Tambulin (BioDeep_00000007930)

 

Secondary id: BioDeep_00000270752

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

化学式: C18H16O7 (344.0896)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(OC)=C(OC)C2OC(C3C=CC(OC)=CC=3)=C(O)C(=O)C=2C(O)=C1
InChI: InChI=1S/C18H16O7/c1-22-10-6-4-9(5-7-10)16-15(21)14(20)13-11(19)8-12(23-2)17(24-3)18(13)25-16/h4-8,19,21H,1-3H3

描述信息

Tambulin, also known as herbacetin 7,8,4-trimethyl ether, is a member of the class of compounds known as flavonols. Flavonols are compounds that contain a flavone (2-phenyl-1-benzopyran-4-one) backbone carrying a hydroxyl group at the 3-position. Thus, tambulin is considered to be a flavonoid lipid molecule. Tambulin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Tambulin can be found in sunflower, which makes tambulin a potential biomarker for the consumption of this food product.

同义名列表

5 个代谢物同义名

3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 3,5-Dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) chromen-4-one; Herbacetin 7,8,4-trimethyl ether; Tambulin; Tambulin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BCL2, HDAC1, HTT, PRKX, PTGS2, SNCA
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 5 BCL2, HDAC1, HTT, PRKX, SNCA
autophagosome 1 HTT
cytosol 5 BCL2, GMPS, HDAC1, HTT, SNCA
dendrite 1 HTT
nucleoplasm 3 HDAC1, HTT, PRKX
Cell membrane 1 HTT
Cell projection, axon 1 SNCA
Multi-pass membrane protein 1 HTT
Synapse 2 HTT, SNCA
cell cortex 1 SNCA
Golgi apparatus 1 HTT
Golgi membrane 1 INS
growth cone 1 SNCA
neuronal cell body 2 HDAC1, SNCA
postsynapse 1 SNCA
presynaptic membrane 1 HTT
Cytoplasm, cytosol 1 GMPS
Lysosome 1 SNCA
plasma membrane 3 HTT, KNG1, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 2 BCL2, SNCA
axon 2 HTT, SNCA
caveola 1 PTGS2
extracellular exosome 1 KNG1
endoplasmic reticulum 3 BCL2, HTT, PTGS2
extracellular space 3 INS, KNG1, SNCA
perinuclear region of cytoplasm 2 HTT, SNCA
mitochondrion 2 BCL2, SNCA
protein-containing complex 5 BCL2, HDAC1, HTT, PTGS2, SNCA
Microsome membrane 1 PTGS2
Secreted 2 INS, SNCA
extracellular region 3 INS, KNG1, SNCA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
actin cytoskeleton 1 SNCA
Early endosome 1 HTT
postsynaptic membrane 1 HTT
heterochromatin 1 HDAC1
Membrane raft 1 HTT
pore complex 1 BCL2
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
collagen-containing extracellular matrix 1 KNG1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 2 HTT, PTGS2
chromatin 1 HDAC1
supramolecular fiber 1 SNCA
centriole 1 HTT
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
Endomembrane system 1 HTT
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 HTT
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 INS, KNG1, PTGS2
transcription repressor complex 1 HDAC1
platelet alpha granule lumen 1 KNG1
axon terminus 1 SNCA
histone deacetylase complex 1 HDAC1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
NuRD complex 1 HDAC1
Sin3-type complex 1 HDAC1
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
inclusion body 2 HTT, SNCA
BAD-BCL-2 complex 1 BCL2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT


文献列表

  • Taruna Pandey, Shreesh Raj Sammi, Zulfa Nooreen, Anjali Mishra, Ateeque Ahmad, Rabi S Bhatta, Rakesh Pandey. Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans. Experimental gerontology. 2019 06; 120(?):50-61. doi: 10.1016/j.exger.2019.02.016. [PMID: 30825547]
  • Muhammad Naveed Mushtaq, Sushmita Ghimire, Alamgeer, Muhammad Shoaib Akhtar, Achyut Adhikari, Cyril Auger, Valérie B Schini-Kerth. Tambulin is a major active compound of a methanolic extract of fruits of Zanthoxylum armatum DC causing endothelium-independent relaxations in porcine coronary artery rings via the cyclic AMP and cyclic GMP relaxing pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):163-170. doi: 10.1016/j.phymed.2018.09.020. [PMID: 30668395]