mycalolide b (BioDeep_00000011474)

   

Marine Natural Products


代谢物信息卡片


mycalolide b

化学式: C52H74N4O17 (1026.5049)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(CC=CC2=NC(=CO2)C3=NC(=CO3)C4=NC(=CO4)C(C(C(=O)C=CCC(CC(=O)OC1CC(C(C)CCC(C(C)C(C(C)C=CN(C)C=O)OC(=O)C)OC(=O)C(COC)OC)OC)O)C)OC)OC
InChI: InChI=1S/C52H74N4O17/c1-30(19-20-42(73-52(62)45(66-11)28-63-8)34(5)48(71-35(6)58)31(2)21-22-56(7)29-57)43(65-10)24-44-33(4)41(64-9)17-14-18-46-53-38(26-68-46)50-55-39(27-70-50)51-54-37(25-69-51)49(67-12)32(3)40(60)16-13-15-36(59)23-47(61)72-44/h13-14,16,18,21-22,25-27,29-34,36,41-45,48-49,59H,15,17,19-20,23-24,28H2,1-12H3

描述信息

D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins

同义名列表

3 个代谢物同义名

mycalolide b; Mycalolide-B; Mycalolide B



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADRA1B, BDNF, CASP1, CDH1, DMPK, FMR1, MARVELD1, MYD88, MYLK, NLRP3, TJP1, TUBB4B
Peripheral membrane protein 2 GORASP1, TJP1
Endosome membrane 1 MYD88
Endoplasmic reticulum membrane 2 DMPK, GJB1
Nucleus 8 ADRA1B, CDH1, FMR1, MARVELD1, MYD88, NLRP3, TJP1, TUBB4B
cytosol 9 CASP1, CDH1, DMPK, FMR1, MYD88, MYLK, NLRP3, TJP1, TUBB4B
dendrite 2 BDNF, FMR1
trans-Golgi network 1 CDH1
nucleoplasm 3 ATP2B1, CDH1, FMR1
Cell membrane 9 ADRA1B, ATP2B1, CASP1, CDH1, DMPK, FMR1, GJB1, MARVELD1, TJP1
Cytoplasmic side 3 DMPK, GORASP1, TJP1
Cleavage furrow 1 MYLK
lamellipodium 2 CDH1, MYLK
Cell projection, axon 1 FMR1
Cell projection, growth cone 1 FMR1
Multi-pass membrane protein 5 ADRA1B, ATP2B1, ATP4A, GJB1, MARVELD1
Golgi apparatus membrane 2 GORASP1, NLRP3
Synapse 3 ATP2B1, FMR1, MYLK
cell junction 2 CDH1, TJP1
cell surface 1 MYD88
glutamatergic synapse 2 ATP2B1, CDH1
Golgi apparatus 2 CDH1, GORASP1
Golgi membrane 2 GORASP1, NLRP3
growth cone 1 FMR1
lysosomal membrane 1 EGF
postsynapse 2 CDH1, FMR1
presynaptic membrane 2 ATP2B1, FMR1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 DMPK, NLRP3
Presynapse 1 FMR1
endosome 1 CDH1
plasma membrane 12 ADRA1B, ATP2B1, ATP4A, CASP1, CDH1, DMPK, EGF, F2, MARVELD1, MYD88, MYLK, TJP1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ADRA1B, ATP2B1, ATP4A, BDNF, CDH1, EGF, FMR1, MARVELD1, NLRP3
apical plasma membrane 2 ATP4A, TJP1
axon 2 BDNF, FMR1
basolateral plasma membrane 2 ATP2B1, TJP1
caveola 1 ADRA1B
extracellular exosome 5 ATP2B1, CDH1, EGF, F2, TUBB4B
endoplasmic reticulum 1 NLRP3
extracellular space 6 ATP4A, BDNF, EGF, F2, IL6, SCT
perinuclear region of cytoplasm 3 BDNF, CDH1, FMR1
Cell junction, tight junction 1 TJP1
adherens junction 2 CDH1, TJP1
apicolateral plasma membrane 1 TJP1
bicellular tight junction 1 TJP1
gap junction 1 TJP1
intercalated disc 1 TJP1
intercellular canaliculus 1 TJP1
mitochondrion 2 NLRP3, TJP1
protein-containing complex 3 CASP1, MYD88, TJP1
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 FMR1
Single-pass type I membrane protein 1 CDH1
Secreted 4 BDNF, F2, IL6, NLRP3
extracellular region 8 BDNF, CDH1, EGF, F2, IL6, NLRP3, SCT, TUBB4B
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 DMPK
mitochondrial outer membrane 1 DMPK
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 3 ADRA1B, CDH1, DMPK
Extracellular vesicle 1 TUBB4B
actin cytoskeleton 2 CDH1, MYLK
dendritic spine 1 FMR1
perikaryon 1 FMR1
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 CASP1, FMR1
apical part of cell 1 TJP1
growth cone filopodium 1 FMR1
postsynaptic membrane 1 FMR1
Apical cell membrane 1 ATP4A
Cell projection, filopodium tip 1 FMR1
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 FMR1
filopodium tip 1 FMR1
Cytoplasm, cytoskeleton 2 MARVELD1, TUBB4B
microtubule 2 CASP1, TUBB4B
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Cell projection, dendritic spine 1 FMR1
collagen-containing extracellular matrix 1 F2
Cell junction, gap junction 1 GJB1
connexin complex 1 GJB1
lateral plasma membrane 3 ATP2B1, CDH1, GJB1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus outer membrane 1 DMPK
nuclear outer membrane 1 DMPK
Postsynaptic cell membrane 1 FMR1
Cell projection, neuron projection 1 FMR1
neuron projection 1 FMR1
cell projection 3 ATP2B1, FMR1, TJP1
mitotic spindle 1 TUBB4B
Chromosome 1 FMR1
cytoskeleton 2 MARVELD1, TUBB4B
Cell projection, podosome 1 TJP1
podosome 1 TJP1
cytoplasmic ribonucleoprotein granule 1 FMR1
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 1 FMR1
blood microparticle 1 F2
Basolateral cell membrane 1 ATP2B1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
Endomembrane system 1 NLRP3
Membrane, caveola 1 ADRA1B
Chromosome, centromere 1 FMR1
axonemal microtubule 1 TUBB4B
microtubule organizing center 1 NLRP3
Cell projection, dendrite 1 FMR1
Cytoplasm, Stress granule 1 FMR1
cytoplasmic stress granule 1 FMR1
Presynaptic cell membrane 2 ATP2B1, FMR1
stress fiber 1 MYLK
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 BDNF, F2, IL6
platelet alpha granule lumen 1 EGF
axon terminus 1 FMR1
tight junction 1 TJP1
azurophil granule lumen 1 TUBB4B
Sarcoplasmic reticulum membrane 1 DMPK
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
immunological synapse 1 ATP2B1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 DMPK
chromosome, centromeric region 1 FMR1
AIM2 inflammasome complex 1 CASP1
clathrin-coated endocytic vesicle membrane 1 EGF
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Cajal body 1 FMR1
ribonucleoprotein complex 1 FMR1
[Isoform 2]: Nucleus 1 CDH1
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
Synapse, synaptosome 1 FMR1
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 FMR1
apical junction complex 2 CDH1, TJP1
canonical inflammasome complex 1 CASP1
intracellular non-membrane-bounded organelle 1 FMR1
chromocenter 1 FMR1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
extrinsic component of plasma membrane 1 MYD88
catenin complex 1 CDH1
neuronal ribonucleoprotein granule 1 FMR1
Nucleus, Cajal body 1 FMR1
glial cell projection 1 FMR1
interleukin-6 receptor complex 1 IL6
[Isoform 6]: Cytoplasm 1 FMR1
dendritic filopodium 1 FMR1
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP4A
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[Isoform 9]: Cytoplasm 1 FMR1
[Isoform 10]: Nucleus 1 FMR1
[Isoform 11]: Nucleus 1 FMR1


