Tylosin (BioDeep_00000397470)

Main id: BioDeep_00000001948

 

Chemicals and Drugs natural product


代谢物信息卡片


2-[(4S,5R,6R,7S,9S,11E,13E,15S,16S)-6-[(2S,3S,4S,5R,6S)-5-[(2R,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2S,3S,4S,5S,6S)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

化学式: C46H77NO17 (915.5191)
中文名称: 泰洛星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC
InChI: InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m0/s1

描述信息

A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
CONFIDENCE standard compound; INTERNAL_ID 2519
CONFIDENCE standard compound; INTERNAL_ID 1057
Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].

同义名列表

4 个代谢物同义名

Tylosin; 2-[(4S,5R,6R,7S,9S,11E,13E,15S,16S)-6-[(2S,3S,4S,5R,6S)-5-[(2R,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2S,3S,4S,5S,6S)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde; Tylosin A; Tylosin



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

77 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, CAT, MEFV, RPL22, TXN
Peripheral membrane protein 2 ATP6V1D, CYP1B1
Endosome membrane 1 ATP6V1D
Endoplasmic reticulum membrane 2 CYP1B1, ZDHHC16
Cytoplasmic vesicle, autophagosome 1 MEFV
Nucleus 6 ALB, ANKRD42, CTBP2, MEFV, RPL22, TXN
autophagosome 1 MEFV
cytosol 6 ALB, ATP6V1D, CAT, MEFV, RPL22, TXN
phagocytic vesicle 1 STX8
trans-Golgi network 1 STX8
centrosome 2 ALB, ATP6V1D
nucleoplasm 3 ATP6V1D, MEFV, TXN
Cell membrane 1 TNF
Cytoplasmic side 1 ATP6V1D
lamellipodium 1 MEFV
Multi-pass membrane protein 1 ZDHHC16
Synapse 1 CTBP2
cell surface 3 LBP, TNF, TNR
glutamatergic synapse 2 RPL22, TNR
Golgi apparatus 2 ALB, ZDHHC16
Golgi membrane 1 ATP6V1D
lysosomal membrane 1 ATP6V1D
neuronal cell body 1 TNF
Presynapse 1 RPL22
endosome 1 STX8
plasma membrane 3 ATP6V1D, STX8, TNF
Membrane 6 ATP6V1D, CAT, CYP1B1, LBP, STX8, ZDHHC16
extracellular exosome 7 ALB, ATP6V1D, CAT, HP, LBP, RPL22, TXN
endoplasmic reticulum 2 ALB, STX8
extracellular space 9 ALB, CRP, CXCL8, HP, IL10, IL6, LBP, TNF, TNR
perinuclear region of cytoplasm 1 STX8
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 2 CAT, CYP1B1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 1 CYP1B1
Secreted 8 ALB, CRP, CXCL8, HP, IL10, IL6, LBP, TXN
extracellular region 11 ALB, CAT, CRP, CXCL8, HP, IL10, IL6, LBP, TNF, TNR, TXN
Single-pass membrane protein 1 STX8
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Cell projection, cilium 1 ATP6V1D
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATP6V1D
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 TNR
cytoplasmic vesicle 1 MEFV
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6V1D
clathrin-coated vesicle membrane 1 ATP6V1D
Early endosome 1 STX8
recycling endosome 2 STX8, TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 STX8
Cell projection, lamellipodium 1 MEFV
Membrane raft 2 TNF, TNR
focal adhesion 2 CAT, RPL22
microtubule 1 MEFV
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 TNR
Cell projection, ruffle 1 MEFV
Late endosome 1 STX8
ruffle 1 MEFV
ciliary basal body 1 ALB
cilium 1 ATP6V1D
microtubule associated complex 1 MEFV
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, HP
Endomembrane system 1 STX8
specific granule membrane 1 ATP6V1D
SNARE complex 1 STX8
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 CTBP2
platelet alpha granule lumen 1 ALB
specific granule lumen 1 HP
tertiary granule lumen 1 HP
extrinsic component of synaptic vesicle membrane 1 ATP6V1D
perineuronal net 1 TNR
Single-pass type IV membrane protein 1 STX8
ribonucleoprotein complex 1 RPL22
[Isoform 2]: Nucleus 1 MEFV
[Isoform 1]: Cytoplasm, cytoskeleton 1 MEFV
canonical inflammasome complex 1 MEFV
