candesartan (BioDeep_00000397561)

Main id: BioDeep_00000001532

 


代谢物信息卡片


candesartan

化学式: C24H20N6O3 (440.1597)
中文名称: 坎地沙坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
InChI: InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)

描述信息

C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2137
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].

同义名列表

3 个代谢物同义名

candesartan; CV 11974; Candesartan



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, ACE2, ALB, ANG, EDN1, NOS2, NOS3, PPARG, TLR4
Endosome membrane 1 TLR4
Nucleus 5 ALB, ANG, NOS2, NOS3, PPARG
cytosol 6 ALB, ANG, NOS2, NOS3, PPARG, PRKCQ
centrosome 1 ALB
nucleoplasm 3 NOS2, NOS3, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 5 ACE, ACE2, AGTR1, TLR4, VCAM1
Multi-pass membrane protein 2 AGTR1, CACNA1I
cell surface 4 ACE2, ADIPOQ, TLR4, VCAM1
Golgi apparatus 3 ALB, NOS3, VCAM1
Golgi membrane 1 NOS3
growth cone 1 ANG
neuronal cell body 1 ANG
sarcolemma 1 VCAM1
Cytoplasm, cytosol 1 NOS2
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 11 ACE, ACE2, AGTR1, CACNA1I, KNG1, NOS2, NOS3, PRKCQ, REN, TLR4, VCAM1
Membrane 7 ACE, ACE2, AGTR1, CACNA1I, REN, TLR4, VCAM1
apical plasma membrane 1 ACE2
caveola 1 NOS3
extracellular exosome 6 ACE, ACE2, AGT, ALB, KNG1, VCAM1
endoplasmic reticulum 3 ADIPOQ, ALB, VCAM1
extracellular space 13 ACE, ACE2, ADIPOQ, AGT, ALB, ANG, CCL2, CRP, EDN1, IL10, KNG1, REN, VCAM1
perinuclear region of cytoplasm 4 NOS2, NOS3, PPARG, TLR4
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 PPARG
filopodium 1 VCAM1
Single-pass type I membrane protein 4 ACE, ACE2, TLR4, VCAM1
Secreted 11 ACE, ACE2, ADIPOQ, AGT, ALB, ANG, CCL2, CRP, EDN1, IL10, REN
extracellular region 12 ACE, ACE2, ADIPOQ, AGT, ALB, ANG, CCL2, CRP, EDN1, IL10, KNG1, REN
basal part of cell 1 EDN1
anchoring junction 1 ALB
Cell projection, cilium 1 ACE2
centriolar satellite 1 PRKCQ
external side of plasma membrane 3 ACE, TLR4, VCAM1
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Early endosome 2 TLR4, VCAM1
apical part of cell 2 REN, VCAM1
Apical cell membrane 1 ACE2
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 ACE2
Peroxisome 1 NOS2
basement membrane 1 ANG
collagen trimer 1 ADIPOQ
peroxisomal matrix 1 NOS2
collagen-containing extracellular matrix 3 ADIPOQ, AGT, KNG1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 PPARG, TLR4
ciliary basal body 1 ALB
cilium 1 ACE2
chromatin 1 PPARG
phagocytic cup 1 TLR4
Chromosome 1 ANG
cytoskeleton 1 NOS3
podosome 1 VCAM1
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 2 ACE, ACE2
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 3 AGT, ALB, KNG1
sperm midpiece 1 ACE
microvillus 1 VCAM1
Cytoplasm, Stress granule 2 ANG, NOS3
cytoplasmic stress granule 2 ANG, NOS3
basal plasma membrane 1 ACE
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 3 ACE2, ALB, KNG1
platelet alpha granule lumen 2 ALB, KNG1
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle membrane 2 ACE2, NOS3
endocytic vesicle 1 ANG
transport vesicle 1 EDN1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Vascular cell adhesion protein 1]: Cell membrane 1 VCAM1
[Soluble Vascular Cell Adhesion Molecule-1]: Secreted 1 VCAM1
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex 1 VCAM1
ciliary transition fiber 1 ALB
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Noha A T Abbas, Fawkia A Fayed, Rabab Saber El Sebaey, Heba A Hassan. Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02771-4. [PMID: 37831115]
  • Jin Wook Lee, Hyun-Oh Gu, Yunshin Jung, YunJae Jung, Seung-Yong Seo, Jeong-Hee Hong, In-Sun Hong, Dae Ho Lee, Ok-Hee Kim, Byung-Chul Oh. Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation. Experimental & molecular medicine. 2023 May; ?(?):. doi: 10.1038/s12276-023-00982-6. [PMID: 37121975]
  • Tian Xia, Lu-Lu Xu, Peng-Yue Guo, Wan-Ting Shi, Yan-Qiong Cheng, Ai-Jun Liu. Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo. Pharmacology research & perspectives. 2023 04; 11(2):e01064. doi: 10.1002/prp2.1064. [PMID: 36810974]
