Chalcone (BioDeep_00000001116)

 

Secondary id: BioDeep_00000014477

natural product PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C15H12O\c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13\h1-12

化学式: C15H12O (208.08881019999998)
中文名称: 反-查耳酮, 查耳酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.95%

分子结构信息

SMILES: C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2
InChI: InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H

描述信息

Chalcone is a member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group. It has a role as a plant metabolite. It is a member of styrenes and a member of chalcones.
Chalcone is a natural product found in Tilia tomentosa, Alpinia hainanensis, and other organisms with data available.
An aromatic KETONE that forms the core molecule of CHALCONES.
A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.
Annotation level-1
Acquisition and generation of the data is financially supported in part by CREST/JST.
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities[1].
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities[1].
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].

同义名列表

101 个代谢物同义名

Chalcone; 1,3-Diphenyl-2-propenone, >=98.0\\% (GC); 2-Propen-1-one, 1,3-diphenyl-, (2E)-; (E)-3-phenyl-1-phenylprop-2-en-1-one; 2-Propen-1-one, 1,3-diphenyl-, (E)-; phenyl (E)--2-phenylethenyl ketone; Phenyl (E)-2-phenylethenyl ketone; (2E)-1,3-Diphenyl-2-propen-1-one; TRANS-CHALCONE-D12, 98 ATOM \\% D; (2E)-1,3-diphenylprop-2-en-1-one; (E)-1,3-diphenyl-prop-2-en-1-one; 2-Propen-1-one,3-diphenyl-, (E)-; (E)-1,3-diphenylprop-2-en-1-one; (E)-1,3-Diphenyl-2-propen-1-one; .omega.-Benzylideneacetophenone; .alpha.-Benzylideneacetophenone; alpha-Benzylideneacetophenone; 2-Propen-1-one, 1,3-diphenyl-; trans-Benzylideneacetophenone; 1, 3-Diphenyl-1-propen-3-one; (E)-Benzylideneacetophenone; 1,3-diphenylprop-2-en-1-one; Phenyl 2-phenylvinyl ketone; 1,3-Diphenyl-1-propen-3-one; 1,3 Diphenyl 2 Propen 1 One; 1,3-Diphenyl-2-Propen-1-One; (E)-1,3-DIPHENYL-PROPENONE; 1-Phenyl-2-benzoylethylene; 1-Benzoyl-2-phenylethylene; .beta.-Phenylacrylophenone; Phenyl trans-styryl ketone; 2-Benzylideneacetophenone; a-Benzylideneacetophenone; PHENYL (E)-STYRYL KETONE; Benzylidene acetophenone; beta-Phenylacrylophenone; 1-Benzoyl-1-phenylethene; trans-Benzalacetophenone; 1-Benzoyl-2-phenylethene; 1,3-Diphenyl-2-propenone; substituted chalcone, 5j; Acrylophenone, 3-phenyl-; Benzylideneacetophenone; chalcone (ACD/Name 4.0); Benzylidenecetophenone; 3-phenyl-Acrylophenone; benzylidenacetophenone; CHALCONE (E)-FORM [MI]; 1,3-Diphenylpropenone; 3-Phenylacrylophenone; .beta.-Benzoylstyrene; b-Phenylacrylophenone; Chalcone methoxyamine; trans-Chalcone, 97\\%; Styryl phenyl ketone; 2-Benzalacetophenone; Phenyl styryl ketone; beta-Benzoylstyrene; phenylstyryl ketone; Benzalacetophenone; CHALCONE (E)-FORM; b-Benzoylstyrene; Cinnamoylbenzene; UNII-5S5A2Q39HX; trans-Chalcone; Cinnamophenone; CHALCONE, (E)-; CHALCONE [MI]; (E)-Chalcone; Chalcone, 13; WLN: RV1U1R; 5S5A2Q39HX; Chalcone 1; AI3-00946; Chalkone; Chalkon; InChI=1\C15H12O\c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13\h1-12; CHALCONE (TRANS) BENZALACETOPHENONE; (E)-1,3-di(phenyl)prop-2-en-1-one; 1,3-di(phenyl)prop-2-en-1-one; EINECS 210-383-8; EINECS 202-330-2; 136123_ALDRICH; NCI60_001320; SMR000059029; ZINC01570604; MLS000069600; AIDS-038601; 11970_FLUKA; AIDS038601; CCRIS 3778; CCRIS 2213; NSC 26612; NSC167107; ST5164547; 614-47-1; NSC26612; 94-41-7; NSC4523; C15589; C01484



