1-Hexacosanol (BioDeep_00000007796)

human metabolite blood metabolite

代谢物信息卡片

1-Hexacosanol, aluminum (1:3) salt

化学式: C26H54O (382.41744339999997)
中文名称: 1-二十六烷醇
谱图信息: 最多检出来源 Viridiplantae(plant) 66.67%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCO
InChI: InChI=1S/C26H54O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27/h27H,2-26H2,1H3

描述信息

同义名列表

8 个代谢物同义名

1-Hexacosanol, aluminum (1:3) salt; Hexacosyl alcohol; Cerylic alcohol; hexacosan-1-ol; N-Hexacosanol; Ceryl alcohol; 1-Hexacosanol; Cerotin

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:28415
KEGG: C08381
PubChem: 68171
HMDB: HMDB0243887
Metlin: METLIN36460
Wikipedia: 1-Hexacosanol
KNApSAcK: C00001255
chemspider: 61478
CAS: 506-52-5
PMhub: MS000021279
PubChem: 10577
LipidMAPS: LMFA05000002
NIKKAJI: J6.230H

分类词条

Fatty alcohols

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

90 个相关的物种来源信息

282722 - Achillea biebersteinii: 10.1021/NP50034A041
29722 - Amaranthus tricolor: 10.1006/BIOO.1993.1007
446974 - Andrachne rotundifolia: 10.1007/BF00568228
300987 - Andrachne telephioides: 10.1007/BF00568228
301693 - Annona squamosa: 10.1006/BIOO.1993.1007
35608 - Artemisia annua: 10.1055/S-0028-1097659
124943 - Azadirachta indica:
72182 - Bocconia frutescens: 10.1139/V65-086
2200776 - Bocconia latisepala: 10.1139/V65-086
45325 - Bombax ceiba: 10.1055/S-0028-1097643
53003 - Buckiella undulata: 10.1016/S0031-9422(00)97390-4
389630 - Calamagrostis arundinacea: 10.3891/ACTA.CHEM.SCAND.30B-0786
41496 - Calendula officinalis: 10.1135/CCCC19610890
53852 - Cassia fistula: 10.1002/JCCS.200100154
508996 - Cassia javanica: 10.1055/S-0028-1097852
54785 - Ceanothus velutinus: 10.1016/S0031-9422(00)97178-4
1526916 - Chamaecrista pumila: 10.1016/S0378-8741(97)00091-3
169569 - Chrysactinia mexicana: 10.1016/S0031-9422(00)88564-7
37490 - Clematis vitalba: 10.1039/CT9140501845
4123 - Convolvulus arvensis: 10.1002/JPS.2600620431
1329283 - Convolvulus microphyllus: 10.1515/ZNB-1978-0231
267599 - Convolvulus prostratus: 10.1515/ZNB-1978-0231
483232 - Coscinium fenestratum: 10.1002/ARDP.19302680505
140997 - Crataegus monogyna: 10.1016/S0021-9673(96)01091-6
52844 - Cryptolepis nigrescens: 10.1002/JPS.2600641019
66014 - Cymbopogon citratus: 10.1055/S-0028-1097851
570484 - Diospyros ebenum: 10.1016/S0031-9422(01)00006-1
413755 - Diospyros malabarica: 10.1016/S0031-9422(00)97175-9
1948899 - Diospyros melanoxylon: 10.1007/BF03046367
233684 - Diploknema butyracea: 10.1055/S-2007-969483
73871 - Dolichandra unguis-cati: 10.1021/NP50037A031
2708827 - Erythrina mildbraedii: 10.1016/S0014-2999(03)01664-9
119951 - Eugenia uniflora: 10.1055/S-0028-1097540
457242 - Euphorbia corollata: 10.1016/S0031-9422(00)85784-2
3993 - Euphorbia esula: 10.1002/JPS.2600570604
154995 - Euphorbia piscatoria: 10.1055/S-2006-959579
