N-phenylanthranilic acid (BioDeep_00000009515)

 

Secondary id: BioDeep_00001871643

human metabolite blood metabolite


代谢物信息卡片


N-Phenyl-ortho-aminobenzoic acid

化学式: C13H11NO2 (213.079)
中文名称: N-苯基邻氨基苯甲酸(钒试剂)
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O
InChI: InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16)

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

22 个代谢物同义名

N-Phenyl-ortho-aminobenzoic acid; Diphenylamine-2-carboxylic acid; Fenamic acid, monosodium salt; N-Phenyl-ortho-aminobenzoate; Diphenylamine-2-carboxylate; Fenamic acid, ca salt (2:1); 2-(phenylamino)benzoic acid; 4-(Phenylamino)benzoic acid; Diphenylamine carboxylate; Ortho-anilinobenzoic acid; N-phenylanthranilic acid; Phenylanthranilic acid; 2-Carboxydiphenylamine; Ortho-anilinobenzoate; 2-Anilinobenzoic acid; N-Phenylanthranilate; Phenylanthranilate; 2-Anilinobenzoate; Fenamic acid; Fenamate; DPC; Fenamic acid



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1C3, AXIN2, CFTR, CLU, HPGDS, MYLK, PTGS1, PTGS2
Peripheral membrane protein 4 CLU, CYP1B1, PTGS1, PTGS2
Endosome membrane 2 CFTR, CLCN5
Endoplasmic reticulum membrane 5 CFTR, CYP1B1, FA2H, PTGS1, PTGS2
Mitochondrion membrane 1 CLU
Nucleus 4 AKR1C3, AXIN2, CFTR, CLU
cytosol 9 AKR1C3, AXIN2, CFTR, CLCN5, CLU, DHODH, HPGDS, MYLK, PRKCQ
mitochondrial membrane 1 CLU
centrosome 1 AXIN2
nucleoplasm 4 DHODH, HPGDS, SCNN1G, TBL3
Cell membrane 3 CFTR, CLCN2, CLCN5
Cytoplasmic side 1 CLU
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Cell projection, axon 1 CLCN2
Early endosome membrane 1 CFTR
Multi-pass membrane protein 7 CATSPER3, CFTR, CLCN2, CLCN5, FA2H, KCNA3, SCNN1G
Golgi apparatus membrane 1 CLCN5
Synapse 2 CLU, MYLK
cell surface 2 CFTR, CLU
glutamatergic synapse 1 KCNA3
Golgi apparatus 3 CLCN5, CLU, PTGS1
Golgi membrane 1 CLCN5
lysosomal membrane 2 CFTR, CLCN5
mitochondrial inner membrane 2 CLU, DHODH
presynaptic membrane 1 KCNA3
synaptic vesicle 1 CLCN5
Cytoplasm, cytosol 1 CLU
acrosomal vesicle 1 CATSPER3
plasma membrane 10 AXIN2, CATSPER3, CFTR, CLCN2, CLCN5, KCNA3, KNG1, MYLK, PRKCQ, SCNN1G
Membrane 7 CFTR, CLCN2, CLCN5, CYP1B1, DHODH, FA2H, KCNA3
apical plasma membrane 2 CFTR, SCNN1G
axon 2 CLCN2, KCNA3
basolateral plasma membrane 1 CLCN2
caveola 1 PTGS2
extracellular exosome 5 AKR1C3, CLU, KNG1, PTGS1, SCNN1G
endoplasmic reticulum 4 CATSPER3, CLU, FA2H, PTGS2
