iodoquinol (BioDeep_00001867835)
Main id: BioDeep_00000003901
代谢物信息卡片
Diiodohydroxyquinoline
化学式: C9H5I2NO (396.8461)
中文名称: 双碘喹啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C(=C(C=C2I)I)O)N=C1
InChI: InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
描述信息
G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AC - Quinoline derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
3 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:5950
- KEGG: C07636
- KEGGdrug: D00581
- PubChem: 3728
- DrugBank: DB09115
- ChEMBL: CHEMBL86754
- MeSH: Iodoquinol
- CAS: 83-73-8
- PubChem: 9838
- NIKKAJI: J4.643D
- RefMet: Iodoquinol
- KNApSAcK: 5950
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Shuofeng Yuan, Jasper F W Chan, Kenn K H Chik, Chris C Y Chan, Jessica O L Tsang, Ronghui Liang, Jianli Cao, Kaiming Tang, Lin-Lei Chen, Kun Wen, Jian-Piao Cai, Zi-Wei Ye, Gang Lu, Hin Chu, Dong-Yan Jin, Kwok-Yung Yuen. Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system.
Pharmacological research.
2020 09; 159(?):104960. doi:
10.1016/j.phrs.2020.104960. [PMID: 32473310] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Akihiro Yamamoto, Maame Debrah-Pinamang, Nicholas J DiModica, Katsuhisa Kurogi, Ali A Naqvi, Ying Hui, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Identification and Characterization of the Human Cytosolic Sulfotransferases Mediating the Sulfation of Clioquinol and Iodoquinol.
Drug metabolism letters.
2016; 10(3):200-205. doi:
10.2174/1872312810666160719142850. [PMID: 27449410] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - G R Banik, J L N Barratt, D Marriott, J Harkness, J T Ellis, D Stark. A case-controlled study of Dientamoeba fragilis infections in children.
Parasitology.
2011 Jun; 138(7):819-23. doi:
10.1017/s0031182011000448. [PMID: 21524324] - Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Robert A Cherny, Colin L Masters, Simon C Drew, Andrew F Hill, Qiao-Xin Li, Peter J Crouch, Kevin J Barnham, Anthony R White. Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.
The Biochemical journal.
2007 Nov; 407(3):435-50. doi:
10.1042/bj20070579. [PMID: 17680773] - Shih-Bin Su, How-Ran Guo, Yin-Ching Chuang, Kow-Ton Chen, Ching-Yih Lin. Eradication of amebiasis in a large institution for adults with mental retardation in Taiwan.
Infection control and hospital epidemiology.
2007 Jun; 28(6):679-83. doi:
10.1086/518351. [PMID: 17520540] - You Jeong Kim, Mi-Yeon Kim, Hyung Ok Kim, Myung Duck Lee, Young Min Park. Acrodermatitis enteropathica-like eruption associated with combined nutritional deficiency.
Journal of Korean medical science.
2005 Oct; 20(5):908-11. doi:
10.3346/jkms.2005.20.5.908. [PMID: 16224175] - R Paniagua, R Claure, D Amato, E Flores, A Pérez, E Exaire. Effects of oral administration of zinc and diiodohydroxyquinolein on plasma zinc levels of uremic patients.
Nephron.
1995; 69(2):147-50. doi:
10.1159/000188430. [PMID: 7723896] - J C Samuelson, A Burke, J M Courval. Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockers.
Antimicrobial agents and chemotherapy.
1992 Nov; 36(11):2392-7. doi:
10.1128/aac.36.11.2392. [PMID: 1283295] - I Grossman, L M Weiss, D Simon, H B Tanowitz, M Wittner. Blastocystis hominis in hospital employees.
The American journal of gastroenterology.
1992 Jun; 87(6):729-32. doi:
. [PMID: 1590309] - C Moschopoulos, A Van Gossum, E Serruys, F Rickaert, M Adler. [Endoscopic diagnosis of a cecal ameboma successfully treated with antibiotic therapy].
Acta gastro-enterologica Belgica.
1987 Nov; 50(6):685-8. doi:
NULL. [PMID: 2902725] - V Millet, M J Spencer, M Chapin, M Stewart, J A Yatabe, T Brewer, L S Garcia. Dientamoeba fragilis, a protozoan parasite in adult members of a semicommunal group.
Digestive diseases and sciences.
1983 Apr; 28(4):335-9. doi:
10.1007/bf01324950. [PMID: 6403320] - M J Spencer, M R Chapin, L S Garcia. Dientamoeba fragilis: a gastrointestinal protozoan infection in adults.
The American journal of gastroenterology.
1982 Aug; 77(8):565-9. doi:
NULL. [PMID: 6808829] - O Araya, A Berríos, V Leyán, R Franjola. Chilomastix as a probable cause of enteritis in two horses.
