Milrinone (BioDeep_00000405907)

Main id: BioDeep_00000000281

 


代谢物信息卡片


Milrinone

化学式: C12H9N3O (211.0746)
中文名称: 米利酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 869; ORIGINAL_PRECURSOR_SCAN_NO 865
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CE - Phosphodiesterase inhibitors
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
D020011 - Protective Agents > D002316 - Cardiotonic Agents
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 859; ORIGINAL_PRECURSOR_SCAN_NO 857
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 857; ORIGINAL_PRECURSOR_SCAN_NO 854
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 861; ORIGINAL_PRECURSOR_SCAN_NO 858
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 861; ORIGINAL_PRECURSOR_SCAN_NO 859
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 863; ORIGINAL_PRECURSOR_SCAN_NO 859
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1584; ORIGINAL_PRECURSOR_SCAN_NO 1582
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1580; ORIGINAL_PRECURSOR_SCAN_NO 1578
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1589; ORIGINAL_PRECURSOR_SCAN_NO 1588
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1605; ORIGINAL_PRECURSOR_SCAN_NO 1603
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1600; ORIGINAL_PRECURSOR_SCAN_NO 1599
CONFIDENCE standard compound; INTERNAL_ID 1122; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1581; ORIGINAL_PRECURSOR_SCAN_NO 1580