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenxin Xia, Yushu Wang, Jiahui Yue, Xueyan Fu. Insights into Q-markers of honey-fried licorice in treating spleen deficiency based on substance and energy metabolism regulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155498. doi: 10.1016/j.phymed.2024.155498. [PMID: 38460491]
  • Wenliang Zhan, Ran Zhou, Piao Mao, Chunmei Yuan, Tao Zhang, Yi Liu, Jiao Tian, Hua Wang, Wei Xue. Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole. Molecular diversity. 2024 Apr; 28(2):461-474. doi: 10.1007/s11030-022-10593-4. [PMID: 36964852]
  • Santosh Pushpa Ramya Ranjan Nayak, Catharine Basty, Seenivasan Boopathi, Loganathan Sumathi Dhivya, Khaloud Mohammed Alarjani, Mohamed Ragab Abdel Gawwad, Raghda Hager, Muthu Kumaradoss Kathiravan, Jesu Arockiaraj. Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection. Journal of microbiology (Seoul, Korea). 2024 Feb; 62(2):75-89. doi: 10.1007/s12275-024-00103-6. [PMID: 38383881]
  • Jia Yu, Xia Wang, Sha Cheng, Xiaoping Zeng, Xinwei Wan, Shinan Wei, Bixue Xu, Heng Luo, Xueling Meng. Design, synthesis and bioevaluation of novel prenylated chalcones derivatives as potential antitumor agents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jan; 192(?):106660. doi: 10.1016/j.ejps.2023.106660. [PMID: 38052256]
  • Yan Ma, Qian Cui, Wenjing Zhu, Mei Wang, Li Zhai, Wenmin Hu, Dongdong Liu, Min Liu, Yongchun Li, Meng Li, Wei Han. A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK. Drug design, development and therapy. 2024; 18(?):1531-1546. doi: 10.2147/dddt.s449139. [PMID: 38737331]
  • Hany M Abd El-Lateef, Nadia A A Elkanzi, Marwa Adel Thabet, Mohamed A Gad, Omran A Omran, Ali M Ali. Design, Characterization and SAR Studies of Novel Bioactive Benzylideneacetophenone Derivatives as Insecticidal Agents against Spodoptera frugiperda (Lepidoptera: Noctuidae). Chemistry & biodiversity. 2024 Jan; 21(1):e202301284. doi: 10.1002/cbdv.202301284. [PMID: 38036947]
  • Nian Zhang, Wei Zeng, Zhiling Sun, Qing Zhou, Kaini Meng, Yuzhi Hu, Yishan Qin, Wei Xue. Design, synthesis, and bioactivity studies of chalcone derivatives containing [1,2,4]-triazole-[4,3-a]-pyridine. Fitoterapia. 2024 Jan; 172(?):105739. doi: 10.1016/j.fitote.2023.105739. [PMID: 37952763]
  • Sondos Alreqeb, Bengü Ergüden. Chalcone derivatives disrupt cell membrane integrity of Saccharomyces cerevisiae cells and alter their biochemical composition. Archives of microbiology. 2023 Dec; 206(1):34. doi: 10.1007/s00203-023-03747-x. [PMID: 38133819]
  • En Hu, Teng Li, Zhilin Li, Hong Su, Qiuju Yan, Lei Wang, Haigang Li, Wei Zhang, Tao Tang, Yang Wang. Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury. Pharmaceutical biology. 2023 Dec; 61(1):1054-1064. doi: 10.1080/13880209.2023.2229379. [PMID: 37416997]
  • Xi Han, Huifen Zhou, Junjun Yin, Jiaqi Zhu, Jiehong Yang, Haitong Wan. Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237829. [PMID: 38067558]
  • Gina Mendez-Callejas, Marco Piñeros-Avila, Juvenal Yosa-Reyes, Roberto Pestana-Nobles, Ruben Torrenegra, María F Camargo-Ubate, Andrea E Bello-Castro, Crispin A Celis. A Novel Tri-Hydroxy-Methylated Chalcone Isolated from Chromolaena tacotana with Anti-Cancer Potential Targeting Pro-Survival Proteins. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015185. [PMID: 37894866]
