Anabaseine (BioDeep_00000011477)

 

Secondary id: BioDeep_00001868706

human metabolite blood metabolite natural product


代谢物信息卡片


3-(3,4,5,6-tetrahydropyridin-2-yl)pyridine

化学式: C10H12N2 (160.1)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(C2=CC=CN=C2)=NCCCC1
InChI: InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8H,1-2,5,7H2

描述信息

D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
Anabaseine is a non-selective nicotinic agonist. Anabaseine stimulates all AChRs, preferentially stimulates skeletal muscle and brain α7 subtypes[1][2]. Anabaseine is also a weak partial agonist at α4β2 nAChRs[3].

同义名列表

5 个代谢物同义名

3-(3,4,5,6-tetrahydropyridin-2-yl)pyridine; Anabaseine dihydrochloride; Anabaseine hydrochloride; Anabaseine; Anabaseine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CA1, CHAT, CYP2A6, DLK1, MAPK3, NFKB1, NR3C1, SPTAN1
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 1 CYP2A6
Nucleus 5 ADRB2, CHAT, MAPK3, NFKB1, NR3C1
cytosol 7 CA1, CHAT, MAPK3, NFKB1, NGF, NR3C1, SPTAN1
dendrite 1 NGF
centrosome 1 NR3C1
nucleoplasm 3 MAPK3, NFKB1, NR3C1
Cell membrane 3 ADRB2, CHRNA7, TNF
Multi-pass membrane protein 3 ADRB2, CACNA1I, CHRNA7
Synapse 3 CHAT, CHRNA7, NR3C1
cell cortex 1 SPTAN1
cell junction 1 SPTAN1
cell surface 2 LBP, TNF
glutamatergic synapse 1 MAPK3
Golgi apparatus 2 ADRB2, MAPK3
neuronal cell body 1 TNF
postsynapse 1 CHRNA7
synaptic vesicle 1 NGF
Lysosome 1 ADRB2
endosome 1 ADRB2
plasma membrane 7 ADRB2, BCHE, CACNA1I, CHRNA7, MAPK3, SPTAN1, TNF
Membrane 8 ADRB2, CACNA1I, CHRNA7, CYP2A6, DLK1, LBP, NR3C1, SPTAN1
apical plasma membrane 1 ADRB2
axon 1 NGF
caveola 1 MAPK3
extracellular exosome 3 CA1, LBP, SPTAN1
extracellular space 8 BCHE, CRP, CXCL8, DLK1, IL10, LBP, NGF, TNF
mitochondrion 3 MAPK3, NFKB1, NR3C1
protein-containing complex 1 NR3C1
intracellular membrane-bounded organelle 2 CYP2A6, SPTAN1
Secreted 6 BCHE, CRP, CXCL8, IL10, LBP, NGF
extracellular region 9 BCHE, CRP, CXCL8, IL10, LBP, NFKB1, NGF, SPTAN1, TNF
Single-pass membrane protein 1 DLK1
mitochondrial matrix 1 NR3C1
transcription regulator complex 1 NFKB1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 1 TNF
Extracellular vesicle 1 SPTAN1
actin cytoskeleton 1 SPTAN1
microtubule cytoskeleton 1 SPTAN1
Early endosome 2 ADRB2, MAPK3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CHRNA7
Membrane raft 1 TNF
Cell junction, focal adhesion 1 MAPK3
Cytoplasm, cytoskeleton 1 SPTAN1
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 1 MAPK3
spindle 1 NR3C1
nuclear speck 1 NR3C1
Postsynaptic cell membrane 1 CHRNA7
Late endosome 1 MAPK3
receptor complex 1 ADRB2
neuron projection 2 CHAT, CHRNA7
chromatin 2 NFKB1, NR3C1
cell projection 1 SPTAN1
phagocytic cup 1 TNF
Chromosome 1 NR3C1
cytoskeleton 1 MAPK3
Cytoplasm, cell cortex 1 SPTAN1
blood microparticle 1 BCHE
nuclear envelope 1 MAPK3
endosome lumen 1 NGF
Membrane, caveola 1 MAPK3
Nucleus, nucleoplasm 1 NR3C1
pseudopodium 1 MAPK3
plasma membrane raft 1 CHRNA7
secretory granule lumen 1 NFKB1
Golgi lumen 1 NGF
endoplasmic reticulum lumen 2 BCHE, MAPK3
cortical actin cytoskeleton 1 SPTAN1
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 2 NFKB1, SPTAN1
tertiary granule lumen 1 SPTAN1
neuronal dense core vesicle 1 ADRB2
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 ADRB2
spectrin 1 SPTAN1
cytoplasmic microtubule 1 CYP2A6
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
acetylcholine-gated channel complex 1 CHRNA7
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
Cytoplasmic granule membrane 1 LBP
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle 1 SPTAN1


文献列表

  • Kristin Andrud, Hong Xing, Bjarne Gabrielsen, Linda Bloom, Vladimir Mahnir, Stephen Lee, Benedict T Green, Jon Lindstrom, William Kem. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Marine drugs. 2019 Oct; 17(11):. doi: 10.3390/md17110614. [PMID: 31671780]
  • B T Green, S T Lee, J W Keele, K D Welch, D Cook, J A Pfister, W R Kem. Complete inhibition of fetal movement in the day 40 pregnant goat model by the piperidine alkaloid anabasine but not related alkaloids. Toxicon : official journal of the International Society on Toxinology. 2018 Mar; 144(?):61-67. doi: 10.1016/j.toxicon.2018.02.007. [PMID: 29452148]
  • Benedict T Green, Stephen T Lee, Kevin D Welch, Daniel Cook, William R Kem. Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids. Toxins. 2016 07; 8(7):. doi: 10.3390/toxins8070204. [PMID: 27384586]
  • Stephen T Lee, Kristin Wildeboer, Kip E Panter, William R Kem, Dale R Gardner, Russell J Molyneux, Cheng-Wei Tom Chang, Ferenc Soti, James A Pfister. Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine. Neurotoxicology and teratology. 2006 Mar; 28(2):220-8. doi: 10.1016/j.ntt.2005.12.010. [PMID: 16488116]