20:3n-6 (BioDeep_00000864683)
Main id: BioDeep_00000628737
BioNovoGene_Lab2019
代谢物信息卡片
8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)- (9CI)
化学式: C20H34O2 (306.2559)
中文名称: 8,11-14-廿碳三烯酸, 顺式-8,11,14-二十碳三烯酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCC=CCCCCCCC(=O)O
InChI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
描述信息
COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
37 个代谢物同义名
8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)- (9CI); 8,11,14-Eicosatrienoic acid, (Z,Z,Z)- (8CI); 8,11,14-eicosatrienoic acid, (8Z,11Z,14Z)-; (8Z,11Z,14Z)-Icosa-8,11,14-trienoic acid; cis,cis,cis-8,11,14-Eicosatrienoic acid; cis-8,cis-11,cis-14-Eicosatrienoic acid; (Z,Z,Z)-8,11,14-Eicosatrienoic acid; 8,11,14-all-cis-Eicosatrienoic acid; all-cis-8,11,14-Eicosatrienoic acid; (Z,Z,Z)-8,11,14-Icosatrienoic acid; (8Z,11Z,14Z)-Icosatrienoic acid; cis-8,11,14-Eicosatrienoic Acid; (Z,Z,Z)-8,11,14-Eicosatrienoate; (Z,Z,Z)-8,11,14-Icosatrienoate; 8Z,11Z,14Z-eicosatrienoic acid; 8, 11, 14-eicosatrienoic acid; bishomo-gamma-linolenic acid; EICOSA-8,11,14-TRIENOIC ACID; dihomo-gamma-linolenic acid; gamma-Homolinolenic acid; 8,11,14-Eicosatrienoate; 8,11,14-Icosatrienoate; NCGC00161350-01; NCGC00161350-02; BSPBio_001286; LMFA01030158; E4504_SIGMA; IDI1_033756; Ro 12-1989; C 20:3 n-6; 1783-84-2; 20:3n-6; C03242; DGLA; LAX; Dihomo-gamma-linolenate; Dihomo-gamma-linolenic acid
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:53486
- KEGG: C03242
- PubChem: 5280581
- DrugBank: DB00154
- ChEMBL: CHEMBL465183
- MeSH: 8,11,14-Eicosatrienoic Acid
- CAS: 1783-84-2
- PubChem: 6112
- LipidMAPS: LMFA01030158
- PDB-CCD: LAX
- 3DMET: B01643
- NIKKAJI: J110.768B
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-977
- KNApSAcK: 53486
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
39 个相关的物种来源信息
- 9646 - Ailuropoda melanoleuca: 10.1371/JOURNAL.PONE.0143417
- 52976 - Bartramia pomiformis: 10.1016/0031-9422(91)83188-Q
- 184619 - Brachythecium buchananii: 10.1016/0031-9422(91)83188-Q
- 98356 - Brotherella henonii: 10.1016/0031-9422(91)83188-Q
- 193026 - Campylopus richardii: 10.1016/0031-9422(91)83188-Q
- 99398 - Cratoneuron filicinum: 10.1016/0031-9422(91)83188-Q
- 455261 - Ctenidium percrassum: 10.1016/0031-9422(91)83188-Q
- 1385677 - Dicranum japonicum: 10.1016/0031-9422(91)83188-Q
- 195670 - Dolichomitra cymbifolia: 10.1016/0031-9422(91)83188-Q
- 113274 - Eurhynchium striatum: 10.1016/0031-9422(91)85024-T
- 2008595 - Fissidens nobilis: 10.1016/0031-9422(91)83188-Q
- 254107 - Grimmia pilifera: 10.1016/0031-9422(91)83188-Q
- 52988 - Hedwigia ciliata: 10.1016/0031-9422(91)83188-Q
- 9606 - Homo sapiens:
- 94452 - Loeskeobryum brevirostre: 10.1016/0031-9422(91)83188-Q
- 3197 - Marchantia polymorpha: 10.1016/0031-9422(91)83188-Q
- 64518 - Mortierella alpina:
- 979708 - Mortierella hygrophila: 10.1007/BF00252518
- 98946 - Myuroclada maximowiczii: 10.1016/0031-9422(91)83188-Q
- 95767 - Niphotrichum canescens: 10.1016/0031-9422(91)83188-Q
- 1852632 - Oncophorus crispifolius: 10.1016/0031-9422(91)83188-Q
- 417139 - Plagiomnium maximoviczii: 10.1016/0031-9422(91)83188-Q
- 90297 - Plagiothecium euryphyllum: 10.1016/0031-9422(91)83188-Q
- 185755 - Pogonatum inflexum: 10.1016/0031-9422(91)83188-Q
- 67399 - Pyrrhobryum spiniforme: 10.1016/0031-9422(91)83188-Q
- 2006508 - Rhizomnium tuomikoskii: 10.1016/0031-9422(91)83188-Q
- 53008 - Rhytidiadelphus squarrosus: 10.1016/0031-9422(91)85024-T
- 116055 - Sargassum pallidum: 10.1016/S0031-9422(98)00662-1
- 146586 - Scopelophila cataractae: 10.1016/0031-9422(91)83188-Q
- 13805 - Sphagnum palustre: 10.1016/0031-9422(91)83188-Q
- 390907 - Thamnobryum plicatulum: 10.1016/0031-9422(91)83188-Q
- 173666 - Thuidium glaucinum: 10.1016/0031-9422(91)83188-Q
- 171374 - Thuidium pristocalyx: 10.1016/0031-9422(91)83188-Q
- 84223 - Thuidium recognitum: 10.1016/0031-9422(91)83188-Q
- 67428 - Thuidium tamariscinum: 10.1016/0031-9422(91)83188-Q
- 140636 - Ulota crispa: 10.1016/0031-9422(91)83188-Q
- 455291 - Vesicularia ferriei: 10.1016/0031-9422(91)83188-Q
- 213177 - Wijkia concavifolia: 10.1016/0031-9422(91)83188-Q
- 33090 - 紫苏: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiroshi Kawashima, Katsuhiko Yoshizawa. The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid.