  • Xiaoxia Liu, Jinmei Jin, Ye Wu, Bolin Du, Lijun Zhang, Dong Lu, Yichen Liu, Xinyi Chen, Jiayi Lin, Hongzhuan Chen, Weidong Zhang, Chunlin Zhuang, Xin Luan. Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy. European journal of medicinal chemistry. 2023 Sep; 257(?):115540. doi: 10.1016/j.ejmech.2023.115540. [PMID: 37301075]
  • Twinkle Vij, Pawase Prashant Anil, Rafeeya Shams, Kshirod Kumar Dash, Rhythm Kalsi, Vinay Kumar Pandey, Endre Harsányi, Béla Kovács, Ayaz Mukarram Shaikh. A Comprehensive Review on Bioactive Compounds Found in Caesalpinia sappan. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176247. [PMID: 37687076]
  • Suji Baek, Sanghee Nah, Joo Yeon Park, Sang Ju Lee, Yong Gil Kang, Seung Hae Kwon, Seung Jun Oh, Kang Pa Lee, Byung Seok Moon. A novel chalcone derivative exerts anticancer effects by promoting apoptotic cell death of human pancreatic cancer cells. Bioorganic & medicinal chemistry. 2023 Aug; 93(?):117458. doi: 10.1016/j.bmc.2023.117458. [PMID: 37634418]
  • Ziyi Chen, Wenwen Ding, Xiaoxue Yang, Tiangong Lu, Ying Liu. Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117059. doi: 10.1016/j.jep.2023.117059. [PMID: 37604329]
  • S P Ramya Ranjan Nayak, L S Dhivya, Reshma R, Bader O Almutairi, Selvaraj Arokiyaraj, M K Kathiravan, Jesu Arockiaraj. Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model. European journal of pharmacology. 2023 Aug; ?(?):175994. doi: 10.1016/j.ejphar.2023.175994. [PMID: 37574161]
  • Zhiwei Miao, Mingjia Gu, Faisal Raza, Hajra Zafar, Jianyi Huang, Yuhang Yang, Muhammad Sulaiman, Jing Yan, Yi Xu. Isoliquiritin Ameliorates Ulcerative Colitis in Rats through Caspase 3/HMGB1/TLR4 Dependent Signaling Pathway. Current gene therapy. 2023 Jul; ?(?):. doi: 10.2174/1566523223666230731115236. [PMID: 37526181]
  • Bo Luo, Chongchong Zhang, Suya Liang, Wei Zhou, Yihan Hu, Yulin Li, Jiayi Hu, Lailiang Qu. Design, Synthesis, and Antifungal Activities of Novel Carboxamides Derivatives Bearing a Chalcone Scaffold as Potential SDHIs. Chemistry & biodiversity. 2023 Jul; ?(?):e202300958. doi: 10.1002/cbdv.202300958. [PMID: 37492004]
  • Ling-Li Wang, Na Liu, Shuang Hu, Rong-Rong Xing, Run-Qin Wang, Li Yang, Xuan Chen. Application of instantaneous nebulization dispersive liquid-phase microextraction combined with HPLC for the determination of chalcone and isoflavone in traditional Chinese medicines. Journal of separation science. 2023 Jul; ?(?):e2300326. doi: 10.1002/jssc.202300326. [PMID: 37485627]
  • Ping Li, Han Ju, Ying Zhang, Jazmin Galvan Achi, Dongwei Kang, Jinmi Zou, Ruikun Du, Qinghua Cui, Xinyong Liu, Lijun Rong, Peng Zhan. Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses. Journal of medical virology. 2023 07; 95(7):e28968. doi: 10.1002/jmv.28968. [PMID: 37489704]
  • Xiaofei Shen, Hongqing Chen, Tian Wen, Lu Liu, Qiongying Hu, Fan Xie, Lun Wang. A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases. European journal of pharmacology. 2023 Jun; ?(?):175840. doi: 10.1016/j.ejphar.2023.175840. [PMID: 37302524]
  • Bolin Du, Xiaoxia Liu, Xin Luan, Weidong Zhang, Chunlin Zhuang. Structure optimization of an F-indole-chalcone (FC116) on 4-methoxyphenyl group and therapeutic potential against colorectal cancers with low cytotoxicity. Bioorganic chemistry. 2023 06; 135(?):106531. doi: 10.1016/j.bioorg.2023.106531. [PMID: 37043882]
  • Lei Ye, Ming Su, Xinyi Qiao, Shaowei Wang, Ke Zheng, Yang Zhu, Huitao Li, Yiyan Wang, Ren-Shan Ge. Chalcone derivatives from licorice inhibit human and rat gonadal 3β-hydroxysteroid dehydrogenases as therapeutic uses. Journal of ethnopharmacology. 2023 May; ?(?):116690. doi: 10.1016/j.jep.2023.116690. [PMID: 37245711]