同义名列表

3 个代谢物同义名

Milrinone; Milrinone; Milrinone



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACE, ADA, AXIN2, CASP3, EDN1, PRKX
Peripheral membrane protein 1 ADA
Endoplasmic reticulum membrane 1 PLN
Mitochondrion membrane 1 PLN
Nucleus 3 AXIN2, CASP3, PRKX
cytosol 6 ADA, AVP, AXIN2, CASP3, GPT, PDE3A
dendrite 1 AVP
mitochondrial membrane 1 PLN
centrosome 1 AXIN2
nucleoplasm 3 ATP2B1, CASP3, PRKX
Cell membrane 5 ACE, ADA, ADRB3, ATP2B1, TNF
Multi-pass membrane protein 4 ADRB3, ATP2B1, CACNA1I, PDE3A
Synapse 1 ATP2B1
cell junction 1 ADA
cell surface 2 ADA, TNF
glutamatergic synapse 2 ATP2B1, CASP3
Golgi membrane 1 INS
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 PDE3A
Lysosome 2 ACE, ADA
endosome 1 ACE
plasma membrane 10 ACE, ADA, ADRB3, ATP2B1, AXIN2, CACNA1I, F2, GCG, REN, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ACE, ADA, ATP2B1, CACNA1I, PDE3A, PLN, REN
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ACE, ATP2B1, F2, GPT
endoplasmic reticulum 1 PLN
extracellular space 10 ACE, AVP, CRP, EDN1, F2, GCG, IL6, INS, REN, TNF
perinuclear region of cytoplasm 1 PLN
mitochondrion 1 PLN
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE
Secreted 9 ACE, AVP, CRP, EDN1, F2, GCG, IL6, INS, REN
extracellular region 10 ACE, AVP, CRP, EDN1, F2, GCG, IL6, INS, REN, TNF
Single-pass membrane protein 1 PLN
basal part of cell 1 EDN1
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 3 ACE, ADA, TNF
beta-catenin destruction complex 1 AXIN2
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
sarcoplasmic reticulum 1 PLN
collagen-containing extracellular matrix 1 F2
secretory granule 1 AVP
lateral plasma membrane 1 ATP2B1
receptor complex 1 ADRB3
cell projection 1 ATP2B1
phagocytic cup 1 TNF
brush border membrane 1 ACE
blood microparticle 1 F2
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
secretory granule lumen 2 GCG, INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 F2, GCG, IL6, INS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 EDN1, INS
Sarcoplasmic reticulum membrane 1 PLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
death-inducing signaling complex 1 CASP3
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
calcium ion-transporting ATPase complex 1 PLN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xueyan Cui, Zhongsu Wang, Xue Dong, Zijie Cheng, Le Zhang, Yan Mu, Xin Huang, Yan Li, Yinglong Hong, Yi Han. Comparative Effectiveness and Safety of Milrinone and Levosimendan as Initial Inotrope Therapy in Patients With Acute Heart Failure With Renal Dysfunction. Journal of cardiovascular pharmacology. 2022 06; 79(6):781-790. doi: 10.1097/fjc.0000000000001255. [PMID: 35507915]
  • Sarah Jane Commander, Daniel Gonzalez, Karan R Kumar, Tracy Spears, Michael Cohen-Wolkowiez, Kanecia O Zimmerman, Stephen J Balevic, Christoph P Hornik. The relationship between simulated milrinone exposure and hypotension in children. Cardiology in the young. 2022 May; 32(5):782-788. doi: 10.1017/s1047951121003103. [PMID: 34350821]
  • Dominik J Vogel, Aimee Brame, Fraser Hanks, Chris Remmington, Natali Chung, Luigi Camporota. Improved oxygenation with inhaled milrinone in mechanically ventilated patients with severe COVID-19. British journal of anaesthesia. 2021 09; 127(3):e111-e113. doi: 10.1016/j.bja.2021.06.002. [PMID: 34218906]
  • Elin M Thorlacius, Maria Vistnes, Tiina Ojala, Juho Keski-Nisula, Mattias Molin, Birgitta S Romlin, Mats Synnergren, Sven-Erik Ricksten, Håkan Wåhlander, Albert Castellheim. Levosimendan Versus Milrinone and Release of Myocardial Biomarkers After Pediatric Cardiac Surgery: Post Hoc Analysis of Clinical Trial Data. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2021 07; 22(7):e402-e409. doi: 10.1097/pcc.0000000000002712. [PMID: 33739957]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Aslak Widerøe Kristoffersen, Per Kristian Knudsen, Thomas Møller. SARS-CoV-2 infection in an infant with severe dilated cardiomyopathy. Cardiology in the young. 2021 Mar; 31(3):485-487. doi: 10.1017/s1047951120004060. [PMID: 33118485]
  • Densel Arac, Mehmet Fatih Erdi, Fatih Keskin, Mehmet Kenan, Gokhan Cuce, Fatma H Y Aydemir, Onder Guney, Yalçın Kocaogullar. Neuroprotective Effects of Milrinone on Experimental Acute Spinal Cord Injury: Rat Model. World neurosurgery. 2021 03; 147(?):e225-e233. doi: 10.1016/j.wneu.2020.12.021. [PMID: 33316484]
  • Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya Prakash. Synthesis and characterization of peptide conjugated human serum albumin nanoparticles for targeted cardiac uptake and drug delivery. PloS one. 2021; 16(9):e0254305. doi: 10.1371/journal.pone.0254305. [PMID: 34591850]
  • Rohan Magoon, ItiShri, Jasvinder Kaur Kohli, Ramesh Kashav. Inhaled milrinone for sick COVID-19 cohort: A pathophysiology driven hypothesis!. Medical hypotheses. 2021 01; 146(?):110441. doi: 10.1016/j.mehy.2020.110441. [PMID: 33308938]
  • Marjolein Blink, Emilie P Buddingh', Luc H P M Filippini, Daniëlle M C Brinkman, Simone A Joosten, Richard H Klein. [COVID-19-associated hyperinflammatory state in a 15-year-old female patient]. Nederlands tijdschrift voor geneeskunde. 2020 10; 164(?):. doi: NULL. [PMID: 33331715]
  • Yixin Han, Rui Hou, Xiaoyu Zhang, Haibo Liu, Yuan Gao, Ximeng Li, Ruijuan Qi, Runlan Cai, Yun Qi. Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages. Biochimica et biophysica acta. Molecular cell research. 2020 10; 1867(10):118766. doi: 10.1016/j.bbamcr.2020.118766. [PMID: 32504661]
  • Shinichi Nakanuma, Hidehiro Tajima, Hiroyuki Takamura, Seisho Sakai, Ryosuke Gabata, Mitsuyoshi Okazaki, Hiroyuki Shinbashi, Yoshinao Ohbatake, Isamu Makino, Hironori Hayashi, Tomoharu Miyashita, Sachio Fushida, Tetsuo Ohta. Pretreatment with a Phosphodiesterase-3 Inhibitor, Milrinone, Reduces Hepatic Ischemia-Reperfusion Injury, Minimizing Pericentral Zone-Based Liver and Small Intestinal Injury in Rats. Annals of transplantation. 2020 Jul; 25(?):e922306. doi: 10.12659/aot.922306. [PMID: 32661218]
  • Yu-Shan Ren, Lan-Fang Li, Tao Peng, Yu-Jun Tan, Ying Sun, Guo-Liang Cheng, Gui-Min Zhang, Jie Li. The effect of milrinone on mortality in adult patients who underwent CABG surgery: a systematic review of randomized clinical trials with a meta-analysis and trial sequential analysis. BMC cardiovascular disorders. 2020 07; 20(1):328. doi: 10.1186/s12872-020-01598-8. [PMID: 32640988]
  • Shintaro Dobashi, Ippei Watanabe, Rine Nakanishi, Shinji Hisatake, Shunsuke Kiuchi, Takayuki Kabuki, Takashi Oka, Takahiro Fujii, Takanori Ikeda. Comparing the effects of milrinone and olprinone in patients with congestive heart failure. Heart and vessels. 2020 Jun; 35(6):776-785. doi: 10.1007/s00380-019-01543-6. [PMID: 31865433]
  • Lukas Lannemyr, Gudrun Bragadottir, Bengt Redfors, Sven-Erik Ricksten. Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. Journal of critical care. 2020 06; 57(?):225-230. doi: 10.1016/j.jcrc.2019.12.022. [PMID: 31919012]
  • Katsuyoshi Chiba, Tomomichi Ishizaka, Yu Yoshimatsu, Kei Mikamoto, Yu Maeda, Takuma Iguchi, Makoto Shirai, Takashi Yamaguchi, Koichi Goto, Ken Sakurai, Satoshi Tamai, Hiroko Kataoka, Miki Hasegawa, Kazuhiko Mori. Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys. Journal of pharmacological and toxicological methods. 2020 May; 103(?):106870. doi: 10.1016/j.vascn.2020.106870. [PMID: 32353509]
  • Julie Kelly, Judy Cheng, Rhynn Malloy, Kenneth Lupi. Comparison of Positive Inotropic Agents in the Management of Acute Decompensated Heart Failure. Journal of cardiovascular pharmacology. 2020 05; 75(5):455-459. doi: 10.1097/fjc.0000000000000811. [PMID: 32091426]
  • Amna Qasim, Sunil K Jain. Milrinone Use in Persistent Pulmonary Hypertension of the Newborn. NeoReviews. 2020 03; 21(3):e165-e178. doi: 10.1542/neo.21-3-e165. [PMID: 32123121]
  • Anne Quynh-Nhu Nguyen, André Y Denault, Yves Théoret, Louis P Perrault, France Varin. Inhaled milrinone in cardiac surgical patients: a pilot randomized controlled trial of jet vs. mesh nebulization. Scientific reports. 2020 02; 10(1):2069. doi: 10.1038/s41598-020-58902-x. [PMID: 32034202]
  • Martin Fredholm, Kirsten Jörgensen, Erik Houltz, Sven-Erik Ricksten. Levosimendan or milrinone for right ventricular inotropic treatment?-A secondary analysis of a randomized trial. Acta anaesthesiologica Scandinavica. 2020 02; 64(2):193-201. doi: 10.1111/aas.13486. [PMID: 31556095]
  • Nahmah Kim-Campbell, Catherine Gretchen, Vladimir B Ritov, Patrick M Kochanek, Goundappa K Balasubramani, Elizabeth Kenny, Mahesh Sharma, Melita Viegas, Clifton Callaway, Valerian E Kagan, Hülya Bayír. Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2020 01; 21(1):33-41. doi: 10.1097/pcc.0000000000002036. [PMID: 31305328]
  • Xianyong Liao, Lin Qian, Song Zhang, Xiang Chen, Jing Lei. Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock. Journal of healthcare engineering. 2020; 2020(?):8862256. doi: 10.1155/2020/8862256. [PMID: 32802302]
