CID 10079877 (BioDeep_00001032857)

   


代谢物信息卡片


CID 10079877

化学式: C60H86O19 (1110.5763)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2CCC3C(=C)CC(O3)CCC45CC6C(O4)C7C(O6)C(O5)C8C(O7)CCC(O8)CC(=O)OC9C(C3C(CC4C(O3)CC3(O4)CC4C(O3)C(CC3(O4)CC(C4C(O3)CC(O4)C(CC(CO)O)O)C)C)OC9CC(C1=C)O2)C
InChI: InChI=1S/C60H86O19/c1-26-13-33-7-9-37-27(2)14-35(65-37)11-12-58-23-46-54(78-58)55-56(72-46)57(79-58)53-38(69-55)10-8-34(67-53)16-48(64)73-52-31(6)51-43(68-42(52)17-39(66-33)30(26)5)19-41-45(71-51)22-60(74-41)24-47-50(77-60)29(4)21-59(76-47)20-28(3)49-44(75-59)18-40(70-49)36(63)15-32(62)25-61/h26,28-29,31-47,49-57,61-63H,2,5,7-25H2,1,3-4,6H3/t26-,28+,29+,31+,32-,33+,34-,35+,36+,37+,38+,39-,40+,41-,42+,43+,44+,45-,46+,47+,49+,50+,51+,52-,53+,54+,55+,56-,57+,58+,59-,60+/m1/s1

描述信息

D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents

同义名列表

2 个代谢物同义名

CID 10079877; Halichondrin B



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, ANXA5, BCL2, CASP3, CDH1, ERBB2, GZMB, MAP4, SMAD4, TUBB4B, VEGFA
Peripheral membrane protein 1 ANXA5
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 2 BCL2, CD4
Nucleus 9 BCL2, CASP3, CDH1, DLST, ERBB2, GZMB, SMAD4, TUBB4B, VEGFA
cytosol 10 ANXA5, BCL2, CASP3, CDH1, DLST, ERBB2, GZMB, MAP4, SMAD4, TUBB4B
trans-Golgi network 1 CDH1
centrosome 1 SMAD4
nucleoplasm 5 CASP3, CDH1, DLST, ERBB2, SMAD4
RNA polymerase II transcription regulator complex 1 SMAD4
Cell membrane 7 ABCB1, CD4, CD69, CD8A, CDH1, ERBB2, HAVCR2
lamellipodium 1 CDH1
ruffle membrane 1 ERBB2
Multi-pass membrane protein 1 ABCB1
cell junction 2 CDH1, HAVCR2
cell surface 4 ABCB1, CD38, HAVCR2, VEGFA
glutamatergic synapse 2 CASP3, CDH1
Golgi apparatus 2 CDH1, VEGFA
neuromuscular junction 1 ERBB2
neuronal cell body 1 CASP3
postsynapse 1 CDH1
presynaptic membrane 1 ERBB2
sarcolemma 1 ANXA5
endosome 1 CDH1
plasma membrane 10 ABCB1, CD38, CD4, CD69, CD8A, CDH1, ERBB2, ITGAE, LAG3, MAP4
Membrane 11 ABCB1, ANXA5, BCL2, CD38, CDH1, DLST, ERBB2, GZMB, HAVCR2, ITGAE, VEGFA
apical plasma membrane 2 ABCB1, ERBB2
axon 1 MAP4
basolateral plasma membrane 2 CD38, ERBB2
extracellular exosome 5 ABCB1, ANXA5, CD38, CDH1, TUBB4B
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 1 VEGFA
perinuclear region of cytoplasm 2 CDH1, ERBB2
adherens junction 2 CDH1, VEGFA
mitochondrion 3 BCL2, DLST, GFM1
protein-containing complex 2 BCL2, CD69
intracellular membrane-bounded organelle 1 GZMB
postsynaptic density 1 CASP3
Single-pass type I membrane protein 7 CD4, CD8A, CDH1, ERBB2, HAVCR2, ITGAE, LAG3
Secreted 2 GZMB, VEGFA
extracellular region 8 ANXA5, CD8A, CDH1, ERBB2, GZMB, LAG3, TUBB4B, VEGFA
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 DLST
mitochondrial matrix 2 DLST, GFM1
anchoring junction 1 HAVCR2
transcription regulator complex 1 SMAD4
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CD38, CDH1
external side of plasma membrane 6 ANXA5, CD4, CD69, CD8A, ITGAE, LAG3
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 CDH1
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 2 MAP4, TUBB4B
Early endosome 3 CD4, ERBB2, HAVCR2
Single-pass type II membrane protein 2 CD38, CD69
Apical cell membrane 1 ABCB1
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 CD4
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 MAP4, TUBB4B
focal adhesion 1 ANXA5
microtubule 2 MAP4, TUBB4B
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
extracellular matrix 1 VEGFA
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
lateral plasma membrane 1 CDH1
axoneme 1 MAP4
Cytoplasm, cytoskeleton, microtubule organizing center 1 MAP4
receptor complex 2 CD8A, ERBB2
Zymogen granule membrane 1 ANXA5
neuron projection 1 MAP4
chromatin 1 SMAD4
mediator complex 1 HAVCR2
microtubule associated complex 1 MAP4
mitotic spindle 2 MAP4, TUBB4B
cytoskeleton 1 TUBB4B
Golgi apparatus, trans-Golgi network 1 CDH1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
microtubule organizing center 1 MAP4
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 1 ERBB2
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 1 CD4
platelet alpha granule lumen 1 VEGFA
azurophil granule lumen 1 TUBB4B
anaphase-promoting complex 1 CDH1
immunological synapse 2 GZMB, HAVCR2
semaphorin receptor complex 1 ERBB2
oxoglutarate dehydrogenase complex 1 DLST
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 CD4
[Isoform 2]: Nucleus 1 CDH1
heteromeric SMAD protein complex 1 SMAD4
SMAD protein complex 1 SMAD4
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
[Isoform 1]: Cell membrane 2 CD8A, ERBB2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
integrin complex 1 ITGAE
activin responsive factor complex 1 SMAD4
oxidoreductase complex 1 DLST
T cell receptor complex 2 CD4, CD8A
ERBB3:ERBB2 complex 1 ERBB2
endothelial microparticle 1 ANXA5
oxoadipate dehydrogenase complex 1 DLST
Cytolytic granule 1 GZMB
cytolytic granule lumen 1 GZMB
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Lymphocyte activation gene 3 protein]: Cell membrane 1 LAG3
[Secreted lymphocyte activation gene 3 protein]: Secreted 1 LAG3


文献列表

  • David J Newman. Developing natural product drugs: Supply problems and how they have been overcome. Pharmacology & therapeutics. 2016 06; 162(?):1-9. doi: 10.1016/j.pharmthera.2015.12.002. [PMID: 26706239]
  • Wanjun Zheng, Boris M Seletsky, Monica H Palme, Paul J Lydon, Lori A Singer, Charles E Chase, Charles A Lemelin, Yongchun Shen, Heather Davis, Lynda Tremblay, Murray J Towle, Kathleen A Salvato, Bruce F Wels, Kimberley K Aalfs, Yoshito Kishi, Bruce A Littlefield, Melvin J Yu. Macrocyclic ketone analogues of halichondrin B. Bioorganic & medicinal chemistry letters. 2004 Nov; 14(22):5551-4. doi: 10.1016/j.bmcl.2004.08.069. [PMID: 15482922]
  • R Bai, Z A Cichacz, C L Herald, G R Pettit, E Hamel. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Molecular pharmacology. 1993 Oct; 44(4):757-66. doi: . [PMID: 8232226]