文献列表

  • Francisco Lázaro-Diéguez, Nuria Jiménez, Holger Barth, Abraham J Koster, Jaime Renau-Piqueras, Juan L Llopis, Koert N J Burger, Gustavo Egea. Actin filaments are involved in the maintenance of Golgi cisternae morphology and intra-Golgi pH. Cell motility and the cytoskeleton. 2006 Dec; 63(12):778-91. doi: 10.1002/cm.20161. [PMID: 16960891]
  • Hiroyuki Sasaki, Hiroshi Ozaki, Hideaki Karaki, Yoshiaki Nonomura. Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells. Biochemical and biophysical research communications. 2004 Apr; 316(2):588-93. doi: 10.1016/j.bbrc.2004.02.088. [PMID: 15020258]
  • T Kojima, N Sawada, M Yamamoto, Y Kokai, M Mori, Y Mochizuki. Disruption of circumferential actin filament causes disappearance of occludin from the cell borders of rat hepatocytes in primary culture without distinct changes of tight junction strands. Cell structure and function. 1999 Feb; 24(1):11-7. doi: 10.1247/csf.24.11. [PMID: 10355874]
  • J Uchida, Y Kiuchi, M Ohno, A Yura, K Oguchi. Ca(2+)-dependent enhancement of [3H]noradrenaline uptake in PC12 cells through calmodulin-dependent kinases. Brain research. 1998 Nov; 809(2):155-64. doi: 10.1016/s0006-8993(98)00850-6. [PMID: 9853106]
  • A Sugidachi, T Ogawa, F Asai, S Saito, H Ozaki, N Fusetani, H Karaki, H Koike. Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D. Thrombosis and haemostasis. 1998 Mar; 79(3):614-9. doi: . [PMID: 9531051]