Pyrrolysine (BioDeep_00000011004)

   


代谢物信息卡片


N~6~-{[(2s,3s)-3-Methyl-3,4-Dihydro-2h-Pyrrol-2-Yl]carbonyl}-L-Lysine

化学式: C12H21N3O3 (255.1583)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 44.04%

分子结构信息

SMILES: CC1CC=NC1C(=O)NCCCCC(C(=O)O)N
InChI: InChI=1S/C12H21N3O3/c1-8-5-7-14-10(8)11(16)15-6-3-2-4-9(13)12(17)18/h7-10H,2-6,13H2,1H3,(H,15,16)(H,17,18)

描述信息

A N(6)-acyl-L-lysine having a (2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarboxy group at the N(6)-position.

同义名列表

4 个代谢物同义名

L-Pyrrolysine; Pyrrolysine; N~6~-{[(2s,3s)-3-Methyl-3,4-Dihydro-2h-Pyrrol-2-Yl]carbonyl}-L-Lysine; L-Pyrrolysine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AARS1, AK8, CDK4, DARS1, DLK1, KARS1, PMP2, RARS1, RBMS3, SARS1
Peripheral membrane protein 2 KARS1, RS1
Endoplasmic reticulum membrane 1 PON1
Nucleus 7 AARS1, CDK4, KARS1, PMP2, RARS1, RBMS3, SARS1
cytosol 11 AARS1, AK8, ARF1, CDK4, DARS1, GOLPH3, KARS1, PMP2, RARS1, RBMS3, SARS1
trans-Golgi network 1 GOLPH3
nucleoplasm 4 CDK4, KARS1, RARS1, SCNN1G
Cell membrane 4 GOLPH3, GPRC5A, KARS1, RS1
Lipid-anchor 1 ARF1
Cytoplasmic side 1 ARF1
Multi-pass membrane protein 2 GPRC5A, SCNN1G
Golgi apparatus membrane 1 ARF1
Synapse 1 DARS1
Golgi apparatus 1 GOLPH3
Golgi membrane 2 ARF1, GOLPH3
mitochondrial inner membrane 1 HADHB
Cytoplasm, cytosol 3 AK8, DARS1, RARS1
endosome 1 GOLPH3
plasma membrane 5 ARF1, GOLPH3, GPRC5A, KARS1, SCNN1G
Membrane 5 AARS1, DARS1, DLK1, GOLPH3, RARS1
apical plasma membrane 1 SCNN1G
extracellular exosome 9 AARS1, ARF1, DARS1, GPRC5A, PMP2, PON1, RARS1, SARS1, SCNN1G
endoplasmic reticulum 1 HADHB
extracellular space 4 DLK1, KARS1, PON1, RS1
bicellular tight junction 1 CDK4
mitochondrion 4 AARS1, GOLPH3, HADHB, KARS1
protein-containing complex 2 ARF1, RS1
intracellular membrane-bounded organelle 2 GOLPH3, GPRC5A
postsynaptic density 1 ARF1
Secreted 2 KARS1, RS1
extracellular region 1 PON1
Mitochondrion outer membrane 1 HADHB
Single-pass membrane protein 1 DLK1
mitochondrial outer membrane 1 HADHB
mitochondrial matrix 1 KARS1
Extracellular side 1 RS1
transcription regulator complex 1 CDK4
photoreceptor inner segment 1 RS1
Nucleus membrane 1 CDK4
nuclear membrane 1 CDK4
external side of plasma membrane 2 RS1, SCNN1G
high-density lipoprotein particle 1 PON1
nucleolus 3 CDK4, GPRC5A, RARS1
vesicle 1 GPRC5A
Apical cell membrane 1 SCNN1G
Mitochondrion inner membrane 1 HADHB
focal adhesion 1 ARF1
mitochondrial nucleoid 1 HADHB
mitochondrial intermembrane space 1 GOLPH3
axoneme 1 AK8
sarcomere 1 ARF1
neuron to neuron synapse 1 RS1
receptor complex 1 GPRC5A
neuron projection 1 ARF1
chromatin 1 CDK4
cell leading edge 1 ARF1
blood microparticle 1 PON1
Cytoplasm, cytoskeleton, cilium axoneme 1 AK8
sperm flagellum 1 AK8
Cytoplasmic vesicle membrane 1 GPRC5A
sodium channel complex 1 SCNN1G
Golgi cisterna membrane 1 GOLPH3
myelin sheath 1 PMP2
mitochondrial fatty acid beta-oxidation multienzyme complex 1 HADHB
mitochondrial envelope 1 HADHB
9+2 motile cilium 1 AK8
Golgi cisterna 1 GOLPH3
ribonucleoprotein complex 1 RBMS3
Synapse, synaptosome 1 ARF1
aminoacyl-tRNA synthetase multienzyme complex 3 DARS1, KARS1, RARS1
cyclin-dependent protein kinase holoenzyme complex 1 CDK4
spherical high-density lipoprotein particle 1 PON1
[Isoform Mitochondrial]: Mitochondrion 1 KARS1
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 KARS1
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4


文献列表

  • Wan-Ling Wu, Shu-Jung Lai, Jhih-Tian Yang, Jeffy Chern, Suh-Yuen Liang, Chi-Chi Chou, Chih-Horng Kuo, Mei-Chin Lai, Shih-Hsiung Wu. Phosphoproteomic analysis of Methanohalophilus portucalensis FDF1(T) identified the role of protein phosphorylation in methanogenesis and osmoregulation. Scientific reports. 2016 06; 6(?):29013. doi: 10.1038/srep29013. [PMID: 27357474]
  • Tomislav Ticak, Duncan J Kountz, Kimberly E Girosky, Joseph A Krzycki, Donald J Ferguson. A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct; 111(43):E4668-76. doi: 10.1073/pnas.1409642111. [PMID: 25313086]
  • Takahito Mukai, Takatsugu Kobayashi, Nobumasa Hino, Tatsuo Yanagisawa, Kensaku Sakamoto, Shigeyuki Yokoyama. Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases. Biochemical and biophysical research communications. 2008 Jul; 371(4):818-22. doi: 10.1016/j.bbrc.2008.04.164. [PMID: 18471995]