proparacaine (BioDeep_00001868253)
Main id: BioDeep_00000006492
代谢物信息卡片
proxymetacaine
化学式: C16H26N2O3 (294.1943)
中文名称: 丙美卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N
InChI: InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:8485
- KEGG: C07383
- KEGGdrug: D08448
- PubChem: 4935
- DrugBank: DB00807
- ChEMBL: CHEMBL1196
- CAS: 499-67-2
- PubChem: 9587
- NIKKAJI: J6.177H
- RefMet: Proparacaine
- KNApSAcK: 8485
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Qian Wen, Tingjun Fan, Suran Bai, Yunlong Sui. Cytotoxicity of proparacaine to human corneal endothelial cells in vitro.
The Journal of toxicological sciences.
2015 Aug; 40(4):427-36. doi:
10.2131/jts.40.427. [PMID: 26165639] - Ying-Lien Chen, Jay H Konieczka, Deborah J Springer, Samantha E Bowen, Jing Zhang, Fitz Gerald S Silao, Alice Alma C Bungay, Ursela G Bigol, Marilou G Nicolas, Soman N Abraham, Dawn A Thompson, Aviv Regev, Joseph Heitman. Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata.
G3 (Bethesda, Md.).
2012 Jun; 2(6):675-91. doi:
10.1534/g3.112.002279. [PMID: 22690377] - Rong Tong, Houman D Hemmati, Robert Langer, Daniel S Kohane. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery.
Journal of the American Chemical Society.
2012 May; 134(21):8848-55. doi:
10.1021/ja211888a. [PMID: 22385538] - Hui Chen, Julie-Thu A Tran, Robert E Anderson, Md Nawajes A Mandal. Caffeic acid phenethyl ester protects 661W cells from H2O2-mediated cell death and enhances electroretinography response in dim-reared albino rats.
Molecular vision.
2012; 18(?):1325-38. doi:
. [PMID: 22690111] - Galina Dvoriantchikova, Dmitry Ivanov, David Barakat, Alexander Grinberg, Rong Wen, Vladlen Z Slepak, Valery I Shestopalov. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.
PloS one.
2012; 7(2):e31991. doi:
10.1371/journal.pone.0031991. [PMID: 22384122] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Swakshyar Saumya Pal, Rajiv Raman, Suganeswari Ganesan, Chinmaya Sahu, Tarun Sharma. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN--DREAMS III): study design and research methodology.
BMC ophthalmology.
2011 Mar; 11(?):7. doi:
10.1186/1471-2415-11-7. [PMID: 21435202] - Jeffrey J Dunmire, Rachida Bouhenni, Michael L Hart, Bassam T Wakim, Anthony M Chomyk, Sarah E Scott, Hiroshi Nakamura, Deepak P Edward. Novel serum proteomic signatures in a non-human primate model of retinal injury.
Molecular vision.
2011 Mar; 17(?):779-91. doi:
NULL. [PMID: 21527995] - Arundhati Anshu, Marianne O Price, Matthew R Richardson, Zaneer M Segu, Xianyin Lai, Mervin C Yoder, Francis W Price. Alterations in the aqueous humor proteome in patients with a glaucoma shunt device.
Molecular vision.
2011; 17(?):1891-900. doi:
NULL. [PMID: 21850163] - Ling Zou, Ashwin Nair, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang. Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants.
PloS one.
2011; 6(12):e28720. doi:
10.1371/journal.pone.0028720. [PMID: 22194895] - Nicolás Belforte, Pablo H Sande, Nuria de Zavalía, Diego C Fernandez, Dafne M Silberman, Mónica S Chianelli, Ruth E Rosenstein. Ischemic tolerance protects the rat retina from glaucomatous damage.
PloS one.
2011; 6(8):e23763. doi:
10.1371/journal.pone.0023763. [PMID: 21887313] - Feng Li, Lea D Marchette, Richard S Brush, Michael H Elliott, Kimberly R Davis, Ashley G Anderson, Robert E Anderson. High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice.
Molecular vision.
2010 Aug; 16(?):1669-79. doi:
NULL. [PMID: 20806040] - Federico Luengo Gimeno, Victoria Lavigne, Silvia Gatto, J Oscar Croxatto, Laura Correa, Juan E Gallo. One-year follow-up of epithelial corneal cell sheet allografts mounted on platelet poor plasma in rabbits.
Molecular vision.
2009 Dec; 15(?):2771-9. doi:
NULL. [PMID: 20019875] - Yu-Chih Hou, I-Jong Wang, Fung-Rong Hu. Ring keratitis associated with topical abuse of a dilute anesthetic after refractive surgery.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2009 Dec; 108(12):967-72. doi:
10.1016/s0929-6646(10)60011-3. [PMID: 20040463] - Feng Li, Lea D Marchette, Richard S Brush, Michael H Elliott, Yun-Zheng Le, Kimberly A Henry, Ashley G Anderson, Chao Zhao, Xufang Sun, Kang Zhang, Robert E Anderson. DHA does not protect ELOVL4 transgenic mice from retinal degeneration.
Molecular vision.
2009 Jun; 15(?):1185-93. doi:
NULL. [PMID: 19536303] - Mario Suwalsky, Carlos Schneider, Beryl Norris, Fernando Villena, Hernán Cárdenas, Francisco Cuevas, Carlos P Sotomayor. The local anesthetic proparacaine modifies sodium transport in toad skin and perturbs the structures of model and cell membranes.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2002 Sep; 57(9-10):930-8. doi:
10.1515/znc-2002-9-1029. [PMID: 12440736] - T M Zollman, R M Bragg, D A Harrison. Clinical effects of oleoresin capsicum (pepper spray) on the human cornea and conjunctiva.
Ophthalmology.
2000 Dec; 107(12):2186-9. doi:
10.1016/s0161-6420(00)00463-2. [PMID: 11097593] - R L Grant, D Acosta. Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells.
Experimental eye research.
1994 Apr; 58(4):469-78. doi:
10.1006/exer.1994.1040. [PMID: 7925683] - A H Krauss, D F Woodward. An atypical vasopermeability response to leukotrienes in the iris-ciliary body.
Prostaglandins.
1991 Jun; 41(6):559-70. doi:
10.1016/0090-6980(91)90061-j. [PMID: 1647045] - P E Hopper, C J Murphy, E C Feldman, R W Nelson, G D Bottoms, C E Franti. Serum glucose and insulin responses to an insulin-containing ophthalmic solution administered topically in clinically normal cats.
American journal of veterinary research.
1991 Jun; 52(6):903-7. doi:
NULL. [PMID: 1883093] - F Gusovsky, Y Nishizawa, W Padgett, E T McNeal, K Rice, C H Kim, C R Creveling, J W Daly. Voltage-dependent sodium channels in synaptoneurosomes: studies with 22Na+ influx and [3H]saxitoxin and [3H]batrachotoxinin-A 20-alpha-benzoate binding. Effects of proparacaine isothiocyanate.
Brain research.
1990 Jun; 518(1-2):101-6. doi:
10.1016/0006-8993(90)90959-f. [PMID: 1697206] - H Brewitt, E Bonatz, H Honegger. Morphological changes of the corneal epithelium after application of topical anaesthetic ointments.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.
1980; 180(4):198-206. doi:
10.1159/000308974. [PMID: 7443191]
