Panaxytriol (BioDeep_00000011408)

 

Secondary id: BioDeep_00000629723

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


1-Heptadecene-4,6-diyne-3,9,10-triol

化学式: C17H26O3 (278.1882)
中文名称: 人参炔三醇
谱图信息: 最多检出来源 Homo sapiens(otcml) 10.01%

分子结构信息

SMILES: C=CC(O)C#CC#CCC(O)C(O)CCCCCCC
InChI: InChI=1S/C17H26O3/c1-3-5-6-7-10-13-16(19)17(20)14-11-8-9-12-15(18)4-2/h4,15-20H,2-3,5-7,10,13-14H2,1H3

描述信息

Panaxytriol is found in tea. Panaxytriol is found in ginsen
Found in ginseng

同义名列表

7 个代谢物同义名

1-Heptadecene-4,6-diyne-3,9,10-triol; heptadeca-1-en-4,6-diyn-3,9,10-triol; heptadec-1-en-4,6-diyne-3,9,10-triol; 1-heptadecen-4,6-diyn-3,9,10-triol; Falcarintriol; Panaxytriol; Panaxytriol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

35 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKR1C3, BDNF, CYP2B6, CYP3A4, EP300, NQO1, NR1I3, NTRK2, PIK3CA, RB1, RXRA
Peripheral membrane protein 1 CYP2B6
Endosome membrane 1 NTRK2
Endoplasmic reticulum membrane 2 CYP2B6, CYP3A4
Nucleus 8 AKR1C3, EP300, GABPA, NQO1, NR1I2, NR1I3, RB1, RXRA
cytosol 10 AKR1C2, AKR1C3, ATP12A, EP300, NQO1, NR1I3, NTRK2, PIK3CA, RB1, RXRA
dendrite 3 BDNF, NQO1, NTRK2
nuclear body 1 NR1I2
nucleoplasm 6 EP300, GABPA, NR1I2, NR1I3, RB1, RXRA
RNA polymerase II transcription regulator complex 1 RXRA
Cell membrane 2 NTRK2, TNF
lamellipodium 1 PIK3CA
Cell projection, axon 1 NTRK2
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 1 ATP12A
Synapse 1 NQO1
cell surface 2 EPCAM, TNF
neuronal cell body 2 NQO1, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 AKR1C2, NQO1
plasma membrane 5 ATP12A, EPCAM, NTRK2, PIK3CA, TNF
terminal bouton 1 NTRK2
Membrane 4 BDNF, CYP3A4, NQO1, NTRK2
apical plasma membrane 2 ATP12A, EPCAM
axon 2 BDNF, NTRK2
basolateral plasma membrane 2 ATP12A, EPCAM
extracellular exosome 2 AKR1C3, EPCAM
extracellular space 2 BDNF, TNF
perinuclear region of cytoplasm 3 BDNF, NTRK2, PIK3CA
Cell junction, tight junction 1 EPCAM
bicellular tight junction 1 EPCAM
intercalated disc 1 PIK3CA
mitochondrion 1 RXRA
intracellular membrane-bounded organelle 2 CYP2B6, CYP3A4
Microsome membrane 2 CYP2B6, CYP3A4
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 2 EPCAM, NTRK2
Secreted 1 BDNF
extracellular region 2 BDNF, TNF
transcription regulator complex 3 EP300, NR1I2, RXRA
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ATP12A
dendritic spine 1 NTRK2
Early endosome 1 NTRK2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ATP12A
Cytoplasm, perinuclear region 1 NTRK2
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 NR1I3
spindle 1 RB1
PML body 1 RB1
lateral plasma membrane 1 EPCAM
receptor complex 2 NTRK2, RXRA
chromatin 6 EP300, GABPA, NR1I2, NR1I3, RB1, RXRA
phagocytic cup 1 TNF
Chromosome 1 EP300
cytoskeleton 1 NR1I3
Cell projection, dendrite 1 NTRK2
intermediate filament cytoskeleton 1 NR1I2
endoplasmic reticulum lumen 1 BDNF
axon terminus 1 NTRK2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
SWI/SNF complex 1 RB1
Lateral cell membrane 1 EPCAM
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
potassium:proton exchanging ATPase complex 1 ATP12A
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Lingming Zhang, Jingdi Yan, Jianming Liu, Chao Meng, Fanglan Liu, Chunhua Xia. Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 101(?):154097. doi: 10.1016/j.phymed.2022.154097. [PMID: 35417848]