  • Lena Neuper, Daniel Kummer, Désirée Forstner, Jacqueline Guettler, Nassim Ghaffari-Tabrizi-Wizsy, Cornelius Fischer, Herbert Juch, Olivia Nonn, Martin Gauster. Candesartan Does Not Activate PPARγ and Its Target Genes in Early Gestation Trophoblasts. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012326. [PMID: 36293183]
  • Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):413-423. doi: 10.1161/hypertensionaha.121.18026. [PMID: 34879704]
  • Sagarika Majhi, Lubhan Singh, Mohd Yasir. Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity. Vascular health and risk management. 2022; 18(?):857-866. doi: 10.2147/vhrm.s381485. [PMID: 36536768]
  • Reetu R Singh, Zoe McArdle, Lindsea C Booth, Clive N May, Geoff A Head, Karen M Moritz, Markus P Schlaich, Kate M Denton. Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage. Hypertension (Dallas, Tex. : 1979). 2022 01; 79(1):261-270. doi: 10.1161/hypertensionaha.121.18354. [PMID: 34739764]
  • Valeria R Martínez, Evelina G Ferrer, Patricia Am Williams. Candesartan, losartan and valsartan Zn(II) complexes interactions with bovine serum albumin. Future medicinal chemistry. 2022 01; 14(1):9-16. doi: 10.4155/fmc-2021-0216. [PMID: 34730021]
  • Germana Silva Vasconcelos, Manuel Alves Dos Santos Júnior, Aline Santos Monte, Francisco Eliclécio Rodrigues da Silva, Camila Nayane de Carvalho Lima, Abelardo Barbosa Moreira Lima Neto, Ingridy da Silva Medeiros, Antonio Lucio Teixeira, David Freitas de Lucena, Silvânia Maria Mendes Vasconcelos, Danielle S Macedo. Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. 2021 12; 111(?):110348. doi: 10.1016/j.pnpbp.2021.110348. [PMID: 33984421]
  • Viktor Rotbain Curovic, Pedro Magalhães, Tianlin He, Tine W Hansen, Harald Mischak, Peter Rossing. Urinary peptidome and diabetic retinopathy in the DIRECT-Protect 1 and 2 trials. Diabetic medicine : a journal of the British Diabetic Association. 2021 09; 38(9):e14634. doi: 10.1111/dme.14634. [PMID: 34228837]
  • Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito. High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation. Journal of the American Heart Association. 2021 07; 10(14):e016543. doi: 10.1161/jaha.120.016543. [PMID: 34259014]
  • Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
  • Antonia Anna Lukito, Allen Widysanto, Theo Audi Yanto Lemuel, Ignatius Bima Prasetya, Billy Massie, Mira Yuniarti, Nicolaski Lumbuun, Raymond Pranata, Cindy Meidy, Eka Julianta Wahjoepramono, Irawan Yusuf. Candesartan as a tentative treatment for COVID-19: A prospective non-randomized open-label study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Jul; 108(?):159-166. doi: 10.1016/j.ijid.2021.05.019. [PMID: 34038766]
  • Xin-Jun Cai, Zeng Wang, Ying-Ying Xu, Gao-Yi Yang, Ruo-Ying Zhang, Yu Wang. Candesartan treatment enhances liposome penetration and anti-tumor effect via depletion of tumor stroma and normalization of tumor vessel. Drug delivery and translational research. 2021 06; 11(3):1186-1197. doi: 10.1007/s13346-020-00842-0. [PMID: 32822012]
  • Aida M Abreu Diaz, Gergana O Drumeva, Philippe Laporte, Luis M Alonso Martinez, Daniil R Petrenyov, Jean-François Carrier, Jean N DaSilva. Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors. Nuclear medicine and biology. 2021 May; 96-97(?):41-49. doi: 10.1016/j.nucmedbio.2021.03.003. [PMID: 33798796]
  • Fedor Simko, Tomas Baka. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?. Clinical science (London, England : 1979). 2021 04; 135(8):1009-1014. doi: 10.1042/cs20210182. [PMID: 33881142]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Lea Wagmann, Aline C Vollmer, Lucas Lauder, Felix Mahfoud, Markus R Meyer. Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis. Molecules (Basel, Switzerland). 2021 Mar; 26(5):. doi: 10.3390/molecules26051495. [PMID: 33803489]
