3-Hydroxytamoxifen (Droloxifene) (BioDeep_00000009816)

 

Secondary id: BioDeep_00000858866

human metabolite Endogenous blood metabolite


代谢物信息卡片


3-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol

化学式: C26H29NO2 (387.2198)
中文名称: 屈洛昔芬
谱图信息: 最多检出来源 Homo sapiens(blood) 10.97%

分子结构信息

SMILES: CCC(=C(C1=CC=C(C=C1)OCCN(C)C)C2=CC(=CC=C2)O)C3=CC=CC=C3
InChI: InChI=1S/C26H29NO2/c1-4-25(20-9-6-5-7-10-20)26(22-11-8-12-23(28)19-22)21-13-15-24(16-14-21)29-18-17-27(2)3/h5-16,19,28H,4,17-18H2,1-3H3/b26-25+

描述信息

3-Hydroxytamoxifen (Droloxifene) is only found in individuals that have used or taken Tamoxifen. 3-Hydroxytamoxifen (Droloxifene) is a metabolite of Tamoxifen. 3-hydroxytamoxifen (droloxifene) belongs to the family of Stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D020011 - Protective Agents > D000975 - Antioxidants
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent
Same as: D03911

同义名列表

9 个代谢物同义名

3-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol; 3-Hydroxytamoxifen (Droloxifene); 3-Hydroxytamoxifen citrate; Meta-hydroxytamoxifen; Droloxifene citrate; 3-Hydroxytamoxifen; DTXSID20274463; Droloxifene; Droloxifene



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, ACE, ADRA2A, BCL2, CYP2D6, CYP3A4, ESR1, MYC, NOL3, PGR
Peripheral membrane protein 2 CYP1B1, ESR1
Endoplasmic reticulum membrane 5 BCL2, CYP19A1, CYP1B1, CYP2D6, CYP3A4
Mitochondrion membrane 1 ABCG2
Nucleus 5 BCL2, ESR1, ESR2, MYC, PGR
cytosol 5 ADRA2B, BCL2, ESR1, NOL3, PGR
mitochondrial membrane 1 ABCG2
nucleoplasm 5 ABCG2, ESR1, ESR2, MYC, PGR
Cell membrane 6 ABCB1, ABCG2, ACE, ADRA2A, ADRA2B, ESR1
Lipid-anchor 1 NOL3
Cytoplasmic side 1 ESR1
Multi-pass membrane protein 5 ABCB1, ABCG2, ADRA2A, ADRA2B, CYP19A1
cell surface 2 ABCB1, ADRA2B
glutamatergic synapse 1 ADRA2A
Golgi apparatus 1 ESR1
lysosomal membrane 1 EGF
neuronal cell body 1 ADRA2A
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 9 ABCB1, ABCG2, ACE, ADRA2A, ADRA2B, EGF, ESR1, PGR, REN
Membrane 13 ABCB1, ABCG2, ACE, BCL2, CYP19A1, CYP1B1, CYP2D6, CYP3A4, EGF, ESR1, MYC, NOL3, REN
apical plasma membrane 2 ABCB1, ABCG2
basolateral plasma membrane 1 ADRA2A
extracellular exosome 5 ABCB1, ACE, AGT, EGF, SHBG
endoplasmic reticulum 3 BCL2, CYP19A1, CYP2D6
extracellular space 5 ACE, AGT, EGF, GNRH1, REN
mitochondrion 5 BCL2, CYP1B1, CYP2D6, ESR2, NOL3
protein-containing complex 3 BCL2, ESR1, MYC
intracellular membrane-bounded organelle 5 ADRA2B, CYP1B1, CYP2D6, CYP3A4, ESR2
Microsome membrane 4 CYP19A1, CYP1B1, CYP2D6, CYP3A4
Single-pass type I membrane protein 1 ACE
Secreted 4 ACE, AGT, REN, SHBG
extracellular region 6 ACE, AGT, EGF, GNRH1, REN, SHBG
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP2D6
mitochondrial outer membrane 2 BCL2, PGR
transcription regulator complex 1 ESR1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ACE
nucleolus 2 MYC, NOL3
sarcoplasm 1 NOL3
apical part of cell 1 REN
presynaptic active zone membrane 1 ADRA2A
Apical cell membrane 2 ABCB1, ABCG2
Membrane raft 1 ABCG2
pore complex 1 BCL2
GABA-ergic synapse 1 ADRA2A
sarcoplasmic reticulum 1 NOL3
collagen-containing extracellular matrix 1 AGT
receptor complex 1 ADRA2A
chromatin 4 ESR1, ESR2, MYC, PGR
brush border membrane 2 ABCG2, ACE
Nucleus, nucleolus 1 MYC
blood microparticle 1 AGT
sperm midpiece 1 ACE
nuclear envelope 1 MYC
Nucleus, nucleoplasm 1 MYC
euchromatin 1 ESR1
myelin sheath 1 BCL2
basal plasma membrane 1 ACE
[Isoform 3]: Cytoplasm 1 NOL3
platelet alpha granule lumen 1 EGF
axon terminus 1 ADRA2A
RNA polymerase II transcription repressor complex 1 MYC
postsynaptic density membrane 1 ADRA2A
[Isoform 2]: Cytoplasm 1 NOL3
clathrin-coated endocytic vesicle membrane 1 EGF
[Isoform 1]: Nucleus 1 ESR1
[Isoform 1]: Nucleus, nucleolus 1 NOL3
external side of apical plasma membrane 2 ABCB1, ABCG2
dopaminergic synapse 1 ADRA2A
Rough endoplasmic reticulum 1 MYC
Myc-Max complex 1 MYC
[Isoform 4]: Mitochondrion outer membrane 1 PGR
BAD-BCL-2 complex 1 BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
nucleoplasmic reticulum 1 MYC


文献列表

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