U-4224 (BioDeep_00000866930)

Main id: BioDeep_00000003143

 


代谢物信息卡片


N,N-Dimethylformamide [UN2265] [Flammable liquid]

化学式: C3H7NO (73.0528)
中文名称: 甲酰胺,N,N-二甲基, N,N-二甲基甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C=O
InChI: InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3



数据库引用编号

12 个数据库交叉引用编号

分类词条

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, AXIN2, CAT, CYP2E1, DNAH5, HPGDS, NFE2L2
Golgi apparatus, trans-Golgi network membrane 1 AP4M1
Peripheral membrane protein 3 AP4M1, CYP2E1, SORD
Endoplasmic reticulum membrane 2 CYP2E1, HMOX1
Mitochondrion membrane 1 SORD
Nucleus 4 ALB, AXIN2, HMOX1, NFE2L2
cytosol 10 ALB, AP4M1, AXIN2, CAT, GPT, HMOX1, HPGDS, LIPE, NFE2L2, SORD
mitochondrial membrane 1 SORD
trans-Golgi network 1 AP4M1
centrosome 3 ALB, AXIN2, NFE2L2
nucleoplasm 4 CD2, HMOX1, HPGDS, NFE2L2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 CD2, LIPE, SLC38A5
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 1 SLC38A5
cell surface 1 CD2
Golgi apparatus 4 ALB, AP4M1, CD2, NFE2L2
Golgi membrane 1 INS
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 CYP2E1
Cytoplasm, cytosol 2 LIPE, NFE2L2
plasma membrane 6 AXIN2, BTC, CD2, EGF, NFE2L2, SLC38A5
Membrane 7 BTC, CAT, EGF, HMOX1, LIPE, SLC38A5, SORD
axon 1 CCK
caveola 1 LIPE
extracellular exosome 7 ALB, AP4M1, CAT, EGF, GPT, LYZ, SORD
endoplasmic reticulum 2 ALB, HMOX1
extracellular space 8 ALB, BTC, CCK, EGF, HMOX1, INS, LYZ, SORD
perinuclear region of cytoplasm 1 HMOX1
mitochondrion 1 CAT
protein-containing complex 3 ALB, CAT, CD2
intracellular membrane-bounded organelle 3 CAT, CYP2E1, HPGDS
Microsome membrane 1 CYP2E1
Single-pass type I membrane protein 1 CD2
Secreted 3 ALB, CCK, INS
extracellular region 9 ALB, BTC, CAT, CCK, CD2, DNAH5, EGF, INS, LYZ
cytoplasmic side of plasma membrane 1 CD2
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
motile cilium 2 DNAH5, SORD
external side of plasma membrane 1 CD2
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 AP4M1
clathrin adaptor complex 1 AP4M1
Early endosome 1 AP4M1
cell-cell junction 1 CD2
Mitochondrion inner membrane 1 CYP2E1
focal adhesion 1 CAT
microtubule 2 DNAH5, DNAH6
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
axoneme 2 DNAH5, DNAH6
ciliary basal body 1 ALB
chromatin 1 NFE2L2
mediator complex 1 NFE2L2
centriole 1 ALB
Golgi apparatus, trans-Golgi network 1 AP4M1
spindle pole 1 ALB
blood microparticle 1 ALB
Cytoplasm, cytoskeleton, cilium axoneme 2 DNAH5, DNAH6
Cell projection, cilium, flagellum 1 SORD
Endomembrane system 1 AP4M1
endosome lumen 2 AP4M1, INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
AP-4 adaptor complex 1 AP4M1
trans-Golgi network membrane 1 AP4M1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 2 ALB, EGF
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
9+2 motile cilium 2 DNAH5, DNAH6
dynein complex 2 DNAH5, DNAH6
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 2 BTC, EGF
protein-DNA complex 1 NFE2L2
catalase complex 1 CAT
ciliary transition fiber 1 ALB
outer dynein arm 1 DNAH5
9+0 motile cilium 1 DNAH5


