1,2-Dichlorobenzene (BioDeep_00000009830)
Secondary id: BioDeep_00001871304
human metabolite blood metabolite
代谢物信息卡片
Ortho-dichlorobenzene
化学式: C6H4Cl2 (145.96900440000002)
中文名称: 混合二氯苯, 邻二氯苯
谱图信息:
最多检出来源 Homo sapiens(blood) 0.16%
分子结构信息
SMILES: C1=CC=C(C(=C1)Cl)Cl
InChI: InChI=1S/C6H4Cl2/c7-5-3-1-2-4-6(5)8/h1-4H
描述信息
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:35290
- KEGG: C14328
- PubChem: 7239
- HMDB: HMDB0244067
- Metlin: METLIN69969
- DrugBank: DB13963
- ChEMBL: CHEMBL298461
- Wikipedia: 1,2-Dichlorobenzene
- MetaCyc: O-DICHLOROBENZENE
- chemspider: 13837988
- CAS: 1219803-83-4
- CAS: 25321-22-6
- CAS: 95-50-1
- PMhub: MS000023649
- PubChem: 17395328
- PDB-CCD: YAN
- NIKKAJI: J3.951I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- 1,2-dichlorobenzene degradation:
1,2-dichlorobenzene + H+ + NADH + O2 ⟶ (1R,2S)-3,4-dichlorocyclohexa-3,5-diene-1,2-diol + NAD+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 54731 Nepeta racemosa: 10.1080/10412905.1993.9698205
- 3635 Gossypium hirsutum: 10.1021/JF60200A011
- 54731 Nepeta racemosa: 10.1080/10412905.1993.9698205
- 3635 Gossypium hirsutum: 10.1021/JF60200A011
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zhongbing Chen, Peter Kuschk, Heidrun Paschke, Matthias Kästner, Heinz Köser. The dynamics of low-chlorinated benzenes in a pilot-scale constructed wetland and a hydroponic plant root mat treating sulfate-rich groundwater.
Environmental science and pollution research international.
2015 Mar; 22(5):3886-94. doi:
10.1007/s11356-014-3618-9. [PMID: 25280503] - Jingwei Feng, Runlong Liu, Pei Chen, Shoujun Yuan, Dayong Zhao, Jibiao Zhang, Zheng Zheng. Degradation of aqueous 3,4-dichloroaniline by a novel dielectric barrier discharge plasma reactor.
Environmental science and pollution research international.
2015 Mar; 22(6):4447-59. doi:
10.1007/s11356-014-3690-1. [PMID: 25315933] - Kiran Morya, Kauresh D Vachhrajani. Impairment of renal structure and function following heterogeneous chemical mixture exposure in rats.
Indian journal of experimental biology.
2014 Apr; 52(4):332-43. doi:
. [PMID: 24772936] - Sarah Mahne, Gin C Chuang, Edward Pankey, Lucy Kiruri, Philip J Kadowitz, Barry Dellinger, Kurt J Varner. Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure.
American journal of physiology. Heart and circulatory physiology.
2012 Nov; 303(9):H1135-42. doi:
10.1152/ajpheart.00545.2012. [PMID: 22942180] - Paul Fitzpatrick, Andrew Rowley, Neil Wright, Laurent Bedel. Nanocatalysis for detoxification technologies.
Journal of nanoscience and nanotechnology.
2012 Jun; 12(6):4911-8. doi:
10.1166/jnn.2012.4899. [PMID: 22905551] - Antonius Indarto. Decomposition of dichlorobenzene in a dielectric barrier discharge.
Environmental technology.
2012 Feb; 33(4-6):663-6. doi:
10.1080/09593330.2011.587026. [PMID: 22629641] - Eveline Snelders, Simone M T Camps, Anna Karawajczyk, Gijs Schaftenaar, Gert H J Kema, Henrich A van der Lee, Corné H Klaassen, Willem J G Melchers, Paul E Verweij. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.
PloS one.
2012; 7(3):e31801. doi:
10.1371/journal.pone.0031801. [PMID: 22396740] - Kevin Lord, David Moll, John K Lindsey, Sarah Mahne, Girija Raman, Tammy Dugas, Stephania Cormier, Dana Troxlair, Slawo Lomnicki, Barry Dellinger, Kurt Varner. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo.