cytosolic ribosome 1 RPL22
vacuolar proton-transporting V-type ATPase, V1 domain 1 ATP6V1D
proton-transporting V-type ATPase complex 1 ATP6V1D
endocytic vesicle lumen 1 HP
haptoglobin-hemoglobin complex 1 HP
ribosome 1 RPL22
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
cytosolic large ribosomal subunit 1 RPL22
Cytoplasmic granule membrane 1 LBP
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Wojciech Baran, Ewa Adamek. Degradation of veterinary antibiotics by Fenton process: Products identification and toxicity assessment. Chemosphere. 2023 Nov; 341(?):139854. doi: 10.1016/j.chemosphere.2023.139854. [PMID: 37619745]
  • Tz-Shian Liao, Ching-Yi Chen, Chuan-Shun Lin, Cheng-Wei T Chang, Jon Y Takemoto, Yuan-Yu Lin. Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets. Journal of animal physiology and animal nutrition. 2023 Aug; ?(?):. doi: 10.1111/jpn.13867. [PMID: 37539819]
  • B-G Liu, M Xie, Y-T Gong, Y Dong, G-M Zheng, H Wu, G-Z Hu, M Bai, E-P Xu. Prevalence, resistance phenotypes, and fluoroquinolone resistance genes of Salmonella isolates from raw milk of healthy dairy cows in Henan province, China. European review for medical and pharmacological sciences. 2022 09; 26(18):6837-6844. doi: 10.26355/eurrev_202209_29786. [PMID: 36196732]
  • Khalid Ibrahim Sallam, Faisal Saad Saud Saad, Adel Abdelkhalek. Health risk assessment of antimicrobial residues in sheep carcasses marketed in Kuwait. Food chemistry. 2022 Jul; 383(?):132401. doi: 10.1016/j.foodchem.2022.132401. [PMID: 35217278]
  • Klaudia Stando, Ewa Korzeniewska, Ewa Felis, Monika Harnisz, Sylwia Bajkacz. Uptake of Pharmaceutical Pollutants and Their Metabolites from Soil Fertilized with Manure to Parsley Tissues. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144378. [PMID: 35889250]
  • Yi Zhang, Zhaoju Wu, Haizhu Shi, Yang Xie, Ming-Yu Wu, Chungu Zhang, Shun Feng. Copper mediated molecularly imprinted polymers for fast recognizing tylosin. Journal of pharmaceutical and biomedical analysis. 2022 May; 213(?):114674. doi: 10.1016/j.jpba.2022.114674. [PMID: 35219066]
  • C Perruchon, E Katsivelou, P A Karas, S Vassilakis, A A Lithourgidis, T A Kotsopoulos, S Sotiraki, S Vasileiadis, D G Karpouzas. Following the route of veterinary antibiotics tiamulin and tilmicosin from livestock farms to agricultural soils. Journal of hazardous materials. 2022 05; 429(?):128293. doi: 10.1016/j.jhazmat.2022.128293. [PMID: 35066227]
  • Denglong Lu, Zhihua Ma, Jianglin Peng, Yibo Zhang, Shan Liu, Qi Li. Integrated comparison of growth and oxidative stress induced by tylosin in two freshwater algae Chlorella vulgaris and Raphidocelis subcapitata. Ecotoxicology (London, England). 2022 Apr; 31(3):376-384. doi: 10.1007/s10646-021-02511-5. [PMID: 35015171]
  • Waleed M Dosoky, Hassan S Zeweil, Mohamed H Ahmed, Soliman M Zahran, Abdallah M Ali, Nader R Abdelsalam, Mohammed A E Naiel. The influences of Tylosine and licorice dietary supplementation in terms of the productive performance, serum parameters, egg yolk lipid profile, antioxidant and immunity status of laying Japanese quail under heat stress condition. Journal of thermal biology. 2021 Jul; 99(?):103015. doi: 10.1016/j.jtherbio.2021.103015. [PMID: 34420647]
  • Ehab A Abu-Basha, Zuhair Bani Ismail, Mohammed M Ababneh, Eyad Hamzeh, Ronette Gehring. Pharmacokinetics and bioavailability of tildipirosin following intravenous and subcutaneous administration in horses. Journal of veterinary pharmacology and therapeutics. 2021 Jul; 44(4):544-551. doi: 10.1111/jvp.12958. [PMID: 33609061]