Lipids in health and disease.
2023 Oct; 22(1):172. doi:
10.1186/s12944-023-01937-6. [PMID: 37838679] - Nicolas G Bazan, Jeff X Ji, Samuel E Baum. Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair.
Neuron.
2023 Oct; 111(19):2945-2948. doi:
10.1016/j.neuron.2023.08.020. [PMID: 37797578] - Joanna Bajerska, Aleksandra Skoczek-Rubińska, Lidia Małczak, Vesna Vucic, Aleksandra Arsic, Milica Kojadinovic, Danijela Ristic-Medic. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women.
Nutrition research (New York, N.Y.).
2023 May; 115(?):47-60. doi:
10.1016/j.nutres.2023.05.008. [PMID: 37300953] - Liman Luo, Yan Yang, Menglu Fu, Jinlan Luo, Wenhua Li, Ling Tu, Ruolan Dong. 11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106740. doi:
10.1016/j.prostaglandins.2023.106740. [PMID: 37119935] - Anne-Mari Mustonen, Petteri Nieminen. Dihomo-γ-Linolenic Acid (20:3n-6)-Metabolism, Derivatives, and Potential Significance in Chronic Inflammation.
International journal of molecular sciences.
2023 Jan; 24(3):. doi:
10.3390/ijms24032116. [PMID: 36768438] - Marcos A Perez, Andrea J Clostio, Isabel R Houston, Jimena Ruiz, Leslie Magtanong, Scott J Dixon, Jennifer L Watts. Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity.
PLoS genetics.
2022 09; 18(9):e1010436. doi:
10.1371/journal.pgen.1010436. [PMID: 36178986] - Marzia Savini, Andrew Folick, Yi-Tang Lee, Feng Jin, André Cuevas, Matthew C Tillman, Jonathon D Duffy, Qian Zhao, Isaiah A Neve, Pei-Wen Hu, Yong Yu, Qinghao Zhang, Youqiong Ye, William B Mair, Jin Wang, Leng Han, Eric A Ortlund, Meng C Wang. Lysosome lipid signalling from the periphery to neurons regulates longevity.
Nature cell biology.
2022 06; 24(6):906-916. doi:
10.1038/s41556-022-00926-8. [PMID: 35681008] - Jie Zhang, Chuang Yang, Hongmei Qiu, Junxia Yang, Ke Wu, Shumei Ding, Chengyan Jiang, Qingsong Jiang. 14,15-EET involved in the development of diabetic cardiac hypertrophy mediated by PPARs.
Prostaglandins & other lipid mediators.
2022 04; 159(?):106620. doi:
10.1016/j.prostaglandins.2022.106620. [PMID: 35091081] - Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus.
Frontiers in immunology.
2022; 13(?):964901. doi:
10.3389/fimmu.2022.964901. [PMID: 36275708] - Nalin Singh, Anders Vik, Daniel B Lybrand, Christophe Morisseau, Bruce D Hammock. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation.
Chemical research in toxicology.
2021 12; 34(12):2579-2591. doi:
10.1021/acs.chemrestox.1c00347. [PMID: 34817988] - Neil K Huang, Mary L Biggs, Nirupa R Matthan, Luc Djoussé, W T Longstreth, Kenneth J Mukamal, David S Siscovick, Alice H Lichtenstein. Serum Nonesterified Fatty Acids and Incident Stroke: The CHS.
Journal of the American Heart Association.
2021 11; 10(22):e022725. doi:
10.1161/jaha.121.022725. [PMID: 34755529] - Yun Ding, Pengjie Tu, Yiyong Chen, Yangyun Huang, Xiaojie Pan, Wenshu Chen. CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
Respiratory research.
