Toralactone (BioDeep_00000861297)

Main id: BioDeep_00000001020

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


9,10-Dihydroxy-7-methoxy-3-methyl-1H-naphtho(2,3-c)pyran-1-one

化学式: C15H12O5 (272.0685)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC2=CC3=CC(=CC(=C3C(=C2C(=O)O1)O)O)OC
InChI: InChI=1S/C15H12O5/c1-7-3-8-4-9-5-10(19-2)6-11(16)12(9)14(17)13(8)15(18)20-7/h3-6,16-17H,1-2H3

描述信息

Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].
Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].

同义名列表

7 个代谢物同义名

9,10-Dihydroxy-7-methoxy-3-methyl-1H-naphtho(2,3-c)pyran-1-one; 9,10-dihydroxy-7-methoxy-3-methyl-benzo[g]isochromen-1-one; 9,10-dihydroxy-7-methoxy-3-methyl-1-benzo[g]isochromenone; 9,10-dihydroxy-7-methoxy-3-methylbenzo[g]isochromen-1-one; Toralactone; 41743-74-2; Toralactone



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AIF1, CALM1, CAMK2A, CASP3, DCX, DNM1, GAP43, HSPA5, MAPK1, NEFH, NEFL, PIK3CA, UNC13A
Peripheral membrane protein 5 AIF1, CLTC, GAP43, MBP, UNC13A
Endoplasmic reticulum membrane 1 HSPA5
Nucleus 8 AIF1, CALB1, CALM1, CAMK2A, CASP3, HSPA5, MAPK1, MBP
cytosol 13 AIF1, CALB1, CALM1, CAMK2A, CASP3, CLTC, DCX, HSPA5, MAPK1, MBP, NCAM1, NEFL, PIK3CA
dendrite 3 CALB1, GAP43, SYN1
centrosome 2 CALM1, MAPK1
nucleoplasm 4 CALM1, CAMK2A, CASP3, MAPK1
Cell membrane 4 DNM1, GAP43, NCAM1, UNC13A
Cytoplasmic side 4 AIF1, CLTC, GAP43, MBP
lamellipodium 2 AIF1, PIK3CA
ruffle membrane 1 AIF1
Cell projection, axon 3 GAP43, NEFH, NEFL
Synapse 7 CALB1, CAMK2A, DNM1, GAP43, MAPK1, MBP, SYN1
cell surface 3 HSPA5, MBP, NCAM1
glutamatergic synapse 4 CALB1, CASP3, DCX, DNM1
Golgi apparatus 2 MAPK1, SYN1
Golgi membrane 1 NCAM1
growth cone 1 NEFL
neuromuscular junction 2 NEFL, UNC13A
neuronal cell body 3 CALB1, CASP3, MBP
presynaptic membrane 1 UNC13A
synaptic vesicle 1 SYN1
Lysosome 1 CLTC
Presynapse 4 DNM1, GAP43, SYN1, UNC13A
endosome 1 CLTC
plasma membrane 10 CALM1, CLTC, DNM1, GAP43, HSPA5, MAPK1, MBP, NCAM1, PIK3CA, UNC13A
presynaptic active zone 2 SYN1, UNC13A
synaptic vesicle membrane 2 SYN1, UNC13A
terminal bouton 2 CALB1, UNC13A
Membrane 3 CLTC, HSPA5, NCAM1
axon 4 CALB1, NEFH, NEFL, SYN1
caveola 1 MAPK1
extracellular exosome 6 CALB1, CLTC, DNM1, HSPA5, MBP, MMP9
endoplasmic reticulum 1 HSPA5
extracellular space 2 IGF1, MMP9
perinuclear region of cytoplasm 2 AIF1, PIK3CA
Schaffer collateral - CA1 synapse 3 NEFH, NEFL, SYN1
intercalated disc 1 PIK3CA
mitochondrion 3 CAMK2A, HSPA5, MAPK1
protein-containing complex 4 CALM1, CLTC, HSPA5, MBP
intracellular membrane-bounded organelle 1 HSPA5
postsynaptic density 5 CAMK2A, CASP3, GAP43, NEFH, SYN1
Single-pass type I membrane protein 1 NCAM1
Secreted 1 IGF1
extracellular region 6 CALM1, IGF1, MAPK1, MBP, MMP9, NCAM1
hippocampal mossy fiber to CA3 synapse 1 CALB1
photoreceptor inner segment 1 DNM1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CALM1, MAPK1
external side of plasma membrane 1 NCAM1
Extracellular vesicle 1 CLTC
Secreted, extracellular space, extracellular matrix 1 MMP9
dendritic spine 2 CALB1, CAMK2A
perikaryon 1 GAP43
cytoplasmic vesicle 1 DNM1
axon cytoplasm 1 NEFL
midbody 1 HSPA5
Early endosome 1 MAPK1
Membrane, clathrin-coated pit 1 DNM1
clathrin-coated pit 1 DNM1
vesicle 1 CALM1
Cell projection, ruffle membrane 1 AIF1
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 3 AIF1, NEFH, NEFL
Cytoplasm, cytoskeleton, spindle 3 CALM1, CLTC, MAPK1
focal adhesion 3 CLTC, HSPA5, MAPK1
microtubule 2 DCX, DNM1
spindle 2 CLTC, MAPK1
GABA-ergic synapse 2 CALB1, GAP43