  • Leonardo Bringhenti, Mariana Pallu, Josiane Silva, Tiago Tomazi, Ana C Tomazi, Marjory X Rodrigues, Livia M Duarte, Todd R Bilby, Rodrigo C Bicalho. Effect of metaphylactic administration of tildipirosin on the incidence of pneumonia and otitis and on the upper respiratory tract and fecal microbiome of preweaning Holstein calves. Journal of dairy science. 2021 May; 104(5):6020-6038. doi: 10.3168/jds.2020-19572. [PMID: 33685693]
  • Hanh T V Le, Rory O Maguire, Kang Xia. Spatial distribution and temporal change of antibiotics in soils amended with manure using two field application methods. The Science of the total environment. 2021 Mar; 759(?):143431. doi: 10.1016/j.scitotenv.2020.143431. [PMID: 33172639]
  • Amir Atabak Ronaghinia, Julie Melsted Birch, Henrik Lauritz Frandsen, Pierre-Louis Toutain, Peter Damborg, Tina Struve. Evaluating a tylosin dosage regimen for treatment of Staphylococcus delphini infection in mink (Neovison vison): a pharmacokinetic-pharmacodynamic approach. Veterinary research. 2021 Feb; 52(1):34. doi: 10.1186/s13567-021-00906-0. [PMID: 33640030]
  • Yike Shen, Hui Li, Elliot T Ryser, Wei Zhang. Comparing root concentration factors of antibiotics for lettuce (Lactuca sativa) measured in rhizosphere and bulk soils. Chemosphere. 2021 Jan; 262(?):127677. doi: 10.1016/j.chemosphere.2020.127677. [PMID: 32763571]
  • Ehab A Abu-Basha, Zuhair Bani Ismail, Hind Abu Alhaijaa, Eyad Hamzeh, Nasir M Idkaidek. Pharmacokinetics and bioavailability of tildipirosin following intravenous and subcutaneous administration in sheep. Journal of veterinary pharmacology and therapeutics. 2021 Jan; 44(1):79-85. doi: 10.1111/jvp.12901. [PMID: 32748450]
  • Daofen Huang, Yibo Xu, Xiaoqin Yu, Zhuozhi Ouyang, Xuetao Guo. Effect of cadmium on the sorption of tylosin by polystyrene microplastics. Ecotoxicology and environmental safety. 2021 Jan; 207(?):111255. doi: 10.1016/j.ecoenv.2020.111255. [PMID: 32905936]
  • Shimaa M Abou-Zeid, Amany I Ahmed, Ashraf Awad, Wafaa A Mohammed, Mohamed M M Metwally, Rafa Almeer, Mohamed M Abdel-Daim, Samah R Khalil. Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):110997. doi: 10.1016/j.biopha.2020.110997. [PMID: 33197759]
  • Yarira Ortiz-Alvarado, David R Clark, Carlos J Vega-Melendez, Zomary Flores-Cruz, Maria G Domingez-Bello, Tugrul Giray. Antibiotics in hives and their effects on honey bee physiology and behavioral development. Biology open. 2020 11; 9(11):. doi: 10.1242/bio.053884. [PMID: 33106276]
  • Honglin Yan, Bing Yu, Jeroen Degroote, Thomas Spranghers, Noémie Van Noten, Maryam Majdeddin, Mario Van Poucke, Luc Peelman, Jo De Vrieze, Nico Boon, Ingrid Gielen, Stefaan De Smet, Daiwen Chen, Joris Michiels. Antibiotic affects the gut microbiota composition and expression of genes related to lipid metabolism and myofiber types in skeletal muscle of piglets. BMC veterinary research. 2020 Oct; 16(1):392. doi: 10.1186/s12917-020-02592-0. [PMID: 33066774]
  • Wanhe Luo, Hua Qin, Dongmei Chen, Mengru Wu, Kuiyu Meng, Aoxue Zhang, Yunahu Pan, Wei Qu, Shuyu Xie. The dose regimen formulation of tilmicosin against Lawsonia intracellularis in pigs by pharmacokinetic-pharmacodynamic (PK-PD) model. Microbial pathogenesis. 2020 Oct; 147(?):104389. doi: 10.1016/j.micpath.2020.104389. [PMID: 32707311]
  • Lydia M Wang, Shiqi Huang, Sebastian Chalupa-Krebzdak, Sandra M Vásquez Mejía, Ira B Mandell, Benjamin M Bohrer. Effects of essential oils and(or) benzoic acid in beef finishing cattle diets on the fatty acid profile and shelf life stability of ribeye steaks and ground beef. Meat science. 2020 Oct; 168(?):108195. doi: 10.1016/j.meatsci.2020.108195. [PMID: 32470759]