  • Ya-Mei Wu, Xue-Qiong Yang, Tong-De Zhao, Wen-Zhi Shi, Li-Jingfei Sun, Rong-Huan Cen, Ya-Bin Yang, Zhong-Tao Ding. Antifeedant and Antifungal Activities of Metabolites Isolated from the Coculture of Endophytic Fungus Aspergillus tubingensis S1120 with Red Ginseng. Chemistry & biodiversity. 2022 Jan; 19(1):e202100608. doi: 10.1002/cbdv.202100608. [PMID: 34786852]
  • Fei Li, Qian Xie, Yan Qin, Chunyi Tong, Bin Liu, Wei Wang. Real-time monitoring and effector screening of APE1 based on rGO assisted DNA nanoprobe. Analytical biochemistry. 2021 11; 633(?):114394. doi: 10.1016/j.ab.2021.114394. [PMID: 34610334]
  • Hua Yang, Lei Liu, Wen Gao, Ke Liu, Lian-Wen Qi, Ping Li. Direct and comprehensive analysis of ginsenosides and diterpene alkaloids in Shenfu injection by combinatory liquid chromatography-mass spectrometric techniques. Journal of pharmaceutical and biomedical analysis. 2014 Apr; 92(?):13-21. doi: 10.1016/j.jpba.2013.12.041. [PMID: 24469096]
  • Hong Liu, Jie-ping Liang, Pei-bo Li, Wei Peng, Yao-yao Peng, Gao-min Zhang, Cheng-shi Xie, Chao-feng Long, Wei-wei Su. Core bioactive components promoting blood circulation in the traditional Chinese medicine compound xueshuantong capsule (CXC) based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects. PloS one. 2014; 9(11):e112675. doi: 10.1371/journal.pone.0112675. [PMID: 25396725]
  • Caiwen Zeng, Fang He, Chunhua Xia, Hong Zhang, Yuqing Xiong. Identification of the active components in Shenmai injection that differentially affect Cyp3a4-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):785-90. doi: 10.1124/dmd.112.048025. [PMID: 23340957]
  • Marlin Halim, Dominic J Yee, Dalibor Sames. Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng. Journal of the American Chemical Society. 2008 Oct; 130(43):14123-8. doi: 10.1021/ja801245y. [PMID: 18826220]
  • Ji Yeon Kim, Ki-Won Lee, Sun-Ho Kim, Jae Joon Wee, Young-Suk Kim, Hyong Joo Lee. Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol. Planta medica. 2002 Feb; 68(2):119-22. doi: 10.1055/s-2002-20240. [PMID: 11859460]
  • G Rao, X Wang, W Jin. [Polyacetylene compounds from Panax notoginsenoside]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 1997 Jun; 20(6):298-9. doi: . [PMID: 12572474]
  • T Saita, M Katano, H Matsunaga, I Kouno, H Fujito, M Mori. Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol. Biological & pharmaceutical bulletin. 1995 Jul; 18(7):933-7. doi: 10.1248/bpb.18.933. [PMID: 7581246]
  • T Saita, H Matsunaga, H Yamamoto, F Nagumo, H Fujito, M Mori, M Katano. A highly sensitive enzyme-linked immunosorbent assay (ELISA) for antitumor polyacetylenic alcohol, panaxytriol. Biological & pharmaceutical bulletin. 1994 Jun; 17(6):798-802. doi: 10.1248/bpb.17.798. [PMID: 7951141]
  • T Saita, M Katano, H Matsunaga, H Yamamoto, H Fujito, M Mori. The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol. Chemical & pharmaceutical bulletin. 1993 Mar; 41(3):549-52. doi: 10.1248/cpb.41.549. [PMID: 8477507]
  • Q Chi, J Guo, Q Dang. [Thin layer chromatography and extractive technology of Panax japonicum C.A. Mey. var. major (Burk.) C. Y. Wu et K. M. Feng growing in Qingba Mountain Area]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1992 Aug; 17(8):478-80, 511. doi: ". [PMID: 1482533]
  • H Matsunaga, M Katano, H Yamamoto, M Mori, K Takata. Studies on the panaxytriol of Panax ginseng C. A. Meyer. Isolation, determination and antitumor activity. Chemical & pharmaceutical bulletin. 1989 May; 37(5):1279-81. doi: 10.1248/cpb.37.1279. [PMID: 2630093]
  • P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. The New England journal of medicine. 1976 Feb; 294(7):361-5. doi: 10.1056/nejm197602122940703. [PMID: 1674]