(E,E)-Trichostachine (BioDeep_00000007926)

 

Secondary id: BioDeep_00000399847

human metabolite Endogenous natural product


代谢物信息卡片


(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)penta-2,4-dien-1-one

化学式: C16H17NO3 (271.1208)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(endogenous) 4.5%

分子结构信息

SMILES: C(=C\c1ccc2c(c1)OCO2)/C=C/C(=O)N1CCCC1
InChI: InChI=1S/C16H17NO3/c18-16(17-9-3-4-10-17)6-2-1-5-13-7-8-14-15(11-13)20-12-19-14/h1-2,5-8,11H,3-4,9-10,12H2/b5-1+,6-2+

描述信息

(E,E)-Trichostachine is found in herbs and spices. (E,E)-Trichostachine is an alkaloid from Piper nigrum (pepper
Alkaloid from Piper nigrum (pepper). (E,E)-Trichostachine is found in herbs and spices and pepper (spice).

同义名列表

8 个代谢物同义名

(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)penta-2,4-dien-1-one; (2E,4E)-5-(1,3-Benzodioxol-5-yl)-1-(1-pyrrolidinyl)-2,4-pentadien-1-one; 1-Piperoyl-(e,e)-pyrrolidine; 1-Piperoylpyrrolidine; (E,E)-Trichostachine; Trichostachine; Piperyline; Piperyline



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

34 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BCL2L1, BDNF, BGLAP, CAT, PTGS2, PTK2, RUNX2, SRARP
Peripheral membrane protein 2 PTGS2, PTK2
Endoplasmic reticulum membrane 3 HMOX1, PTGS2, SPP1
Mitochondrion membrane 1 BCL2L1
Nucleus 5 GABPA, HMOX1, PTK2, RUNX2, SRARP
cytosol 6 BCL2L1, CAT, GSR, HMOX1, PTK2, RUNX2
dendrite 2 BDNF, BGLAP
centrosome 2 BCL2L1, PTK2
nucleoplasm 3 GABPA, HMOX1, RUNX2
Cell membrane 2 PTK2, SPP1
Cytoplasmic side 3 BCL2L1, HMOX1, PTK2
Multi-pass membrane protein 1 SPP1
cell cortex 1 PTK2
Golgi apparatus 1 SPP1
mitochondrial inner membrane 1 BCL2L1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 BCL2L1
plasma membrane 2 PTK2, SPP1
synaptic vesicle membrane 1 BCL2L1
Membrane 3 BDNF, CAT, HMOX1
axon 1 BDNF
caveola 1 PTGS2
extracellular exosome 3 CAT, GSR, SPP1
endoplasmic reticulum 3 BCL2L1, HMOX1, PTGS2
extracellular space 4 BDNF, BGLAP, HMOX1, SPP1
perinuclear region of cytoplasm 4 BDNF, HMOX1, PTK2, SPP1
mitochondrion 3 BCL2L1, CAT, GSR
protein-containing complex 2 CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, PTK2
Microsome membrane 1 PTGS2
Secreted 3 BDNF, BGLAP, SPP1
extracellular region 4 BDNF, BGLAP, CAT, SPP1
Mitochondrion outer membrane 1 BCL2L1
Single-pass membrane protein 1 BCL2L1
mitochondrial outer membrane 2 BCL2L1, HMOX1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 3 BCL2L1, CAT, GSR
anchoring junction 1 PTK2
transcription regulator complex 1 RUNX2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, PTK2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 1 BCL2L1
Bcl-2 family protein complex 1 BCL2L1
nuclear membrane 1 BCL2L1
external side of plasma membrane 1 GSR
dendritic spine 1 PTK2
perikaryon 1 BGLAP
vesicle 1 BGLAP
Cytoplasm, perinuclear region 1 PTK2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 2 CAT, PTK2
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 PTK2
chromatin 2 GABPA, RUNX2
cell projection 2 PTK2, SPP1
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
Cytoplasm, cell cortex 1 PTK2
stress fiber 1 PTK2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 4 BDNF, BGLAP, PTGS2, SPP1
Single-pass type IV membrane protein 1 HMOX1
catalase complex 1 CAT
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Lara Dürr, Tanja Hell, Maciej Dobrzyński, Alberto Mattei, Anika John, Nathanja Augsburger, Gloria Bradanini, Jakob K Reinhardt, Florian Rossberg, Milos Drobnjakovic, Mahabir P Gupta, Matthias Hamburger, Olivier Pertz, Eliane Garo. High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of natural products. 2022 04; 85(4):1006-1017. doi: 10.1021/acs.jnatprod.1c01154. [PMID: 35231173]
  • Janine Zaugg, Igor Baburin, Barbara Strommer, Hyun-Jung Kim, Steffen Hering, Matthias Hamburger. HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site. Journal of natural products. 2010 Feb; 73(2):185-91. doi: 10.1021/np900656g. [PMID: 20085307]
  • Kun Wei, Wei Li, Kazuo Koike, Yuping Pei, Yingjie Chen, Tamotsu Nikaido. New amide alkaloids from the roots of Piper nigrum. Journal of natural products. 2004 Jun; 67(6):1005-9. doi: 10.1021/np030475e. [PMID: 15217283]
  • J Watkins, A Padfield, J D Alderson. Underlying immunopathology as a cause of adverse responses to two intravenous anaesthetic agents. British medical journal. 1978 May; 1(6121):1180-1. doi: 10.1136/bmj.1.6121.1180. [PMID: 638678]