Journal of receptor and signal transduction research.
2011 Apr; 31(2):157-67. doi:
10.3109/10799893.2011.555767. [PMID: 21385100] - Nynke I Kramer, Frans J M Busser, Mattheus T T Oosterwijk, Kristin Schirmer, Beate I Escher, Joop L M Hermens. Development of a partition-controlled dosing system for cell assays.
Chemical research in toxicology.
2010 Nov; 23(11):1806-14. doi:
10.1021/tx1002595. [PMID: 20961080] - Christine L Kielb, Cristian I Pantea, Lenore J Gensburg, Robert L Jansing, Syni-An Hwang, Alice D Stark, Edward F Fitzgerald. Concentrations of selected organochlorines and chlorobenzenes in the serum of former Love Canal residents, Niagara Falls, New York.
Environmental research.
2010 Apr; 110(3):220-5. doi:
10.1016/j.envres.2009.11.004. [PMID: 20117765] - Ans Punt, Alicia Paini, Marelle G Boersma, Andreas P Freidig, Thierry Delatour, Gabriele Scholz, Benoît Schilter, Peter J van Bladeren, Ivonne M C M Rietjens. Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Aug; 110(2):255-69. doi:
10.1093/toxsci/kfp102. [PMID: 19447879] - Magdalena V Monferran, Silvia F Pesce, Jimena Cazenave, Daniel A Wunderlin. Detoxification and antioxidant responses in diverse organs of Jenynsia multidentata experimentally exposed to 1,2- and 1,4-dichlorobenzene.
Environmental toxicology.
2008 Apr; 23(2):184-92. doi:
10.1002/tox.20326. [PMID: 18214911] - Bing Song Zheng, Elin Rönnberg, Lenita Viitanen, Tiina A Salminen, Krister Lundgren, Thomas Moritz, Johan Edqvist. Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings.
Journal of experimental botany.
2008; 59(12):3485-99. doi:
10.1093/jxb/ern201. [PMID: 18687588] - Susana Redondo-Gómez, Lucía Cox, Juan Cornejo, Enrique Figueroa. Combined effect of diuron and simazine on photosystem II photochemistry in a sandy soil and soil amended with solid olive-mill waste.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2007 Mar; 42(3):249-54. doi:
10.1080/03601230701229122. [PMID: 17454377] - Duy-Phong Pham-Huu, Jeffrey R Deschamps, Shanghao Liu, Bertha K Madras, Peter C Meltzer. Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Bioorganic & medicinal chemistry.
2007 Jan; 15(2):1067-82. doi:
10.1016/j.bmc.2006.10.016. [PMID: 17070057] - Shiau-Chian Soh, Md Pauzi Abdullah. Determination of volatile organic compounds pollution sources in malaysian drinking water using multivariate analysis.
Environmental monitoring and assessment.
2007 Jan; 124(1-3):39-50. doi:
10.1007/s10661-006-9207-8. [PMID: 16967208] - Jianying Zhang, Wei Zhao, Jun Pan, Limin Qiu, Yinmei Zhu. Tissue-dependent distribution and accumulation of chlorobenzenes by vegetables in urban area.
Environment international.
2005 Aug; 31(6):855-60. doi:
10.1016/j.envint.2005.05.034. [PMID: 16002141] - Stacey A Lomenzo, Jill B Rhoden, Sari Izenwasser, Dean Wade, Theresa Kopajtic, Jonathan L Katz, Mark L Trudell. Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
Journal of medicinal chemistry.
2005 Mar; 48(5):1336-43. doi:
10.1021/jm0401614. [PMID: 15743177] - Hoh-Gyu Hahn, Heong Sub Oh, Seung Hoon Cheon, Min Ho Oak, Young-Ran Kim, Kyeong-Man Kim. Excavation of lead compounds that inhibit mast cell degranulation by combinatorial chemistry and activity-guided.
Archives of pharmacal research.
2004 May; 27(5):518-23. doi:
10.1007/bf02980125. [PMID: 15202557] - Guolin Li, Andrew Graham, Yihui Chen, Mahabeer P Dobhal, Janet Morgan, Gang Zheng, Andrei Kozyrev, Allan Oseroff, Thomas J Dougherty, Ravindra K Pandey. Synthesis, comparative photosensitizing efficacy, human serum albumin (site II) binding ability, and intracellular localization characteristics of novel benzobacteriochlorins derived from vic-dihydroxybacteriochlorins.
