2-Adenylic acid (BioDeep_00000406259)

Main id: BioDeep_00000003258

 

PANOMIX_OTCML-2023


代谢物信息卡片


Adenosine-2-monophosphate

化学式: C10H14N5O7P (347.0631)
中文名称: 腺苷2(3)-单磷酸盐混合异构体
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)OP(=O)(O)O)N
InChI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(22-23(18,19)20)6(17)4(1-16)21-10/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

同义名列表

7 个代谢物同义名

Adenosine-2-monophosphate; 2-Adenylic acid; 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate; Adenosine-2'-monophosphate; Adenosine 2'-phosphate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CNP, GAPDH, ITPR3, NQO1, TXN
Peripheral membrane protein 2 FDXR, HSD17B6
Endoplasmic reticulum membrane 2 DHRS9, ITPR3
Nucleus 6 GAPDH, NQO1, PNKP, REPIN1, TRIM33, TXN
cytosol 8 GAPDH, GSR, GYPA, NQO1, NT5E, PAPSS2, REPIN1, TXN
dendrite 3 NQO1, P2RY1, PCDH8
nucleoplasm 7 GYPA, ITPR3, NT5E, PNKP, REPIN1, TRIM33, TXN
Cell membrane 4 GYPA, NT5E, P2RY1, PCDH8
Lipid-anchor 1 CNP
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 ITPR3, NNT, P2RY1
Synapse 2 CNP, NQO1
cell surface 2 NT5E, P2RY1
glutamatergic synapse 2 P2RY1, PCDH8
mitochondrial inner membrane 3 CNP, FDXR, NNT
neuronal cell body 2 ITPR3, NQO1
presynaptic membrane 1 PCDH8
Cytoplasm, cytosol 3 GAPDH, NQO1, REPIN1
plasma membrane 7 GAPDH, GYPA, IFNLR1, ITPR3, NT5E, P2RY1, PCDH8
Membrane 9 CNP, GAPDH, GYPA, IFNLR1, ITPR3, NNT, NQO1, NT5E, PNKP
apical plasma membrane 1 P2RY1
basolateral plasma membrane 1 P2RY1
brush border 1 ITPR3
extracellular exosome 5 CNP, GAPDH, GSR, NT5E, TXN
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, ITPR3
extracellular space 1 CNP
perinuclear region of cytoplasm 2 CNP, GAPDH
Schaffer collateral - CA1 synapse 1 PCDH8
mitochondrion 3 FDXR, GSR, NNT
intracellular membrane-bounded organelle 3 DHRS9, GAPDH, HSD17B6
Microsome membrane 2 DHRS9, HSD17B6
postsynaptic density 1 P2RY1
Single-pass type I membrane protein 3 GYPA, IFNLR1, PCDH8
Secreted 1 TXN
extracellular region 1 TXN
Single-pass membrane protein 1 GYPA
mitochondrial outer membrane 1 CNP
mitochondrial matrix 2 FDXR, GSR
nuclear membrane 2 GAPDH, REPIN1
external side of plasma membrane 2 GSR, NT5E
microtubule cytoskeleton 1 GAPDH
nucleolus 2 ITPR3, PNKP
apical part of cell 1 ITPR3
vesicle 1 GAPDH
postsynaptic membrane 2 P2RY1, PCDH8
presynaptic active zone membrane 1 P2RY1
Cytoplasm, perinuclear region 1 GAPDH
Mitochondrion inner membrane 2 FDXR, NNT
Matrix side 1 NNT
Cytoplasm, cytoskeleton 1 GAPDH
microtubule 1 CNP
sarcoplasmic reticulum 1 ITPR3
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
cilium 1 P2RY1
chromatin 1 TRIM33
Chromosome 2 PNKP, REPIN1
cytoskeleton 1 GAPDH
Lipid-anchor, GPI-anchor 1 NT5E
site of double-strand break 1 PNKP
microvillus 1 CNP
Lipid droplet 1 GAPDH
Cell projection, dendrite 1 PCDH8
Melanosome 1 CNP
respiratory chain complex 1 NNT
cell body 1 P2RY1
side of membrane 1 NT5E
pseudopodium 1 CNP
secretory granule membrane 1 ITPR3
ribonucleoprotein complex 1 GAPDH
platelet dense tubular network membrane 1 ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
GAIT complex 1 GAPDH
transport vesicle membrane 1 ITPR3
ankyrin-1 complex 1 GYPA
myelin sheath abaxonal region 1 CNP
myelin sheath adaxonal region 1 CNP
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
interleukin-28 receptor complex 1 IFNLR1


