Carmofur (BioDeep_00000177049)
Main id: BioDeep_00000009435
human metabolite blood metabolite
代谢物信息卡片
5-fluoro-N-hexyl-4-hydroxy-2-oxo-1,2-dihydropyrimidine-1-carboximidic acid
化学式: C11H16FN3O3 (257.1176)
中文名称: 氟脲己胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCN=C(O)N1C=C(F)C(O)=NC1=O
InChI: InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D000970 - Antineoplastic Agents
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI)[1][2][3].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:31360
- KEGG: C75879
- PubChem: 2577
- HMDB: HMDB0249685
- DrugBank: DB09010
- ChEMBL: CHEMBL460499
- Wikipedia: Carmofur
- chemspider: 2479
- CAS: 61422-45-5
- medchemexpress: HY-B0182
- KEGG: C13252
- PubChem: 585996
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Nature structural & molecular biology.
2020 06; 27(6):529-532. doi:
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