C18:0 (BioDeep_00000229697)

Main id: BioDeep_00000001515

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


n-Octadecanoic acid

化学式: C18H36O2 (284.2715)
中文名称: 硬脂酸, 十八酸, 十八烷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCCCCCCC)CCCCCCCCC(=O)O
InChI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)

描述信息

Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

同义名列表

14 个代谢物同义名

n-Octadecanoic acid; Stearophanic acid; Octadecanoic acid; Cetylacetic acid; Lactaric acid; Bassinic acid; Octadecanoate; stearic acid; Talgic acid; Stearate; FA 18:0; C18:0; Octadecanoic acid; Octadecanoic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, AKT1, ALB, APOB, CASP3, FASN, PPARG, SREBF1, TLR4
Peripheral membrane protein 1 LPL
Endosome membrane 2 APOB, TLR4
Endoplasmic reticulum membrane 5 APOB, ELOVL6, SCD, SLN, SREBF1
Nucleus 6 AKT1, ALB, CASP3, PPARA, PPARG, SREBF1
cytosol 9 AKT1, ALB, APOB, CASP3, FASN, LEP, LIPE, PPARG, SREBF1
centrosome 1 ALB
nucleoplasm 5 AKT1, CASP3, PPARA, PPARG, SREBF1
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 6 ABCB1, AKT1, LIPE, LPL, TLR4, TNF
lamellipodium 1 AKT1
Multi-pass membrane protein 4 ABCB1, ELOVL6, SCD, SREBF1
Golgi apparatus membrane 1 SREBF1
cell cortex 1 AKT1
cell surface 4 ABCB1, LPL, TLR4, TNF
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ALB, FASN
Golgi membrane 2 INS, SREBF1
neuronal cell body 3 APOB, CASP3, TNF
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 1 LIPE
plasma membrane 8 ABCB1, AKT1, APOB, F7, FASN, LPL, TLR4, TNF
Membrane 7 ABCB1, AKT1, FASN, LIPE, SCD, SLN, TLR4
apical plasma membrane 1 ABCB1
caveola 1 LIPE
extracellular exosome 4 ABCB1, ALB, APOB, FASN
endoplasmic reticulum 4 ALB, ELOVL6, SCD, SREBF1
extracellular space 8 ALB, APOB, F7, IL6, INS, LEP, LPL, TNF
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 2 PPARG, TLR4
protein-containing complex 3 AKT1, ALB, SREBF1
intracellular membrane-bounded organelle 2 APOB, PPARG
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 7 ALB, APOB, F7, IL6, INS, LEP, LPL
extracellular region 8 ALB, APOB, F7, IL6, INS, LEP, LPL, TNF
Single-pass membrane protein 1 SLN
Extracellular side 1 LPL
anchoring junction 1 ALB
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 2 APOB, LPL
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 2 APOB, LPL
microtubule cytoskeleton 1 AKT1
nucleolus 1 SCD
Early endosome 2 APOB, TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, F7
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
spindle 1 AKT1
sarcoplasmic reticulum 1 SLN
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 F7
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 PPARG, TLR4
ciliary basal body 2 AKT1, ALB
chromatin 3 PPARA, PPARG, SREBF1
phagocytic cup 2 TLR4, TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 SREBF1
endosome lumen 2 APOB, INS
Lipid droplet 2 APOB, LIPE
Membrane, caveola 1 LIPE
Cytoplasmic vesicle membrane 1 SREBF1
Melanosome 1 FASN
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 2 F7, INS
endoplasmic reticulum lumen 5 ALB, APOB, F7, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Sarcoplasmic reticulum membrane 1 SLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
ER to Golgi transport vesicle membrane 1 SREBF1
clathrin-coated endocytic vesicle membrane 1 APOB
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
endocytic vesicle lumen 1 APOB
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
catalytic complex 1 LPL
interleukin-6 receptor complex 1 IL6
serine-type peptidase complex 1 F7
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
glycogen granule 1 FASN
ciliary transition fiber 1 ALB
fatty acid elongase complex 1 ELOVL6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Hongchen Wan, Da-Wen Sun, Zhiwei Zhu, Leyin Zeng. Fabrication and characterization of biomimetic plant cuticles from pullulan - graphene oxide (PU-GO) and beeswax - stearic acid (BW-SA) for Citrus Limon Rosso preservation. International journal of biological macromolecules. 2024 Jan; 254(Pt 2):127776. doi: 10.1016/j.ijbiomac.2023.127776. [PMID: 37907180]