  • Jincheng Xiong, Yuliang Xu, Shuang He, Yanfang Zhang, Zile Wang, Sihan Wang, Haiyang Jiang. Pharmacokinetics and bioavailability of tildipirosin in rabbits following single-dose intravenous and intramuscular administration. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):448-453. doi: 10.1111/jvp.12882. [PMID: 32542744]
  • Ewelina Patyra, Krzysztof Kwiatek, Carolina Nebot, Rosa Elvira Gavilán. Quantification of Veterinary Antibiotics in Pig and Poultry Feces and Liquid Manure as a Non-Invasive Method to Monitor Antibiotic Usage in Livestock by Liquid Chromatography Mass-Spectrometry. Molecules (Basel, Switzerland). 2020 Jul; 25(14):. doi: 10.3390/molecules25143265. [PMID: 32709030]
  • Nan Zhang, Zhenxian Liu, Yanzhe Wei, Chuanzhen Zhang, Chunxiao Mao, Qinren Cai, Xiangguang Shen, Huanzhong Ding. Comparison of the pharmacokinetics of tilmicosin in plasma and lung tissue in healthy chickens and chickens experimentally infected with Mycoplasma gallisepticum. Journal of veterinary pharmacology and therapeutics. 2020 Jul; 43(4):347-354. doi: 10.1111/jvp.12847. [PMID: 32133660]
  • Langsha Yi, Linzi Zuo, Chenhui Wei, Heyun Fu, Xiaolei Qu, Shourong Zheng, Zhaoyi Xu, Yong Guo, Hui Li, Dongqiang Zhu. Enhanced adsorption of bisphenol A, tylosin, and tetracycline from aqueous solution to nitrogen-doped multiwall carbon nanotubes via cation-π and π-π electron-donor-acceptor (EDA) interactions. The Science of the total environment. 2020 Jun; 719(?):137389. doi: 10.1016/j.scitotenv.2020.137389. [PMID: 32120097]
  • Ashraf Awad, Samah R Khalil, Basma M Hendam, Reda M Abd El-Aziz, Mohamed M M Metwally, Tamer S Imam. Protective potency of Astragalus polysaccharides against tilmicosin- induced cardiac injury via targeting oxidative stress and cell apoptosis-encoding pathways in rat. Environmental science and pollution research international. 2020 Jun; 27(17):20861-20875. doi: 10.1007/s11356-020-08565-y. [PMID: 32246429]
  • Nao Kamei-Ishikawa, Takeki Maeda, Misaki Soma, Naoto Yoshida, Yota Sameshima, Makoto Sasamoto, Yumi Higashiyama, Eiko Touno, Ayumi Ito. Tylosin degradation during manure composting and the effect of the degradation byproducts on the growth of green algae. The Science of the total environment. 2020 May; 718(?):137295. doi: 10.1016/j.scitotenv.2020.137295. [PMID: 32087586]
  • Błażej Poźniak, Marta Tikhomirov, Karolina Motykiewicz-Pers, Kamila Bobrek, Marcin Świtała. Allometric analysis of tylosin tartrate pharmacokinetics in growing male turkeys. Journal of veterinary science. 2020 May; 21(3):e35. doi: 10.4142/jvs.2020.21.e35. [PMID: 32476311]
  • S A Murray, A C Holbert, K N Norman, S D Lawhon, J E Sawyer, H M Scott. Macrolide-susceptible probiotic Enterococcus faecium ST296 exhibits faecal-environmental-oral microbial community cycling among beef cattle in feedlots. Letters in applied microbiology. 2020 Apr; 70(4):274-281. doi: 10.1111/lam.13269. [PMID: 31883125]
  • Samah R Khalil, Sabry M Abdel-Motal, Mohamed Abd-Elsalam, Noura E Abd El-Hameed, Ashraf Awad. Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways. Gene. 2020 Mar; 730(?):144272. doi: 10.1016/j.gene.2019.144272. [PMID: 31812513]
  • Qian Zhang, Haifeng Yang, Benazir Sahito, Xinyu Li, Lin Peng, Xiuge Gao, Hui Ji, Liping Wang, Shanxiang Jiang, Dawei Guo. Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin. Colloids and surfaces. B, Biointerfaces. 2020 Mar; 187(?):110649. doi: 10.1016/j.colsurfb.2019.110649. [PMID: 31767412]
  • Benazir Sahito, Qian Zhang, Haifeng Yang, Lin Peng, Xiuge Gao, Jam Kashif, Zain Ul Aabdin, Shanxiang Jiang, Liping Wang, Dawei Guo. Synthesis of Tilmicosin Nanostructured Lipid Carriers for Improved Oral Delivery in Broilers: Physiochemical Characterization and Cellular Permeation. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020315. [PMID: 31941074]
