propylene glycol (BioDeep_00000014932)

Main id: BioDeep_00000014549

 

PANOMIX_OTCML-2023


代谢物信息卡片


(R)-(-)-1,2-Propanediol

化学式: C3H8O2 (76.0524)
中文名称: 丙二醇, R-(-)-1,2-丙二醇, R-1,2-丙二醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CO)O
InChI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

描述信息

D010592 - Pharmaceutic Aids > D014677 - Pharmaceutical Vehicles
D012997 - Solvents
(R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes[1].
(R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes[1].

同义名列表

8 个代谢物同义名

propylene glycol; (R)-(-)-1,2-Propanediol; Propane-1,2-diol; 1,2-Propanediol; Propane-1,2-diol; (R)-Propane-1,2-diol; Propylene glycol; R-1,2-Propanediol



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, AQP3, CASP3, CAT, CYP2E1
Peripheral membrane protein 3 CYP1B1, CYP2E1, HSD17B6
Endoplasmic reticulum membrane 2 CYP1B1, CYP2E1
Nucleus 3 ALB, CASP3, EMX2
cytosol 5 ALB, CASP3, CAT, GPT, LIPE
centrosome 1 ALB
nucleoplasm 2 AQP3, CASP3
Cell membrane 4 AQP3, LIPE, TNF, TRPA1
Cell projection, axon 1 EMX2
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 AQP3, TRPA1
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ALB
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 1 LIPE
plasma membrane 5 AQP3, GCG, MUC5AC, TNF, TRPA1
Membrane 5 AQP3, CAT, CYP1B1, LIPE, TRPA1
axon 1 EMX2
basolateral plasma membrane 1 AQP3
caveola 1 LIPE
extracellular exosome 5 ALB, CAT, GPT, MMP9, MUC5AC
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 10 ALB, CCL2, CXCL8, GCG, GNRH1, IL6, INS, MMP9, MUC5AC, TNF
mitochondrion 2 CAT, CYP1B1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 4 CAT, CYP1B1, CYP2E1, HSD17B6
Microsome membrane 3 CYP1B1, CYP2E1, HSD17B6
postsynaptic density 1 CASP3
Secreted 7 ALB, CCL2, CXCL8, GCG, IL6, INS, MUC5AC
extracellular region 11 ALB, CAT, CCL2, CXCL8, GCG, GNRH1, IL6, INS, MMP9, MUC5AC, TNF
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
cell-cell junction 1 AQP3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNF
focal adhesion 1 CAT
extracellular matrix 1 MUC5AC
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 MMP9
ciliary basal body 1 ALB
chromatin 1 EMX2
stereocilium bundle 1 TRPA1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 AQP3
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
ficolin-1-rich granule lumen 2 CAT, MMP9
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 2 INS, MUC5AC
endoplasmic reticulum lumen 4 ALB, GCG, IL6, INS
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 MMP9
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
death-inducing signaling complex 1 CASP3
mucus layer 1 MUC5AC
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jade Mistry, Rebecca Notman. Mechanisms of the Drug Penetration Enhancer Propylene Glycol Interacting with Skin Lipid Membranes. The journal of physical chemistry. B. 2024 Apr; 128(16):3885-3897. doi: 10.1021/acs.jpcb.3c06784. [PMID: 38622775]
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  • Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu. Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity. Molecules (Basel, Switzerland). 2023 Dec; 29(1):. doi: 10.3390/molecules29010066. [PMID: 38202649]
  • Alena Koigerova, Alevtina Gosteva, Artemiy Samarov, Nikita Tsvetov. Deep Eutectic Solvents Based on Carboxylic Acids and Glycerol or Propylene Glycol as Green Media for Extraction of Bioactive Substances from Chamaenerion angustifolium (L.) Scop. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196978. [PMID: 37836820]
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  • Stephanie Johne, Marco van der Toorn, Anita R Iskandar, Shoaib Majeed, Laura O Torres, Julia Hoeng, Manuel C Peitsch. An in vitro evaluation of e-vapor products: The contributions of chemical adulteration, concentration, and device power. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Mar; 175(?):113708. doi: 10.1016/j.fct.2023.113708. [PMID: 36889430]
  • Bruna P Soares, Ana M Ferreira, Marina Justi, Luiz Gustavo Gonçalves Rodrigues, J Vladimir Oliveira, Simão P Pinho, João A P Coutinho. Juçara Fruit (Euterpe Edulis Martius) Valorization Combining Emergent Extraction Technologies and Aqueous Solutions of Alkanediols. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041607. [PMID: 36838595]
  • Mariana Leal, María Alejandra Moreno, Patricia Liliana Albornoz, María Inés Mercado, Iris Catiana Zampini, María Inés Isla. Nicotiana tabacum Leaf Waste: Morphological Characterization and Chemical-Functional Analysis of Extracts Obtained from Powder Leaves by Using Green Solvents. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031396. [PMID: 36771071]
  • Patrycja Szumała, Jolanta Kaplińska, Balbina Makurat-Kasprolewicz, Szymon Mania. Microemulsion Delivery Systems with Low Surfactant Concentrations: Optimization of Structure and Properties by Glycol Cosurfactants. Molecular pharmaceutics. 2023 01; 20(1):232-240. doi: 10.1021/acs.molpharmaceut.2c00599. [PMID: 36354760]
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  • Monique van de Lagemaat, Laura A van de Pol, Inge A Zonnenberg, Bregje C M Witjes, Petra J W Pouwels. MR Spectroscopy Shows Long Propylene Glycol Half-Life in Neonatal Brain. Neonatology. 2021; 118(6):693-701. doi: 10.1159/000519282. [PMID: 34670216]
  • Lucas W Smedley, Denise Rios, Colleen A Barthol, Rachel E Garvin. Iatrogenic Propylene Glycol Intoxication Due to High-Dose Pentobarbital for Refractory Intracranial Hypertension: A Case Report. Journal of pharmacy practice. 2020 Dec; 33(6):895-898. doi: 10.1177/0897190019854575. [PMID: 31238770]
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