文献列表

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  • Jiajia Yang, Jun Liu, Weiyang Kuang, Yuqi Lin, Saiyi Zhong, Supaluck Kraithong, Xiaoyong Zhang, Io Nam Wong, Riming Huang. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius. International journal of biological macromolecules. 2024 Apr; 265(Pt 1):130703. doi: 10.1016/j.ijbiomac.2024.130703. [PMID: 38458279]
  • Xuemeng Zhao, Wen Li, Xiliu Li, Zhenhua Jia, Shuishan Song, Qian Zhao. The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051074. [PMID: 38474586]
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  • Pranav Bharadwaj, Sachin M Shet, Meena Bisht, Dheeraj Kumar Sarkar, Gregory Franklin, Nataraj Sanna Kotrappanavar, Dibyendu Mondal. Suitability of Adenosine Derivatives in Improving the Activity and Stability of Cytochrome c under Stress: Insights into the Effect of Phosphate Groups. The journal of physical chemistry. B. 2024 Jan; 128(1):86-95. doi: 10.1021/acs.jpcb.3c05996. [PMID: 38127495]
  • Hong Gil Lee, Seo Young Jang, Eun Yee Jie, Seung Hee Choi, Ok-Sun Park, Soon Hyung Bae, Hyun-Soon Kim, Suk Weon Kim, Geum-Sook Hwang, Pil Joon Seo. Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis. Molecular plant. 2023 12; 16(12):1867-1870. doi: 10.1016/j.molp.2023.10.004. [PMID: 37817411]
  • Liu Bingbing, L I Jieru, S I Jianchao, Chen Qi, Yang Shengchang, J I Ensheng. Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 10; 43(5):906-914. doi: 10.19852/j.cnki.jtcm.20221206.004. [PMID: 37679978]
  • Chao Yang, Xibao Li, Jun Zhou, Caiji Gao. Autophagy contributes to positive feedback regulation of SnRK1 signaling in plants. Autophagy. 2023 Aug; ?(?):1-3. doi: 10.1080/15548627.2023.2247741. [PMID: 37584544]
  • Haiyan Yang, Qiang Wang, Yuemei Xi, Wei Yu, De Xie, Hiroko Morisaki, Takayuki Morisaki, Jidong Cheng. AMPD2 plays important roles in regulating hepatic glucose and lipid metabolism. Molecular and cellular endocrinology. 2023 Aug; ?(?):112039. doi: 10.1016/j.mce.2023.112039. [PMID: 37567359]
  • Mengrong Yan, Mengyuan Ma, Rong Chen, Yangzi Cao, Wei Zhang, Xiang Liu. Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis. Acta crystallographica. Section F, Structural biology communications. 2023 Aug; 79(Pt 8):208-216. doi: 10.1107/s2053230x23005836. [PMID: 37522751]
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  • Ling Lin, Shumin Han, Zhihua Gong, Furong Ding, Zhonghua Liu, Wenjun Xiao. L-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1. Food & function. 2023 Jun; ?(?):. doi: 10.1039/d3fo01001e. [PMID: 37338809]
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  • Aniqua Tasnim Chowdhury, Md Nazmul Hasan, Fahmid H Bhuiyan, Md Qamrul Islam, Md Rakib Wazed Nayon, Md Mashiur Rahaman, Hammadul Hoque, Nurnabi Azad Jewel, Md Ashrafuzzaman, Shamsul H Prodhan. Identification, characterization of Apyrase (APY) gene family in rice (Oryza sativa) and analysis of the expression pattern under various stress conditions. PloS one. 2023; 18(5):e0273592. doi: 10.1371/journal.pone.0273592. [PMID: 37163561]