  • Lizbeth Martínez-Acevedo, Moises Job Galindo-Pérez, Gustavo Vidal-Romero, Alicia Del Real, María de la Luz Zambrano-Zaragoza, David Quintanar-Guerrero. Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Dec; 193(?):262-273. doi: 10.1016/j.ejpb.2023.11.004. [PMID: 37944711]
  • Xiaoru Yang, Xinyue Lu, Liping Wang, Linfeng Bai, Ruiyuan Yao, Zhibo Jia, Yuze Ma, Yuhao Chen, Huifang Hao, Xiaotong Wu, Zhigang Wang, Yanfeng Wang. Stearic acid promotes lipid synthesis through CD36/Fyn/FAK/mTORC1 axis in bovine mammary epithelial cells. International journal of biological macromolecules. 2023 Oct; ?(?):127324. doi: 10.1016/j.ijbiomac.2023.127324. [PMID: 37838116]
  • Hana Nůsková, Fabiola Garcia Cortizo, Lena Sophie Schwenker, Timo Sachsenheimer, Egor Diakonov, Marcel Tiebe, Martin Schneider, Jasmin Lohbeck, Carissa Reid, Annette Kopp-Schneider, Dominic Helm, Britta Brügger, Aubry K Miller, Aurelio A Teleman. Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome. The Journal of biological chemistry. 2023 Jul; ?(?):105088. doi: 10.1016/j.jbc.2023.105088. [PMID: 37495107]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • A N Omelchenko, T N Igonina, E Y Brusentsev, K A Okotrub, S Y Amstislavsky, N V Surovtsev. Cryopreservation increases accumulation of exogenous stearic acid in mouse embryos. Cryobiology. 2022 12; 109(?):44-52. doi: 10.1016/j.cryobiol.2022.09.005. [PMID: 36179820]
  • Lais Alonso, Laryssa Ketelyn Lima Pimenta, André Kipnis, Antonio Alonso. Mycobacterium abscessus cell wall and plasma membrane characterization by EPR spectroscopy and effects of amphotericin B, miltefosine and nerolidol. Biochimica et biophysica acta. Biomembranes. 2022 05; 1864(5):183872. doi: 10.1016/j.bbamem.2022.183872. [PMID: 35085568]
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  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Merel A van Rooijen, Jogchum Plat, Wendy A M Blom, Peter L Zock, Ronald P Mensink. Dietary stearic acid and palmitic acid do not differently affect ABCA1-mediated cholesterol efflux capacity in healthy men and postmenopausal women: A randomized controlled trial. Clinical nutrition (Edinburgh, Scotland). 2021 03; 40(3):804-811. doi: 10.1016/j.clnu.2020.08.016. [PMID: 32900520]
  • Nafisha Shaedi, Idanawati Naharudin, Chee Yan Choo, Tin Wui Wong. Design of oral intestinal-specific alginate-vitexin nanoparticulate system to modulate blood glucose level of diabetic rats. Carbohydrate polymers. 2021 Feb; 254(?):117312. doi: 10.1016/j.carbpol.2020.117312. [PMID: 33357875]
  • Linlin Zhang, Jiapei Lv, Chengshui Chen, Xiangdong Wang. Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism. Cell biology and toxicology. 2021 02; 37(1):15-34. doi: 10.1007/s10565-020-09520-w. [PMID: 32347412]
  • Mohammed Dalli, Nour Elhouda Daoudi, Salah-Eddine Azizi, Hind Benouda, Mohamed Bnouham, Nadia Gseyra. Chemical Composition Analysis Using HPLC-UV/GC-MS and Inhibitory Activity of Different Nigella sativa Fractions on Pancreatic α-Amylase and Intestinal Glucose Absorption. BioMed research international. 2021; 2021(?):9979419. doi: 10.1155/2021/9979419. [PMID: 34258287]
  • Mekdes Megeressa, Bushra Siraj, Shamshad Zarina, Aftab Ahmed. Structural characterization and in vitro lipid binding studies of non-specific lipid transfer protein 1 (nsLTP1) from fennel (Foeniculum vulgare) seeds. Scientific reports. 2020 12; 10(1):21243. doi: 10.1038/s41598-020-77278-6. [PMID: 33277525]
  • Aakriti Singh, Ganesh Yadagiri, Shabi Parvez, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Formulation, characterization and in vitro anti-leishmanial evaluation of amphotericin B loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate. Materials science & engineering. C, Materials for biological applications. 2020 Dec; 117(?):111279. doi: 10.1016/j.msec.2020.111279. [PMID: 32919641]