文献列表

  • Zhuo Zhang, Guizhou Hao, Xuemei Sun, Feibo Wang, Dengbo Zhang, Dedong Hu. PVP/aprepitant microcapsules produced by supercritical antisolvent process. Scientific reports. 2024 05; 14(1):10679. doi: 10.1038/s41598-024-60323-z. [PMID: 38724534]
  • Xuan Gao, Longhui Xu, Tao Zhong, Xinxin Song, Hong Zhang, Xiaohui Liu, Yongbin Jiang. The proliferation of antibiotic resistance genes (ARGs) and microbial communities in industrial wastewater treatment plant treating N,N-dimethylformamide (DMF) by AAO process. PloS one. 2024; 19(4):e0299740. doi: 10.1371/journal.pone.0299740. [PMID: 38598457]
  • Shiwangi Maurya, Chetan Kumar Arya, Nidhi Parmar, Nitish Sathyanarayanan, Chaitanya G Joshi, Gurunath Ramanathan. Genomic profiling and characteristics of a C1 degrading heterotrophic fresh-water bacterium Paracoccus sp. strain DMF. Archives of microbiology. 2023 Nov; 206(1):6. doi: 10.1007/s00203-023-03729-z. [PMID: 38015256]
  • Yoichi Otsuka, Nijiho Ote, Mengze Sun, Shuichi Shimma, Osamu Urakawa, Shinichi Yamaguchi, Tomoya Kudo, Michisato Toyoda. Solvent effects of N,N-dimethylformamide and methanol on mass spectrometry imaging by tapping-mode scanning probe electrospray ionization. The Analyst. 2023 Feb; ?(?):. doi: 10.1039/d2an01953a. [PMID: 36810589]
  • Kartik Dhar, Logeshwaran Panneerselvan, Kadiyala Venkateswarlu, Mallavarapu Megharaj. Efficient bioremediation of PAHs-contaminated soils by a methylotrophic enrichment culture. Biodegradation. 2022 12; 33(6):575-591. doi: 10.1007/s10532-022-09996-9. [PMID: 35976498]
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  • Aloke Purkait, Debasish Rana, Argha Banerjee, Dipak Kumar Hazra, Pabitra Kumar Biswas, Ramen Kumar Kole. Selection of green carrier solvent for the effective creation of bio-inspired liquid formulation and anti-fungal potency evaluation. Archives of microbiology. 2022 Oct; 204(11):669. doi: 10.1007/s00203-022-03280-3. [PMID: 36224280]
  • Maryna Stasevych, Viktor Zvarych, Olena Yaremkevych, Mykhaylo Vovk, Alla Vaskevych, Tetiana Halenova, Olexii Savchuk. N-(9,10-Dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) Acetamides: Synthesis, Antioxidant and Antiplatelet Activity. Acta chimica Slovenica. 2022 Sep; 69(3):584-595. doi: 10.17344/acsi.2022.7463. [PMID: 36196813]
  • Hong Liu, Ming-Jun Li, Xiu-Ning Zhang, Shuo Wang, Long-Xia Li, Fang-Fang Guo, Tao Zeng. N,N-dimethylformamide-induced acute liver damage is driven by the activation of NLRP3 inflammasome in liver macrophages of mice. Ecotoxicology and environmental safety. 2022 Jun; 238(?):113609. doi: 10.1016/j.ecoenv.2022.113609. [PMID: 35551047]
  • Thalles C M Moura, Lúcia C P Arruda, Robespierre A J Araújo Silva, Raquel P F Silva, Aline S Oliveira, Lucas F M Tobal, André M Batista, Gustavo F Carneiro, Maria M P Guerra. Diluent Containing Dimethylformamide Added With Sucrose Improves In Vitro Quality After Freezing/Thawing Stallion Sperm. Journal of equine veterinary science. 2022 02; 109(?):103825. doi: 10.1016/j.jevs.2021.103825. [PMID: 34843891]
  • Hannah L Wapshott-Stehli, Amy M Grunden. Temperature and solvent exposure response of three fatty acid peroxygenase enzymes for application in industrial enzyme processes. Biochemical and biophysical research communications. 2021 09; 571(?):60-65. doi: 10.1016/j.bbrc.2021.07.052. [PMID: 34303964]
  • Dhulfiqar Ali Abed, Sumi Lee, Xia Wen, Ahmed R Ali, Vaibhav Mangipudy, Lauren M Aleksunes, Longqin Hu. Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation. Bioorganic & medicinal chemistry. 2021 08; 44(?):116300. doi: 10.1016/j.bmc.2021.116300. [PMID: 34252790]
