Cholesteryl oleate (BioDeep_00001871849)

Main id: BioDeep_00000004106

 

PANOMIX_OTCML-2023 natural product BioNovoGene_Lab2019


代谢物信息卡片


Cholesteryl cis-9-octadecenoate

化学式: C45H78O2 (650.6001)
中文名称: 胆固醇油酸酯, 胆甾醇油酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
InChI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1

描述信息

The (Z)-stereoisomer of cholesteryl octadec-9-enoate.
Cholesteryl oleate is an esterified form of Cholesterol. Cholesteryl oleate can be used in the generation of solid lipid nanoparticle (SLN, a nanoparticle-based method for gene therapy)[1][2].

同义名列表

4 个代谢物同义名

Cholesteryl cis-9-octadecenoate; Cholest-5-en-3-beta-yl oleate; Cholesteryl oleate; Cholesteryl oleate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, APOB, APOE, CEL, PRKX
Peripheral membrane protein 1 LPL
Endosome membrane 2 APOB, LDLR
Endoplasmic reticulum membrane 6 ABCA1, ACAT1, APOB, SLN, SOAT1, SOAT2
Nucleus 3 ALB, APOE, PRKX
cytosol 5 ALB, APOA1, APOB, LIPA, LIPE
dendrite 1 APOE
phagocytic vesicle 1 ABCA1
centrosome 1 ALB
nucleoplasm 2 LIPA, PRKX
Cell membrane 4 ABCA1, LDLR, LIPE, LPL
Multi-pass membrane protein 4 ABCA1, ACAT1, SOAT1, SOAT2
cell surface 2 LDLR, LPL
glutamatergic synapse 1 APOE
Golgi apparatus 4 ABCA1, ALB, APOE, LDLR
Golgi membrane 1 INS
neuronal cell body 2 APOB, APOE
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 1 LIPE
Lysosome 2 LDLR, LIPA
endosome 1 ABCA1
plasma membrane 6 ABCA1, APOA1, APOB, APOE, LDLR, LPL
Membrane 9 ABCA1, ACAT1, APOE, LCAT, LDLR, LIPE, SLN, SOAT1, SOAT2
basolateral plasma membrane 2 ABCA1, LDLR
brush border 1 SOAT2
caveola 1 LIPE
extracellular exosome 9 ACAT1, ALB, APOA1, APOB, APOC3, APOE, CEL, CETP, LCAT
endoplasmic reticulum 5 ACAT1, ALB, APOE, SOAT1, SOAT2
extracellular space 11 ALB, APOA1, APOB, APOC3, APOE, CEL, CETP, INS, LCAT, LPL, PNLIP
lysosomal lumen 2 APOB, LIPA
perinuclear region of cytoplasm 1 ABCA1
mitochondrion 1 ACAT1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 ABCA1, APOB, LIPA
Single-pass type I membrane protein 1 LDLR
Secreted 11 ALB, APOA1, APOB, APOC3, APOE, CEL, CETP, INS, LCAT, LPL, PNLIP
extracellular region 11 ALB, APOA1, APOB, APOC3, APOE, CEL, CETP, INS, LCAT, LPL, PNLIP
Single-pass membrane protein 2 LDLR, SLN
mitochondrial matrix 1 ACAT1
Extracellular side 1 LPL
anchoring junction 1 ALB
external side of plasma membrane 2 ABCA1, LDLR
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOA1, APOE
Secreted, extracellular space, extracellular matrix 2 APOE, LPL
chylomicron 5 APOA1, APOB, APOC3, APOE, LPL
high-density lipoprotein particle 4 APOA1, APOE, CETP, LCAT
low-density lipoprotein particle 4 APOA1, APOB, APOE, LDLR
multivesicular body 1 APOE
very-low-density lipoprotein particle 5 APOA1, APOB, APOC3, APOE, LPL
cytoplasmic vesicle 1 APOA1
Early endosome 5 APOA1, APOB, APOC3, APOE, LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
vesicle 1 CETP
Membrane raft 1 ABCA1
extracellular matrix 1 APOE
intracellular vesicle 1 ABCA1
sarcoplasmic reticulum 1 SLN
collagen-containing extracellular matrix 3 APOA1, APOC3, APOE
Late endosome 1 LDLR
receptor complex 1 LDLR
ciliary basal body 1 ALB
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 3 ALB, APOA1, APOE
fibrillar center 1 LIPA
Endomembrane system 1 LDLR
endosome lumen 2 APOB, INS
sorting endosome 1 LDLR
Lipid droplet 2 APOB, LIPE
Membrane, caveola 1 LIPE
Melanosome 1 APOE
secretory granule lumen 2 APOA1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, APOA1, APOB, APOE, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle 2 ABCA1, APOA1
transport vesicle 1 INS
Sarcoplasmic reticulum membrane 1 SLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 3 APOB, APOE, LDLR
synaptic cleft 1 APOE
endolysosome membrane 1 LDLR
somatodendritic compartment 1 LDLR
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 2 APOA1, APOC3
endocytic vesicle lumen 3 APOA1, APOB, APOE
PCSK9-LDLR complex 1 LDLR
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 3 APOB, APOC3, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mature chylomicron 1 APOB
catalytic complex 1 LPL
ciliary transition fiber 1 ALB


文献列表

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  • María J Limeres, Marc Suñé-Pou, Silvia Prieto-Sánchez, Cristina Moreno-Castro, Alejandro D Nusblat, Cristina Hernández-Munain, Guillermo R Castro, Carlos Suñé, Josep M Suñé-Negre, María L Cuestas. Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system. Colloids and surfaces. B, Biointerfaces. 2019 Dec; 184(?):110533. doi: 10.1016/j.colsurfb.2019.110533. [PMID: 31593829]
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  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
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