Gypenoside LXXV (BioDeep_00000001023)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(beta,12beta)-3,12-dihydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside

化学式: C42H72O13 (784.4972662)
中文名称: 绞股蓝皂苷LXXV
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 97.3%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)O)O)C
InChI: InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,55-37-35(51)33(49)31(47)25(54-37)20-52-36-34(50)32(48)30(46)24(19-43)53-36)22-11-16-41(7)29(22)23(44)18-27-39(5)15-13-28(45)38(3,4)26(39)12-17-40(27,41)6/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36+,37-,39-,40+,41+,42-/m0/s1

描述信息

Gypenoside LXXV is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite. It is a 12beta-hydroxy steroid, a beta-D-glucoside, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid, a 3beta-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Gypenoside LXXV is a natural product found in Gynostemma pentaphyllum with data available.
A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.

同义名列表

4 个代谢物同义名

(beta,12beta)-3,12-dihydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; Ginsenoside LXXV; Gypenoside LXXV; Gypenoside LXXV; Ginsenoside LXXV



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiangbao Meng, Yuan Zhang, Zongyang Li, Guoxu Ma, Xiejun Zhang, Di Zhang, Weiwei Cao, Sicen Wang, Qian Cai, Ping Cui, Guodong Huang. Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease. Phytotherapy research : PTR. 2023 Feb; 37(2):611-626. doi: 10.1002/ptr.7639. [PMID: 36325883]
  • Wei Li, Xinlong Wu, Mengfan Wu, Jiaxin Yin, Hui Ding, Tong Wu, Songtao Bie, Fangyi Li, Yongzhi He, Lifeng Han, Wenzhi Yang, Xinbo Song, Heshui Yu, Zheng Li. Ultrahigh-performance liquid chromatography coupled to ion mobility quadrupole time-of-flight mass spectrometry profiling and unveiling the transformation of ginsenosides by the dual conditions of citric acid and high-pressure steaming. Rapid communications in mass spectrometry : RCM. 2022 Oct; 36(20):e9363. doi: 10.1002/rcm.9363. [PMID: 35902380]
  • Zhouqian Jiang, Haiyun Gao, Rong Liu, Meng Xia, Yun Lu, Jiadian Wang, Xiaochao Chen, Yifeng Zhang, Dan Li, Yuru Tong, Panting Liu, Yuan Liu, Yunfeng Luo, Jie Gao, Yan Yin, Luqi Huang, Wei Gao. Key Glycosyltransferase Genes of Panax notoginseng: Identification and Engineering Yeast Construction of Rare Ginsenosides. ACS synthetic biology. 2022 07; 11(7):2394-2404. doi: 10.1021/acssynbio.2c00094. [PMID: 35687875]
  • Xiangbao Meng, Yuan Zhang, Zongyang Li, Jinxian Hu, Di Zhang, Weiwei Cao, Min Li, Guoxu Ma, Sicen Wang, Ping Cui, Qian Cai, Guodong Huang. A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice. Phytotherapy research : PTR. 2022 Apr; 36(4):1770-1784. doi: 10.1002/ptr.7413. [PMID: 35192202]
  • Jin Ha Lee, Ji Young Oh, Soo Hyun Kim, In Jeong Oh, Yong-Ho Lee, Keun Woo Lee, Woong Hee Lee, Jeong-Hwan Kim. Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH). Biomolecules. 2020 10; 10(10):. doi: 10.3390/biom10101426. [PMID: 33050067]
  • Sungjoo Park, Eunsu Ko, Jun Hyoung Lee, Yoseb Song, Chang-Hao Cui, Jingang Hou, Byeong Min Jeon, Hun Sik Kim, Sun Chang Kim. Gypenoside LXXV Promotes Cutaneous Wound Healing In Vivo by Enhancing Connective Tissue Growth Factor Levels Via the Glucocorticoid Receptor Pathway. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081595. [PMID: 31018484]