Azaspiracid (BioDeep_00000011478)

   

Marine Natural Products natural product


代谢物信息卡片


Azaspiracid-1

化学式: C47H71NO12 (841.4976)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 92.59%

分子结构信息

SMILES: C=C(CC12CC(C)CC(O1)C1OC3(CC1O2)NCC(C)CC3C)C1OC(O)(C(O)C2CC3OC4(CCC5(C=CCC(C=CCCC(=O)O)O5)O4)C(C)CC3O2)C(C)CC1C
InChI: InChI=1S/C47H71NO12/c1-26-18-36-41-38(24-45(58-41)30(5)17-27(2)25-48-45)56-44(22-26,55-36)23-29(4)40-28(3)19-32(7)47(52,59-40)42(51)37-21-35-34(53-37)20-31(6)46(57-35)16-15-43(60-46)14-10-12-33(54-43)11-8-9-13-39(49)50/h8,10-11,14,26-28,30-38,40-42,48,51-52H,4,9,12-13,15-25H2,1-3,5-7H3,(H,49,50)/b11-8+/t26-,27+,28+,30-,31+,32-,33-,34+,35+,36-,37-,38+,40+,41+,42+,43+,44-,45?,46-,47-/m1/s1

描述信息

D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins

同义名列表

4 个代谢物同义名

Azaspiracid-1; CID 56928094; Azaspiracid; Azaspiracid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CASP10, CASP2, CASP3, CASP7, GGPS1, MAPK8, PIK3C3, PIK3CA, PRKX, SPX
Endosome membrane 2 CTSD, LDLR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 7 APCS, CASP2, CASP3, CASP7, JUN, MAPK8, PRKX
autophagosome 1 PIK3C3
cytosol 9 CASP10, CASP2, CASP3, CASP7, GGPS1, MAPK8, PIK3C3, PIK3CA, PRKCQ
dendrite 1 KCNH1
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 7 CASP3, CASP7, GGPS1, JUN, MAPK8, PRKX, SCNN1G
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 3 KCNH1, KCNH2, LDLR
lamellipodium 1 PIK3CA
Cell projection, axon 1 KCNH1
Early endosome membrane 1 KCNH1
Multi-pass membrane protein 4 KCNA3, KCNH1, KCNH2, SCNN1G
Synapse 1 MAPK8
cell surface 2 KCNH2, LDLR
glutamatergic synapse 3 CASP3, KCNA3, PIK3C3
Golgi apparatus 1 LDLR
lysosomal membrane 1 CTSD
neuronal cell body 1 CASP3
presynaptic membrane 2 KCNA3, KCNH1
Cytoplasm, cytosol 1 CASP7
Cytoplasmic vesicle, secretory vesicle 1 SPX
Lysosome 2 CTSD, LDLR
endosome 1 PIK3C3
plasma membrane 7 KCNA3, KCNH1, KCNH2, LDLR, PIK3CA, PRKCQ, SCNN1G
Membrane 5 KCNA3, KCNH1, KCNH2, LDLR, PIK3C3
apical plasma membrane 1 SCNN1G
axon 3 KCNA3, KCNH1, MAPK8
basolateral plasma membrane 1 LDLR
extracellular exosome 3 APCS, CTSD, SCNN1G
extracellular space 4 APCS, CASP7, CTSD, SPX
lysosomal lumen 1 CTSD
perinuclear region of cytoplasm 4 GGPS1, KCNA3, KCNH2, PIK3CA
intercalated disc 1 PIK3CA
intracellular membrane-bounded organelle 1 KCNH1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 LDLR
Secreted 1 APCS
extracellular region 3 APCS, CTSD, SPX
Single-pass membrane protein 1 LDLR
transcription regulator complex 1 JUN
centriolar satellite 1 PRKCQ
external side of plasma membrane 2 LDLR, SCNN1G
low-density lipoprotein particle 1 LDLR
perikaryon 1 KCNH1
Z disc 1 GGPS1
nucleolus 1 CASP2
midbody 1 PIK3C3
Early endosome 1 LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 SCNN1G
Cytoplasm, perinuclear region 1 GGPS1
Membrane raft 2 CTSD, KCNA3
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
collagen-containing extracellular matrix 2 APCS, CTSD
axoneme 1 PIK3C3
Nucleus inner membrane 1 KCNH1
nuclear inner membrane 1 KCNH1
Late endosome 2 LDLR, PIK3C3
receptor complex 1 LDLR
chromatin 1 JUN
phagocytic vesicle membrane 1 PIK3C3
Secreted, extracellular space 2 CASP7, SPX
nuclear chromosome 1 JUN
blood microparticle 1 APCS
[Isoform 2]: Cell membrane 1 KCNA3
Endomembrane system 1 LDLR
endosome lumen 1 CTSD
sorting endosome 1 LDLR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
monoatomic ion channel complex 2 KCNH1, KCNH2
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 KCNH1
Melanosome 1 CTSD
euchromatin 1 JUN
Presynaptic cell membrane 1 KCNH1
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 3 KCNA3, KCNH1, KCNH2
ficolin-1-rich granule lumen 1 CTSD
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 CTSD
tertiary granule lumen 1 CTSD
dense core granule 1 SPX
transport vesicle 1 SPX
postsynaptic density membrane 1 KCNH1
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 LDLR
endolysosome membrane 1 LDLR
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP10
death-inducing signaling complex 1 CASP3
ripoptosome 1 CASP10
[Isoform 1]: Cell membrane 1 KCNA3
somatodendritic compartment 1 LDLR
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 JUN
PCSK9-LDLR complex 1 LDLR
Autolysosome 1 PIK3C3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
endopeptidase complex 1 CASP2