extracellular space 3 CLU, KNG1, SCT
perinuclear region of cytoplasm 2 CLU, KCNA3
mitochondrion 3 CLU, CYP1B1, DHODH
protein-containing complex 3 CFTR, CLU, PTGS2
intracellular membrane-bounded organelle 4 CLU, CYP1B1, HPGDS, PTGS1
Microsome membrane 4 CYP1B1, FA2H, PTGS1, PTGS2
Secreted 1 CLU
extracellular region 3 CLU, KNG1, SCT
Single-pass membrane protein 1 DHODH
astrocyte end-foot 1 CLCN2
centriolar satellite 1 PRKCQ
motile cilium 1 CATSPER3
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 1 SCNN1G
actin cytoskeleton 1 MYLK
perikaryon 1 CLCN2
beta-catenin destruction complex 1 AXIN2
nucleolus 1 TBL3
Early endosome 2 CFTR, CLCN5
apical part of cell 1 CLCN5
recycling endosome 1 CFTR
postsynaptic membrane 2 CLCN2, KCNA3
Apical cell membrane 2 CFTR, SCNN1G
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 CLU
Mitochondrion inner membrane 1 DHODH
Membrane raft 1 KCNA3
collagen-containing extracellular matrix 2 CLU, KNG1
lateral plasma membrane 1 CLCN2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
Secreted, extracellular space 1 KNG1
Nucleus, nucleolus 1 TBL3
blood microparticle 2 CLU, KNG1
Basolateral cell membrane 1 CLCN2
[Isoform 2]: Cell membrane 1 KCNA3
Recycling endosome membrane 1 CFTR
Endomembrane system 1 PTGS1
chloride channel complex 2 CFTR, CLCN2
Cell projection, cilium, flagellum membrane 1 CATSPER3
sodium channel complex 1 SCNN1G
axon initial segment 1 CLCN2
Golgi-associated vesicle membrane 1 CFTR
myelin sheath 1 CLCN2
stress fiber 1 MYLK
[Isoform 4]: Cytoplasm 1 CLU
voltage-gated potassium channel complex 1 KCNA3
Microsome 1 CLU
endoplasmic reticulum lumen 2 KNG1, PTGS2
platelet alpha granule lumen 2 CLU, KNG1
small-subunit processome 1 TBL3
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 CFTR
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
apical dendrite 1 CLU
[Isoform 1]: Cell membrane 1 KCNA3
90S preribosome 1 TBL3
Cell projection, dendritic spine membrane 1 CLCN2
dendritic spine membrane 1 CLCN2
spherical high-density lipoprotein particle 1 CLU
[Isoform 1]: Secreted 1 CLU
neurofibrillary tangle 1 CLU
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 CLU
chromaffin granule 1 CLU
[Isoform 6]: Cytoplasm 1 CLU
perinuclear endoplasmic reticulum lumen 1 CLU
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
CatSper complex 1 CATSPER3


