Riboprine (BioDeep_00000408658)

Main id: BioDeep_00000003153

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Isopentenyladenine riboside

化学式: C15H21N5O4 (335.1593)
中文名称: N6-异戊烯基腺苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O)C
InChI: InChI=1S/C15H21N5O4/c1-8(2)3-4-16-13-10-14(18-6-17-13)20(7-19-10)15-12(23)11(22)9(5-21)24-15/h3,6-7,9,11-12,15,21-23H,4-5H2,1-2H3,(H,16,17,18)/t9-,11+,12+,15+/m1/s1

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins
Same as: D05726
CONFIDENCE standard compound; INTERNAL_ID 306
N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].

同义名列表

6 个代谢物同义名

Isopentenyladenine riboside; N6-Isopentenyladenosine; isopentenyl adenosine; Isopentenyladenosine; Riboprine; Isopentenyl adenosine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANG, CASP3, CAT, CCL5, CCND1, EGFR, FBXW7, FDPS, GPX1, MCL1, MYC, PRKAA2, STAT3, STAT5A, TP53
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 12 ADK, ANG, CASP3, CCND1, EGFR, FBXW7, MCL1, MYC, PRKAA2, STAT3, STAT5A, TP53
cytosol 14 ADK, ANG, CASP3, CAT, CCND1, CDK5RAP1, FBXW7, FDPS, GPX1, MCL1, PRKAA2, STAT3, STAT5A, TP53
dendrite 1 PRKAA2
centrosome 2 CCND1, TP53
nucleoplasm 12 ADK, CASP3, CCND1, CDK5RAP1, FBXW7, FDPS, MCL1, MYC, PRKAA2, STAT3, STAT5A, TP53
RNA polymerase II transcription regulator complex 2 STAT3, STAT5A
Cell membrane 1 EGFR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 2 FBXW7, PRKAA2
Golgi membrane 1 EGFR
growth cone 1 ANG
neuronal cell body 3 ANG, CASP3, PRKAA2
endosome 1 EGFR
plasma membrane 3 ADK, EGFR, STAT3
Membrane 8 CAT, EGFR, FBXW7, FDPS, MCL1, MYC, PRKAA2, TP53
apical plasma membrane 1 EGFR
axon 1 PRKAA2
basolateral plasma membrane 1 EGFR
extracellular exosome 1 CAT
endoplasmic reticulum 2 FBXW7, TP53
extracellular space 4 ANG, CCL5, EGFR, IL2
perinuclear region of cytoplasm 2 EGFR, FBXW7
bicellular tight junction 1 CCND1
mitochondrion 7 CAT, CDK5RAP1, FBXW7, GPX1, MCL1, TP53, TRIT1
protein-containing complex 5 CAT, EGFR, FBXW7, MYC, TP53
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 3 ANG, CCL5, IL2
extracellular region 4 ANG, CAT, CCL5, IL2
Single-pass membrane protein 1 MCL1
mitochondrial outer membrane 1 MCL1
Mitochondrion matrix 1 TP53
mitochondrial matrix 5 CAT, FDPS, GPX1, TP53, TRIT1
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 CCND1
Bcl-2 family protein complex 1 MCL1
nuclear membrane 2 CCND1, EGFR
actin cytoskeleton 1 ANG
nucleolus 4 ANG, FBXW7, MYC, TP53
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 CAT, EGFR
Peroxisome 2 CAT, FDPS
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
nuclear speck 1 PRKAA2
receptor complex 1 EGFR
chromatin 4 MYC, STAT3, STAT5A, TP53
Chromosome 2 ANG, FBXW7
[Isoform 5]: Cytoplasm 1 TRIT1
[Isoform 1]: Mitochondrion 1 TRIT1
Nucleus, nucleolus 2 ANG, MYC
site of double-strand break 1 TP53
nuclear envelope 1 MYC
myosin complex 1 MCL1
Nucleus, nucleoplasm 2 MCL1, MYC
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 EGFR
[Isoform 3]: Cytoplasm 1 TRIT1
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
endocytic vesicle 1 ANG
RNA polymerase II transcription repressor complex 1 MYC
[Isoform 2]: Cytoplasm 3 ADK, FBXW7, TRIT1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 2 ADK, TP53
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
nucleotide-activated protein kinase complex 1 PRKAA2
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 FBXW7
[Isoform 1]: Nucleus, nucleoplasm 1 FBXW7
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Isoform 4]: Mitochondrion 1 TRIT1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
SCF ubiquitin ligase complex 1 FBXW7
cyclin D1-CDK4 complex 1 CCND1
cyclin D1-CDK6 complex 1 CCND1
[Isoform 3]: Nucleus, nucleolus 1 FBXW7
nucleoplasmic reticulum 1 MYC


文献列表

  • Yuanyuan Li, Hongling Zhou, Shasha Chen, Yinan Li, Yuyang Guo, Xiaoqian Chen, Sheng Wang, Li Wang, Youfang Gan, Shusheng Zhang, Ya Ying Zheng, Jia Sheng, Zhipeng Zhou, Rui Wang. Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA. Nucleic acids research. 2024 Apr; 52(6):2808-2820. doi: 10.1093/nar/gkae150. [PMID: 38426933]
  • Rakesh K Upadhyay, Vaclav Motyka, Eva Pokorna, Petre I Dobrev, Jozef Lacek, Jonathan Shao, Kim S Lewers, Autar K Mattoo. Comprehensive profiling of endogenous phytohormones and expression analysis of 1-aminocyclopropane-1-carboxylic acid synthase gene family during fruit development and ripening in octoploid strawberry (Fragaria× ananassa). Plant physiology and biochemistry : PPB. 2023 Jan; 196(?):186-196. doi: 10.1016/j.plaphy.2023.01.031. [PMID: 36724703]
  • Muhammad Saqlain Zaheer, Hafiz Haider Ali, Kehinde O Erinle, Shabir Hussain Wani, Okon Godwin Okon, Muhammad Azhar Nadeem, Muhammad Nawaz, Muhammad Adnan Bodlah, Muhammad Mohsin Waqas, Javaid Iqbal, Ali Raza. Inoculation of Azospirillum brasilense and exogenous application of trans-zeatin riboside alleviates arsenic induced physiological damages in wheat (Triticum aestivum). Environmental science and pollution research international. 2022 May; 29(23):33909-33919. doi: 10.1007/s11356-021-18106-w. [PMID: 35031990]
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