  • Wenjiao Sang, Longjie Mei, Cheng Zhan, Qian Zhang, Xi Jin, Shaohui Zhang, Shiyang Zhang, Cuihua Li, Min Li. Removal of N,N-dimethylformamide by dielectric barrier discharge plasma combine with manganese activated carbon. Environmental science and pollution research international. 2021 Aug; 28(31):41698-41711. doi: 10.1007/s11356-021-13729-5. [PMID: 33786771]
  • Brandon M Kenwood, Pritha Bagchi, Luyu Zhang, Wanzhe Zhu, David M Chambers, Benjamin C Blount, Víctor R De Jesús. Characterization of US population levels of urinary methylcarbamoyl mercapturic acid, a metabolite of N,N-dimethylformamide and methyl isocyanate, in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2011-2016. Environmental science and pollution research international. 2021 Apr; 28(13):16781-16791. doi: 10.1007/s11356-020-12135-7. [PMID: 33398732]
  • Bo Zhao, Norihide Nakada. Contribution of N,N-dimethylformamide to formation of N-nitrosodimethylamine by chloramination in sewage treatment plants and receiving rivers. Water research. 2021 Mar; 191(?):116827. doi: 10.1016/j.watres.2021.116827. [PMID: 33476799]
  • Lin Xu, Qianwen Zhao, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Yufei Hou, Meiyao Feng, Ying Wang, Jing Chen, Jinquan Zhao, Yuxin Zheng, Dianke Yu. Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity. Ecotoxicology and environmental safety. 2020 Dec; 205(?):111166. doi: 10.1016/j.ecoenv.2020.111166. [PMID: 32827966]
  • Lin Pan, Peng Chang, Jing Jin, Qingli Yang, Fuguo Xing. Dimethylformamide Inhibits Fungal Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus by Down-Regulating Glucose Metabolism and Amino Acid Biosynthesis. Toxins. 2020 10; 12(11):. doi: 10.3390/toxins12110683. [PMID: 33138160]
  • Kazuki Kurahayashi, Kengo Hanaya, Shuhei Higashibayashi, Takeshi Sugai. Improved preparation of vitexin from hot water extract of Basella alba, the commercially available vegetable Malabar spinach ("Tsurumurasaki" in Japanese) and the application to semisynthesis of chafuroside B. Bioscience, biotechnology, and biochemistry. 2020 Aug; 84(8):1554-1559. doi: 10.1080/09168451.2020.1761286. [PMID: 32351166]
  • Bin Wang, Shijie Yang, Yanjun Guo, Yanjian Wan, Weihong Qiu, Man Cheng, Xing Wang, Meng Yang, Yan Yu, Jixuan Ma, Yun Zhou, Wei Li, Shiming Gan, Tingming Shi, Jing Yuan, Weihong Chen. Association of urinary dimethylformamide metabolite with lung function decline: The potential mediating role of systematic inflammation estimated by C-reactive protein. The Science of the total environment. 2020 Jul; 726(?):138604. doi: 10.1016/j.scitotenv.2020.138604. [PMID: 32305772]
  • Zhi-Yong Hu, Jie Chang, Fei-Fei Guo, Han-Yi Deng, Guo-Tao Pan, Bing-Yan Li, Zeng-Li Zhang. The effects of dimethylformamide exposure on liver and kidney function in the elderly population: A cross-sectional study. Medicine. 2020 Jul; 99(27):e20749. doi: 10.1097/md.0000000000020749. [PMID: 32629651]
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  • Camilo Hernández-Avilés, Andrea Ruíz-Cristancho, Mónica Vergara-Galván, Jorge Zambrano-Varón, Claudia Jiménez-Escobar. The Effect of N-N-Dimethylformamide on the Membrane Characteristics of Canine Spermatozoa After Cryopreservation, and its Relationship With Post-Thaw Motility. Topics in companion animal medicine. 2020 Mar; 38(?):100372. doi: 10.1016/j.tcam.2019.100372. [PMID: 32115080]