Cell projection, dendritic spine 1 CAMK2A
collagen-containing extracellular matrix 3 MBP, MMP9, NCAM1
intermediate filament 1 NEFL
Late endosome 1 MAPK1
ruffle 1 AIF1
sarcomere 1 CALM1
Cell projection, neuron projection 1 DCX
neuron projection 3 CAMK2A, DCX, UNC13A
microtubule associated complex 1 DCX
Cell projection, phagocytic cup 1 AIF1
cell projection 2 DNM1, SYN1
phagocytic cup 1 AIF1
cell periphery 1 MBP
mitotic spindle 2 CLTC, MAPK1
cytoskeleton 4 DCX, MAPK1, NEFH, SYN1
[Isoform 3]: Nucleus 1 MBP
spindle pole 1 CALM1
actin filament 1 AIF1
Cell projection, cilium, flagellum 1 CALM1
sperm midpiece 1 CALM1
Lipid-anchor, GPI-anchor 1 NCAM1
Cytoplasm, cytoskeleton, spindle pole 1 CALM1
Endomembrane system 1 CLTC
Membrane, caveola 1 MAPK1
stereocilium 1 CALB1
Cytoplasmic vesicle membrane 1 CLTC
Cell projection, dendrite 2 CAMK2A, GAP43
Melanosome 2 CLTC, HSPA5
Presynaptic cell membrane 1 UNC13A
cell body 1 SYN1
myelin sheath 2 CALM1, MBP
pseudopodium 1 MAPK1
filopodium membrane 1 GAP43
clathrin-coated vesicle 1 CLTC
voltage-gated potassium channel complex 1 CALM1
trans-Golgi network membrane 1 CLTC
exocytic vesicle 1 IGF1
ficolin-1-rich granule lumen 3 MAPK1, MBP, MMP9
endoplasmic reticulum lumen 2 HSPA5, MAPK1
platelet alpha granule lumen 1 IGF1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
endocytic vesicle membrane 1 CAMK2A
endocytic vesicle 1 DNM1
transport vesicle 1 MBP
extrinsic component of synaptic vesicle membrane 1 SYN1
azurophil granule lumen 1 MAPK1
clathrin-coated endocytic vesicle 1 CLTC
neurofilament 2 NEFH, NEFL
presynaptic active zone cytoplasmic component 1 UNC13A
calyx of Held 2 CALB1, CALM1
clathrin-coated endocytic vesicle membrane 1 CLTC
calcium channel complex 1 CALM1
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
spindle microtubule 1 CALM1
endolysosome membrane 1 CLTC
synaptonemal complex 1 SYN1
death-inducing signaling complex 1 CASP3
clathrin coat of coated pit 1 CLTC
membrane coat 1 DNM1
postsynaptic cytosol 1 CALB1
Membrane, coated pit 1 CLTC
Cell projection, filopodium membrane 1 GAP43
cuticular plate 1 CALB1
presynaptic cytosol 2 CALB1, CALM1
mitotic spindle microtubule 1 CLTC
clathrin coat of trans-Golgi network vesicle 1 CLTC
glial cell projection 1 AIF1
cholinergic synapse 1 NEFL
compact myelin 1 MBP
internode region of axon 1 MBP
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
catalytic complex 1 CALM1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 SYN1
postsynaptic intermediate filament cytoskeleton 2 NEFH, NEFL
presynaptic intermediate filament cytoskeleton 1 NEFL
neurofibrillary tangle 1 NEFH
endoplasmic reticulum chaperone complex 1 HSPA5
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 DNM1
chromaffin granule 1 DNM1
clathrin coat 1 CLTC
clathrin complex 1 CLTC
presynaptic endocytic zone membrane 1 DNM1
Myb complex 1 CLTC
[Isoform 4]: Cell membrane 1 NCAM1
[Isoform 6]: Secreted 1 NCAM1
photoreceptor ribbon synapse 1 DNM1
[Bone marrow proteoglycan]: Secreted 1 MBP
Cell projection, growth cone membrane 1 GAP43
growth cone membrane 1 GAP43
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
Myelin membrane 1 MBP
calcium- and calmodulin-dependent protein kinase complex 1 CAMK2A


文献列表

  • Ali Mahmoud El-Halawany, Mi Hwa Chung, Norio Nakamura, Chao-Mei Ma, Tsutomu Nishihara, Masao Hattori. Estrogenic and anti-estrogenic activities of Cassia tora phenolic constituents. Chemical & pharmaceutical bulletin. 2007 Oct; 55(10):1476-82. doi: 10.1248/cpb.55.1476. [PMID: 17917292]