  • Christoph P Hornik, Ram Yogev, Peter M Mourani, Kevin M Watt, Janice E Sullivan, Andrew M Atz, David Speicher, Amira Al-Uzri, Michelle Adu-Darko, Elizabeth H Payne, Casey E Gelber, Susan Lin, Barrie Harper, Chiara Melloni, Michael Cohen-Wolkowiez, Daniel Gonzalez. Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. Journal of clinical pharmacology. 2019 12; 59(12):1606-1619. doi: 10.1002/jcph.1499. [PMID: 31317556]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jaewon Huh, Hyewon Chung, Wonjung Hwang. Comparison of the Effects of Milrinone, Sodium Nitroprusside, and Nitroglycerine for Induced Hypotension in Elderly Patients Undergoing Spine Surgery: A Randomized Controlled Trial. Clinical spine surgery. 2019 10; 32(8):E366-E371. doi: 10.1097/bsd.0000000000000884. [PMID: 31503048]
  • Peta M A Alexander, Ayse Akcan-Arikan, Lara S Shekerdemian. Another Outcome Lost to the Benefits of Levosimendan?. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 10; 20(10):992-994. doi: 10.1097/pcc.0000000000002019. [PMID: 31580276]
  • Elin M Thorlacius, Pertti K Suominen, Håkan Wåhlander, Juho Keski-Nisula, Maria Vistnes, Sven-Erik Ricksten, Mats Synnergren, Birgitta S Romlin, Albert Castellheim. The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 10; 20(10):947-956. doi: 10.1097/pcc.0000000000002017. [PMID: 31274775]
  • Maarja Hallik, Mari-Liis Ilmoja, Tõnis Tasa, Joseph F Standing, Kalev Takkis, Rūta Veigure, Karin Kipper, Tiiu Jalas, Maila Raidmäe, Karin Uibo, Joel Starkopf, Tuuli Metsvaht. Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2019 07; 20(7):621-629. doi: 10.1097/pcc.0000000000001879. [PMID: 30664589]
  • Tomoyuki Mizuno, Katja M Gist, Zhiqian Gao, Michael F Wempe, Jeffrey Alten, David S Cooper, Stuart L Goldstein, Alexander A Vinks. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clinical pharmacokinetics. 2019 06; 58(6):793-803. doi: 10.1007/s40262-018-0729-3. [PMID: 30607889]
  • Osama Mahmoud Mehanna, Ahmad El Askary, Saad Al-Shehri, Basem El-Esawy. Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats. Archives of physiology and biochemistry. 2018 Dec; 124(5):424-429. doi: 10.1080/13813455.2017.1419267. [PMID: 29271249]
  • Erdal Uysal, Mehmet Dokur, Serdar Altınay, Eyup İlker Saygılı, Kadir Batcıoglu, Mehmet S Ceylan, Hatem Kazımoglu, Burcin A Uyumlu, Mehmet Karadag. Investigation of the Effect of Milrinone on Renal Damage in an Experimental Non-Heart Beating Donor Model. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2018 Oct; 31(5):402-411. doi: 10.1080/08941939.2017.1343880. [PMID: 28708967]
  • Paul Gavra, André Y Denault, Yves Théoret, Louis P Perrault, France Varin. Pharmacokinetics and Pharmacodynamics of Nebulized and Intratracheal Milrinone in a Swine Model of Hypercapnia Pulmonary Hypertension. Journal of cardiothoracic and vascular anesthesia. 2018 10; 32(5):2130-2138. doi: 10.1053/j.jvca.2018.01.031. [PMID: 29525196]
  • Shane Nanayakkara, Vivian Mak, Karina Crannitch, Melissa Byrne, David M Kaye. Extended Release Oral Milrinone, CRD-102, for Advanced Heart Failure. The American journal of cardiology. 2018 09; 122(6):1017-1020. doi: 10.1016/j.amjcard.2018.06.009. [PMID: 30064857]
  • Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn-Schmiedeberg's archives of pharmacology. 2018 09; 391(9):1021-1032. doi: 10.1007/s00210-018-1527-z. [PMID: 29922941]
  • Nikita Lomis, Francis Gaudreault, Meenakshi Malhotra, Susan Westfall, Dominique Shum-Tim, Satya Prakash. Novel Milrinone Nanoformulation for Use in Cardiovascular Diseases: Preparation and in Vitro Characterization. Molecular pharmaceutics. 2018 07; 15(7):2489-2502. doi: 10.1021/acs.molpharmaceut.7b00360. [PMID: 28837343]
  • Anna Cavigelli-Brunner, Maja I Hug, Hitendu Dave, Oskar Baenziger, Christoph Buerki, Dominique Bettex, Vincenzo Cannizzaro, Christian Balmer. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2018 07; 19(7):619-625. doi: 10.1097/pcc.0000000000001533. [PMID: 29538053]
  • Katja M Gist, David S Cooper, Julia Wrona, Sarah Faubel, Christopher Altmann, Zhiqian Gao, Bradley S Marino, Jeffrey Alten, Kristal M Hock, Tomoyuki Mizuno, Alexander A Vinks, Melanie S Joy, Michael F Wempe, Michael R Bennett, Stuart L Goldstein. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Therapeutic drug monitoring. 2018 04; 40(2):186-194. doi: 10.1097/ftd.0000000000000496. [PMID: 29529007]
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