2021 Nov; 22(1):291. doi:
10.1186/s12931-021-01891-w. [PMID: 34774051] - Dennis Winston T Nilsen, Peder Langeland Myhre, Are Kalstad, Erik Berg Schmidt, Harald Arnesen, Ingebjørg Seljeflot. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103475. [PMID: 34684479] - Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103399. [PMID: 34684398] - Christian B Bergmann, Bruce D Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C Caldwell, Dorothy M Supp. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function.
Scientific reports.
2021 08; 11(1):16555. doi:
10.1038/s41598-021-96014-2. [PMID: 34400718] - Shuiqing Hu, Jinlan Luo, Menglu Fu, Liman Luo, Yueting Cai, Wenhua Li, Yuanyuan Li, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu. Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1.
American journal of physiology. Heart and circulatory physiology.
2021 08; 321(2):H353-H368. doi:
10.1152/ajpheart.00979.2020. [PMID: 34142887] - Shanthi Nagarajan, Zu Yuan Qian, Parthiban Marimuthu, Nabil J Alkayed, Sanjiv Kaul, Anthony P Barnes. Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors.
Journal of chemical information and modeling.
2021 07; 61(7):3442-3452. doi:
10.1021/acs.jcim.1c00335. [PMID: 34242503] - Jacqueline Pontes Monteiro, Carlos A Fuzo, Fábio V Ued, Jim Kaput. Dietary patterns related to zinc and polyunsaturated fatty acids intake are associated with serum linoleic/dihomo-γ-linolenic ratio in NHANES males and females.
Scientific reports.
2021 06; 11(1):12215. doi:
10.1038/s41598-021-91611-7. [PMID: 34108562] - Rozenn N Lemaitre, Paul N Jensen, Maxwell Zeigler, Julie Denham, Amanda M Fretts, Jason G Umans, Barbara V Howard, Colleen M Sitlani, Barbara McKnight, Sina A Gharib, Irena B King, David S Siscovick, Bruce M Psaty, Nona Sotoodehnia, Rheem A Totah. Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study.
EBioMedicine.
2021 Apr; 66(?):103279. doi:
10.1016/j.ebiom.2021.103279. [PMID: 33752126] - John D Imig, Md Abdul Hye Khan, Anna Burkhan, Guan Chen, Adeniyi Michael Adebesin, John R Falck. Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062793. [PMID: 33801911] - Yosuke Tsuchiya, Hisashi Ueda, Kenichi Yanagimoto, Ayaka Kato, Eisuke Ochi. 4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions.
Journal of the International Society of Sports Nutrition.
2021 Mar; 18(1):18. doi:
10.1186/s12970-021-00411-x. [PMID: 33648546] - Menglu Fu, Jing Yu, Zhihui Chen, Ying Tang, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Ling Tu, Xizhen Xu. Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells.
Molecular and cellular endocrinology.
2021 03; 523(?):111149. doi:
10.1016/j.mce.2020.111149. [PMID: 33387601] - Stefanie Liening, Jana Fischer, Hans Jagusch, Georg Pohnert, Oliver Höcker, Christian Neusüß, Oliver Werz, Gerhard K E Scriba, Ulrike Garscha. 12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets.
Prostaglandins & other lipid mediators.
2021 02; 152(?):106480. doi:
10.1016/j.prostaglandins.2020.106480. [PMID: 33172790] - Naoaki Matsuo, Toru Miyoshi, Atsushi Takaishi, Takao Kishinoue, Kentaro Yasuhara, Masafumi Tanimoto, Yukari Nakano, Nobuhiko Onishi, Masayuki Ueeda, Hiroshi Ito. High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020371. [PMID: 33530352] - Tomoaki Okada, Toru Miyoshi, Masayuki Doi, Kosuke Seiyama, Wataru Takagi, Masahiro Sogo, Kazumasa Nosaka, Masahiko Takahashi, Keisuke Okawa, Hiroshi Ito. Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study.
Nutrients.
2021 Jan; 13(1):. doi:
10.3390/nu13010253. [PMID: 33477264] - Zhe Jiang, Takuya Hayashi, Kentaro Kashima, Kayo Kurotani, Bungo Shirouchi, Tetsuya Mizoue, Masao Sato. Alteration of Serum Phospholipid n-6 Polyunsaturated Fatty Acid Compositions in Nonalcoholic Fatty Liver Disease in the Japanese Population: A Cross-Sectional Study.
Lipids.
2020 11; 55(6):599-614. doi:
10.1002/lipd.12251. [PMID: 32691411] - Ella J Baker, Carina A Valenzuela, Wies T M van Dooremalen, Leyre Martínez-Fernández, Parveen Yaqoob, Elizabeth A Miles, Philip C Calder. Gamma-Linolenic and Pinolenic Acids Exert Anti-Inflammatory Effects in Cultured Human Endothelial Cells Through Their Elongation Products.
Molecular nutrition & food research.
