Pilocarpine (BioDeep_00000398745)

Main id: BioDeep_00000002077

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Pilocarpine

化学式: C11H16N2O2 (208.1212)
中文名称: 匹罗卡品, 毛果芸香碱
谱图信息: 最多检出来源 Homo sapiens(blood) 13.37%

分子结构信息

SMILES: CCC(C(=O)2)C(CO2)Cc(c1)n(C)cn1
InChI: InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3

描述信息

S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.053
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.052
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

同义名列表

3 个代谢物同义名

Pilocarpine; Pilocarpine; Pilocarpine



数据库引用编号

54 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIF1, AKT1, ALB, BDNF, CHAT, DCX, NTRK2, P2RX7, PVALB, RBFOX3
Peripheral membrane protein 1 AIF1
Endosome membrane 1 NTRK2
Nucleus 6 AIF1, AKT1, ALB, CHAT, FOS, RBFOX3
cytosol 9 AIF1, AKT1, ALB, CHAT, DCX, FOS, NTRK2, PRKCQ, SST
dendrite 2 BDNF, NTRK2
centrosome 1 ALB
nucleoplasm 2 AKT1, FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 5 AKT1, AQP5, GRID1, NTRK2, P2RX7
Cytoplasmic side 1 AIF1
lamellipodium 2 AIF1, AKT1
ruffle membrane 1 AIF1
Cell projection, axon 1 NTRK2
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 5 AQP5, CACNA1I, GRID1, P2RX7, SYP
Synapse 2 CHAT, PVALB
cell cortex 1 AKT1
glutamatergic synapse 3 AKT1, DCX, GRID1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuromuscular junction 2 P2RX7, SYP
neuronal cell body 2 P2RX7, SST
postsynapse 2 AKT1, P2RX7
presynaptic membrane 1 SYP
synaptic vesicle 2 BDNF, SYP
Presynapse 1 P2RX7
plasma membrane 8 AKT1, AQP5, BCHE, CACNA1I, GRID1, NTRK2, P2RX7, PRKCQ
presynaptic active zone 1 SYP
synaptic vesicle membrane 1 SYP
terminal bouton 2 NTRK2, SYP
Membrane 6 AKT1, BDNF, CACNA1I, NTRK2, P2RX7, SYP
apical plasma membrane 1 AQP5
axon 4 BDNF, CCK, NTRK2, PVALB
extracellular exosome 3 ALB, AQP5, GRID1
endoplasmic reticulum 3 ALB, AQP5, FOS
extracellular space 6 ALB, BCHE, BDNF, CCK, INS, SST
perinuclear region of cytoplasm 4 AIF1, BDNF, NTRK2, SYP
Schaffer collateral - CA1 synapse 1 SYP
mitochondrion 1 P2RX7
protein-containing complex 2 AKT1, ALB
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 1 NTRK2
Secreted 6 ALB, BCHE, BDNF, CCK, INS, SST
extracellular region 6 ALB, BCHE, BDNF, CCK, INS, SST
excitatory synapse 1 SYP
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYP
external side of plasma membrane 1 P2RX7
dendritic spine 1 NTRK2
perikaryon 1 RBFOX3
microtubule cytoskeleton 1 AKT1
Early endosome 1 NTRK2
cell-cell junction 2 AKT1, P2RX7
vesicle 1 AKT1
postsynaptic membrane 1 GRID1
Apical cell membrane 1 AQP5
Cell projection, ruffle membrane 1 AIF1
Cytoplasm, perinuclear region 1 NTRK2
Cytoplasm, cytoskeleton 1 AIF1
microtubule 1 DCX
spindle 1 AKT1
GABA-ergic synapse 2 GRID1, SST
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Postsynaptic cell membrane 1 GRID1
ruffle 1 AIF1
receptor complex 1 NTRK2
Cell projection, neuron projection 1 DCX
neuron projection 3 CHAT, DCX, SYP
ciliary basal body 2 AKT1, ALB
chromatin 1 FOS
microtubule associated complex 1 DCX
Cell projection, phagocytic cup 1 AIF1
phagocytic cup 1 AIF1
cytoskeleton 1 DCX
centriole 1 ALB
spindle pole 1 ALB
actin filament 1 AIF1
blood microparticle 2 ALB, BCHE
Endomembrane system 1 SYP
endosome lumen 1 INS
microvillus 1 AQP5
Cytoplasmic vesicle membrane 1 AQP5
Cell projection, dendrite 1 NTRK2
basal plasma membrane 1 AQP5
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, BDNF, INS
nuclear matrix 1 FOS
platelet alpha granule lumen 1 ALB
axon terminus 1 NTRK2
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
nuclear envelope lumen 1 BCHE
Synapse, synaptosome 1 SYP
protein-DNA complex 1 FOS
bleb 1 P2RX7
glial cell projection 1 AIF1
transcription factor AP-1 complex 1 FOS
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB


文献列表

  • Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek. CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model. Cell and tissue research. 2024 Jun; 396(3):371-397. doi: 10.1007/s00441-024-03880-z. [PMID: 38499882]
  • Riccardo Lorrai, Dario Cavaterra, Sara Giammaria, Diego Sbardella, Grazia Raffaella Tundo, Alessandra Boccaccini. Eye Diseases: When the Solution Comes from Plant Alkaloids. Planta medica. 2024 May; 90(6):426-439. doi: 10.1055/a-2283-2350. [PMID: 38452806]
  • Hanbing Xu, Yubo Wang, Congcong Yu, Chunhong Han, Huifei Cui. Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress. ACS chemical neuroscience. 2024 May; 15(9):1937-1947. doi: 10.1021/acschemneuro.4c00188. [PMID: 38630556]
  • Karen Paola Ramos-Riera, Luis Beltrán-Parrazal, Consuelo Morgado-Valle, Francisca Pérez-Severiano, Pablo Eliasib Martínez-Gopar, María Leonor López-Meraz. Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress. Epilepsia open. 2024 Apr; 9(2):665-678. doi: 10.1002/epi4.12905. [PMID: 38321819]
  • Letícia Meier, Estevan Bruginski, Joseane Righes Marafiga, Letícia Barbieri Caus, Mayara Vendramin Pasquetti, Maria Elisa Calcagnotto, Francinete Ramos Campos. Hippocampal metabolic profile during epileptogenesis in the pilocarpine model of epilepsy. Biomedical chromatography : BMC. 2023 Dec; ?(?):e5820. doi: 10.1002/bmc.5820. [PMID: 38154955]
  • Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Juan Manuel Castañeda-Morales, Joel Jahaziel Díaz-Vallejo, Óscar Rosales-Sánchez, Juan Francisco Rodríguez-Landa. The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in rats. BMC complementary medicine and therapies. 2023 Sep; 23(1):343. doi: 10.1186/s12906-023-04179-2. [PMID: 37759286]
  • Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu. Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087356. [PMID: 37108518]
  • Amira E El-Nahas, Heba M Elbedaiwy, Inas M Masoud, Rania G Aly, Maged W Helmy, Amal H El-Kamel. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Apr; ?(?):. doi: 10.1016/j.ejpb.2023.04.008. [PMID: 37068561]
  • Hushuai Fan, Xiaomin Huang, Ziru Zhang, Ting Wang, Ludan Wang, Yajun Zhang. Immobilization of M3 Muscarinic Receptor to Rapidly Analyze Drug-Protein Interactions and Bioactive Components in a Natural Plant. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087171. [PMID: 37108332]
  • Maxwell Blesdel Adassi, Gwladys Temkou Ngoupaye, Francis Bray Yassi, Aurelien Fossueh Foutsop, Tatiana Diebo Kom, Elisabeth Ngo Bum. Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. Journal of ethnopharmacology. 2023 Mar; 303(?):115995. doi: 10.1016/j.jep.2022.115995. [PMID: 36509255]
  • Supriya Sharma, Anil Kumar Rana, Shubham Nilkanth Rahmatkar, Vikram Patial, Damanpreet Singh. Protective effect of Nardostachys jatamansi extract against lithium-pilocarpine-induced spontaneous recurrent seizures and associated cardiac irregularities in a rat model. Journal of ethnopharmacology. 2023 Feb; ?(?):116280. doi: 10.1016/j.jep.2023.116280. [PMID: 36813245]
  • Chang Yu Kan, Jing Xuan H'ng, Andy Goh, Frederick Smales, Eng Lai Tan, Shiming Zhang, Mallikarjuna Rao Pichika, Abhishek Parolia. Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice. International dental journal. 2023 Feb; 73(1):63-70. doi: 10.1016/j.identj.2022.04.011. [PMID: 35725589]
  • Kenjirou Ogawa, Karin Urata, Saki Maeda, Yuta Ohno, Keitaro Satoh, Yoshiyuki Yamada, Yosuke Suzuki, Yasuko Koga, Kazuhiro Sugamoto, Makiko Kawaguchi, Hisato Kunitake, Kazuo Nishiyama, Y O Goto, Takayuki Nakayama, Masao Yamasaki. Blueberry Leaf Extract Prevents Lacrimal Hyposecretion in Sjögren's Syndrome-like Model of Non-obese Diabetic Mice. In vivo (Athens, Greece). 2023 Jan; 37(1):149-162. doi: 10.21873/invivo.13064. [PMID: 36593026]
  • Michaela Shishmanova-Doseva, Katerina Georgieva, Yordanka Uzunova, Lyubka Ioanidu, Milena Atanasova, Zlatina Nenchovska, Jana Tchekalarova. Pre- and Post-Endurance Training Mitigates the Rat Pilocarpine-Induced Status Epilepticus and Epileptogenesis-Associated Deleterious Consequences. International journal of molecular sciences. 2022 Oct; 23(21):. doi: 10.3390/ijms232113188. [PMID: 36361978]