1046501 - Euphorbia polygonifolia: 10.1016/S0031-9422(00)85859-8
482938 - Euphorbia pseudocactus: 10.1016/0031-9422(90)80134-3
464037 - Festuca argentina:
1504337 - Festuca hieronymi: 10.1016/0305-1978(96)00011-7
182117 - Ficus macrophylla: 10.1071/CH9650226
1009471 - Ficus pandurata: 10.1080/14786410902757899
201509 - Gmelina arborea: 10.1055/S-0028-1097561
3635 - Gossypium hirsutum: 10.1086/333834
1604314 - Gynura japonica: 10.1002/JCCS.200400211
147773 - Haplopappus foliosus: 10.1016/0031-9422(73)80397-8
106681 - Helinus integrifolius: 10.1039/CT9201700140
47605 - Hibiscus: 10.1007/BF00573559
229543 - Hibiscus cannabinus: 10.1002/1099-1565(200011/12)11:6<345::AID-PCA540>3.0.CO;2-T
63066 - Holoptelea integrifolia: 10.1055/S-0028-1099406
9606 - Homo sapiens: -
65561 - Hypericum perforatum: 10.1021/NP50030A025
318058 - Ixeris chinensis: 10.4268/CJCMM20131021
1519174 - Ixeris japonica: 10.1248/YAKUSHI1947.103.3_356
1239738 - Jasminum azoricum: 10.1021/NP50034A036
84810 - Jasminum fluminense: 10.1021/NP50034A036
75948 - Lactuca saligna: 10.3109/13880209209054625
313081 - Lathyrus davidii: 10.4268/CJCMM20100813
86643 - Leucophyllum frutescens: 10.1055/S-0028-1099866
2879286 - Leucophyllum texanum: 10.1055/S-0028-1099866
475890 - Lithodora fruticosa: 10.1021/NP50034A043
566153 - Lonicera quinquelocularis: 10.1016/S0031-9422(99)00426-4
317856 - Madhuca longifolia: 10.1016/S0031-9422(00)90058-X
463330 - Mallotus metcalfianus: 10.1016/J.PHYTOCHEM.2008.10.008
353996 - Mansoa alliacea: 10.1006/BIOO.1993.1007
3538 - Mirabilis jalapa: 10.1135/CCCC19760295
43879 - Peganum harmala: 10.1007/S10600-006-0086-6
51475 - Phormium tenax: 10.1021/NP50052A039
58046 - Platycladus orientalis: 10.1002/JCCS.199900110
1504338 - Poa huecu: 10.1021/NP50052A040
1224216 - Polygonum recumbens: 10.1016/S0031-9422(00)97297-2
73824 - Populus balsamifera: 10.1515/ZNC-1989-5-603
1616482 - Populus candicans: 10.1515/ZNC-1989-5-603
3693 - Populus tremuloides: 10.1139/B91-288
102697 - Prosopis glandulosa: 10.1055/S-0028-1097595
32242 - Prunus laurocerasus: 10.1016/0031-9422(96)00241-5
23207 - Prunus serotina: 10.1039/CT9109701099
470525 - Pyrus pashia: 10.1016/S0031-9422(00)97297-2
4202 - Sambucus nigra:
796159 - Sidera lenis: 10.1055/S-0028-1097438
50193 - Sonchus asper: 10.1135/CCCC19793391
126913 - Suaeda maritima: 10.1002/JPS.3030350906
1735025 - Suaeda nudiflora: 10.1002/JPS.3030350906
44982 - Tacca plantaginea: 10.1016/0031-9422(88)80711-8
4588 - Thinopyrum elongatum: 10.1016/0031-9422(83)80097-1
320161 - Tortella inclinata: 10.1016/S0031-9422(00)97390-4
261649 - Tragopogon orientalis: 10.5586/ASBP.1988.008
41653 - Tragopogon pratensis: 10.5586/ASBP.1988.008
4407 - Trochodendron aralioides: 10.1248/YAKUSHI1947.91.4_492
264981 - Ziziphus spina-christi: 10.21608/BFSA.1985.75704