  • Minghui Zhou, Shuang Li, Sheng Shi, Shaolong He, Yanni Ma, Wenping Wang. Hepatic targeting of glycyrrhetinic acid via nanomicelles based on stearic acid-modified fenugreek gum. Artificial cells, nanomedicine, and biotechnology. 2020 Dec; 48(1):1105-1113. doi: 10.1080/21691401.2020.1813740. [PMID: 32880189]
  • Jianwei Chen, Yaojia Lu, Xinyi Ye, Mahmoud Emam, Huawei Zhang, Hong Wang. Current advances in Vibrio harveyi quorum sensing as drug discovery targets. European journal of medicinal chemistry. 2020 Dec; 207(?):112741. doi: 10.1016/j.ejmech.2020.112741. [PMID: 32871343]
  • Jose Rodríguez-Morató, Jean Galluccio, Gregory G Dolnikowski, Alice H Lichtenstein, Nirupa R Matthan. Comparison of the Postprandial Metabolic Fate of U-13C Stearic Acid and U-13C Oleic Acid in Postmenopausal Women. Arteriosclerosis, thrombosis, and vascular biology. 2020 12; 40(12):2953-2964. doi: 10.1161/atvbaha.120.315260. [PMID: 32998517]
  • Maroula G Kokotou, Alexandros C Kokotos, Dimitrios Gkikas, Olga G Mountanea, Christiana Mantzourani, Abdulaziz Almutairi, Xiaoyong Lei, Sasanka Ramanadham, Panagiotis K Politis, George Kokotos. Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis. Journal of medicinal chemistry. 2020 11; 63(21):12666-12681. doi: 10.1021/acs.jmedchem.0c00844. [PMID: 33124824]
  • Takanori Saito, Rina Ishii, Masaaki Akamatsu, Takaya Sakai, Kenichi Sakai, Hideki Sakai. α-Gel (α-Form Hydrated Crystal) Prepared by Eco-Friendly Cationic Surfactant. Journal of oleo science. 2020 Nov; 69(11):1403-1409. doi: 10.5650/jos.ess20094. [PMID: 33055438]
  • Si-Jun Wu, Ping Qiu, Pian Li, Zheng Li, Wen-Long Li. A near-infrared spectroscopy-based end-point determination method for the blending process of Dahuang soda tablets. Journal of Zhejiang University. Science. B. 2020 Nov; 21(11):897-910. doi: 10.1631/jzus.b2000417. [PMID: 33150773]
  • Ashok Kumar Jangid, Krunal Patel, Poonam Jain, Sunita Patel, Nitin Gupta, Deep Pooja, Hitesh Kulhari. Inulin-pluronic-stearic acid based double folded nanomicelles for pH-responsive delivery of resveratrol. Carbohydrate polymers. 2020 Nov; 247(?):116730. doi: 10.1016/j.carbpol.2020.116730. [PMID: 32829852]
  • Yongxiang Li, Hanyu Wu, Ruixue Zhang, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Qingyan Jiang, Lina Wang. Diet containing stearic acid increases food reward-related behaviors in mice compared with oleic acid. Brain research bulletin. 2020 11; 164(?):45-54. doi: 10.1016/j.brainresbull.2020.08.012. [PMID: 32822805]
  • Ashok Kumar Jangid, Hina Agraval, Divya Bharti Rai, Poonam Jain, Umesh Cs Yadav, Deep Pooja, Hitesh Kulhari. Baicalin encapsulating lipid-surfactant conjugate based nanomicelles: Preparation, characterization and anticancer activity. Chemistry and physics of lipids. 2020 11; 233(?):104978. doi: 10.1016/j.chemphyslip.2020.104978. [PMID: 32991905]
  • Juan E Cervantes-Ramírez, Angel H Cabrera-Ramirez, Eduardo Morales-Sánchez, Mario E Rodriguez-García, Maria de la Luz Reyes-Vega, Aurea K Ramírez-Jiménez, Brenda L Contreras-Jiménez, Marcela Gaytán-Martínez. Amylose-lipid complex formation from extruded maize starch mixed with fatty acids. Carbohydrate polymers. 2020 Oct; 246(?):116555. doi: 10.1016/j.carbpol.2020.116555. [PMID: 32747238]
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  • Ruxandra Birjega, Andreea Matei, Valentina Marascu, Angela Vlad, Maria Daniela Ionita, Maria Dinescu, Rodica Zăvoianu, Mihai Cosmin Corobea. Stearic Acid/Layered Double Hydroxides Composite Thin Films Deposited by Combined Laser Techniques. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184097. [PMID: 32911637]
  • Manickam Pavunraj, Kathirvelu Baskar, Selvaraj Arokiyaraj, Krishnamoorthy Rajapandiyan, Abdulaziz A Alqarawi, Elsayed Fathi Abd Allah. Silver nanoparticles containing stearic acid isolated from Catharanthus roseus: Ovicidal and oviposition-deterrent activities on Earias vittella and ecotoxicological studies. Pesticide biochemistry and physiology. 2020 Sep; 168(?):104640. doi: 10.1016/j.pestbp.2020.104640. [PMID: 32711773]
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