文献列表

  • M Pelin, J Kilcoyne, C Nulty, S Crain, P Hess, A Tubaro, S Sosa. Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, -2 and -3 in mice. Toxicology letters. 2018 Jan; 282(?):136-146. doi: 10.1016/j.toxlet.2017.10.016. [PMID: 29107028]
  • Sara F Ferreiro, Natalia Vilariño, Cristina Carrera, M Carmen Louzao, Antonio G Cantalapiedra, Germán Santamarina, J Manuel Cifuentes, Andrés C Vieira, Luis M Botana. Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2016 05; 151(1):104-14. doi: 10.1093/toxsci/kfw025. [PMID: 26865666]
  • Bernd Luckas, Katrin Erler, Bernd Krock. Analysis of Marine Biotoxins Using LC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2015; 1308(?):277-97. doi: 10.1007/978-1-4939-2684-8_18. [PMID: 26108513]
  • John A B Aasen, Arild Espenes, Philipp Hess, Tore Aune. Sub-lethal dosing of azaspiracid-1 in female NMRI mice. Toxicon : official journal of the International Society on Toxinology. 2010 Dec; 56(8):1419-25. doi: 10.1016/j.toxicon.2010.08.007. [PMID: 20800607]
  • Mirella Bellocci, Gian Luca Sala, Federica Callegari, Gian Paolo Rossini. Azaspiracid-1 inhibits endocytosis of plasma membrane proteins in epithelial cells. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Sep; 117(1):109-21. doi: 10.1093/toxsci/kfq172. [PMID: 20547569]
  • Michael J Twiner, James C Ryan, Jeanine S Morey, Kent J Smith, Samar M Hammad, Frances M Van Dolah, Philipp Hess, Terry McMahon, Masayuki Satake, Takeshi Yasumoto, Gregory J Doucette. Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid. Genomics. 2008 Mar; 91(3):289-300. doi: 10.1016/j.ygeno.2007.10.015. [PMID: 18191373]
  • Amparo Alfonso, Yolanda Román, Mercedes R Vieytes, Katsuya Ofuji, Masayuki Satake, Takeshi Yasumoto, Luis M Botana. Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes. Biochemical pharmacology. 2005 Jun; 69(11):1627-36. doi: 10.1016/j.bcp.2005.03.022. [PMID: 15896342]
  • K C Nicolaou, Scott A Snyder. Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation. Angewandte Chemie (International ed. in English). 2005 Feb; 44(7):1012-1044. doi: 10.1002/anie.200460864. [PMID: 15688428]