文献列表

  • Armel L Mbani O, Evan F Bonnand, Awawou G Paboudam, Jacob P Brannon, Kevyn D Gardner-Ricossa, S Chantal E Stieber, Moise O Agwara. Synthesis, structural analysis, and docking studies with SARS-CoV-2 of a trinuclear zinc complex with N-phenylanthranilic acid ligands. Acta crystallographica. Section C, Structural chemistry. 2022 04; 78(Pt 4):231-239. doi: 10.1107/s205322962200239x. [PMID: 35380126]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Brian N Chorley, Heidrun Ellinger-Ziegelbauer, Michael Tackett, Frank J Simutis, Alison H Harrill, James McDuffie, Elnaz Atabakhsh, Rounak Nassirpour, Laurence O Whiteley, Jean-François Léonard, Gleta K Carswell, Ernie Harpur, Connie L Chen, Jean-Charles Gautier. Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron. Toxicological sciences : an official journal of the Society of Toxicology. 2021 02; 180(1):1-16. doi: 10.1093/toxsci/kfaa181. [PMID: 33367795]
  • Vitalina Gryshkova, Mabel Cotter, Portia McGhan, Jana Obajdin, Renaud Fleurance, Andre Nogueira da Costa. Phosphoprotein expression profiles in rat kidney injury: Source for potential mechanistic biomarkers. Journal of cellular and molecular medicine. 2019 03; 23(3):2251-2255. doi: 10.1111/jcmm.14103. [PMID: 30636369]
  • Stéphanie F Glineur, Etienne Hanon, Sarah Dremier, Sara Snelling, Caroline Berteau, Pierrette De Ron, André Nogueira da Costa. Assessment of a Urinary Kidney MicroRNA Panel as Potential Nephron Segment-Specific Biomarkers of Subacute Renal Toxicity in Preclinical Rat Models. Toxicological sciences : an official journal of the Society of Toxicology. 2018 12; 166(2):409-419. doi: 10.1093/toxsci/kfy213. [PMID: 30169741]
  • Jana Obajdin, Mabel Cotter, Sara Snelling, Sarah Dremier, Pierrette De Ron, Renaud Fleurance, Jean-Pierre Valentin, André Nogueira da Costa, Vitalina Gryshkova. Fatty-Acid Binding Protein 4 (FABP4) as a Potential Preclinical Biomarker of Drug-Induced Kidney Injury. Toxicological sciences : an official journal of the Society of Toxicology. 2018 Dec; 166(2):441-450. doi: 10.1093/toxsci/kfy204. [PMID: 30215792]
  • Cyril Hamiaux, Revel S M Drummond, Zhiwei Luo, Hui Wen Lee, Prachi Sharma, Bart J Janssen, Nigel B Perry, William A Denny, Kimberley C Snowden. Inhibition of strigolactone receptors by N-phenylanthranilic acid derivatives: Structural and functional insights. The Journal of biological chemistry. 2018 04; 293(17):6530-6543. doi: 10.1074/jbc.ra117.001154. [PMID: 29523686]
  • Xiao-Fang Lu, Meng-Di Jia, Sheng-Sheng Zhang, Lu-Qing Zhao. Effects of Hemp seed soft capsule on colonic ion transport in rats. World journal of gastroenterology. 2017 Nov; 23(42):7563-7571. doi: 10.3748/wjg.v23.i42.7563. [PMID: 29204056]
  • Rui Shi, Zi-Ting Xiao, Yi-Jun Zheng, Yi-Lin Zhang, Jia-Wen Xu, Jie-Hong Huang, Wen-Liang Zhou, Pei-Bo Li, Wei-Wei Su. Naringenin Regulates CFTR Activation and Expression in Airway Epithelial Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 44(3):1146-1160. doi: 10.1159/000485419. [PMID: 29179179]
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  • Yan-Ju Liu, Xian-Jiao Fu, Xi-Feng Li, Tian-Bao Qiu, Huai-Xia Yang. Poly[[tetra-kis-(μ-2-anilinobenzoato-κO:O')tetra-μ(1,1,1)-azido-tetra-μ(1,1)-azido-octa-methano-lhexa-nickel(II)] methanol hexa-solvate]. Acta crystallographica. Section E, Structure reports online. 2011 Feb; 67(Pt 3):m307-8. doi: 10.1107/s1600536811003473. [PMID: 21522244]
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  • Chiaki Kondo, Yohsuke Minowa, Takeki Uehara, Yasushi Okuno, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology. 2009 Nov; 265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. [PMID: 19761811]
  • Ciara Leydon, Kimberly V Fisher, Danielle Lodewyck-Falciglia. The cystic fibrosis transmembrane conductance regulator and chloride-dependent ion fluxes of ovine vocal fold epithelium. Journal of speech, language, and hearing research : JSLHR. 2009 Jun; 52(3):745-54. doi: 10.1044/1092-4388(2008/07-0192). [PMID: 18806217]
  • Daniel E Westholm, David D Stenehjem, Jon N Rumbley, Lester R Drewes, Grant W Anderson. Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb; 150(2):1025-32. doi: 10.1210/en.2008-0188. [PMID: 18845642]