  • Luis Michel Alonso Martinez, Jean N DaSilva. Development of a novel [18 F]fluorobenzyl derivative of the AT1 receptor antagonist Candesartan. Journal of labelled compounds & radiopharmaceuticals. 2021 03; 64(3):120-128. doi: 10.1002/jlcr.3892. [PMID: 33084079]
  • Zhe Li, Yuxi Lin, Yi-You Huang, Runduo Liu, Chang-Guo Zhan, Xin Wang, Hai-Bin Luo. Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2021 02; 118(8):. doi: 10.1073/pnas.2024937118. [PMID: 33568500]
  • Chunlong Ma, Jun Wang. Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2021 02; 118(8):. doi: 10.1073/pnas.2024420118. [PMID: 33568498]
  • Maria A Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M Labandeira, Gemma Navarro, Rafael Franco, Jose L Labandeira-Garcia, Ana I Rodriguez-Perez. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical science (London, England : 1979). 2021 02; 135(3):465-481. doi: 10.1042/cs20201511. [PMID: 33479758]
  • Christine Trabolsi, Wafaa Takash Chamoun, Akram Hijazi, Cendrine Nicoletti, Marc Maresca, Mohamad Nasser. Study of Neuroprotection by a Combination of the Biological Antioxidant (Eucalyptus Extract) and the Antihypertensive Drug Candesartan against Chronic Cerebral Ischemia in Rats. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26040839. [PMID: 33562701]
  • Kristina Gundlach, Katharina Wolf, Isam Salem, Olaf Randerath, Dan Seiler. Safety of Candesartan, Amlodipine, and Atorvastatin in Combination: Interaction Study in Healthy Subjects. Clinical pharmacology in drug development. 2021 02; 10(2):190-197. doi: 10.1002/cpdd.787. [PMID: 32388918]
  • Kristina Rodionova, Martin Hindermann, Karl Hilgers, Christian Ott, Roland E Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting. AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects?. Kidney & blood pressure research. 2021; 46(3):331-341. doi: 10.1159/000515616. [PMID: 34034251]
  • Nahla E El-Ashmawy, Hoda A El-Bahrawy, Heba H Ashmawy, Eman G Khedr. Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis. PloS one. 2021; 16(5):e0251408. doi: 10.1371/journal.pone.0251408. [PMID: 33984042]
  • Takaichi Suehiro, Kazuhiko Tsuruya, Hisako Yoshida, Hiroaki Tsujikawa, Shunsuke Yamada, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Takanari Kitazono. Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial. Kidney & blood pressure research. 2021; 46(2):173-184. doi: 10.1159/000512365. [PMID: 33677450]
  • Chang-Mu Chen, Yao-Pang Chung, Chia-Hung Liu, Kuo-Tong Huang, Siao-Syun Guan, Chih-Kang Chiang, Chen-Tien Wu, Shing-Hwa Liu. Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153352. doi: 10.1016/j.phymed.2020.153352. [PMID: 33007732]
  • Ravinder Verma, Deepak Kaushik. Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential. Drug delivery. 2020 Dec; 27(1):756-771. doi: 10.1080/10717544.2020.1760961. [PMID: 32397771]
  • N Morollón, R Belvís, A De Dios, N Pagès, C González-Oria, G Latorre, S Santos-Lasaosa. Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology's Headache Study Group. Neurologia (Barcelona, Spain). 2020 Nov; 35(9):628-632. doi: 10.1016/j.nrl.2020.07.007. [PMID: 32896463]
  • Abdel G Elkahloun, Juan M Saavedra. Candesartan could ameliorate the COVID-19 cytokine storm. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110653. doi: 10.1016/j.biopha.2020.110653. [PMID: 32942152]
  • Hongyu Yang, Xiaoshan Song, Zhimiao Wei, Chunmei Xia, Jijiang Wang, Linlin Shen, Jin Wang. TLR4/MyD88/NF-κB Signaling in the Rostral Ventrolateral Medulla Is Involved in the Depressor Effect of Candesartan in Stress-Induced Hypertensive Rats. ACS chemical neuroscience. 2020 10; 11(19):2978-2988. doi: 10.1021/acschemneuro.0c00029. [PMID: 32898417]
  • Mohammad AlQudah, Taben M Hale, Michael P Czubryt. Targeting the renin-angiotensin-aldosterone system in fibrosis. Matrix biology : journal of the International Society for Matrix Biology. 2020 09; 91-92(?):92-108. doi: 10.1016/j.matbio.2020.04.005. [PMID: 32422329]