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Ji Hae Lee, Yaoyao Jia, Trung Thanh Thach, Yuri Han, Bobae Kim, Chunyan Wu, Yeonji Kim, Woo Duck Seo, Sung-Joon Lee. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. Nutrition research (New York, N.Y.). 2017 Jul; 43(?):89-99. doi: 10.1016/j.nutres.2017.05.013. [PMID: 28676202]
Sriramya Gade, Maheshwari Rajamanikyam, Varahalarao Vadlapudi, Krishna Madhav Nukala, Rajendar Aluvala, Chandrasekhar Giddigari, Naga Jyothi Karanam, Nabin C Barua, Richa Pandey, Vijaya Saradhi V Upadhyayula, Prabhakar Sripadi, Ramars Amanchy, Suryanarayana Murty Upadhyayula. Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata. Biochimica et biophysica acta. General subjects. 2017 Mar; 1861(3):541-550. doi: 10.1016/j.bbagen.2016.11.044. [PMID: 27916676]
Anderson Marques de Oliveira, Lucia M Conserva, Jamylle N De Souza Ferro, Fabíola de Almeida Brito, Rosângela P Lyra Lemos, Emiliano Barreto. Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice. International journal of molecular sciences. 2012; 13(2):1598-1611. doi: 10.3390/ijms13021598. [PMID: 22408410]
P Daisy, K Saipriya. Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus. International journal of nanomedicine. 2012; 7(?):1189-202. doi: 10.2147/ijn.s26650. [PMID: 22419867]
Dong Min Jung, Mi Jin Lee, Suk Hoo Yoon, Mun Yhung Jung. A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. Journal of food science. 2011 Aug; 76(6):C891-9. doi: 10.1111/j.1750-3841.2011.02232.x. [PMID: 22417487]
Xiang-Gang Zhang, Wen-Qiang Yan, Yan-Ting Lin, Xiao-Jing Liu, Xiao-Yan Lin, Yong-Hong Zhang. [Studies on the diterpenoids of Wedelia prostrata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Mar; 34(3):383-6. doi: . [PMID: 21823454]
Khozirah Shaari, Seema Zareen, Muhammad Nadeem Akhtar, Nordin Hj Lajis. Chemical constituents of Melicope ptelefolia. Natural product communications. 2011 Mar; 6(3):343-8. doi: . [PMID: 21485271]
Anton Hansjakob, Sebastian Bischof, Gerhard Bringmann, Markus Riederer, Ulrich Hildebrandt. Very-long-chain aldehydes promote in vitro prepenetration processes of Blumeria graminis in a dose- and chain length-dependent manner. The New phytologist. 2010 Dec; 188(4):1039-54. doi: 10.1111/j.1469-8137.2010.03419.x. [PMID: 20731784]
Faouzi Sakouhi, Christelle Absalon, Guido Flamini, Pier Luigi Cioni, Habib Kallel, Sadok Boukhchina. Lipid components of olive oil from Tunisian Cv. Sayali: characterization and authenticity. Comptes rendus biologies. 2010 Sep; 333(9):642-8. doi: 10.1016/j.crvi.2010.05.001. [PMID: 20816644]
Amanda K Broz, Corey D Broeckling, Clelia De-la-Peña, Matthew R Lewis, Erick Greene, Ragan M Callaway, Lloyd W Sumner, Jorge M Vivanco. Plant neighbor identity influences plant biochemistry and physiology related to defense. BMC plant biology. 2010 Jun; 10(?):115. doi: 10.1186/1471-2229-10-115. [PMID: 20565801]
Berit Ebert, Daniela Zöller, Alexander Erban, Ines Fehrle, Jürgen Hartmann, Annette Niehl, Joachim Kopka, Joachim Fisahn. Metabolic profiling of Arabidopsis thaliana epidermal cells. Journal of experimental botany. 2010 Mar; 61(5):1321-35. doi: 10.1093/jxb/erq002. [PMID: 20150518]
