3-Hydroxy-L-proline (BioDeep_00000017847)

 

Secondary id: BioDeep_00000001474, BioDeep_00001869161

human metabolite Endogenous natural product


代谢物信息卡片


(2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid

化学式: C5H9NO3 (131.0582)
中文名称: 反式-3-羟基-L-脯氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 12.01%

分子结构信息

SMILES: C1CNC(C1O)C(=O)O
InChI: InChI=1S/C5H9NO3/c7-3-1-2-6-4(3)5(8)9/h3-4,6-7H,1-2H2,(H,8,9)

描述信息

Constituent of collagen and the antibiotic Telomycin (Combined Chemical Dictionary).

同义名列表

8 个代谢物同义名

(2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid; (2R,3S)-3-hydroxypyrrolidine-2-carboxylic acid; 3-Hydroxypyrrolidine-2-carboxylic acid; Procollagen trans-3-hydroxy-L-proline; Trans-3-hydroxy-L-proline; cis-3-Hydroxy-D-proline; 3-Hydroxy-L-proline; 3-Hydroxyproline



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ARG1, COL1A1, CRYM, DYRK1A, HYPK, P3H1
Peripheral membrane protein 1 CTSB
Nucleus 6 ALAD, ARG1, CRYM, DYRK1A, HYPK, P3H1
cytosol 4 ALAD, ARG1, CRYM, P3H2
dendrite 1 DYRK1A
nucleoplasm 4 DYRK1A, HYPK, P3H2, PRODH
Cell membrane 1 NPHS1
Cytoplasmic granule 1 ARG1
Golgi apparatus 1 P3H2
Golgi membrane 1 INS
mitochondrial inner membrane 1 PRODH
Lysosome 2 CTSB, GALNS
plasma membrane 2 NID1, NPHS1
Membrane 3 COL1A1, FKBP10, P3H1
apical plasma membrane 1 CTSB
axon 1 DYRK1A
extracellular exosome 8 ALAD, COL1A2, CRYM, CTSB, GALNS, NID1, NPHS1, P3H1
endoplasmic reticulum 6 CRTAP, FKBP10, P3H1, P3H2, P3H3, P3H4
extracellular space 6 ARG1, COL1A1, COL1A2, CRTAP, CTSB, INS
lysosomal lumen 1 GALNS
perinuclear region of cytoplasm 1 CTSB
mitochondrion 2 CRYM, PRODH
protein-containing complex 3 CRTAP, HYPK, P3H1
intracellular membrane-bounded organelle 3 P3H2, P3H4, PRODH
Single-pass type I membrane protein 1 NPHS1
Secreted 2 COL1A2, INS
extracellular region 8 ALAD, ARG1, COL1A1, COL1A2, CTSB, GALNS, INS, NID1
mitochondrial matrix 1 PRODH
Extracellular side 1 CTSB
external side of plasma membrane 1 CTSB
Secreted, extracellular space, extracellular matrix 4 COL1A1, COL1A2, CRTAP, P3H1
slit diaphragm 1 NPHS1
microtubule cytoskeleton 1 HYPK
nucleolus 1 P3H4
cell-cell junction 1 NPHS1
Apical cell membrane 1 CTSB
focal adhesion 1 NPHS1
basement membrane 2 NID1, P3H2
collagen trimer 2 COL1A1, COL1A2
sarcoplasmic reticulum 1 P3H2
peroxisomal matrix 1 CRYM
mitochondrial intermembrane space 1 FKBP10
collagen-containing extracellular matrix 4 COL1A1, COL1A2, CTSB, NID1
secretory granule 1 COL1A1
nuclear speck 1 DYRK1A
cell projection 1 NPHS1
cytoskeleton 1 DYRK1A
[Isoform 1]: Endoplasmic reticulum 1 P3H1
Secreted, extracellular space 1 CTSB
endosome lumen 1 INS
Melanosome 1 CTSB
Nucleus speckle 1 DYRK1A
ficolin-1-rich granule lumen 2 ALAD, CTSB
secretory granule lumen 2 ALAD, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 7 COL1A1, COL1A2, CRTAP, FKBP10, INS, P3H1, P3H2
specific granule lumen 1 ARG1
transport vesicle 1 INS
azurophil granule lumen 2 ARG1, GALNS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
condensed nuclear chromosome 1 P3H4
ribonucleoprotein complex 1 DYRK1A
synaptonemal complex 1 P3H4
protein complex involved in cell-matrix adhesion 1 NID1
peptidase inhibitor complex 1 CTSB
collagen type I trimer 2 COL1A1, COL1A2
catalytic complex 2 P3H3, P3H4
endolysosome lumen 1 CTSB


