Diazepam (BioDeep_00000001458)

 

Secondary id: BioDeep_00000405800

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

化学式: C16H13ClN2O (284.0716)
中文名称: 地西泮
谱图信息: 最多检出来源 Homo sapiens(blood) 41.85%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Diazepam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/diazepam (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001458). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI: InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

描述信息

Diazepam is a benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589).
Diazepam, first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine derivative drug. It is commonly used for treating anxiety, insomnia, seizures including status epilepticus, muscle spasms (such as in cases of tetanus), restless legs syndrome, alcohol withdrawal, benzodiazepine withdrawal and Ménières disease. Diazepam is found in potato and common wheat.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2626
CONFIDENCE standard compound; INTERNAL_ID 4084
CONFIDENCE standard compound; INTERNAL_ID 1608
CONFIDENCE standard compound; INTERNAL_ID 8560

同义名列表

15 个代谢物同义名

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; Methyl diazepinone; Methyldiazepinone; Diazemuls; Stesolid; diazepam; Relanium; Faustan; Diastat; Seduxen; Apaurin; Sibazon; Valium; Diazepam



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BDNF, CA1, CAT, CNR1, CYP2C9, POMC
Peripheral membrane protein 2 ACHE, CYP1B1
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 3 CYP1A2, CYP1B1, CYP2C9
Nucleus 2 ACHE, FOS
cytosol 4 CA1, CAT, CLCN5, FOS
dendrite 2 BDNF, HTR1A
nucleoplasm 1 FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 ACHE, CLCN5, CNR1, HTR1A, OPRD1
Cell projection, axon 1 CNR1
Multi-pass membrane protein 5 CACNA1I, CLCN5, CNR1, HTR1A, OPRD1
Golgi apparatus membrane 1 CLCN5
Synapse 3 ACHE, CRH, HTR1A
cell surface 1 ACHE
glutamatergic synapse 1 CNR1
Golgi apparatus 2 ACHE, CLCN5
Golgi membrane 2 CLCN5, INS
growth cone 1 CNR1
lysosomal membrane 1 CLCN5
neuromuscular junction 1 ACHE
presynaptic membrane 2 CNR1, OPRD1
synaptic vesicle 2 BDNF, CLCN5
Presynapse 1 CNR1
plasma membrane 8 ACHE, BCHE, CACNA1I, CLCN5, CNR1, CYP2C9, HTR1A, OPRD1
synaptic vesicle membrane 1 OPRD1
Membrane 7 ACHE, BDNF, CACNA1I, CAT, CLCN5, CYP1B1, OPRD1
axon 3 BDNF, CCK, CNR1
extracellular exosome 2 CA1, CAT
endoplasmic reticulum 1 FOS
extracellular space 8 ACHE, BCHE, BDNF, CCK, CRH, IL6, INS, POMC
perinuclear region of cytoplasm 2 ACHE, BDNF
mitochondrion 3 ABAT, CAT, CYP1B1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 4 CAT, CYP1A2, CYP1B1, CYP2C9
Microsome membrane 3 CYP1A2, CYP1B1, CYP2C9
Secreted 8 ACHE, BCHE, BDNF, CCK, CRH, IL6, INS, POMC
extracellular region 9 ACHE, BCHE, BDNF, CAT, CCK, CRH, IL6, INS, POMC
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
mitochondrial matrix 2 ABAT, CAT
Extracellular side 1 ACHE
varicosity 1 CRH
actin cytoskeleton 1 CNR1
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
Membrane raft 1 CNR1
focal adhesion 1 CAT
GABA-ergic synapse 1 CNR1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 POMC
neuron projection 1 OPRD1
chromatin 1 FOS
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Cell projection, dendrite 1 HTR1A
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, BDNF, IL6, INS
nuclear matrix 1 FOS
axon terminus 1 OPRD1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
protein-DNA complex 1 FOS
dendrite membrane 1 OPRD1
transcription factor AP-1 complex 1 FOS
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
spine apparatus 1 OPRD1
4-aminobutyrate transaminase complex 1 ABAT


文献列表

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