2020 10; 64(20):e2000382. doi:
10.1002/mnfr.202000382. [PMID: 32898315] - Takahisa Mori, Kazuhiro Yoshioka, Yuhei Tanno, Shigen Kasakura. Association of Serum Fatty Acids at Admission with the Age of Onset of Intracerebral Hemorrhage.
Nutrients.
2020 Sep; 12(10):. doi:
10.3390/nu12102903. [PMID: 32977415] - Ekaterina Novichkova, Katya Chumin, Noy Eretz-Kdosha, Sammy Boussiba, Jacob Gopas, Guy Cohen, Inna Khozin-Goldberg. DGLA from the Microalga Lobosphaera Incsa P127 Modulates Inflammatory Response, Inhibits iNOS Expression and Alleviates NO Secretion in RAW264.7 Murine Macrophages.
Nutrients.
2020 Sep; 12(9):. doi:
10.3390/nu12092892. [PMID: 32971852] - Souha Hammouda, Imen Ghzaiel, Wided Khamlaoui, Sonia Hammami, Samia Younes Mhenni, Slim Samet, Mohamed Hammami, Amira Zarrouk. Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 09; 160(?):102159. doi:
10.1016/j.plefa.2020.102159. [PMID: 32682282] - Marcos A Perez, Leslie Magtanong, Scott J Dixon, Jennifer L Watts. Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells.
Developmental cell.
2020 08; 54(4):447-454.e4. doi:
10.1016/j.devcel.2020.06.019. [PMID: 32652074] - Takahisa Mori, Kazuhiro Yoshioka, Yuhei Tanno, Shigen Kasakura. Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke.
Nutrients.
2020 Aug; 12(8):. doi:
10.3390/nu12082411. [PMID: 32806540] - Hugo F Olivares-Rubio, J J Espinosa-Aguirre. Role of epoxyeicosatrienoic acids in the lung.
Prostaglandins & other lipid mediators.
2020 08; 149(?):106451. doi:
10.1016/j.prostaglandins.2020.106451. [PMID: 32294527] - Kodai Ishihara, Kazuhiro P Izawa, Masahiro Kitamura, Takayuki Shimogai, Yuji Kanejima, Tomoyuki Morisawa, Ikki Shimizu. Serum concentration of dihomo-γ-linolenic acid is associated with cognitive function and mild cognitive impairment in coronary artery disease patients.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 07; 158(?):102038. doi:
10.1016/j.plefa.2019.102038. [PMID: 31767440] - John D Imig, Wojciech K Jankiewicz, Abdul H Khan. Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Hypertension (Dallas, Tex. : 1979).
2020 07; 76(1):3-15. doi:
10.1161/hypertensionaha.120.13898. [PMID: 32475311] - Cuiping Zhang, Zuojian Hu, Ke Wang, Lujie Yang, Yue Li, Hartmut Schlüter, Pengyuan Yang, Jiaxu Hong, Hongxiu Yu. Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions.
The Analyst.
2020 Jun; 145(11):3967-3976. doi:
10.1039/d0an00263a. [PMID: 32319474] - Ming-Xiao Wang, Li-Jun Wang, Yu Xiao, Dan-Dan Zhang, Xin-Peng Duan, Wen-Hui Wang. Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule.
American journal of physiology. Renal physiology.
2020 06; 318(6):F1369-F1376. doi:
10.1152/ajprenal.00018.2020. [PMID: 32308018] - Susan Sergeant, Brian Hallmark, Rasika A Mathias, Tammy L Mustin, Priscilla Ivester, Maggie L Bohannon, Ingo Ruczinski, Laurel Johnstone, Michael C Seeds, Floyd H Chilton. Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.
The American journal of clinical nutrition.
2020 05; 111(5):1068-1078. doi:
10.1093/ajcn/nqaa023. [PMID: 32167131] - Mercè Pallàs, Santiago Vázquez, Coral Sanfeliu, Carles Galdeano, Christian Griñán-Ferré. Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy.
Biomolecules.
2020 05; 10(5):. doi:
10.3390/biom10050703. [PMID: 32369955] - Marco Rahm, Juliane Merl-Pham, Jerzy Adamski, Stefanie M Hauck. Time-resolved phosphoproteomic analysis elucidates hepatic 11,12-Epoxyeicosatrienoic acid signaling pathways.
Prostaglandins & other lipid mediators.
2020 02; 146(?):106387. doi:
10.1016/j.prostaglandins.2019.106387. [PMID: 31669255] - Carolina Shene, Paris Paredes, Daniela Vergara, Allison Leyton, Marcelo Garcés, Liset Flores, Mónica Rubilar, Mariela Bustamante, Roberto Armenta. Antarctic thraustochytrids: Producers of long-chain omega-3 polyunsaturated fatty acids.
MicrobiologyOpen.