Journal of medicinal chemistry.
2003 Dec; 46(25):5349-59. doi:
10.1021/jm030341y. [PMID: 14640543] - Bram J Versonnen, Katrien Arijs, Tim Verslycke, Wouter Lema, Colin R Janssen. In vitro and in vivo estrogenicity and toxicity of o-, m-, and p-dichlorobenzene.
Environmental toxicology and chemistry.
2003 Feb; 22(2):329-35. doi:
NULL. [PMID: 12558164] - Zhu-Sheng Ji, Cong-Gang Li, Xi-An Mao, Mai-Li Liu, Ji-Ming Hu. NMR study on the low-affinity interaction of human serum albumin with diclofenac sodium.
Chemical & pharmaceutical bulletin.
2002 Aug; 50(8):1017-21. doi:
10.1248/cpb.50.1017. [PMID: 12192129] - T Takayasu, T Ohshima, T Kondo. Rapid analysis of pesticide components, xylene, o-dichlorbenzene, cresol and dichlorvos, in blood and urine by pulse heating-gas chromatography-mass spectrometry.
Legal medicine (Tokyo, Japan).
2001 Sep; 3(3):157-61. doi:
10.1016/s1344-6223(01)00024-4. [PMID: 12935521] - H S Younis, N C Hoglen, R K Kuester, L Gunawardhana, I G Sipes. 1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats.
Toxicology and applied pharmacology.
2000 Mar; 163(2):141-8. doi:
10.1006/taap.1999.8860. [PMID: 10698672] - N C Hoglen, H S Younis, D P Hartley, L Gunawardhana, R C Lantz, I G Sipes. 1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent.
Toxicological sciences : an official journal of the Society of Toxicology.
1998 Dec; 46(2):376-85. doi:
10.1006/toxs.1998.2523. [PMID: 10048141] - M Ban, D Hettich, M Goutet, S Binet. Serum-borne factor(s) of 1,1-dichloroethylene and 1,2-dichlorobenzene-treated mice inhibited in vitro antibody forming cell response and natural killer cell activity.
Toxicology letters.
1998 Jan; 94(2):93-101. doi:
10.1016/s0378-4274(97)00109-4. [PMID: 9574806] - B G Lake, M E Cunninghame, R J Price. Comparison of the hepatic and renal effects of 1,4-dichlorobenzene in the rat and mouse.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1997 Sep; 39(1):67-75. doi:
10.1006/faat.1997.2350. [PMID: 9325029] - Y Kato, R Kimura. Role of 3,4-dichlorophenyl methyl sulfone, a metabolite of o-dichlorobenzene, in the changes in hepatic microsomal drug-metabolizing enzymes caused by o-dichlorobenzene administration in rats.
Toxicology and applied pharmacology.
1997 Aug; 145(2):277-84. doi:
10.1006/taap.1997.8191. [PMID: 9266800] - S Kumagai, I Matsunaga. Quantitative determination of urinary metabolites of o-dichlorobenzene using a gas chromatograph.
Industrial health.
1997 Jul; 35(3):399-403. doi:
10.2486/indhealth.35.399. [PMID: 9248225] - S G Kulkarni, A Warbritton, T J Bucci, H M Mehendale. Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats.
Toxicology.
1997 Jun; 120(2):79-88. doi:
10.1016/s0300-483x(97)03627-5. [PMID: 9184194] - D W Herr, W K Boyes. A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs).
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1997 Jan; 35(1):31-48. doi:
10.1006/faat.1996.2255. [PMID: 9024671] - L P Zenser, A Lang, U Knecht. N-acetyl-S-(dichlorophenyl)cysteines as suitable biomarkers for the monitoring of occupational exposure to 1,2-dichlorobenzene.
International archives of occupational and environmental health.
1997; 69(4):252-4. doi:
10.1007/s004200050144. [PMID: 9137999] - T Umemura, M Saito, A Takagi, Y Kurokawa. Isomer-specific acute toxicity and cell proliferation in livers of B6C3F1 mice exposed to dichlorobenzene.
Toxicology and applied pharmacology.