  • Pachara Thananurak, Napapach Chuaychu-Noo, Yupin Phasuk, Thevin Vongpralub. Comparison of TNC and standard extender on post-thaw quality and in vivo fertility of Thai native chicken sperm. Cryobiology. 2020 02; 92(?):197-202. doi: 10.1016/j.cryobiol.2020.01.011. [PMID: 31962103]
  • Wenjiao Sang, Jiaqi Cui, Longjie Mei, Qian Zhang, Yunyang Li, Danyi Li, Wanjun Zhang, Zhixuan Li. Degradation of liquid phase N,N-dimethylformamide by dielectric barrier discharge plasma: Mechanism and degradation pathways. Chemosphere. 2019 Dec; 236(?):124401. doi: 10.1016/j.chemosphere.2019.124401. [PMID: 31344625]
  • Patrícia Diogo, Gil Martins, Rita Nogueira, Ana Marreiros, Paulo J Gavaia, Elsa Cabrita. Cryoprotectants synergy improve zebrafish sperm cryopreservation and offspring skeletogenesis. Cryobiology. 2019 12; 91(?):115-127. doi: 10.1016/j.cryobiol.2019.10.001. [PMID: 31605703]
  • Novina Malviya, Chanchal Sonkar, Rakesh Ganguly, Suman Mukhopadhyay. Cobalt Metallogel Interface for Selectively Sensing l-Tryptophan among Essential Amino Acids. Inorganic chemistry. 2019 Jun; 58(11):7324-7334. doi: 10.1021/acs.inorgchem.9b00455. [PMID: 31081333]
  • Charles Pudrith, William N Dudley. Sensorineural hearing loss and volatile organic compound metabolites in urine. American journal of otolaryngology. 2019 May; 40(3):409-412. doi: 10.1016/j.amjoto.2019.03.001. [PMID: 30871731]
  • Xiaoyue Zhang, Haiyue Jiang, Jiayang Shen, Yu Zhang, Yiyang Gu, Jing Xiao, Yulong Lian. Relationship between N,N-dimethylformamide exposure, PNPLA3, GCKR, COL13A1 and TM6SF2 genes, and liver injury. Ecotoxicology and environmental safety. 2019 Apr; 171(?):347-351. doi: 10.1016/j.ecoenv.2018.12.055. [PMID: 30616151]
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  • Silvia Grande, Pieter Cools, Mahtab Asadian, Joachim Van Guyse, Iuliia Onyshchenko, Heidi Declercq, Rino Morent, Richard Hoogenboom, Nathalie De Geyter. Fabrication of PEOT/PBT Nanofibers by Atmospheric Pressure Plasma Jet Treatment of Electrospinning Solutions for Tissue Engineering. Macromolecular bioscience. 2018 12; 18(12):e1800309. doi: 10.1002/mabi.201800309. [PMID: 30353664]
  • Paula Domingo, Maite Olaciregui, Noelia González, Ignacio De Blas, Lydia Gil. Effects of seminal plasma and different cryoprotectants on rabbit sperm preservation at 16°C. Experimental animals. 2018 Nov; 67(4):413-420. doi: 10.1538/expanim.17-0152. [PMID: 29899185]
  • Farideh Mohammadi, Afsaneh Valipouri, Dariush Semnani, Fereshteh Alsahebfosoul. Nanofibrous Tubular Membrane for Blood Hemodialysis. Applied biochemistry and biotechnology. 2018 Oct; 186(2):443-458. doi: 10.1007/s12010-018-2744-0. [PMID: 29644596]
  • Mirjam Seitz, Sonja Kilo, Elisabeth Eckert, Johannes Müller, Hans Drexler, Thomas Göen. Validity of different biomonitoring parameters for the assessment of occupational exposure to N,N-dimethylformamide (DMF). Archives of toxicology. 2018 07; 92(7):2183-2193. doi: 10.1007/s00204-018-2219-7. [PMID: 29748790]
  • Zhijun Wu, Qiang Liu, Chunmin Wang, Bo Xu, Mingyue Guan, Meng Ye, Hai Jiang, Min Zheng, Man Zhang, Wenjin Zhao, Xiao Jiang, Shuguang Leng, Juan Cheng. A Comparative Benchmark Dose Study for N, N-Dimethylformamide Induced Liver Injury in a Chinese Occupational Cohort. Toxicological sciences : an official journal of the Society of Toxicology. 2017 07; 158(1):140-150. doi: 10.1093/toxsci/kfx076. [PMID: 28505332]
  • Z J Wu, M Y Guan, M Zheng, M Zhang, W J Zhao, L J Shao, Y C Zhai, Y L Zhu, J Cheng. [Delayed effect of liver injury and metabolism of dimethylformamide after high exposures in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2017 Jun; 35(6):402-407. doi: 10.3760/cma.j.issn.1001-9391.2017.06.002. [PMID: 28780813]