2020 01; 9(1):e00950. doi:
10.1002/mbo3.950. [PMID: 31637873] - Dariusz Kotlega, Agnieszka Zembron-Lacny, Barbara Morawin, Monika Golab-Janowska, Przemyslaw Nowacki, Malgorzata Szczuko. Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients.
Mediators of inflammation.
2020; 2020(?):6676247. doi:
10.1155/2020/6676247. [PMID: 33343231] - Walter Adams, Rudra Bhowmick, Elsa N Bou Ghanem, Kristin Wade, Mikhail Shchepetov, Jeffrey N Weiser, Beth A McCormick, Rodney K Tweten, John M Leong. Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
Journal of immunology (Baltimore, Md. : 1950).
2020 01; 204(1):101-111. doi:
10.4049/jimmunol.1800748. [PMID: 31776202] - Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Molecular neurobiology.
2019 Dec; 56(12):8451-8474. doi:
10.1007/s12035-019-01669-8. [PMID: 31257558] - Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu, Andreas Pohlmann, Jan Hentschel, Karen Arakelyan, Erdmann Seeliger, Bert Flemming, Dennis Gürgen, Michael Rothe, Thoralf Niendorf, Vijaya L Manthati, John R Falck, Michael Haase, Wolf-Hagen Schunck, Duska Dragun. A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Acta physiologica (Oxford, England).
2019 10; 227(2):e13297. doi:
10.1111/apha.13297. [PMID: 31077555] - Boye L Jensen. Protection against acute kidney injury is afforded by a 14,15-epoxy-eicosatrienoic acid (EET) analog-A potential druggable pathway.
Acta physiologica (Oxford, England).
2019 10; 227(2):e13330. doi:
10.1111/apha.13330. [PMID: 31177630] - Margaret L Ong, Robert S Venick, Stephen B Shew, James C Y Dunn, Laurie Reyen, Tristan Grogan, Kara L Calkins. Intravenous Fish Oil and Serum Fatty Acid Profiles in Pediatric Patients With Intestinal Failure-Associated Liver Disease.
JPEN. Journal of parenteral and enteral nutrition.
2019 08; 43(6):717-725. doi:
10.1002/jpen.1532. [PMID: 30900274] - Prabha Tiwari, Takahiro Nagatake, So-Ichiro Hirata, Kento Sawane, Azusa Saika, Yuki Shibata, Sakiko Morimoto, Tetsuya Honda, Jun Adachi, Yuichi Abe, Junko Isoyama, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Jun Kunisawa. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.
Allergy.
2019 08; 74(8):1522-1532. doi:
10.1111/all.13762. [PMID: 30843234] - Leah Gramlich, Carol Ireton-Jones, John M Miles, Maya Morrison, Alessandro Pontes-Arruda. Essential Fatty Acid Requirements and Intravenous Lipid Emulsions.
JPEN. Journal of parenteral and enteral nutrition.
2019 08; 43(6):697-707. doi:
10.1002/jpen.1537. [PMID: 30908685] - Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Sakda Khoomrung, Chanikul Chutrakul, Kobkul Laoteng. Reengineering lipid biosynthetic pathways of Aspergillus oryzae for enhanced production of γ-linolenic acid and dihomo-γ-linolenic acid.
Gene.
2019 Jul; 706(?):106-114. doi:
10.1016/j.gene.2019.04.074. [PMID: 31039437] - Marco Raffaele, Lars Bellner, Shailendra P Singh, Gaia Favero, Rita Rezzani, Luigi Fabrizio Rodella, John R Falck, Nader G Abraham, Luca Vanella. Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling.
Experimental cell research.
2019 07; 380(2):180-187. doi:
10.1016/j.yexcr.2019.04.029. [PMID: 31039348] - Benjamin Gollasch, Inci Dogan, Michael Rothe, Maik Gollasch, Friedrich C Luft. Maximal exercise and plasma cytochrome P450 and lipoxygenase mediators: a lipidomics study.
Physiological reports.
2019 07; 7(13):e14165. doi:
10.14814/phy2.14165. [PMID: 31304687] - Parker N Hyde, Teryn N Sapper, Christopher D Crabtree, Richard A LaFountain, Madison L Bowling, Alex Buga, Brandon Fell, Fionn T McSwiney, Ryan M Dickerson, Vincent J Miller, Debbie Scandling, Orlando P Simonetti, Stephen D Phinney, William J Kraemer, Sarah A King, Ronald M Krauss, Jeff S Volek. Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss.
JCI insight.
2019 06; 4(12):. doi:
10.1172/jci.insight.128308. [PMID: 31217353] - Giovanni Brotzu, Anna Maria Fadda, Maria Letizia Manca, Thomas Manca, Francesca Marongiu, Monica Campisi, Francesca Consolaro. A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation.
Dermatologic therapy.
2019 01; 32(1):e12778. doi:
10.1111/dth.12778. [PMID: 30371981] - Marcus O D Sjödin, Antonio Checa, Mingxing Yang, Sven-Erik Dahlén, Åsa M Wheelock, Anders Eklund, Johan Grunewald, Craig E Wheelock. Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study.