1996 Apr; 137(2):268-74. doi:
10.1006/taap.1996.0080. [PMID: 8661352] - S G Kulkarni, H Duong, R Gomila, H M Mehendale. Strain differences in tissue repair response to 1,2-dichlorobenzene.
Archives of toxicology.
1996; 70(11):714-23. doi:
10.1007/s002040050332. [PMID: 8896717] - A M Hissink, B Van Ommen, P J Van Bladeren. Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital.
Xenobiotica; the fate of foreign compounds in biological systems.
1996 Jan; 26(1):89-105. doi:
10.3109/00498259609046691. [PMID: 8851824] - M A Valentovic, J G Ball, D Anestis, E Madan. Modification of P450 activity and its effect on 1,2-dichlorobenzene toxicity in Fischer 344 rats.
Toxicology.
1993 May; 79(3):169-80. doi:
10.1016/0300-483x(93)90209-b. [PMID: 8316947] - L Gunawardhana, S A Mobley, I G Sipes. Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells.
Toxicology and applied pharmacology.
1993 Apr; 119(2):205-13. doi:
10.1006/taap.1993.1061. [PMID: 8386865] - M A Valentovic, J G Ball, D Anestis, E Madan. Acute hepatic and renal toxicity of dichlorobenzene isomers in Fischer 344 rats.
Journal of applied toxicology : JAT.
1993 Jan; 13(1):1-7. doi:
10.1002/jat.2550130103. [PMID: 8440869] - R L Fisher, A J Gandolfi, I G Sipes, K Brendel. Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver.
Drug and chemical toxicology.
1993; 16(4):321-39. doi:
10.3109/01480549308998224. [PMID: 8281887] - C den Besten, J J Vet, H T Besselink, G S Kiel, B J van Berkel, R Beems, P J van Bladeren. The liver, kidney, and thyroid toxicity of chlorinated benzenes.
Toxicology and applied pharmacology.
1991 Oct; 111(1):69-81. doi:
10.1016/0041-008x(91)90135-2. [PMID: 1949037] - E R Stine, L Gunawardhana, I G Sipes. The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity.
Toxicology and applied pharmacology.
1991 Jul; 109(3):472-81. doi:
10.1016/0041-008x(91)90010-c. [PMID: 1853346] - M Robinson, J P Bercz, H P Ringhand, L W Condie, M J Parnell. Ten- and ninety-day toxicity studies of 1,2-dichlorobenzene administered by oral gavage to Sprague-Dawley rats.
Drug and chemical toxicology.
1991; 14(1-2):83-112. doi:
10.3109/01480549109017870. [PMID: 1889379] - A Colacci, S Bartoli, B Bonora, A Niero, P Silingardi, S Grilli. In vivo and in vitro interaction of 1,2-dichlorobenzene with nucleic acids and proteins of mice and rats.
Tumori.
1990 Aug; 76(4):339-44. doi:
10.1177/030089169007600407. [PMID: 1697992] - M T Brondeau, M Ban, P Bonnet, J P Guenier, J de Ceaurriz. Acetone compared to other ketones in modifying the hepatotoxicity of inhaled 1,2-dichlorobenzene in rats and mice.
Toxicology letters.
1989 Oct; 49(1):69-78. doi:
10.1016/0378-4274(89)90103-3. [PMID: 2554539] - M Charbonneau, J Strasser, E A Lock, M J Turner, J A Swenberg. Involvement of reversible binding to alpha 2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity.
Toxicology and applied pharmacology.
1989 Jun; 99(1):122-32. doi:
10.1016/0041-008x(89)90117-8. [PMID: 2471290] - J De Ceaurriz, F Gagnaire, M Ban, P Bonnet. Assessment of the relative hazard involved with airborne irritants with additional hepatotoxic or nephrotoxic properties in mice.
Journal of applied toxicology : JAT.
1988 Dec; 8(6):417-22. doi:
10.1002/jat.2550080606. [PMID: 2852685] - M T Brondeau, M Ban, P Bonnet, J P Guenier, J De Ceaurriz. Concentration-related changes in blood and tissue parameters of hepatotoxicity and their interdependence in rats exposed to bromobenzene and 1,2-dichlorobenzene.
Toxicology letters.
1986 May; 31(2):159-66. doi:
10.1016/0378-4274(86)90010-x. [PMID: 3012827]