  • Isaac Zamora-Bello, Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa. Anticonvulsant Effect of Turmeric and Resveratrol in Lithium/Pilocarpine-Induced Status Epilepticus in Wistar Rats. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123835. [PMID: 35744955]
  • Michele Pereira Mallmann, Fernanda Kulinski Mello, Bruna Neuberger, Karine Gabriela da Costa Sobral, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Mauro Schneider Oliveira. Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats. Brain research. 2022 06; 1784(?):147883. doi: 10.1016/j.brainres.2022.147883. [PMID: 35300975]
  • Jian-Bo Lin, Nan-Long Lin, Xu Li, Ming-Qiang Kang. Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis. Annals of clinical and translational neurology. 2022 06; 9(6):786-794. doi: 10.1002/acn3.51558. [PMID: 35393764]
  • Wei Yang, Lijuan He. The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor. Bioengineered. 2022 04; 13(4):8689-8698. doi: 10.1080/21655979.2022.2054596. [PMID: 35322725]
  • Marwa M Nagib, Sicheng Zhang, Nelufar Yasmen, Lexiao Li, Ruida Hou, Ying Yu, Vijay K Boda, Zhongzhi Wu, Wei Li, Jianxiong Jiang. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. Epilepsia. 2022 04; 63(4):1003-1015. doi: 10.1111/epi.17190. [PMID: 35179226]
  • Simon Pale, Sidiki Neteydji, Germain Sotoing Taiwe, Nadège Kouemou Emegam, Elisabeth Ngo Bum. Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. Journal of ethnopharmacology. 2022 Mar; 286(?):114863. doi: 10.1016/j.jep.2021.114863. [PMID: 34838617]
  • Inas A Harb, Hend Ashour, Abeer Mostafa, Hala M El Hanbuli, Eman Hassan Nadwa. Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction. Clinical and experimental pharmacology & physiology. 2022 03; 49(3):406-418. doi: 10.1111/1440-1681.13615. [PMID: 34796981]
  • Akiko Tanaka, Hiroyuki Nakano, Kunio Yoneto, Chika Yoneto, Tomoyuki Furubayashi, Kei Suzuki, Azusa Okae, Takaaki Ueno, Toshiyasu Sakane. Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine. Biological & pharmaceutical bulletin. 2022; 45(4):403-408. doi: 10.1248/bpb.b21-00763. [PMID: 35370264]
  • Hagar N Abd Allah, Manal Abdul-Hamid, Ayman M Mahmoud, Eman S Abdel-Reheim. Melissa officinalis L. ameliorates oxidative stress and inflammation and upregulates Nrf2/HO-1 signaling in the hippocampus of pilocarpine-induced rats. Environmental science and pollution research international. 2022 Jan; 29(2):2214-2226. doi: 10.1007/s11356-021-15825-y. [PMID: 34363578]
  • Peng Wang, Kang Ma, Lu Yang, Guodong Zhang, Mengyi Ye, Siqi Wang, Shuangshuang Wei, Zhangping Chen, Jinghai Gu, Lianxiang Zhang, Jianguo Niu, Sun Tao. Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study. International journal of biological macromolecules. 2021 Dec; 193(Pt B):1457-1470. doi: 10.1016/j.ijbiomac.2021.10.209. [PMID: 34742844]
  • Tao Xiang, Xiaodan Luo, Chunmei Zeng, Sijun Li, Meigang Ma, Yuan Wu. Klotho ameliorated cognitive deficits in a temporal lobe epilepsy rat model by inhibiting ferroptosis. Brain research. 2021 12; 1772(?):147668. doi: 10.1016/j.brainres.2021.147668. [PMID: 34592245]
  • You Wang, Jinxian Yuan, Xinyuan Yu, Xi Liu, Changhong Tan, Yangmei Chen, Tao Xu. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity. Cell death & disease. 2021 10; 12(10):936. doi: 10.1038/s41419-021-04233-2. [PMID: 34642320]
  • Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wang. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. Brain research. 2021 08; 1764(?):147468. doi: 10.1016/j.brainres.2021.147468. [PMID: 33831409]
  • Michaela Shishmanova-Doseva, Dimitrinka Atanasova, Yordanka Uzunova, Lyubka Yoanidu, Lyudmil Peychev, Pencho Marinov, Jana Tchekalarova. Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094667. [PMID: 33925082]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Shuaishuai Xia, Ping Yang, Feng Li, Qian Yu, Weiping Kuang, Yong Zhu, Jun Lu, Huaying Wu, Liang Li, Huiyong Huang. Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons. Journal of ethnopharmacology. 2021 Apr; 270(?):113794. doi: 10.1016/j.jep.2021.113794. [PMID: 33422654]