Respiratory research.
2018 Dec; 19(1):236. doi:
10.1186/s12931-018-0939-0. [PMID: 30509266] - Ann M Gregus, Matthew W Buczynski, Darren S Dumlao, Paul C Norris, Ganesha Rai, Anton Simeonov, David J Maloney, Ajit Jadhav, Qinghao Xu, Spencer C Wei, Bethany L Fitzsimmons, Edward A Dennis, Tony L Yaksh. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
Pain.
2018 Dec; 159(12):2620-2629. doi:
10.1097/j.pain.0000000000001373. [PMID: 30130298] - Sara Bonafini, Alice Giontella, Angela Tagetti, Denise Marcon, Martina Montagnana, Marco Benati, Rossella Gaudino, Paolo Cavarzere, Mirjam Karber, Michael Rothe, Pietro Minuz, Franco Antonazzi, Claudio Maffeis, Wolf Hagen Schunck, Cristiano Fava. Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children.
Nutrients.
2018 Nov; 10(11):. doi:
10.3390/nu10111689. [PMID: 30400671] - Maxwell Zeigler, Dale Whittington, Nona Sotoodehnia, Rozenn N Lemaitre, Rheem A Totah. A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.
Chemistry and physics of lipids.
2018 11; 216(?):162-170. doi:
10.1016/j.chemphyslip.2018.09.004. [PMID: 30201384] - Tomoharu Mizukami, Kazutaka Ikeda, Yuta Shimanaka, Katsunari Korogi, Chunyu Zhou, Hiroshi Takase, Hitomi Tsuiji, Nozomu Kono, Takao Kohno, Hiroyuki Arai, Makoto Arita, Mitsuharu Hattori. Reelin deficiency leads to aberrant lipid composition in mouse brain.
Biochemical and biophysical research communications.
2018 10; 505(1):81-86. doi:
10.1016/j.bbrc.2018.09.089. [PMID: 30241938] - Yuya Tsurutani, Kosuke Inoue, Chiho Sugisawa, Jun Saito, Masao Omura, Tetsuo Nishikawa. Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes.
Internal medicine (Tokyo, Japan).
2018 Oct; 57(20):2929-2935. doi:
10.2169/internalmedicine.0816-18. [PMID: 29877283] - Eduardo Villamor, Luis A Villar, Anyela Lozano-Parra, Víctor M Herrera, Oscar F Herrán. Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome.
The British journal of nutrition.
2018 10; 120(7):787-796. doi:
10.1017/s0007114518002039. [PMID: 30105961] - Lai Wang, Gan Luo, Long-Fei Zhang, Hui-Xia Geng. Neuroprotective effects of epoxyeicosatrienoic acids.
Prostaglandins & other lipid mediators.
2018 09; 138(?):9-14. doi:
10.1016/j.prostaglandins.2018.07.002. [PMID: 30031209] - Lu Liu, Nitin Puri, Marco Raffaele, Joseph Schragenheim, Shailendra P Singh, J Alyce Bradbury, Lars Bellner, Luca Vanella, Darryl C Zeldin, Jian Cao, Nader G Abraham. Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.
Prostaglandins & other lipid mediators.
2018 09; 138(?):1-8. doi:
10.1016/j.prostaglandins.2018.07.004. [PMID: 30041041] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Junko Yamaguchi, Kosaku Kinoshita, Shingo Ihara, Makoto Furukawa, Atsushi Sakurai. The Clinical Significance of Low Serum Arachidonic Acid in Sepsis Patients with Hypoalbuminemia.
Internal medicine (Tokyo, Japan).
2018 Jul; 57(13):1833-1840. doi:
10.2169/internalmedicine.9124-17. [PMID: 29491308] - Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P Singh, David Bamshad, John A McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T Stier, Nader G Abraham. EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.
Prostaglandins & other lipid mediators.
2018 07; 137(?):30-39. doi:
10.1016/j.prostaglandins.2018.05.008. [PMID: 29787809] - Yi-Er Qiu, Jun Qin, Yang Luo, Shao-Lan Qin, Yi-Fei Mu, Ran Cun, Hou-Li Jiang, Jian-Jun Chen, Min-Hao Yu, Ming Zhong. Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.
Prostaglandins & other lipid mediators.
2018 05; 136(?):9-14. doi:
10.1016/j.prostaglandins.2018.03.004. [PMID: 29580941] - Pinming Liu, Shaoling Zhang, Jingwei Gao, Ying Lin, Guangzi Shi, Wanbing He, Rhian M Touyz, Li Yan, Hui Huang. Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary Aldosteronism.
Hypertension (Dallas, Tex. : 1979).
2018 04; 71(4):592-598. doi:
10.1161/hypertensionaha.117.10644. [PMID: 29440332] - Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins, Steven Y Qian. Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism.