  • D A El-Badry, R H Mohamed, H A El-Metwally, T R Abo Al-Naga. The effect of some cryoprotectants on dromedary camel frozen-thawed semen. Reproduction in domestic animals = Zuchthygiene. 2017 Jun; 52(3):522-525. doi: 10.1111/rda.12934. [PMID: 28176384]
  • Simone Alves da Silva, Geni Rodrigues Sampaio, Elizabeth Aparecida Ferraz da Silva Torres. Optimization and validation of a method using UHPLC-fluorescence for the analysis of polycyclic aromatic hydrocarbons in cold-pressed vegetable oils. Food chemistry. 2017 Apr; 221(?):809-814. doi: 10.1016/j.foodchem.2016.11.098. [PMID: 27979277]
  • Chao Wang, Xiang-Jie Li, Jian Yang, Yong-Xin Zhao, Zhao-Sheng Liu, Haji Akber Aisa. Preparation of ionic liquid-mediated imprinted monolith for selective capture and purification of corilagin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jan; 1041-1042(?):98-103. doi: 10.1016/j.jchromb.2016.12.023. [PMID: 28027522]
  • Man Zhang, Min Zheng, Zhijun Wu, Mingyue Guan, Shuai Liu, Wenjin Zhao, Juan Cheng. Alteration of gut microbial community after N,N-Dimethylformamide exposure. The Journal of toxicological sciences. 2017; 42(2):241-250. doi: 10.2131/jts.42.241. [PMID: 28321050]
  • Jibo Xiao, Shuyi Chu, Guangming Tian, Ronald W Thring, Lingzhou Cui. An Eco-tank system containing microbes and different aquatic plant species for the bioremediation of N,N-dimethylformamide polluted river waters. Journal of hazardous materials. 2016 Dec; 320(?):564-570. doi: 10.1016/j.jhazmat.2016.07.037. [PMID: 27501878]
  • Juliana P Alves, Carine D Corcini, Estela F Silva, Josie S Caldas, Tainã F Cardoso, Sergio R N Piedras, Rodrigo D Jardim, Antonio S Varela. The role of amides in seminal cryopreservation of wild silverside, Odontesthes bonariensis. Cryobiology. 2016 12; 73(3):383-387. doi: 10.1016/j.cryobiol.2016.09.001. [PMID: 27609248]
  • Sonja Kilo, Thomas Göen, Hans Drexler. Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance. International archives of occupational and environmental health. 2016 Nov; 89(8):1309-1320. doi: 10.1007/s00420-016-1164-0. [PMID: 27587219]
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  • Jinjiang He, Jie Liu, Yulin Kong, Weiwei Yang, Zengli Zhang. Serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide. International journal of occupational medicine and environmental health. 2015; 28(2):395-8. doi: 10.13075/ijomeh.1896.00086. [PMID: 26182934]
  • Massimiliano Sgroi, Paolo Roccaro, Gregg L Oelker, Shane A Snyder. N-nitrosodimethylamine formation upon ozonation and identification of precursors source in a municipal wastewater treatment plant. Environmental science & technology. 2014 Sep; 48(17):10308-15. doi: 10.1021/es5011658. [PMID: 25029629]
  • Zeyou Chen, Hui Li, Anping Peng, Yanzheng Gao. Oxidation of polycyclic aromatic hydrocarbons by horseradish peroxidase in water containing an organic cosolvent. Environmental science and pollution research international. 2014 Sep; 21(18):10696-705. doi: 10.1007/s11356-014-3005-6. [PMID: 24894750]
  • Suresh Ramraj Subashchandrabose, Kannan Krishnan, Enrico Gratton, Mallavarapu Megharaj, Ravi Naidu. Potential of fluorescence imaging techniques to monitor mutagenic PAH uptake by microalga. Environmental science & technology. 2014 Aug; 48(16):9152-60. doi: 10.1021/es500387v. [PMID: 25020149]
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