  • Chih-Sheng Yang, Sheng-Chun Chiu, Ping-Yen Liu, Sheng-Nan Wu, Ming-Chi Lai, Chin-Wei Huang. Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. Journal of ethnopharmacology. 2021 Apr; 269(?):113751. doi: 10.1016/j.jep.2020.113751. [PMID: 33359863]
  • Philip Hampel, Kerstin Römermann, Björn Gailus, Marie Johne, Birthe Gericke, Edith Kaczmarek, Wolfgang Löscher. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. Neuropharmacology. 2021 03; 185(?):108449. doi: 10.1016/j.neuropharm.2021.108449. [PMID: 33450274]
  • Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar. Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. Behavioural neurology. 2021; 2021(?):5549638. doi: 10.1155/2021/5549638. [PMID: 34149964]
  • Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Emmanuel Awintiig Adakudugu, Daniel Anokwah, Lovia Serwaa Agyemang, Eric Woode, Elvis Ofori Ameyaw. The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae). Neural plasticity. 2021; 2021(?):5566890. doi: 10.1155/2021/5566890. [PMID: 34257639]
  • Gary P Brennan, Sebastian Bauer, Tobias Engel, Eva M Jimenez-Mateos, Federico Del Gallo, Thomas D M Hill, Niamh M C Connolly, Lara S Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R Reschke, Norman Delanty, Jochen H M Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C Henshall. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy. Neurobiology of disease. 2020 10; 144(?):105048. doi: 10.1016/j.nbd.2020.105048. [PMID: 32800995]
  • Ping Yang, You Qin, Yong Zhu, Feng Li, Shuai-Shuai Xia, Bin Zhou, Qin Wang, Jun Lu, Liang Li, Hui-Yong Huang. Chaihu-Longgu-Muli decoction relieves epileptic symptoms by improving autophagy in hippocampal neurons. Journal of ethnopharmacology. 2020 Sep; 259(?):112990. doi: 10.1016/j.jep.2020.112990. [PMID: 32442588]
  • Pedro Everson Alexandre de Aquino, Jéssica Rabelo Bezerra, Tyciane de Souza Nascimento, Juliete Tavares, Ítalo Rosal Lustosa, Adriano José Maia Chaves Filho, Melina Mottin, Danielle Macêdo Gaspar, Geanne Matos de Andrade, Kelly Rose Tavares Neves, Giuseppe Biagini, Edilberto Rocha Silveira, Glauce Socorro de Barros Viana. A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice. International journal of molecular sciences. 2020 Jun; 21(11):. doi: 10.3390/ijms21114188. [PMID: 32545390]
  • Lin Luo, Gaoshan Zhang, Liuliu Mao, Pengbo Wang, Chenghao Xi, Gaoyong Shi, Jianmei W Leavenworth. Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway. Toxicology and applied pharmacology. 2020 05; 395(?):114978. doi: 10.1016/j.taap.2020.114978. [PMID: 32234387]
  • Yanrong Zhang, Haiyan Zhou, Haibo Qu, Chengde Liao, Hong Jiang, Siqin Huang, Sara Natasha Ghobadi, Arsenii Telichko, Ningrui Li, Frezghi G Habte, Tim Doyle, James P Woznak, Edward H Bertram, Kevin S Lee, Max Wintermark. Effects of Non-invasive, Targeted, Neuronal Lesions on Seizures in a Mouse Model of Temporal Lobe Epilepsy. Ultrasound in medicine & biology. 2020 05; 46(5):1224-1234. doi: 10.1016/j.ultrasmedbio.2020.01.008. [PMID: 32081583]
  • Chu-Xin Deng, Zhi-Bing Wu, Yi Chen, Zheng-Miao Yu. Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats. Chinese journal of integrative medicine. 2020 Feb; 26(2):138-145. doi: 10.1007/s11655-019-2944-7. [PMID: 31093879]
  • G Smilin Bell Aseervatham, E Abbirami, T Sivasudha, K Ruckmani. Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice. Metabolic brain disease. 2020 01; 35(1):159-173. doi: 10.1007/s11011-019-00501-5. [PMID: 31728889]
  • Florencia Chena-Becerra, Genaro Alfonso Coria-Avila, Luis Beltrán-Parrazal, Jorge Manzo, María Leonor López-Meraz. Long-term effects of status epilepticus during infancy in male rats: Sexual behavior and brain response upon exposure to sexually receptive females. Epilepsy & behavior : E&B. 2020 01; 102(?):106676. doi: 10.1016/j.yebeh.2019.106676. [PMID: 31756620]
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