Nurhan T Dunford, Jeff Edwards. Nutritional bioactive components of wheat straw as affected by genotype and environment. Bioresource technology. 2010 Jan; 101(1):422-5. doi: 10.1016/j.biortech.2009.08.009. [PMID: 19716291]
Anna Ringelmann, Michael Riedel, Markus Riederer, Ulrich Hildebrandt. Two sides of a leaf blade: Blumeria graminis needs chemical cues in cuticular waxes of Lolium perenne for germination and differentiation. Planta. 2009 Jun; 230(1):95-105. doi: 10.1007/s00425-009-0924-4. [PMID: 19352695]
Anna Lytovchenko, Romina Beleggia, Nicolas Schauer, Tal Isaacson, Jan E Leuendorf, Hanjo Hellmann, Jocelyn Kc Rose, Alisdair R Fernie. Application of GC-MS for the detection of lipophilic compounds in diverse plant tissues. Plant methods. 2009 Apr; 5(?):4. doi: 10.1186/1746-4811-5-4. [PMID: 19393072]
Angeles Fernández-Arche, Ana Marquez-Martín, Rocío de la Puerta Vazquez, Javier S Perona, Carmen Terencio, Carmen Perez-Camino, Valentina Ruiz-Gutierrez. Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators. The Journal of nutritional biochemistry. 2009 Mar; 20(3):155-62. doi: 10.1016/j.jnutbio.2008.01.007. [PMID: 18555679]
M A Ramadan, A S Ahmad, A M Nafady, A I Mansour. Chemical composition of the stem bark and leaves of Ficus pandurata Hance. Natural product research. 2009; 23(13):1218-30. doi: 10.1080/14786410902757899. [PMID: 19731141]
Shinichi Okada, Motoaki Saito, Emi Kazuyama, Takuya Hanada, Yasuo Kawaba, Atsushi Hayashi, Keisuke Satoh, Susumu Kanzaki. Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy. Molecular and cellular biochemistry. 2008 Aug; 315(1-2):169-77. doi: 10.1007/s11010-008-9804-7. [PMID: 18528636]
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Yoshiji Ohta, Koji Ohashi, Tatsuya Matsura, Kenji Tokunaga, Akira Kitagawa, Kazuo Yamada. Octacosanol attenuates disrupted hepatic reactive oxygen species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. Journal of clinical biochemistry and nutrition. 2008 Mar; 42(2):118-25. doi: 10.3164/jcbn.2008017. [PMID: 18385828]
Teng Peng, Yong-qin Tu, Yun Deng, Xu Zhang. [Studies on chemical constituents of Primula sikkmensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2008 Jan; 31(1):44-6. doi: . [PMID: 18589747]
Vanessa Zabka, Michaela Stangl, Gerhard Bringmann, Gerd Vogg, Markus Riederer, Ulrich Hildebrandt. Host surface properties affect prepenetration processes in the barley powdery mildew fungus. The New phytologist. 2008; 177(1):251-263. doi: 10.1111/j.1469-8137.2007.02233.x. [PMID: 17937760]
Mark A Teece, Thomas Zengeya, Timothy A Volk, Lawrence B Smart. Cuticular wax composition of Salix varieties in relation to biomass productivity. Phytochemistry. 2008 Jan; 69(2):396-402. doi: 10.1016/j.phytochem.2007.08.015. [PMID: 17900636]
Nizar Nasri, Bruno Fady, Saïda Triki. Quantification of sterols and aliphatic alcohols in Mediterranean stone pine (Pinus pinea L.) populations. Journal of agricultural and food chemistry. 2007 Mar; 55(6):2251-5. doi: 10.1021/jf062911j. [PMID: 17309279]
Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Hiroto Suzuki, Masashi Yamada, Takeshi Watanabe, Keisuke Satoh. Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. European urology. 2007 Feb; 51(2):479-87; discussion 487. doi: 10.1016/j.eururo.2006.06.024. [PMID: 16842904]