  • Ming-Jia Chen, Yu-Jia Wei, Xing-Xuan Dong, Jie-Yu Liu, Qiu-Yu Chen, Guo-Xing Zhang. The effect of candesartan on chronic stress induced imbalance of glucose homeostasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Aug; 128(?):110300. doi: 10.1016/j.biopha.2020.110300. [PMID: 32485572]
  • Natsumi Yamamura-Miyazaki, Toshimi Michigami, Kenichi Satomura, Maki Urushihara, Shoji Kagami, Katsusuke Yamamoto. Reduction in urinary angiotensinogen levels and improvement of proteinuria by renin-angiotensin system blockade in pediatric chronic kidney disease patients with very low birth weight. Pediatric nephrology (Berlin, Germany). 2020 07; 35(7):1307-1314. doi: 10.1007/s00467-020-04520-8. [PMID: 32162100]
  • Juyoung Shin, Hun-Sung Kim, Tong Min Kim, Hyunah Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon. The short-term effects of angiotensin II receptor blockers on albuminuria and renal function in Korean patients. Basic & clinical pharmacology & toxicology. 2020 May; 126(5):424-431. doi: 10.1111/bcpt.13369. [PMID: 31765038]
  • Aimin Tan, Xuan Gui, Molly Wong, Hui Deng, Guifen Gu, Constantine Fanaras, John C Fanaras. Simultaneous quantification of candesartan and irbesartan in rabbit eye tissues by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2020 May; 34(5):e4808. doi: 10.1002/bmc.4808. [PMID: 32100318]
  • Abdel G Elkahloun, Juan M Saavedra. Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. Molecular neurobiology. 2020 Mar; 57(3):1656-1673. doi: 10.1007/s12035-019-01800-9. [PMID: 31811565]
  • Sofia Kiriakidi, Christos Chatzigiannis, Christina Papaemmanouil, Andreas G Tzakos, Thomas Mavromoustakos. Exploring the role of the membrane bilayer in the recognition of candesartan by its GPCR AT1 receptor. Biochimica et biophysica acta. Biomembranes. 2020 03; 1862(3):183142. doi: 10.1016/j.bbamem.2019.183142. [PMID: 31830465]
  • Misari Patel, Charmy Kothari. Quantitative bio-analysis of pitavastatin and candesartan in rat plasma by HPLC-UV: Assessment of pharmacokinetic drug-drug interaction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Feb; 1138(?):121962. doi: 10.1016/j.jchromb.2019.121962. [PMID: 31915110]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Misari Patel, Charmy Kothari. A simple, rapid and fully validated HPLC method for simultaneous quantitative bio-analysis of rosuvastatin and candesartan in rat plasma: Application to pharmacokinetic interaction study. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4607. doi: 10.1002/bmc.4607. [PMID: 31141832]
  • Elle Dagmar Coberger, Berit Packert Jensen, Judith Maree Dalrymple. Transfer of Candesartan Into Human Breast Milk. Obstetrics and gynecology. 2019 09; 134(3):481-484. doi: 10.1097/aog.0000000000003446. [PMID: 31403599]
  • Dandan Wu, Xiaoting Tang, Liliqiang Ding, Jingang Cui, Peiwei Wang, Xiaoye Du, Jianyun Yin, Wenjian Wang, Yu Chen, Teng Zhang. Candesartan attenuates hypertension-associated pathophysiological alterations in the gut. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Aug; 116(?):109040. doi: 10.1016/j.biopha.2019.109040. [PMID: 31170664]
  • Dirk Thomas, Yuwang Liu, Herbert Stein, Boris Weimann. Investigation of bioequivalence, safety, and tolerability of a fixed-dose combination of nifedipine GITS and candesartan compared with the corresponding loose-dose combination under fed conditions
. International journal of clinical pharmacology and therapeutics. 2019 Aug; 57(8):420-428. doi: 10.5414/cp203200. [PMID: 31232274]
  • Robert P Carroll, Sue Deayton, Timothy Emery, Watsala Munasinghe, Eleni Tsiopelas, Adrian Fleet, Meg Lake, Ian Humphreys, Maisarah Jalalonmuhali, Patrick Coates. Proactive treatment of angiotensin receptor antibodies in kidney transplantation with plasma exchange and/or candesartan is safe and associated with excellent graft survival at 4 years: A single centre Australian experience. Human immunology. 2019 Aug; 80(8):573-578. doi: 10.1016/j.humimm.2019.04.005. [PMID: 31014826]
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