The Veterinary record.
1981 Nov; 109(22):494. doi:
10.1136/vr.109.22.494. [PMID: 6798752] - K M Hambidge, P A Walravens, K H Neldner. The role of zinc in the pathogenesis and treatment of acrodermatitis enteropathica.
Progress in clinical and biological research.
1977; 14(?):329-42. doi:
". [PMID: 343115] - S I Soliman, M Hafez, A Ibrahim, N A Shaaban, T A Hafez, S W Mehareb. Clinical, biochemical and histochemical studies on infants with Acrodermatitis enteropathica chronica.
The Gazette of the Egyptian Paediatric Association.
1976 Jul; 24(3-4):217-35. doi:
. [PMID: 829655] - F S Hirsh, B Michel, W H Strain. Gluconate zinc in acrodermatitis enteropathica.
Archives of dermatology.
1976 Apr; 112(4):475-8. doi:
NULL. [PMID: 773310] - K H Neldner, K M Hambidge. Zinc therapy of acrodermatitis enteropathica.
The New England journal of medicine.
1975 Apr; 292(17):879-82. doi:
10.1056/nejm197504242921702. [PMID: 1090826] - S T Donta. Changing concepts of infectious diarrheas.
Geriatrics.
1975 Mar; 30(3):123-6. doi:
NULL. [PMID: 1090482] - . Blindness and neuropathy from diiodohydroxyquin-like drugs. Committee on drugs.
Pediatrics.
1974 Sep; 54(3):378-9. doi:
. [PMID: 4278011] - A F Robertson, G S Schuerger, R R Brown, W B Karp. Tryptophan metabolism in acrodermatitis enteropathica.
The Journal of pediatrics.
1973 Dec; 83(6):1012-6. doi:
10.1016/s0022-3476(73)80537-2. [PMID: 4585826] - F Pittman, M Westphal. S.M.O.N. and inflammation of the colon.
Lancet (London, England).
1973 Sep; 2(7828):566-7. doi:
10.1016/s0140-6736(73)92388-x. [PMID: 4125330] - I M Braverman, I Cohen, E O'Keefe. Metabolic and ultrastructural studies in a patient with pustular psoriasis (von Zumbusch).
Archives of dermatology.
1972 Feb; 105(2):189-96. doi:
NULL. [PMID: 4334267] - K Berg, N Danbolt, A Espedal, O Royneland, E Wollebaek. Presence of -lipoprotein in serum of patients treated for acrodermatitis enteropathica (Danbolt's disease).
Clinical genetics.
1972; 3(5):401-3. doi:
10.1111/j.1399-0004.1972.tb01474.x. [PMID: 4343518] - B Rukmono, S A Naumar, R W Talogo. Infantile diarrhoea in a population of low socio-economic group.
The Southeast Asian journal of tropical medicine and public health.
1971 Jun; 2(2):249-55. doi:
NULL. [PMID: 4332826] - A Martuscelli, M Villa Michel. [Acute intestinal amebiasis in infants].
Revista de investigacion en salud publica.
1969 Jul; 29(3):197-218. doi:
NULL. [PMID: 4314865] - G K Wharton, M Biddle. Clinical evaluation of an intradermal skin test for amebiasis.
The American journal of gastroenterology.
1967 Sep; 48(3):233-43. doi:
NULL. [PMID: 4295033] - A F Robertson, J Putz. Serum and erythrocyte fatty acids in a case of acrodermatitis enteropathica.
The Journal of pediatrics.
1967 Feb; 70(2):279-81. doi:
10.1016/s0022-3476(67)80425-6. [PMID: 5334980] - R E KING, D L PRAEGER, J W HALLETT. AMEBIC CHOROIDOSIS.
Archives of ophthalmology (Chicago, Ill. : 1960).
1964 Jul; 72(?):16-22. doi:
10.1001/archopht.1964.00970020018005. [PMID: 14149739] - R P LEVY, J W DURKIN. The effect of diiodohydroxyquin (floraquin) vaginal suppositories on the level of serum protein-bound iodine.
The Journal of clinical endocrinology and metabolism.
1958 Apr; 18(4):417-9. doi:
10.1210/jcem-18-4-417. [PMID: 13513741] - D GIVNER. Renal displacement and pyelographic deformity produced by amebic infection of the liver.
The Journal of urology.
1954 Jan; 71(1):32-4. doi:
10.1016/s0022-5347(17)67753-x. [PMID: 13131437] - W T HASKINS, G W LUTTERMOSER. Urinary excretions of vioform and diodoquin in rabbits.
The Journal of pharmacology and experimental therapeutics.
1953 Oct; 109(2):201-5. doi:
NULL. [PMID: 13097352]
