 Oct; 59(10):1442-6. doi:
NULL. [PMID: 6229260] - J Bugajski, Z Janusz. Central histaminergic stimulation of pituitary--adrenocortical response in the rat.
Life sciences.
1983 Sep; 33(12):1179-89. doi:
10.1016/0024-3205(83)90023-1. [PMID: 6224995] - J Bugajski, A Gadek. Central H1- and H2-histaminergic stimulation of pituitary-adrenocortical response under stress in rats.
Neuroendocrinology.
1983 Jun; 36(6):424-30. doi:
10.1159/000123493. [PMID: 6224096] - J G Gerber, A S Nies. The role of histamine receptors in the release of renin.
British journal of pharmacology.
1983 May; 79(1):57-61. doi:
10.1111/j.1476-5381.1983.tb10495.x. [PMID: 6223680] - A O Donoso, M B Zárate. Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized, steroid-treated rats under ether anesthesia.
Experimental brain research.
1983; 52(2):277-80. doi:
10.1007/bf00236637. [PMID: 6139293] - S P Peters, A Kagey-Sobotka, D W MacGlashan, M I Siegel, L M Lichtenstein. The modulation of human basophil histamine release by products of the 5-lipoxygenase pathway.
Journal of immunology (Baltimore, Md. : 1950).
1982 Aug; 129(2):797-803. doi:
". [PMID: 6177784] - K B Mirbahar, P Eyre. Autacoid and autonomic reactivity of bovine and ovine bronchus: modifications by antigenic sensitization.
Archives internationales de pharmacodynamie et de therapie.
1982 Jul; 258(1):60-70. doi:
NULL. [PMID: 6215904] - J Bugajski, A Gadek. The involvement of central histamine receptors in stress-induced responses of serum corticosterone and free fatty acids and in gastric ulcer development.
Agents and actions.
1981 Apr; 11(1-2):151-5. doi:
10.1007/bf01991486. [PMID: 6113742] - Z S Ercan, R K Türker. Alternation by histamine receptor agonists of the release of adrenergic transmitter in the isolated perfused rabbit kidney.
Archives internationales de pharmacodynamie et de therapie.
1981 Feb; 249(2):203-12. doi:
. [PMID: 6452863] - A P Baker, L W Chakrin, D A Holden, W J Smith, C P Sung. Effect of histamine agonists and antagonists on the production of murine reaginic antibodies.
International journal of immunopharmacology.
1981; 3(4):349-56. doi:
10.1016/0192-0561(81)90030-8. [PMID: 6460705] - W W Pawlik, E D Jacobson, R O Banks. Effects of dimaprit, prostacyclin, and acetylcholine on renal blood flow and function.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1980 Mar; 163(3):344-9. doi:
10.3181/00379727-163-40775. [PMID: 6444728] - M A Beaven, R E Shaff. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488.
Agents and actions.
1979 Dec; 9(5-6):455-60. doi:
10.1007/bf01968110. [PMID: 161853] - H E Aksulu, Z S Ercan, R K Türker. A comparative study with impromidine (SKF 92676), a potent agonist for histamine H2-receptors.
Agents and actions.
1979 Dec; 9(5-6):461-6. doi:
10.1007/bf01968111. [PMID: 161854] - . .
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