  • Qianqian Ran, Linlan Tao, Xiang Zhou, Shu-Ming Li, Chun-Mao Yuan, Song Yang, Kang Zhou. Geranylation of Chalcones by a Fungal Aromatic Prenyltransferase. Journal of agricultural and food chemistry. 2023 Mar; 71(11):4675-4682. doi: 10.1021/acs.jafc.2c08743. [PMID: 36893066]
  • Chunhua Zhang, Qifan Ding, Zhuolu Xia, Hengyu Wang, Feng Jiang, Yuanyuan Lu. Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy. Chemistry & biodiversity. 2023 Feb; 20(2):e202201117. doi: 10.1002/cbdv.202201117. [PMID: 36536551]
  • Fernanda Hohana Almeida E Sá, Anderson Roberto Nery Silva, Thalyta Julyanne Silva de Oliveira, Amanda Leite Guimarães, Francisco Roberto de Azevedo, Miriam Brito Dos Santos, Aline Taiane de Macedo Pinto, Jair Fernandes Virginio, Edilson Beserra de Alencar Filho. A chalcone identified by in silico and in vitro assays possesses high larvicidal activity against Aedes aegypti. Acta tropica. 2023 Feb; 238(?):106791. doi: 10.1016/j.actatropica.2022.106791. [PMID: 36493854]
  • Albert E Russell, Brandon R Gines. Chalcones: Potential Chemotherapeutic Compounds and Educational Tools for Closing the Loop in STEM. Accounts of chemical research. 2023 Jan; ?(?):. doi: 10.1021/acs.accounts.2c00583. [PMID: 36696370]
  • Nichole Osti Silva, Laiane Souza da Silva, Mariele Paludetto Sanches, Thyelle Rodrigues Dos Santos, Monike Konzgen, Alexandre Luís Parize, Edgar Aparecido Sanches, Gabriel Jorge Sagrera Darelli, Vânia Rodrigues de Lima. Structure and interaction roles in the release profile of chalcone-loaded liposomes. Biophysical chemistry. 2023 01; 292(?):106930. doi: 10.1016/j.bpc.2022.106930. [PMID: 36395546]
  • Yukiko Matsuo, Takuya Fujii, Hironao Kato, Kazuki Tomizawa, Haruhiko Fukaya, Katsunori Miyake, Minpei Kuroda, Yoshihiro Mimaki. Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation. Journal of natural medicines. 2023 Jan; 77(1):109-117. doi: 10.1007/s11418-022-01651-0. [PMID: 36068394]
  • Yushu Wang, Wenxin Xia, Mengxin Tao, Xueyan Fu. Oncopreventive and Oncotherapeutic Potential of Licorice Chalcone Compounds: Molecular Insights. Mini reviews in medicinal chemistry. 2023; 23(6):662-699. doi: 10.2174/1389557522666220827161943. [PMID: 36043713]
  • Sarah van Dinteren, Jocelijn Meijerink, Renger Witkamp, Bo van Ieperen, Jean-Paul Vincken, Carla Araya-Cloutier. Valorisation of liquorice (Glycyrrhiza) roots: antimicrobial activity and cytotoxicity of prenylated (iso)flavonoids and chalcones from liquorice spent (G. glabra, G. inflata, and G. uralensis). Food & function. 2022 Nov; 13(23):12105-12120. doi: 10.1039/d2fo02197h. [PMID: 36377761]
  • Pin-Jian Xiao, Jia-Cheng Zeng, Ping Lin, Dao-Bang Tang, En Yuan, Yong-Gang Tu, Qing-Feng Zhang, Ji-Guang Chen, Da-Yong Peng, Zhong-Ping Yin. Chalcone-1-Deoxynojirimycin Heterozygote Reduced the Blood Glucose Concentration and Alleviated the Adverse Symptoms and Intestinal Flora Disorder of Diabetes Mellitus Rats. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217583. [PMID: 36364410]
  • Yu Du, Chang Li, Shouchao Xu, Jiehong Yang, Haitong Wan, Yu He. LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154432. doi: 10.1016/j.phymed.2022.154432. [PMID: 36113188]
  • Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin, Xi Liu. Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer. Journal of experimental & clinical cancer research : CR. 2022 Oct; 41(1):293. doi: 10.1186/s13046-022-02500-4. [PMID: 36199122]
  • Haobei Qin, Dewen Bi, Fengqiu Li, Ruilong Luo, Hongdan Zhuang, Liqin Wang. Two new C-benzylated chalcones and one new mimosin-type homoisoflavonoid from the twigs and leaves of Caesalpinia digyna. Fitoterapia. 2022 Oct; 162(?):105279. doi: 10.1016/j.fitote.2022.105279. [PMID: 35964851]
  • Zhipei Sang, Ping Bai, Yujuan Ban, Keren Wang, Anguo Wu, Jing Mi, Jiaqi Hu, Rui Xu, Gaofeng Zhu, Jianta Wang, Jiquan Zhang, Changning Wang, Zhenghuai Tan, Lei Tang. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorganic chemistry. 2022 10; 127(?):106007. doi: 10.1016/j.bioorg.2022.106007. [PMID: 35849893]
  • Jun-Ren Chen, Xiao-Fang Xie, Xiao-Yu Cao, Gang-Min Li, Yan-Peng Yin, Cheng Peng. [Research progress on mechanism of Carthamus tinctorius in ischemic stroke therapy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4574-4582. doi: 10.19540/j.cnki.cjcmm.20220217.701. [PMID: 36164862]
  • Serkan Koldas, Ibrahim Demirtas, Dogukan Mutlu, Mehmet Nuri Atalar, Hakan Ünver, Şevki Arslan. New cytotoxic chalcone derivatives from Astragalus ponticus Pall. Natural product research. 2022 Sep; 36(18):4672-4680. doi: 10.1080/14786419.2021.2012771. [PMID: 34866505]
  • Cátia Vilas-Boas, Logan Running, Daniela Pereira, Honorina Cidade, Marta Correia-da-Silva, Gunes Ekin Atilla-Gokcumen, Diana S Aga. Impact of Tralopyril and Triazolyl Glycosylated Chalcone in Human Retinal Cells' Lipidome. Molecules (Basel, Switzerland). 2022 Aug; 27(16):. doi: 10.3390/molecules27165247. [PMID: 36014486]
  • Chao Li, Qiang-Yu Chen, Yuan He, Yu-Hai Liu, Xiao-Ming Meng, Ming-Ming Liu. Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury. Clinical and experimental pharmacology & physiology. 2022 08; 49(8):824-835. doi: 10.1111/1440-1681.13670. [PMID: 35579574]
  • Dandan Bao, Xiaowei Xie, Mengying Cheng, Ke Zhang, Tianxiang Yue, Aidi Liu, Weixiang Fang, Yinghui Wei, Hangsheng Zheng, Ji-Gang Piao, Donghang Xu, Yuxian Li. Hydroxy-safflower yellow A composites: An effective strategy to enhance anti-myocardial ischemia by improving intestinal permeability. International journal of pharmaceutics. 2022 Jul; 623(?):121918. doi: 10.1016/j.ijpharm.2022.121918. [PMID: 35716973]
  • Luis Bustos, Carlos Echiburú-Chau, Alejandro Castro-Alvarez, Ben Bradshaw, Mario J Simirgiotis, Marco Mellado, Claudio Parra, Mauricio Cuellar. Cytotoxic Effects on Breast Cancer Cell Lines of Chalcones Derived from a Natural Precursor and Their Molecular Docking Analysis. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144387. [PMID: 35889260]
  • Pukar Khanal, Vishal S Patil, Vishwambhar V Bhandare, Prarambh S R Dwivedi, C S Shastry, B M Patil, Shailendra S Gurav, Darasaguppe R Harish, Subarna Roy. Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compounds. Computers in biology and medicine. 2022 07; 146(?):105668. doi: 10.1016/j.compbiomed.2022.105668. [PMID: 35667894]
  • Zhuya Yang, Xiaohong Li, Rongbing Fu, Min Hu, Yijie Wei, Xuhong Hu, Wenhong Tan, Xiaoyun Tong, Feng Huang. Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123789. [PMID: 35744915]
  • Qianqian Chen, Jiayang Wan, Yangyang Zhang, Yu He, Yida Bao, Li Yu, Jiehong Yang. Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112950. doi: 10.1016/j.biopha.2022.112950. [PMID: 35427818]
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