  • Michelle Y Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren. CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue. Frontiers in immunology. 2023; 14(?):1308456. doi: 10.3389/fimmu.2023.1308456. [PMID: 38264660]
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  • Xu-Dong Wen, Yao-Lei Zhang, Ling Yang, Zhen Ye, Guo-Chuan Fu, Yong-He Hu, Tao Pan, Qiao-Bo Ye. Angelica sinensis Polysaccharide and Astragalus membranaceus Polysaccharide Accelerate Liver Regeneration by Enhanced Glycolysis via Activation of JAK2/STAT3/HK2 Pathway. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227890. [PMID: 36431990]
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  • Yuwei Liu, Shen Shen, Zhimin Hao, Qing Wang, Yumei Zhang, Yulan Zhao, Yameng Tong, Fanli Zeng, Jingao Dong. Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica. Molecular plant pathology. 2022 11; 23(11):1608-1619. doi: 10.1111/mpp.13253. [PMID: 35929228]
  • Juanjuan Cheng, Lieqiang Xu, Qiuxia Yu, Guoshu Lin, Xingdong Ma, Mengyao Li, Fengkun Guan, Yuhong Liu, Xiaoqi Huang, Jianhui Xie, Jiannan Chen, Ziren Su, Yucui Li. Metformin alleviates long-term high-fructose diet-induced skeletal muscle insulin resistance in rats by regulating purine nucleotide cycle. European journal of pharmacology. 2022 Oct; 933(?):175234. doi: 10.1016/j.ejphar.2022.175234. [PMID: 36058289]
  • Ping-An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao. Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats. European journal of pharmacology. 2022 Oct; 932(?):175236. doi: 10.1016/j.ejphar.2022.175236. [PMID: 36044971]
  • Lu Wang, Yuwei Zhang, Yafeng Ren, Xue Yang, Haijing Ben, Fulan Zhao, Sijin Yang, Li Wang, Jie Qing. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis. European journal of pharmacology. 2022 Oct; 932(?):175241. doi: 10.1016/j.ejphar.2022.175241. [PMID: 36058291]
  • Xue Mei Fang, Ying Liu, Ji Wang, Xin Zhang, Lei Wang, Li Zhang, Hong Ping Zhang, Lei Liu, Dan Huang, Dan Liu, Ke Deng, Feng Ming Luo, Hua Jing Wan, Wei Min Li, Gang Wang, Brian G Oliver. Endogenous Adenosine 5'-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations. Lung. 2022 10; 200(5):579-589. doi: 10.1007/s00408-022-00570-x. [PMID: 36156139]
  • Atsuko Kitano, Toshio Norikura, Isao Matsui-Yuasa, Hiromi Shimakawa, Makoto Kamezawa, Akiko Kojima-Yuasa. Black carrot extract protects against hepatic injury through epigenetic modifications. Journal of food biochemistry. 2022 10; 46(10):e14292. doi: 10.1111/jfbc.14292. [PMID: 35762419]
  • Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy. Journal of cardiovascular pharmacology. 2022 10; 80(4):600-608. doi: 10.1097/fjc.0000000000001315. [PMID: 35881898]
  • Qing Lu, Anaxi Houbaert, Qian Ma, Jingjing Huang, Lieven Sterck, Cheng Zhang, René Benjamins, Frederik Coppens, Frank Van Breusegem, Eugenia Russinova. Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization. The Plant cell. 2022 09; 34(10):3844-3859. doi: 10.1093/plcell/koac203. [PMID: 35876813]
  • Tomasz K Bednarski, Monika K Duda, Pawel Dobrzyn. Alterations of Lipid Metabolism in the Heart in Spontaneously Hypertensive Rats Precedes Left Ventricular Hypertrophy and Cardiac Dysfunction. Cells. 2022 09; 11(19):. doi: 10.3390/cells11193032. [PMID: 36230994]