BMC cancer.
2018 03; 18(1):330. doi:
10.1186/s12885-018-4250-8. [PMID: 29587668] - Yuan Guo, Fei Luo, Xv Zhang, Jingyuan Chen, Li Shen, Yi Zhu, Danyan Xu. TPPU enhanced exercise-induced epoxyeicosatrienoic acid concentrations to exert cardioprotection in mice after myocardial infarction.
Journal of cellular and molecular medicine.
2018 03; 22(3):1489-1500. doi:
10.1111/jcmm.13412. [PMID: 29265525] - Jyrki K Virtanen, Jason H Y Wu, Sari Voutilainen, Jaakko Mursu, Tomi-Pekka Tuomainen. Serum n-6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study.
The American journal of clinical nutrition.
2018 03; 107(3):427-435. doi:
10.1093/ajcn/nqx063. [PMID: 29566193] - Tsitsi Chimhashu, Linda Malan, Jeannine Baumgartner, Paul J van Jaarsveld, Valeria Galetti, Diego Moretti, Cornelius M Smuts, Michael B Zimmermann. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children.
The British journal of nutrition.
2018 03; 119(6):610-619. doi:
10.1017/s000711451700366x. [PMID: 29352828] - Marija Knez, Elad Tako, Raymond P Glahn, Nikolai Kolba, Emma de Courcy-Ireland, James C R Stangoulis. Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus).
Journal of agricultural and food chemistry.
2018 Feb; 66(6):1394-1400. doi:
10.1021/acs.jafc.7b04905. [PMID: 29359556] - Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu. 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.
Journal of experimental & clinical cancer research : CR.
2018 Feb; 37(1):23. doi:
10.1186/s13046-018-0694-6. [PMID: 29426357] - Yuri Hayashi, Ayano Shimamura, Tomoko Ishikawa, Yoko Fujiwara, Ikuyo Ichi. FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion.
Biochemical and biophysical research communications.
2018 02; 496(2):549-555. doi:
10.1016/j.bbrc.2018.01.064. [PMID: 29353041] - Fernando Elijovich, Ginger L Milne, Nancy J Brown, Michal Laniado-Schwartzman, Cheryl L Laffer. Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects.
Hypertension (Dallas, Tex. : 1979).
2018 02; 71(2):346-355. doi:
10.1161/hypertensionaha.117.10392. [PMID: 29279315] - Jung-Ung An, Yong-Seok Song, Kyoung-Rok Kim, Yoon-Joo Ko, Do-Young Yoon, Deok-Kun Oh. Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.
Nature communications.
2018 01; 9(1):128. doi:
10.1038/s41467-017-02543-8. [PMID: 29317615] - Xiaoyan Huang, Yuguang Wang, Yi Wang, Liang Yang, Jia Wang, Yue Gao. Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(4):1646-1658. doi:
10.1159/000493500. [PMID: 30227401] - Emma Kjellberg, Josefine Roswall, Stefan Bergman, Birgitta Strandvik, Jovanna Dahlgren. Serum n-6 and n-9 Fatty Acids Correlate With Serum IGF-1 and Growth Up to 4 Months of Age in Healthy Infants.
Journal of pediatric gastroenterology and nutrition.
2018 01; 66(1):141-146. doi:
10.1097/mpg.0000000000001691. [PMID: 28753183] - Qi Zhang, Xiang Wang, Guifang Yan, Juan Lei, Yu Zhou, Lei Wu, Ting Wang, Xiao Zhang, Duyun Ye, Yongsheng Li. Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(4):1377-1389. doi:
10.1159/000487563. [PMID: 29462800] - Mohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami. Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction.
Lipids in health and disease.
2017 Dec; 16(1):241. doi:
10.1186/s12944-017-0637-9. [PMID: 29233142] - Bing-Qing Deng, Ying Luo, Xin Kang, Chang-Bin Li, Christophe Morisseau, Jun Yang, Kin Sing Stephen Lee, Jian Huang, Da-Yong Hu, Ming-Yu Wu, Ai Peng, Bruce D Hammock, Jun-Yan Liu. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2017 11; 114(47):12608-12613. doi:
10.1073/pnas.1705615114. [PMID: 29109264] - Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand. Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids.
Archives of toxicology.
2017 Nov; 91(11):3571-3585. doi:
10.1007/s00204-017-2060-4. [PMID: 28975360] - Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah. Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
Free radical biology & medicine.
2017 11; 112(?):131-140. doi:
10.1016/j.freeradbiomed.2017.07.015. [PMID: 28734877] - William B Campbell, John D Imig, James M Schmitz, John R Falck. Orally Active Epoxyeicosatrienoic Acid Analogs.
Journal of cardiovascular pharmacology.
2017 Oct; 70(4):211-224. doi:
10.1097/fjc.0000000000000523. [PMID: 28937442] - Megumi Haruna, Mie Shiraishi, Masayo Matsuzaki, Yuko Yatsuki, SeonAe Yeo. Effect of tailored dietary guidance for pregnant women on nutritional status: A double-cohort study.