  • Sunhapas Soodvilai, Zhanjun Jia, Tianxin Yang. Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2. American journal of physiology. Renal physiology. 2007 Nov; 293(5):F1571-6. doi: 10.1152/ajprenal.00132.2007. [PMID: 17699556]
  • Paraskevi Gaganis, John O Miners, Kathleen M Knights. Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7. Biochemical pharmacology. 2007 May; 73(10):1683-91. doi: 10.1016/j.bcp.2007.01.030. [PMID: 17343829]
  • Yi-Xiang J Wang, Graham Betton, Eike Floettmann, Carsten Liess. MRI histopathology correlation of N-phenylanthranilic acid induced nephropathy in rats. The British journal of radiology. 2006 Dec; 79(948):1009-10. doi: 10.1259/bjr/47913384. [PMID: 17213305]
  • A Muñoz de la Peña, A Espinosa Mansilla, N Mora Díez, D Bohoyo Gil, A C Olivieri, G M Escandar. Second-order calibration of excitation-emission matrix fluorescence spectra for the determination of N-phenylanthranilic acid derivatives. Applied spectroscopy. 2006 Mar; 60(3):330-8. doi: 10.1366/000370206776342643. [PMID: 16608576]
  • Lata Kaphalia, Bhupendra S Kaphalia, Santosh Kumar, Mary F Kanz, Mary Treinen-Moslen. Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4'-hydroxydiclofenac in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(2):231-7. doi: 10.1016/j.jchromb.2005.10.045. [PMID: 16301007]
  • Antonella Liantonio, Alessandra Picollo, Elena Babini, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Vincenzo Tortorella, Michael Pusch, Diana Conte Camerino. Activation and inhibition of kidney CLC-K chloride channels by fenamates. Molecular pharmacology. 2006 Jan; 69(1):165-73. doi: 10.1124/mol.105.017384. [PMID: 16244177]
  • Masayuki Takahira, Mayumi Sakurai, Norimasa Sakurada, Kazuhisa Sugiyama. Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels. Pflugers Archiv : European journal of physiology. 2005 Dec; 451(3):474-8. doi: 10.1007/s00424-005-1492-5. [PMID: 16075240]
  • Graham R Betton, Kerstin Kenne, Rebecca Somers, Andrew Marr. Protein biomarkers of nephrotoxicity; a review and findings with cyclosporin A, a signal transduction kinase inhibitor and N-phenylanthranilic acid. Cancer biomarkers : section A of Disease markers. 2005; 1(1):59-67. doi: 10.3233/cbm-2005-1107. [PMID: 17192032]
  • Sabrina Sandrasagra, John E Cuffe, Emma L Regardsoe, Christoph Korbmacher. PGE2 stimulates Cl- secretion in murine M-1 cortical collecting duct cells in an autocrine manner. Pflugers Archiv : European journal of physiology. 2004 Jul; 448(4):411-21. doi: 10.1007/s00424-004-1260-y. [PMID: 15127302]
  • Antonella Liantonio, Michael Pusch, Alessandra Picollo, Patrizia Guida, Annamaria De Luca, Sabata Pierno, Giuseppe Fracchiolla, Fulvio Loiodice, Paolo Tortorella, Diana Conte Camerino. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers. Journal of the American Society of Nephrology : JASN. 2004 Jan; 15(1):13-20. doi: 10.1097/01.asn.0000103226.28798.ea. [PMID: 14694153]
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  • Rebecca E Williams, Lisa Cottrell, Matthew Jacobsen, Lasantha R Bandara, Mike D Kelly, Sandy Kennedy, Edward A Lock. 1H-Nuclear magnetic resonance pattern recognition studies with N-phenylanthranilic acid in the rat: time- and dose-related metabolic effects. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2003 Nov; 8(6):472-90. doi: 10.1080/13547500310001647030. [PMID: 15195679]
  • Zhiqiang Qu, Raymond W Wei, H Criss Hartzell. Characterization of Ca2+-activated Cl- currents in mouse kidney inner medullary collecting duct cells. American journal of physiology. Renal physiology. 2003 Aug; 285(2):F326-35. doi: 10.1152/ajprenal.00034.2003. [PMID: 12724129]
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  • John E Cuffe, Dominic P J Howard, Marko Bertog, Christoph Korbmacher. Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells. Pflugers Archiv : European journal of physiology. 2002 Dec; 445(3):381-9. doi: 10.1007/s00424-002-0878-x. [PMID: 12466941]
  • Chia-Mei Wang, Yuan-Yi Chang, Jon-Son Kuo, Synthia H Sun. Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism. Glia. 2002 Jan; 37(1):8-18. doi: 10.1002/glia.10004. [PMID: 11746779]
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