  • Sara T Elazab, Nahla S Elshater, Yousreya H Hashem, Seung-Chun Park, Walter H Hsu. Pharmacokinetics, tissue residues, and ex vivo pharmacodynamics of tylosin against Mycoplasma anatis in ducks. Journal of veterinary pharmacology and therapeutics. 2020 Jan; 43(1):57-66. doi: 10.1111/jvp.12819. [PMID: 31667880]
  • Margaret D Weinroth, Jennifer N Martin, Enrique Doster, Ifigenia Geornaras, Jennifer K Parker, Clay R Carlson, Jessica L Metcalf, Paul S Morley, Keith E Belk. Investigation of tylosin in feed of feedlot cattle and effects on liver abscess prevalence, and fecal and soil microbiomes and resistomes1. Journal of animal science. 2019 Nov; 97(11):4567-4578. doi: 10.1093/jas/skz306. [PMID: 31563955]
  • Alison C Manchester, Craig B Webb, Amanda B Blake, Fatima Sarwar, Jonathan A Lidbury, Jörg M Steiner, Jan S Suchodolski. Long-term impact of tylosin on fecal microbiota and fecal bile acids of healthy dogs. Journal of veterinary internal medicine. 2019 Nov; 33(6):2605-2617. doi: 10.1111/jvim.15635. [PMID: 31674054]
  • Zhen Li, Miao Li, Tongli Zheng, Yandan Li, Xiang Liu. Removal of tylosin and copper from aqueous solution by biochar stabilized nano-hydroxyapatite. Chemosphere. 2019 Nov; 235(?):136-142. doi: 10.1016/j.chemosphere.2019.06.091. [PMID: 31255753]
  • Yizhao Shen, Taylor Davedow, Tao Ran, Atef M Saleem, Ilkyu Yoon, Claudia Narvaez, Tim Angus Mcallister, Wenzhu Yang. Ruminally protected and unprotected Saccharomyces cerevisiae fermentation products as alternatives to antibiotics in finishing beef steers1. Journal of animal science. 2019 Oct; 97(10):4323-4333. doi: 10.1093/jas/skz270. [PMID: 31410465]
  • Xiaofeng Ji, Hua Yang, Jianmei Wang, Wei Zhou, Xiaoli Wang, Mingrong Qian. Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers. Journal of food science. 2019 Oct; 84(10):3054-3062. doi: 10.1111/1750-3841.14794. [PMID: 31524951]
  • J Xiong, Q Zhu, S Yang, Y Zhao, L Cui, F Zhuang, Y Qiu, J Cao. Comparison of pharmacokinetics of tilmicosin in healthy pigs and pigs experimentally infected with Actinobacillus pleuropneumoniae. New Zealand veterinary journal. 2019 Sep; 67(5):257-263. doi: 10.1080/00480169.2019.1633434. [PMID: 31208293]
  • Lili Zhang, Zhiyao Li, Xiaohong Deng, Jiansheng Li, Taomei Li, Yingjun Lv. Tylvalosin administration in pregnant sows attenuates the enlargement and bluish coloration of inguinal lymph nodes in newborn piglets. Research in veterinary science. 2019 Aug; 125(?):148-152. doi: 10.1016/j.rvsc.2019.06.006. [PMID: 31228738]
  • Tuvshinjargal Budragchaa, Bernhard Westermann, Ludger A Wessjohann. Multicomponent synthesis of α-acylamino and α-acyloxy amide derivatives of desmycosin and their activity against gram-negative bacteria. Bioorganic & medicinal chemistry. 2019 08; 27(15):3237-3247. doi: 10.1016/j.bmc.2019.05.046. [PMID: 31229422]
  • Laura E Burns, David J Borts. Rapid untargeted screening for drug residues in animal tissues with liquid microjunction surface sampling probe mass spectrometry. Analytica chimica acta. 2019 Jul; 1063(?):75-81. doi: 10.1016/j.aca.2019.01.029. [PMID: 30967188]
  • Mayada Ragab Farag, Wlaa M Elhady, Sarah Y A Ahmed, Heba S A Taha, Mahmoud Alagawany. Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway. Research in veterinary science. 2019 Jun; 124(?):137-148. doi: 10.1016/j.rvsc.2019.03.010. [PMID: 30901666]
  • Jincheng Xiong, Qianqian Zhu, Yaxin Zhao, Shuaike Yang, Jiyue Cao, Yinsheng Qiu. Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. Journal of veterinary pharmacology and therapeutics. 2019 May; 42(3):336-345. doi: 10.1111/jvp.12753. [PMID: 30801755]
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