Maternal & child nutrition.
2017 10; 13(4):. doi:
10.1111/mcn.12391. [PMID: 27896937] - Masaru Hiki, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Tatsuro Aikawa, Shohei Ouchi, Tomoyuki Shiozawa, Kiyoshi Takasu, Shuhei Takahashi, Atsutoshi Takagi, Katsumi Miyauchi, Hiroyuki Daida. Significance of Serum Polyunsaturated Fatty Acid Level Imbalance in Patients with Acute Venous Thromboembolism.
Journal of atherosclerosis and thrombosis.
2017 Oct; 24(10):1016-1022. doi:
10.5551/jat.37424. [PMID: 28344195] - Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu. Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells.
Biochimica et biophysica acta. Biomembranes.
2017 Oct; 1859(10):1967-1973. doi:
10.1016/j.bbamem.2017.07.001. [PMID: 28688796] - Julia M Santos, Jung-A Park, Aby Joiakim, David A Putt, Robert N Taylor, Hyesook Kim. The role of soluble epoxide hydrolase in preeclampsia.
Medical hypotheses.
2017 Oct; 108(?):81-85. doi:
10.1016/j.mehy.2017.07.033. [PMID: 29055406] - Xuehong Liu, Zu-Yuan Qian, Fuchun Xie, Wei Fan, Jonathan W Nelson, Xiangshu Xiao, Sanjiv Kaul, Anthony P Barnes, Nabil J Alkayed. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid.
Prostaglandins & other lipid mediators.
2017 09; 132(?):31-40. doi:
10.1016/j.prostaglandins.2016.09.002. [PMID: 27649858] - Sha Lei, Fengjie Huang, Aihua Zhao, Tianlu Chen, Wenlian Chen, Guoxiang Xie, Xiaojiao Zheng, Yunjing Zhang, Haoyong Yu, Pin Zhang, Cynthia Rajani, Yuqian Bao, Weiping Jia, Wei Jia. The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2017 09; 31(9):3904-3912. doi:
10.1096/fj.201700055r. [PMID: 28490483] - Jennifer Yeung, Michael Holinstat. Who is the real 12-HETrE?.
Prostaglandins & other lipid mediators.
2017 09; 132(?):25-30. doi:
10.1016/j.prostaglandins.2017.02.005. [PMID: 28259546] - Xiaoyan Huang, Yuguang Wang, Zhaoyan Zhang, Yuan Wang, Xiangmei Chen, Yi Wang, Yue Gao. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs.
Biochemical and biophysical research communications.
2017 08; 490(2):123-133. doi:
10.1016/j.bbrc.2017.06.007. [PMID: 28587983] - Shohei Ouchi, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Azusa Murata, Takao Kato, Tatsuro Aikawa, Shoko Suda, Tomoyuki Shiozawa, Masaru Hiki, Shuhei Takahashi, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida. Decreased circulating dihomo-gamma-linolenic acid levels are associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure.
Lipids in health and disease.
2017 Aug; 16(1):150. doi:
10.1186/s12944-017-0542-2. [PMID: 28806965] - Marija Knez, James C R Stangoulis, Maria Glibetic, Elad Tako. The Linoleic Acid: Dihomo-γ-Linolenic Acid Ratio (LA:DGLA)-An Emerging Biomarker of Zn Status.
Nutrients.
2017 Aug; 9(8):. doi:
10.3390/nu9080825. [PMID: 28763004] - Zhigang Liu, Yongfang Liu, Haixiao Zhou, Xiangyun Fu, Gang Hu. Epoxyeicosatrienoic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting inflammatory factors and pannexin-1.
Molecular medicine reports.
2017 Aug; 16(2):2179-2184. doi:
10.3892/mmr.2017.6831. [PMID: 28656267] - Bogdan Barnych, Amy A Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D Hammock. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.
Organic & biomolecular chemistry.
2017 May; 15(20):4308-4313. doi:
10.1039/c7ob00789b. [PMID: 28470279] - Yong Zhou, Tian Liu, Jia-Xi Duan, Ping Li, Guo-Ying Sun, Yong-Ping Liu, Jun Zhang, Liang Dong, Kin Sing Stephen Lee, Bruce D Hammock, Jian-Xin Jiang, Cha-Xiang Guan. Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice.
Shock (Augusta, Ga.).
2017 05; 47(5):638-645. doi:
10.1097/shk.0000000000000767. [PMID: 27753791] - Amy A Rand, Bogdan Barnych, Christophe Morisseau, Tomas Cajka, Kin Sing Stephen Lee, Dipak Panigrahy, Bruce D Hammock. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
Proceedings of the National Academy of Sciences of the United States of America.
2017 04; 114(17):4370-4375. doi:
10.1073/pnas.1616893114. [PMID: 28396419]