  • George Kogkos, Foteini Gkartziou, Spyridon Mourtas, Kostas K Barlos, Pavlos Klepetsanis, Kleomenis Barlos, Sophia G Antimisiaris. Liposomal Entrapment or Chemical Modification of Relaxin2 for Prolongation of Its Stability and Biological Activity. Biomolecules. 2022 09; 12(10):. doi: 10.3390/biom12101362. [PMID: 36291571]
  • Hidetoshi Urakawa, Michael A Kratz, Taylor L Hancock, Rick A Armstrong. QT-AMP: Sequencing PCR amplicons from Quanti-Tray wells to analyze enterococci communities. The Science of the total environment. 2022 Sep; 839(?):156188. doi: 10.1016/j.scitotenv.2022.156188. [PMID: 35618132]
  • Tobias Kruse. Function of Molybdenum Insertases. Molecules (Basel, Switzerland). 2022 Aug; 27(17):. doi: 10.3390/molecules27175372. [PMID: 36080140]
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  • Ahmed H Abdelazim, Sherif Ramzy. Spectrophotometric quantitative analysis of remdesivir using acid dye reagent selected by computational calculations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Aug; 276(?):121188. doi: 10.1016/j.saa.2022.121188. [PMID: 35395463]
  • Chunyang Du, Yan Zhu, Yan Yang, Lin Mu, Xue Yan, Ming Wu, Chenming Zhou, Haijiang Wu, Wei Zhang, Yanhui Wu, Guoyu Zhang, Yue Hu, Yunzhuo Ren, Yonghong Shi. C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway. The international journal of biochemistry & cell biology. 2022 08; 149(?):106247. doi: 10.1016/j.biocel.2022.106247. [PMID: 35753650]
  • Katja Merches, Leonie Breunig, Julia Fender, Theresa Brand, Vanessa Bätz, Svenja Idel, Laxmikanth Kollipara, Yvonne Reinders, Albert Sickmann, Angela Mally, Kristina Lorenz. The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro. Archives of toxicology. 2022 08; 96(8):2341-2360. doi: 10.1007/s00204-022-03306-1. [PMID: 35579693]
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  • Marko Lucijanic, Tomislav Cikara, Petra Bistrovic, Ivan Papic, Maja Ortner Hadziabdic, Nikolina Busic, Marina Lackovic, Natalia Cesar, Valentina Koscak, Josko Mitrovic, Bruno Barsic, Tomo Lucijanic. Remdesivir use in COVID-19 patients might predispose bacteremia, matched case-control analysis. The Journal of infection. 2022 Aug; 85(2):174-211. doi: 10.1016/j.jinf.2022.04.045. [PMID: 35513188]
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  • Kevin Baudry, Félix Barbut, Séverine Domenichini, Damien Guillaumot, Mai Pham Thy, Hélène Vanacker, Wojciech Majeran, Anja Krieger-Liszkay, Emmanuelle Issakidis-Bourguet, Claire Lurin. Adenylates regulate Arabidopsis plastidial thioredoxin activities through the binding of a CBS domain protein. Plant physiology. 2022 08; 189(4):2298-2314. doi: 10.1093/plphys/kiac199. [PMID: 35736508]
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  • Issa Haddad, Priyal Agarwal, Mohamed Hassanein. Remdesivir use in COVID-19 patients with end-stage kidney disease on intermittent hemodialysis: An absolute contraindication?. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2022 Aug; 26(4):850-851. doi: 10.1111/1744-9987.13833. [PMID: 35261170]
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