文献列表

  • Sanjay Morzaria, Brian D Westerberg, Frederick K Kozak. Evidence-based algorithm for the evaluation of a child with bilateral sensorineural hearing loss. The Journal of otolaryngology. 2005 Oct; 34(5):297-303. doi: 10.2310/7070.2005.34501. [PMID: 16181590]
  • A J Bos, P Yuan, A Maruta, S Matsuyama, M Arai, I Okazaki. [Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis]. Nihon eiseigaku zasshi. Japanese journal of hygiene. 1994 Oct; 49(4):797-806. doi: 10.1265/jjh.49.797. [PMID: 7807707]
  • G L Wijffels, M Panaccio, L Salvatore, L Wilson, I D Walker, T W Spithill. The secreted cathepsin L-like proteinases of the trematode, Fasciola hepatica, contain 3-hydroxyproline residues. The Biochemical journal. 1994 May; 299 ( Pt 3)(?):781-90. doi: 10.1042/bj2990781. [PMID: 8192668]
  • B Lubec, K Arbeiter. Determination of the urinary D/L trans-3-hydroxyproline ratio: a noninvasive screening test for Alport syndrome. The Journal of pediatrics. 1993 Nov; 123(5):748-51. doi: 10.1016/s0022-3476(05)80852-2. [PMID: 8229484]
  • I Okazaki, S Matsuyama, F Suzuki, K Maruyama, A Maruta, K Kubochi, K Yoshino, Y Kobayashi, O Abe, M Tsuchiya. Endogenous urinary 3-hydroxyproline has 96\% specificity and 44\% sensitivity for cancer screening. The Journal of laboratory and clinical medicine. 1992 Dec; 120(6):908-20. doi: . [PMID: 1453112]
  • B Bartosch, W Vycudilik, C Popow, G Lubec. Urinary 3-hydroxyproline excretion in Alport's syndrome: a non-invasive screening test?. Archives of disease in childhood. 1991 Feb; 66(2):248-51. doi: 10.1136/adc.66.2.248. [PMID: 2001113]
  • M T Weiss, M Weninger, J Häusler, G Lubec. The determination of urinary 3-trans-hydroxyproline (3 OHP). I. Normal values in school children and adults. Padiatrie und Padologie. 1988; 23(1):9-14. doi: NULL. [PMID: 3387116]
  • G Bellon, A Bisker, F X Maquart, H Thoanes, J P Borel. Improved method for the evaluation of 3-hydroxyproline and 4-hydroxyproline in the urine. Journal of chromatography. 1982 Jul; 230(2):420-6. doi: 10.1016/s0378-4347(00)80493-4. [PMID: 7107786]
  • K T Lin. Simplified procedure for the analysis of 3- and 4-hydroxyproline. Journal of chromatography. 1982 Feb; 227(2):341-8. doi: 10.1016/s0378-4347(00)80388-6. [PMID: 7061650]
  • J Chanard, A Szymanowicz, J P Brunois, O Toupance, J P Melin, P Birembaut, A Randoux, P J Borel. Increased renal excretion of 3 hydroxyproline in patients with active glomerular nephropathies and with polycystic renal disease. Clinical nephrology. 1982 Feb; 17(2):64-9. doi: NULL. [PMID: 7067168]
  • S Fujiwara, Y Nagai. Bovine renal cortex type I collagen: high contents of 3- and 4-hydroxyprolines. Journal of biochemistry. 1981 May; 89(5):1397-401. doi: 10.1093/oxfordjournals.jbchem.a133331. [PMID: 7275945]
  • J Chanard, A Szymanowicz, J P Brunois, O Toupance, P Birembaut, P J Borel. Urinary 3-hydroxyproline in renal disease. Renal physiology. 1980; 3(1-6):163-8. doi: 10.1159/000172757. [PMID: 7323410]