Chiko Shinbori, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Tomoharu Kono, Takuya Hanada, Eiji Nanba, Kaori Adachi, Hiroto Suzuki, Masashi Yamada, Keisuke Satoh. N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat. European journal of pharmacology. 2006 Sep; 545(2-3):177-84. doi: 10.1016/j.ejphar.2006.06.043. [PMID: 16872599]
Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Tomoharu Kono, Takuya Hanada, Jiro Uemasu, Hiroto Suzuki, Masashi Yamada, Keisuke Satoh. N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy. European journal of pharmacology. 2006 Aug; 544(1-3):132-7. doi: 10.1016/j.ejphar.2006.06.001. [PMID: 16859672]
Hiroto Suzuki, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Tomoharu Kono, Chiko ShinBori, Sylakos Anastasios, Masashi Yamada, Keisuke Satoh. Preventive effects of cyclohexenonic long-chain fatty alcohol on diabetic cystopathy in the rat. Canadian journal of physiology and pharmacology. 2006 Feb; 84(2):195-201. doi: 10.1139/y05-114. [PMID: 16900945]
Takuya Hanada, Motoaki Saito, Susumu Kanzaki. Treatment with cyclohexenonic long-chain fatty alcohol reverses diabetes-induced tracheal dysfunction in the rat. Pharmacology. 2006; 78(2):51-60. doi: 10.1159/000095120. [PMID: 16912516]
Pilar López, José Martiń. Age related differences in lipophilic compounds found in femoral gland secretions of male spiny-footed lizards, Acanthodactylus erythrurus. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Nov; 60(11-12):915-20. doi: 10.1515/znc-2005-11-1215. [PMID: 16402553]
Franka Gniwotta, Gerd Vogg, Vanessa Gartmann, Tim L W Carver, Markus Riederer, Reinhard Jetter. What do microbes encounter at the plant surface? Chemical composition of pea leaf cuticular waxes. Plant physiology. 2005 Sep; 139(1):519-30. doi: 10.1104/pp.104.053579. [PMID: 16113231]
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David Nash, Rhys Leeming, Leigh Clemow, Murray Hannah, David Halliwell, David Allen. Quantitative determination of sterols and other alcohols in overland flow from grazing land and possible source materials. Water research. 2005 Aug; 39(13):2964-78. doi: 10.1016/j.watres.2005.04.063. [PMID: 15998530]
Sibel Irmak, Nurhan Turgut Dunford. Policosanol contents and compositions of wheat varieties. Journal of agricultural and food chemistry. 2005 Jul; 53(14):5583-6. doi: 10.1021/jf050508r. [PMID: 15998118]
I El-Gibaly, S K Abdel-Ghaffar. Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation. International journal of pharmaceutics. 2005 Apr; 294(1-2):33-51. doi: 10.1016/j.ijpharm.2004.12.027. [PMID: 15814229]
Yuguang Lin, Mike Rudrum, Reggy P J van der Wielen, Elke A Trautwein, Gerald McNeill, Aafje Sierksma, Gert W Meijer. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism: clinical and experimental. 2004 Oct; 53(10):1309-14. doi: 10.1016/j.metabol.2004.05.006. [PMID: 15375787]
B Singh, S Singh. Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. Phytotherapy research : PTR. 2003 Aug; 17(7):814-6. doi: 10.1002/ptr.1202. [PMID: 12916085]
Ji-ren Lii, Xiu-fen Gao, Tie-min Ai, Yu-ying Zhao. [Lipid compounds from Echinacea purpurea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Jan; 27(1):40-2. doi: ". [PMID: 12774354]
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